Jul. 9 at 4:31 PM
Wild - last time
$GSK moved off an alzheimer drug was on May 13, 2025 -- cancelling iTeos partnership that was 625 million upfront 1.45 billion in milestones and tiered royalties.
The very next day May 14, 2025 GSK announced a 2B acquisition of a drug from Boston pharma (1.2 billion upfront and 800 million milestones)
Why can't GSK
$SPRO agree to an upfront value for Uztebi on a "base case" NPV of say
$1.5 billion PYS -- to get to a ~
$600 million upfront number and keep 10-12% royalty on sales over
$1.5 billion so SPRO NewCo still participates in tebi upside. GSK would have to pay Meiji license up to 1.5 billion, then SPRO would handle it over 1.5 billion?
Could always buy out the remainder later.
Solves problem of getting SPRO cash upfront, retaining some upside for SPRO and giving GSK some certainty/lower risk by only doing base case upfront.
One in one out strategy I guess.