Market Cap 13.09B
Revenue (ttm) 943.71M
Net Income (ttm) -381.39M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -40.41%
Debt to Equity Ratio 0.00
Volume 2,301,800
Avg Vol 1,915,990
Day's Range N/A - N/A
Shares Out 165.26M
Stochastic %K 90%
Beta 0.36
Analysts Strong Sell
Price Target $103.87

Company Profile

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; DAWNZERA for prophylaxis to prevent attacks of hereditary angioedema in adults; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult pat...

Industry: Biotechnology
Sector: Healthcare
Phone: 760 931 9200
Address:
2855 Gazelle Court, Carlsbad, United States
Quantumup
Quantumup Jul. 2 at 11:57 AM
H.C. Wainwright reiterated $ARWR Buy-$100 $IONS AZN $TCT.X REGN $LLY SLN Here's what H.C. Wainwright said in its note: https://x.com/Quantumup1/status/2072650476017922159?s=20
1 · Reply
JuggernautRaider
JuggernautRaider Jun. 30 at 5:03 PM
$IONS beautiful 🤩
0 · Reply
FibonacciTrader_
FibonacciTrader_ Jun. 30 at 1:46 PM
Notable options flow hitting the tape - mix of high-beta tech + cyclicals + speculative positioning. $DRAM -80C 7/31 exp, $6M flow, 5.01 avg $HD - 380C 9/18 exp, $1.5M flow, 7.6 avg $IONS - 87.5C 9/18 exp, $1.2M flow, 4.26 avg $AOSL - 50C 7/17 exp, $660K flow, 2.58 avg $SPCX - 165C 8/21 exp, $8M flow, 17 avg What stands out here is dispersion: aggressive upside bets in both growth semis and large-cap cyclicals, suggesting traders are still leaning into momentum rather than hedging for downside. Flow like this doesn’t predict direction on its own-but it does show where positioning pressure is building before price confirms it.
0 · Reply
Doozio
Doozio Jun. 29 at 11:32 PM
$IONS it’s only obvious wen it’s obvious. ENTA 🐒🍌🧠⏰♾️
0 · Reply
Doozio
Doozio Jun. 29 at 11:31 PM
$IONS everything happens wen it’s ⏰. MNDY 🐑 🎁 s ENTA 🐒🍌🧠⏰♾️
0 · Reply
Joe_Mama
Joe_Mama Jun. 29 at 2:09 PM
$IONS New ATH coming
0 · Reply
TwongStocks
TwongStocks Jun. 26 at 10:10 PM
End of June PDUFAs $IONS - PDUFA Jun 30. Approval announced Jun 24. $LNTH - PDUFA Jun 29. CRL announced today. $VRDN - PDUFA Jun 30. Approval announced today. Still waiting on $UNCY. PDUFA Jun 29.
3 · Reply
BillionerOfKing
BillionerOfKing Jun. 26 at 7:37 PM
$IONS Current Stock Price: $80.50 Contracts to trade: $80.0 IONS Jul 17 2026 Call Entry: $3.30 Exit: $5.12 ROI: 55% Hold ~28 days Shared as daily free alerts and for educational purposes only. https://dailypickai.com/freealerts
0 · Reply
EddieHayes
EddieHayes Jun. 25 at 8:00 PM
$IONS Big catalyst here. Tryngolza just got FDA approval for severe hypertriglyceridemia, expanding from a tiny orphan indication into a ~3M patient market. This is a major step-change: from niche rare disease asset → potential commercial cardiometabolic franchise. Clinical data is strong (up to ~72% triglyceride reduction, lower pancreatitis risk), and importantly, it’s the first approved therapy in this indication with no direct competitor yet. Market reaction (+3%) is still relatively muted compared to the size of the label expansion, which suggests the story may still be early in being repriced. Now it shifts from “pipeline story” to real commercial execution.
1 · Reply
Quantumup
Quantumup Jun. 25 at 7:20 PM
Needham reiterated $IONS Buy; $105 and said: We model $3.6B in WW peak revenues, which is slightly higher than the VA consensus estimate of $3.1B (pre-sHTG approval). $ARWR $LLY RHHBY H.C. Wainwright⬆️lonis Pharmaceuticals' PT to $130.00 and reiterated Buy Here's what H.C. Wainwright had to say: https://x.com/Quantumup1/status/2070224663708573989?s=20
0 · Reply
Latest News on IONS
Ionis Pharmaceuticals Transcript: FDA announcement

