TechnoFunctional
Nov 10, 5:55 PM
$ABVX has identified α4β7 as its leading candidate mechanism for an Obefazimod combination, they will confirm their molecule for combo before JPM in Jan 27.
Following companies have developed molecules that inhibit α4β7
$LLY Zotemtegrast (MORF-057 / LY4268989)
$GILD Emvistegrast (GS-1427) — an oral, once-daily α4β7 inhibitor
$ABBV ABBV-382 — an anti-α4β7 monoclonal antibody
$SNY HXN-1002 — a bispecific antibody targeting both TL1A and α4β7.
For a company that already owns an α4β7 molecule, acquiring Abivax could potentially create a combination franchise with two complementary mechanisms.
Lilly is particularly interesting here. It already owns an oral α4β7 inhibitor and is actively testing it in combination with mirikizumab. Adding obefazimod could give Lilly another potential combination option, with a different mechanism from both drugs.
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