Market Cap 13.39B
Revenue (ttm) 705.14M
Net Income (ttm) -453.90M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -64.37%
Debt to Equity Ratio 0.00
Volume 1,788,900
Avg Vol 2,164,366
Day's Range N/A - N/A
Shares Out 161.97M
Stochastic %K 83%
Beta 0.28
Analysts Strong Sell
Price Target $91.78

Company Profile

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treat...

Industry: Biotechnology
Sector: Healthcare
Phone: 760 931 9200
Address:
2855 Gazelle Court, Carlsbad, United States
Night_Owl_Biotech
Night_Owl_Biotech Feb. 2 at 2:17 AM
As shown on the attached graph, $KALV FY26 - FY35 analyst consensus revenue estimates are consistent with the 10-year revenue forecasts prepared by the managements of 3 peer commercial-stage bios (CTIC, KDMN & SRRA) that were acquired for enterprise values ranging from $1.7B to $1.9B within 15 months of FDA approval. Based on KALV's Q325 10Q, Sebetralstat generates competitive gross margins (91%). Our simple question, if analysts forecast Sebetralstat to generate the same sales at roughly the same gross margins, does that suggest KALV would be worth the same ($1.7 to $1.9B) if KALV is ever acquired? This is not investment advice. New drugs are generally worth some multiple and/or NPV of projected sales, so we're simply trying to understand the upside if KALV is ever acquired (i.e. competing HAE therapies). Per Seeking Alpha, KALV's market cap is ~$800MM where cash more or less = debt (so EV is about the same) $IONS $THTX $XBI $IBB NOTE: SRRA was acquired before PDUFA
1 · Reply
SuperGreenToday
SuperGreenToday Jan. 29 at 4:38 AM
$IONS Share Price: $81.94 Contract Selected: Jul 17, 2026 $80 Calls Buy Zone: $9.78 – $12.08 Target Zone: $18.58 – $22.70 Potential Upside: 79% ROI Time to Expiration: 169 Days | Updates via https://fxcapta.com/stockinfo/
0 · Reply
Dr_Stoxx
Dr_Stoxx Jan. 28 at 7:27 PM
$IONS not bad here. I've been holding a remnant from our last trade (hit our raised stop).
0 · Reply
StockConsultant
StockConsultant Jan. 28 at 1:48 PM
$IONS Ionis Pharmaceuticals stock watch for a narrow range breakout
0 · Reply
Dr_Stoxx
Dr_Stoxx Jan. 26 at 7:51 PM
$IONS our old friend...still just sitting there...a little up, a little down...
0 · Reply
Merlintrader
Merlintrader Jan. 23 at 2:17 PM
$IONS https://www.merlintrader.com/ions-ionis-pharmaceuticals/
0 · Reply
ZacksResearch
ZacksResearch Jan. 22 at 5:43 PM
EU green light for $IONS — Dawnzera just expanded its reach 🇪🇺💥 Ionis secured EU approval for Dawnzera in hereditary angioedema, following FDA clearance in the United States in August last year — regulatory momentum on both sides of the Atlantic. See what this approval means for the story 👉 https://www.zacks.com/stock/news/2821375/ionis-dawnzera-gets-eu-approval-for-hereditary-angioedema?cid=sm-stocktwits-2-2821375-teaser-30058&ADID=SYND_STOCKTWITS_TWEET_2_2821375_TEASER_30058
0 · Reply
ZacksResearch
ZacksResearch Jan. 22 at 4:43 PM
$IONS gains EU approval for Dawnzera—what's next for the stock? 🚀 The European Commission's nod for Dawnzera, backed by strong Phase III data, grants Ionis a $15M milestone and tiered royalties up to 30% on sales. Shares are up 2.5% on the news and have surged 130.5% over the past year against the industry's 3.3% fall. Discover the impact of this approval on IONS here 👉 https://www.zacks.com/stock/news/2821375/ionis-dawnzera-gets-eu-approval-for-hereditary-angioedema?cid=sm-stocktwits-2-2821375-body-30057&ADID=SYND_STOCKTWITS_TWEET_2_2821375_BODY_30057
0 · Reply
Dr_Stoxx
Dr_Stoxx Jan. 22 at 2:59 PM
$IONS STOPPED US OUT LAST WEEK IN THE LIVE TRADING ROOM BUT IT'S BACK AND LOOKING GOOD HERE.
0 · Reply
Greenamay
Greenamay Jan. 21 at 3:30 PM
$IONS https://stocks.apple.com/AOI5oTv1FQwm3Vu9wXf4qYg
0 · Reply
Latest News on IONS
Biogen Completes Acquisition of Alcyone Therapeutics

Nov 14, 2025, 4:05 PM EST - 2 months ago

Biogen Completes Acquisition of Alcyone Therapeutics

BIIB


Ionis to present at upcoming investor conferences

Nov 12, 2025, 4:00 PM EST - 2 months ago

Ionis to present at upcoming investor conferences


Ionis to hold third quarter 2025 financial results webcast

Oct 16, 2025, 7:05 AM EDT - 3 months ago

Ionis to hold third quarter 2025 financial results webcast


Ionis' brain disorder drug shows promise in clinical trial

Sep 22, 2025, 7:10 AM EDT - 4 months ago

Ionis' brain disorder drug shows promise in clinical trial


Ionis to host investors and analysts for Innovation Day 2025

Sep 8, 2025, 4:00 PM EDT - 5 months ago

Ionis to host investors and analysts for Innovation Day 2025


Is The 35% Rally In IONS Stock Just The Beginning?

