Market Cap 13.26B
Revenue (ttm) 705.14M
Net Income (ttm) -453.90M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -64.37%
Debt to Equity Ratio 0.00
Volume 2,317,800
Avg Vol 2,543,904
Day's Range N/A - N/A
Shares Out 161.97M
Stochastic %K 83%
Beta 0.30
Analysts Strong Sell
Price Target $84.09

Company Profile

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treat...

Industry: Biotechnology
Sector: Healthcare
Phone: 760 931 9200
Address:
2855 Gazelle Court, Carlsbad, United States
Iightning
Iightning Dec. 5 at 2:04 AM
1ightning® Premium Options Alert (Actionable) Ticker: $IONS Contract: Dec 19 $85C Entry: 1.52 Exit: 2.71 Return: +77.93% ROI Unlock VIP Access → https://1ightning.com
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Iightning
Iightning Dec. 4 at 8:36 PM
1ightning® Premium Options Alert (Actionable) Ticker: $IONS Contract: Dec 19 $85C Entry: 1.52 Exit: 2.71 Return: +77.93% ROI Unlock VIP Access → https://1ightning.com
0 · Reply
johnnygogogo
johnnygogogo Dec. 4 at 2:17 PM
$ARWR $IONS Monte Carlo https://ir.arrowheadpharma.com/static-files/a0dcc705-2870-4fae-bdf2-03cc588c08da
1 · Reply
Iightning
Iightning Dec. 4 at 4:19 AM
1ightning® Premium Options Alert (Actionable) Ticker: $IONS Contract: Dec 19 $82.5C Entry: 2.82 Exit: 5.24 Return: +85.34% ROI Unlock VIP Access → https://1ightning.com
0 · Reply
BillionerOfKing
BillionerOfKing Dec. 3 at 8:39 PM
$IONS Current Stock Price: $82.51 Contracts to trade: $80 IONS Dec 19 2025 Call Entry: $2.85 Exit: $3.93 ROI: 38% Hold ~23 days Shared as daily free alerts and for educational purposes only. https://dailypickai.com/freealerts
0 · Reply
Quantumup
Quantumup Dec. 3 at 1:45 PM
TD Cowen Named $IONS a 2026 Best Idea, reiterated at a Buy, a $99 PT and said, Best Ideas 2026: New Launches And Key Pipeline Catalysts To Drive Upside $ARWR $TAK BCRX NVS $RHHBY - $PTCT TD Cowen added, We see robust sales growth in FY26 driven by Tryngolza in sHTG, Dawnzera in HAE, zilganersen in AxD, and incremental Spinraza growth. Key Ph3 data in '26 include Wainua in TTR-CM (H2) & pelacarsen in Lp(a) (H1). We see upside from overlooked catalysts: Ph3 bepi in HBV (H1), Ph2 BIIB080 in AD (mid-'26). RARE's GTX-102 Ph3 in Angelman (H2) should clarify ION582's future in this multi-$ B market.
0 · Reply
Quantumup
Quantumup Dec. 3 at 1:13 PM
H.C. Wainwright⬆️ $ARWR's PT to $85 from $80 and reiterated at a Buy rating. $IONS $REGN $ALNY $NVS Here's what H.C. Wainwright had to say in its note to investors: https://x.com/Quantumup1/status/1996204804981313869?s=20
0 · Reply
Iightning
Iightning Dec. 3 at 8:48 AM
1ightning® Premium Options Alert (Actionable) Ticker: $IONS Contract: Dec 19 $50C Entry: 21.90 Exit: 40.73 Return: +85.98% ROI Unlock VIP Access → https://1ightning.com
0 · Reply
johnnygogogo
johnnygogogo Dec. 3 at 5:14 AM
$ARWR $IONS World Congress of Insulin Resistance, Diabetes and Cardiovascular Disease (WCIRDC) – December 4-6, 2025 “Title: A Monte Carlo Simulation Comparing TG Lowering with Plozasiran versus Olezarsan in Patients with FCS Presenter: Nihar Desai”
0 · Reply
OpenOutcrier
OpenOutcrier Dec. 2 at 1:44 PM
$IONS (+0.6% pre) Ionis (Nasdaq: IONS) nets FDA Breakthrough status, eyes Q1 2026 NDA for AxD https://ooc.bz/l/85925
0 · Reply
Latest News on IONS
Biogen Completes Acquisition of Alcyone Therapeutics