Jun 24, 2026, 3:30 PM EDT - 8 days ago

Ionis Pharmaceuticals Transcript: FDA announcement


Ionis Pharmaceuticals Slides: FDA announcement

Jun 24, 2026, 3:30 PM EDT - 8 days ago

Ionis Pharmaceuticals Slides: FDA announcement


Ionis Pharmaceuticals Press release: FDA announcement

Jun 24, 2026, 3:30 PM EDT - 8 days ago

Ionis Pharmaceuticals Press release: FDA announcement


Ionis Pharmaceuticals Slides: FY 2026

Jun 10, 2026, 8:40 AM EDT - 23 days ago

Ionis Pharmaceuticals Slides: FY 2026


Ionis Pharmaceuticals appoints Hantson to Board of Directors

2026-06-08T11:21:43.000Z - 25 days ago

Ionis Pharmaceuticals appoints Hantson to Board of Directors


Ionis Pharmaceuticals Transcript: AGM 2026

Jun 4, 2026, 5:30 PM EDT - 4 weeks ago

Ionis Pharmaceuticals Transcript: AGM 2026


Ionis Pharmaceuticals Slides: FY 2026

Jun 4, 2026, 5:30 PM EDT - 4 weeks ago

Ionis Pharmaceuticals Slides: FY 2026


Ionis to host 2026 virtual Annual Meeting of Stockholders

May 4, 2026, 7:05 AM EDT - 2 months ago

Ionis to host 2026 virtual Annual Meeting of Stockholders


Ionis to present at upcoming investor conferences

May 1, 2026, 7:05 AM EDT - 2 months ago

Ionis to present at upcoming investor conferences


Ionis Pharmaceuticals Earnings Call Transcript: Q1 2026

Apr 29, 2026, 8:30 AM EDT - 2 months ago

Ionis Pharmaceuticals Earnings Call Transcript: Q1 2026


Ionis Pharmaceuticals Earnings release: Q1 2026

Apr 29, 2026, 8:30 AM EDT - 2 months ago

Ionis Pharmaceuticals Earnings release: Q1 2026


Ionis Pharmaceuticals Slides: Q1 2026

Apr 29, 2026, 8:30 AM EDT - 2 months ago

Ionis Pharmaceuticals Slides: Q1 2026


Ionis Pharmaceuticals Quarterly report: Q1 2026

Apr 29, 2026, 8:30 AM EDT - 2 months ago

Ionis Pharmaceuticals Quarterly report: Q1 2026


Ionis Pharmaceuticals reports Q1 EPS (56c), consensus (77c)

2026-04-29T11:41:17.000Z - 2 months ago

Ionis Pharmaceuticals reports Q1 EPS (56c), consensus (77c)


