Dec. 25 at 9:02 PM
$SLS A few biostatistician experts on this board have proven by running numerous GPS trial modeling using the publicly available data announced by Sellas since 2022. One statistically significant combination number is 39 BAT/21 GPS. I was told this could have triggered HALT in Jan 2025 during the IA, and the expert’s assumption is the actual combination was close to 38/22.
Now after reading this 3-year old post from Sellas saying the GPS P3 trial “could PARALLEL these findings”, and back to the REGAL trial, could this potentially suggest GPS was so successful and the patients on the GPS arm mostly survived after the BAT arm failed miserably at the 60th event in Dec 2024, such as 50 BAT/ 10 GPS in a wild guess (maybe not wild at all), which should have triggered the HALT. The reason, as the expert told me, could be that SELLAS simply wants to prove how far GPS can go for the CR2 patients. If true, that is a real “parallel finding” as the company said 3 years ago. THAT will be WILD.