Nov 14, 2025, 4:05 PM EST - 20 days ago

Biogen Completes Acquisition of Alcyone Therapeutics

BIIB


Ionis to present at upcoming investor conferences

Nov 12, 2025, 4:00 PM EST - 22 days ago

Ionis to present at upcoming investor conferences


Ionis to hold third quarter 2025 financial results webcast

Oct 16, 2025, 7:05 AM EDT - 7 weeks ago

Ionis to hold third quarter 2025 financial results webcast


Ionis' brain disorder drug shows promise in clinical trial

Sep 22, 2025, 7:10 AM EDT - 2 months ago

Ionis' brain disorder drug shows promise in clinical trial


Ionis to host investors and analysts for Innovation Day 2025

Sep 8, 2025, 4:00 PM EDT - 3 months ago

Ionis to host investors and analysts for Innovation Day 2025


Is The 35% Rally In IONS Stock Just The Beginning?

Sep 3, 2025, 10:41 AM EDT - 3 months ago

Is The 35% Rally In IONS Stock Just The Beginning?


mRNA Biotechs - Long-Term Value Risks Abound

Aug 28, 2025, 6:20 AM EDT - 3 months ago

mRNA Biotechs - Long-Term Value Risks Abound

ALNY BNTX DHR GRAL ILMN MRNA RGEN


US FDA approves Ionis' drug for rare genetic disorder

Aug 21, 2025, 11:58 AM EDT - 3 months ago

US FDA approves Ionis' drug for rare genetic disorder


Ionis (IONS) Q2 Revenue Soars 101%

Jul 31, 2025, 12:37 PM EDT - 4 months ago

Ionis (IONS) Q2 Revenue Soars 101%


Iightning
Iightning Dec. 5 at 2:04 AM
1ightning® Premium Options Alert (Actionable) Ticker: $IONS Contract: Dec 19 $85C Entry: 1.52 Exit: 2.71 Return: +77.93% ROI Unlock VIP Access → https://1ightning.com
0 · Reply
Iightning
Iightning Dec. 4 at 8:36 PM
1ightning® Premium Options Alert (Actionable) Ticker: $IONS Contract: Dec 19 $85C Entry: 1.52 Exit: 2.71 Return: +77.93% ROI Unlock VIP Access → https://1ightning.com
0 · Reply
johnnygogogo
johnnygogogo Dec. 4 at 2:17 PM
$ARWR $IONS Monte Carlo https://ir.arrowheadpharma.com/static-files/a0dcc705-2870-4fae-bdf2-03cc588c08da
1 · Reply
Iightning
Iightning Dec. 4 at 4:19 AM
1ightning® Premium Options Alert (Actionable) Ticker: $IONS Contract: Dec 19 $82.5C Entry: 2.82 Exit: 5.24 Return: +85.34% ROI Unlock VIP Access → https://1ightning.com
0 · Reply
BillionerOfKing
BillionerOfKing Dec. 3 at 8:39 PM
$IONS Current Stock Price: $82.51 Contracts to trade: $80 IONS Dec 19 2025 Call Entry: $2.85 Exit: $3.93 ROI: 38% Hold ~23 days Shared as daily free alerts and for educational purposes only. https://dailypickai.com/freealerts
0 · Reply
Quantumup
Quantumup Dec. 3 at 1:45 PM
TD Cowen Named $IONS a 2026 Best Idea, reiterated at a Buy, a $99 PT and said, Best Ideas 2026: New Launches And Key Pipeline Catalysts To Drive Upside $ARWR $TAK BCRX NVS $RHHBY - $PTCT TD Cowen added, We see robust sales growth in FY26 driven by Tryngolza in sHTG, Dawnzera in HAE, zilganersen in AxD, and incremental Spinraza growth. Key Ph3 data in '26 include Wainua in TTR-CM (H2) & pelacarsen in Lp(a) (H1). We see upside from overlooked catalysts: Ph3 bepi in HBV (H1), Ph2 BIIB080 in AD (mid-'26). RARE's GTX-102 Ph3 in Angelman (H2) should clarify ION582's future in this multi-$ B market.
0 · Reply
Quantumup
Quantumup Dec. 3 at 1:13 PM
H.C. Wainwright⬆️ $ARWR's PT to $85 from $80 and reiterated at a Buy rating. $IONS $REGN $ALNY $NVS Here's what H.C. Wainwright had to say in its note to investors: https://x.com/Quantumup1/status/1996204804981313869?s=20
0 · Reply
Iightning
Iightning Dec. 3 at 8:48 AM
1ightning® Premium Options Alert (Actionable) Ticker: $IONS Contract: Dec 19 $50C Entry: 21.90 Exit: 40.73 Return: +85.98% ROI Unlock VIP Access → https://1ightning.com
0 · Reply