Ionis Pharmaceuticals Proxy statement: Proxy filing

Apr 23, 2026, 8:00 AM EDT - 2 months ago

Ionis Pharmaceuticals Proxy statement: Proxy filing


Ionis Pharmaceuticals Proxy statement: Proxy filing

Apr 23, 2026, 8:00 AM EDT - 2 months ago

Ionis Pharmaceuticals Proxy statement: Proxy filing


Ionis to hold first quarter 2026 financial results webcast

Apr 15, 2026, 7:05 AM EDT - 2 months ago

Ionis to hold first quarter 2026 financial results webcast


Ionis Pharmaceuticals Transcript: Stifel 2026 Virtual CNS Forum

Mar 17, 2026, 12:00 PM EDT - 3 months ago

Ionis Pharmaceuticals Transcript: Stifel 2026 Virtual CNS Forum


Ionis announces changes to Board of Directors

Mar 9, 2026, 7:00 AM EDT - 4 months ago

Ionis announces changes to Board of Directors


Ionis Pharmaceuticals Earnings Call Transcript: Q4 2025

Feb 25, 2026, 8:30 AM EST - 4 months ago

Ionis Pharmaceuticals Earnings Call Transcript: Q4 2025


Ionis Pharmaceuticals Annual report: Q4 2025

Feb 25, 2026, 8:30 AM EST - 4 months ago

Ionis Pharmaceuticals Annual report: Q4 2025


Ionis Pharmaceuticals Earnings release: Q4 2025

Feb 25, 2026, 8:30 AM EST - 4 months ago

Ionis Pharmaceuticals Earnings release: Q4 2025


Ionis Pharmaceuticals Slides: Q4 2025

Feb 25, 2026, 8:30 AM EST - 4 months ago

Ionis Pharmaceuticals Slides: Q4 2025


Biogen Completes Acquisition of Alcyone Therapeutics

Nov 14, 2025, 4:05 PM EST - 8 months ago

Biogen Completes Acquisition of Alcyone Therapeutics

BIIB


Ionis Pharmaceuticals Transcript: Study Update

Nov 8, 2025, 3:00 PM EST - 8 months ago

Ionis Pharmaceuticals Transcript: Study Update


Ionis Pharmaceuticals Slides: Study Update

Nov 8, 2025, 3:00 PM EST - 8 months ago

Ionis Pharmaceuticals Slides: Study Update


Ionis Pharmaceuticals Earnings Call Transcript: Q3 2025

Oct 29, 2025, 11:30 AM EDT - 8 months ago

Ionis Pharmaceuticals Earnings Call Transcript: Q3 2025


Ionis Pharmaceuticals Quarterly report: Q3 2025

Oct 29, 2025, 11:30 AM EDT - 8 months ago

Ionis Pharmaceuticals Quarterly report: Q3 2025


Ionis Pharmaceuticals Earnings release: Q3 2025

Oct 29, 2025, 11:30 AM EDT - 8 months ago

Ionis Pharmaceuticals Earnings release: Q3 2025


Ionis Pharmaceuticals Slides: Q3 2025

Oct 29, 2025, 11:30 AM EDT - 8 months ago

Ionis Pharmaceuticals Slides: Q3 2025


Ionis to hold third quarter 2025 financial results webcast

Oct 16, 2025, 7:05 AM EDT - 9 months ago

Ionis to hold third quarter 2025 financial results webcast


Ionis Pharmaceuticals Transcript: Innovation Day 2025

Oct 7, 2025, 8:30 AM EDT - 9 months ago

Ionis Pharmaceuticals Transcript: Innovation Day 2025


Ionis Pharmaceuticals Press release: FY 2025

Oct 7, 2025, 8:30 AM EDT - 9 months ago

Ionis Pharmaceuticals Press release: FY 2025


Ionis Pharmaceuticals Slides: FY 2025

Oct 7, 2025, 8:30 AM EDT - 9 months ago

Ionis Pharmaceuticals Slides: FY 2025


Ionis' brain disorder drug shows promise in clinical trial

Sep 22, 2025, 7:10 AM EDT - 10 months ago

Ionis' brain disorder drug shows promise in clinical trial


Ionis to host investors and analysts for Innovation Day 2025

Sep 8, 2025, 4:00 PM EDT - 10 months ago

Ionis to host investors and analysts for Innovation Day 2025


Is The 35% Rally In IONS Stock Just The Beginning?

Sep 3, 2025, 10:41 AM EDT - 10 months ago

Is The 35% Rally In IONS Stock Just The Beginning?