Sep 3, 2025, 10:41 AM EDT - 5 months ago

Is The 35% Rally In IONS Stock Just The Beginning?


mRNA Biotechs - Long-Term Value Risks Abound

Aug 28, 2025, 6:20 AM EDT - 5 months ago

mRNA Biotechs - Long-Term Value Risks Abound

ALNY BNTX DHR GRAL ILMN MRNA RGEN


Night_Owl_Biotech
Night_Owl_Biotech Feb. 2 at 2:17 AM
As shown on the attached graph, $KALV FY26 - FY35 analyst consensus revenue estimates are consistent with the 10-year revenue forecasts prepared by the managements of 3 peer commercial-stage bios (CTIC, KDMN & SRRA) that were acquired for enterprise values ranging from $1.7B to $1.9B within 15 months of FDA approval. Based on KALV's Q325 10Q, Sebetralstat generates competitive gross margins (91%). Our simple question, if analysts forecast Sebetralstat to generate the same sales at roughly the same gross margins, does that suggest KALV would be worth the same ($1.7 to $1.9B) if KALV is ever acquired? This is not investment advice. New drugs are generally worth some multiple and/or NPV of projected sales, so we're simply trying to understand the upside if KALV is ever acquired (i.e. competing HAE therapies). Per Seeking Alpha, KALV's market cap is ~$800MM where cash more or less = debt (so EV is about the same) $IONS $THTX $XBI $IBB NOTE: SRRA was acquired before PDUFA
1 · Reply
SuperGreenToday
SuperGreenToday Jan. 29 at 4:38 AM
$IONS Share Price: $81.94 Contract Selected: Jul 17, 2026 $80 Calls Buy Zone: $9.78 – $12.08 Target Zone: $18.58 – $22.70 Potential Upside: 79% ROI Time to Expiration: 169 Days | Updates via https://fxcapta.com/stockinfo/
0 · Reply
Dr_Stoxx
Dr_Stoxx Jan. 28 at 7:27 PM
$IONS not bad here. I've been holding a remnant from our last trade (hit our raised stop).
0 · Reply
StockConsultant
StockConsultant Jan. 28 at 1:48 PM
$IONS Ionis Pharmaceuticals stock watch for a narrow range breakout
0 · Reply
Dr_Stoxx
Dr_Stoxx Jan. 26 at 7:51 PM
$IONS our old friend...still just sitting there...a little up, a little down...
0 · Reply
Merlintrader
Merlintrader Jan. 23 at 2:17 PM
$IONS https://www.merlintrader.com/ions-ionis-pharmaceuticals/
0 · Reply
ZacksResearch
ZacksResearch Jan. 22 at 5:43 PM
EU green light for $IONS — Dawnzera just expanded its reach 🇪🇺💥 Ionis secured EU approval for Dawnzera in hereditary angioedema, following FDA clearance in the United States in August last year — regulatory momentum on both sides of the Atlantic. See what this approval means for the story 👉 https://www.zacks.com/stock/news/2821375/ionis-dawnzera-gets-eu-approval-for-hereditary-angioedema?cid=sm-stocktwits-2-2821375-teaser-30058&ADID=SYND_STOCKTWITS_TWEET_2_2821375_TEASER_30058
0 · Reply
ZacksResearch
ZacksResearch Jan. 22 at 4:43 PM
$IONS gains EU approval for Dawnzera—what's next for the stock? 🚀 The European Commission's nod for Dawnzera, backed by strong Phase III data, grants Ionis a $15M milestone and tiered royalties up to 30% on sales. Shares are up 2.5% on the news and have surged 130.5% over the past year against the industry's 3.3% fall. Discover the impact of this approval on IONS here 👉 https://www.zacks.com/stock/news/2821375/ionis-dawnzera-gets-eu-approval-for-hereditary-angioedema?cid=sm-stocktwits-2-2821375-body-30057&ADID=SYND_STOCKTWITS_TWEET_2_2821375_BODY_30057
0 · Reply
Dr_Stoxx
Dr_Stoxx Jan. 22 at 2:59 PM
$IONS STOPPED US OUT LAST WEEK IN THE LIVE TRADING ROOM BUT IT'S BACK AND LOOKING GOOD HERE.
0 · Reply
Greenamay
Greenamay Jan. 21 at 3:30 PM
$IONS https://stocks.apple.com/AOI5oTv1FQwm3Vu9wXf4qYg
0 · Reply
johnnygogogo
johnnygogogo Jan. 20 at 4:11 PM
$ARWR on what date in the future will Arrowhead have a larger mkt cap than $IONS ? And what future date will they be larger than $ALNY ? Serious and unserious answers welcome.
3 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Jan. 16 at 11:37 PM
$IONS RSI: 39.47, MACD: -0.0102 Vol: 1.65, MA20: 79.79, MA50: 78.26 🟢 BUY - Uptrend + healthy RSI 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
Quantumup
Quantumup Jan. 16 at 6:23 PM