johnnygogogo
johnnygogogo Dec. 3 at 5:14 AM
$ARWR $IONS World Congress of Insulin Resistance, Diabetes and Cardiovascular Disease (WCIRDC) – December 4-6, 2025 “Title: A Monte Carlo Simulation Comparing TG Lowering with Plozasiran versus Olezarsan in Patients with FCS Presenter: Nihar Desai”
0 · Reply
OpenOutcrier
OpenOutcrier Dec. 2 at 1:44 PM
$IONS (+0.6% pre) Ionis (Nasdaq: IONS) nets FDA Breakthrough status, eyes Q1 2026 NDA for AxD https://ooc.bz/l/85925
0 · Reply
Thestocktraderhubzee
Thestocktraderhubzee Dec. 2 at 12:05 PM
$IONS The FDA Has Granted Breakthrough Therapy Designation To Ionis Pharmaceuticals' Zilganersen For Alexander Disease, On Track To Submit New Drug Application In Q1 2026
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Iightning
Iightning Dec. 1 at 10:30 PM
**1ightning® Premium Options Alert (Actionable)** **Ticker:** $IONS **Contract:** Dec 19 $82.5C **Entry:** 3.20 **Exit:** 4.33 **Return:** **+35.34% ROI** This is the level of accuracy our VIP desk delivers daily. If you want **institutional-grade scalps without the noise**, join us. **Unlock VIP Access → https://1ightning.com**
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OpenOutcrier
OpenOutcrier Dec. 1 at 1:48 PM
$IONS (+0.9% pre) Ionis receives FDA breakthrough therapy status for severe hypertriglyceridemia drug https://ooc.bz/l/85796
0 · Reply
Joe_Mama
Joe_Mama Nov. 27 at 12:51 AM
$IONS WOW. She’s a BEAST 🚀
0 · Reply
Iightning
Iightning Nov. 26 at 1:17 AM
1ightning® Options Trade Alert (Actionable) | Buy $IONS Dec 19 $80 Call | Enter: $2.50 Exit: $3.87 | Profit: 54.94% ROI | https://1ightning.com
0 · Reply
harmongreg
harmongreg Nov. 25 at 7:39 PM
added $FDX Dec 12 Exp 275/285 call spreads, $IONS Dec 82.50 calls and $W Dec 111/120 call spreads
0 · Reply
Joe_Mama
Joe_Mama Nov. 25 at 4:28 PM
$IONS ATH in the crosshairs $86
0 · Reply
BioRich
BioRich Nov. 25 at 4:27 PM
$ALT $SNY $IVA $IONS $MDGL My apologies for the PermaPumpers from the $ALT board immaturely trying to degrade anything that isn't $ALT. This guy @NotLee was Bearish on $ALT until he saw I posted, and now he wants to hate on me. To his points though: 1) Lancet Publication and AASLD Presentations highlighted that $ALT admittedly dosed a subject assigned to the Placebo group with the drug (1.2mg Pemvi) and performed an invasive test on a subject that shouldn't have received it. 2) They also highlighted that Weight Loss was less impressive than first reported in 24W top line data. 3) References to independent validation refers to unapproved AI and NITs, not validation of "actual" fibrosis improvement, which, as we know, $ALT failed miserably. 4) Dual mechanism is useless if the drug doesn't work. 5) Partners/BO speculation is driven by the $ALT ST board, not merit. $ALT has consistently said they are Going It Alone (GIA), which $ALT's recent hires with Commerical experience support.
0 · Reply
StockConsultant
StockConsultant Nov. 25 at 2:26 PM
$IONS Ionis Pharmaceuticals stock breakout
0 · Reply
Iightning
Iightning Nov. 25 at 11:24 AM
1ightning® Options Trade Alert (Actionable) | Buy $IONS Dec 19 $80 Call | Enter: $2.50 Exit: $3.87 | Profit: 54.94% ROI | https://1ightning.com
0 · Reply
Iightning
Iightning Nov. 25 at 12:19 AM
1ightning® Options Trade Alert (Actionable) | Buy $IONS Dec 19 $80 Call | Enter: $2.50 Exit: $3.87 | Profit: 54.94% ROI | https://1ightning.com
0 · Reply
johnnygogogo
johnnygogogo Nov. 24 at 6:24 PM
$ARWR Daniel Day Anzalone to $ALNY and $IONS (this GIF is too good to leave buried in another thread).
1 · Reply