Ionis Pharmaceuticals Transcript: Study Result

Sep 2, 2025, 8:30 AM EDT - 10 months ago

Ionis Pharmaceuticals Transcript: Study Result


Ionis Pharmaceuticals Press release: Study Result

Sep 2, 2025, 8:30 AM EDT - 10 months ago

Ionis Pharmaceuticals Press release: Study Result


Ionis Pharmaceuticals Slides: Study Result

Sep 2, 2025, 8:30 AM EDT - 10 months ago

Ionis Pharmaceuticals Slides: Study Result


Quantumup
Quantumup Jul. 2 at 11:57 AM
H.C. Wainwright reiterated $ARWR Buy-$100 $IONS AZN $TCT.X REGN $LLY SLN Here's what H.C. Wainwright said in its note: https://x.com/Quantumup1/status/2072650476017922159?s=20
1 · Reply
JuggernautRaider
JuggernautRaider Jun. 30 at 5:03 PM
$IONS beautiful 🤩
0 · Reply
FibonacciTrader_
FibonacciTrader_ Jun. 30 at 1:46 PM
Notable options flow hitting the tape - mix of high-beta tech + cyclicals + speculative positioning. $DRAM -80C 7/31 exp, $6M flow, 5.01 avg $HD - 380C 9/18 exp, $1.5M flow, 7.6 avg $IONS - 87.5C 9/18 exp, $1.2M flow, 4.26 avg $AOSL - 50C 7/17 exp, $660K flow, 2.58 avg $SPCX - 165C 8/21 exp, $8M flow, 17 avg What stands out here is dispersion: aggressive upside bets in both growth semis and large-cap cyclicals, suggesting traders are still leaning into momentum rather than hedging for downside. Flow like this doesn’t predict direction on its own-but it does show where positioning pressure is building before price confirms it.
0 · Reply
Doozio
Doozio Jun. 29 at 11:32 PM
$IONS it’s only obvious wen it’s obvious. ENTA 🐒🍌🧠⏰♾️
0 · Reply
Doozio
Doozio Jun. 29 at 11:31 PM
$IONS everything happens wen it’s ⏰. MNDY 🐑 🎁 s ENTA 🐒🍌🧠⏰♾️
0 · Reply
Joe_Mama
Joe_Mama Jun. 29 at 2:09 PM
$IONS New ATH coming
0 · Reply
TwongStocks
TwongStocks Jun. 26 at 10:10 PM
End of June PDUFAs $IONS - PDUFA Jun 30. Approval announced Jun 24. $LNTH - PDUFA Jun 29. CRL announced today. $VRDN - PDUFA Jun 30. Approval announced today. Still waiting on $UNCY. PDUFA Jun 29.
3 · Reply
BillionerOfKing
BillionerOfKing Jun. 26 at 7:37 PM
$IONS Current Stock Price: $80.50 Contracts to trade: $80.0 IONS Jul 17 2026 Call Entry: $3.30 Exit: $5.12 ROI: 55% Hold ~28 days Shared as daily free alerts and for educational purposes only. https://dailypickai.com/freealerts
0 · Reply
EddieHayes
EddieHayes Jun. 25 at 8:00 PM
$IONS Big catalyst here. Tryngolza just got FDA approval for severe hypertriglyceridemia, expanding from a tiny orphan indication into a ~3M patient market. This is a major step-change: from niche rare disease asset → potential commercial cardiometabolic franchise. Clinical data is strong (up to ~72% triglyceride reduction, lower pancreatitis risk), and importantly, it’s the first approved therapy in this indication with no direct competitor yet. Market reaction (+3%) is still relatively muted compared to the size of the label expansion, which suggests the story may still be early in being repriced. Now it shifts from “pipeline story” to real commercial execution.
1 · Reply
Quantumup
Quantumup Jun. 25 at 7:20 PM
Needham reiterated $IONS Buy; $105 and said: We model $3.6B in WW peak revenues, which is slightly higher than the VA consensus estimate of $3.1B (pre-sHTG approval). $ARWR $LLY RHHBY H.C. Wainwright⬆️lonis Pharmaceuticals' PT to $130.00 and reiterated Buy Here's what H.C. Wainwright had to say: https://x.com/Quantumup1/status/2070224663708573989?s=20
0 · Reply
ripster47
ripster47 Jun. 25 at 2:40 PM
$IONS | Oppenheimer Reiterates Ionis Pharmaceuticals at Outperform with $110.00 PT on Tryngolza Approval and >$3B Commercial Opportunity Oppenheimer stays bullish as Tryngolza approval strengthens differentiation and supports strong launch trajectory.
0 · Reply
killbilltrader
killbilltrader Jun. 25 at 3:33 AM
$IONS with a broader and clean label, any chance we go back up to $85-90 tomorrow?
2 · Reply
StocktwitsNews
StocktwitsNews Jun. 24 at 11:54 PM
IONS Stock Jumps 4% After-Hours — Goldman Sachs Lifts Price Target On Tryngolza Approval $IONS $ARWR $VTI $VB https://stocktwits.com/news/equity/markets/ions-stock-jumps-after-hours-goldman-sachs-lifts-price-target-on-tryngolza/cZKyqXNR7QE
0 · Reply
Merlintrader
Merlintrader Jun. 24 at 7:46 PM
$IONS Ionis Pharmaceuticals (Nasdaq: $IONS): TRYNGOLZA Wins FDA Approval in Severe Hypertriglyceridemia https://www.merlintrader.com/ions-pharmaceuticals-june2026-approval/
0 · Reply
johnnygogogo
johnnygogogo Jun. 24 at 7:23 PM
$IONS congrats on the SHTG approval for Tryngolza. cc $ARWR
0 · Reply
johnnygogogo
johnnygogogo Jun. 23 at 3:17 PM
$ARWR so will ARWR start off-labeling REDEMPLO for SHTG right after the $IONS PDUFA on June 30? @skeezbag @GMH21
2 · Reply
JuggernautRaider
JuggernautRaider Jun. 21 at 12:12 PM
$IONS hmm tell me more
0 · Reply
johnnygogogo
johnnygogogo Jun. 18 at 7:26 PM
$ARWR $IONS don’t tell Art, but A-roar and I-yawns are within $1B of each other on mkt cap. One has had a ton of recent insider sales and the other is the next Amgen. @skeezbag
4 · Reply
keypatience
keypatience Jun. 17 at 5:56 PM
0 · Reply
killbilltrader
killbilltrader Jun. 16 at 11:50 PM
I want $SPRO $VRDN $IONS and $VERA get approved. So that I can buy even more $SLS. Currently holding 17000 shares with an average of $1.7
2 · Reply
Joe_Mama
Joe_Mama Jun. 12 at 9:31 PM
$IONS Preparring for next move
0 · Reply
killbilltrader
killbilltrader Jun. 10 at 5:52 PM
$SPRO $VRDN $IONS $VERA all of them to be approved.
0 · Reply