Cantor reiterated Top Pick $VERA Overweight; $100. $TVTX $NVS OTSKY $JBIO VRTX AZN $IONS RHHBY Here's what Cantor had to say: We caught up with VERA, a "Top Pick," and discussed atacicept's (APRIL/BAFF inh; BTD) potential approval in IgA nephropathy (IgAN) and commercial launch preparations... Our overall takeaway is that all the pieces are in place for a successful regulatory outcome as VERA lays the framework for a strong commercial launch.
0 · Reply
Quantumup
Quantumup Jan. 16 at 1:20 PM
Cantor reiterated $ARWR at an Overweight rating. $LLY $IONS $RHHBY REGN TEVA $WVE Here's what Cantor had to say: Early data for the INHBE and tirzepatide combination in obese and diabetic patients are very intriguing, but management also acknowledged the data are still very early. For the next update, ARWR aims to provide a more comprehensive readout across cohorts, which is why the company is not committing to specific timelines except to say "additional data in 2026." Due to the current regulatory environment for obesity drugs, the goal is to demonstrate incremental (higher quality) weight loss, which is one of the key reasons to prioritize the obese and diabetic cohort.
0 · Reply
johnnygogogo
johnnygogogo Jan. 16 at 2:21 AM
$IONS since April 30, 2025, I-Yawns has closed above the 50-day moving average literally every single day (congrats longs). Until today. Note the Nov. 13 volume sell. Note the gap between Sept 2 and Sept 3 ($58 area). I’m guessing a close below $73 triggers a move in the direction of that gap. Also, technical analysis is absolute garbage. I’m literally guessing (and admitting it’s a guess) what the computers and degens are seeing, which has been also been created by computers for computers (and degens). Happy guessing. No position yet but I might take one. Cracks forming but also what Pee Wee says. Cc: @skeezbag
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Dr_Stoxx
Dr_Stoxx Jan. 14 at 2:24 PM
$IONS BELOW 80 IS USUALLY A GOOD BUY. SOONER OR LATER THIS SQUEEZES ABOVE 83.7
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Quantumup
Quantumup Jan. 13 at 1:18 PM
Piper Sandler⬆️ $ARWR's PT to $110 and reit'd at Overweight $IONS $WVE $RHHBY $REGN TEVA Piper Sandler said in its note: Arrowhead launched Redemplo for familial chylomicronemia syndrome (FCS), and we conservatively forecast sales of $8.4 million in FY:26 to grow to $41.6 million in FY:27. We are confident Arrowhead will report positive Phase III Redemplo data in severe hypertriglyceridemia in 3Q:26 with potential blockbuster label expansion in CY:27. Arrowhead reported impressive weight and fat loss data from the ongoing Phase I/II studies of ARO-INHBE and ARO-ALK7 with more data this year. Arrowhead initiated Phase I/ lla studies of ARO-DIMER-PA for ASCVD and ARO-MAPT for early Alzheimer's disease patients, both with initial data in 2026. Arrowhead issued $700 million in zero coupon convertible debt and raised $230 million in equity bringing pro forma cash to ~$2.09 billion and debt to ~$955 million. We reiterate our Overweight rating and are increasing our price target to $110 from $100.
1 · Reply
Quantumup
Quantumup Jan. 12 at 7:42 PM
TD Cowen reiterated $BBIO Buy; PT 95 $ALNY $PFE $AZN - $IONS NVO Here's what TD Cowen had to say: Attruby Q4 sales of $146MM beat expectations by 9%, leading to an impressive first full year of sales of $362MM. New patient starts surged with an estimated 25% NBRx share, signaling growing market leadership. The late-stage pipeline anchors the next leg of growth, with Phase III wins for LGMD21 and ADH1, while infi's Q1 data could easily support a best-in-class profile — each with $1B+ potential.
0 · Reply
REDBEAR
REDBEAR Jan. 9 at 7:28 PM
$IONS guys, funnymentally what's happening? It looks like a b/o. I only look at charts so appreciate the info. thanks.
1 · Reply
StockConsultant
StockConsultant Jan. 8 at 2:25 PM
$IONS Ionis Pharmaceuticals stock with a top of range breakout watch, target 92 area
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skeezbag
skeezbag Jan. 8 at 1:52 PM
$ARWR 78% short volume yesterday. Short the common the day any converts are announced by the hedgies. It doesn't last though. See $IONS $ALNY Overall 0% interest on converts in smid bio means arrowhead has arrived and investors want the common upside
1 · Reply
victorgn
victorgn Jan. 7 at 7:48 PM
$IONS tgt: $90
0 · Reply