Market Cap 13.47B
Revenue (ttm) 705.14M
Net Income (ttm) -453.90M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -64.37%
Debt to Equity Ratio 0.00
Volume 2,832,400
Avg Vol 2,060,776
Day's Range N/A - N/A
Shares Out 161.97M
Stochastic %K 50%
Beta 0.29
Analysts Strong Sell
Price Target $92.33

Company Profile

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treat...

Industry: Biotechnology
Sector: Healthcare
Phone: 760 931 9200
Address:
2855 Gazelle Court, Carlsbad, United States
RalphMBB
RalphMBB Feb. 19 at 12:14 AM
$IONS Wish I had bought more back in July. I checked and it was 23.5% of my portfolio. It has been my second best performer of '25. Great company and much valued innovatove medicines in development.
0 · Reply
Dr_Stoxx
Dr_Stoxx Feb. 18 at 4:25 PM
$IONS: long swing hold for me and I'll be dumping before the ER, but it does look primed here.
0 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Feb. 18 at 9:57 AM
$IONS RSI: 47.71, MACD: 0.6553 Vol: 2.17, MA20: 82.52, MA50: 80.88 🔴 SELL - Downtrend 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
Fingerlickengood
Fingerlickengood Feb. 9 at 3:07 PM
$CDXS $IONS https://biz.chosun.com/en/en-science/2026/02/09/Z5RDWXQNSJDCREPPUK2VFBPFPU/
1 · Reply
johnnygogogo
johnnygogogo Feb. 5 at 11:23 PM
$IONS hey kiddos, Arrowhead is already taking market share. “And patients switching from Olezarsen” @skeezbag
1 · Reply
Fingerlickengood
Fingerlickengood Feb. 5 at 6:35 PM
$CDXS $IONS This is interesting! https://www.investing.com/news/insider-trading-news/ionis-pharma-ceo-monia-sells-52-million-in-shares-93CH-4480511
4 · Reply
Joe_Mama
Joe_Mama Feb. 5 at 3:08 PM
$IONS Target reached. Looks like she wants more …
0 · Reply
SuperGreenToday
SuperGreenToday Feb. 5 at 12:10 PM
$IONS Share Price: $84.92 Contract Selected: Jul 17, 2026 $85 Calls Buy Zone: $9.13 – $11.27 Target Zone: $15.69 – $19.18 Potential Upside: 62% ROI Time to Expiration: 161 Days | Updates via https://fxcapta.com/stockinfo/
0 · Reply
NodeNoble
NodeNoble Feb. 4 at 11:06 AM
$IONS faces competitive and commercial challenges for its later-generation RNA therapies in a crowded landscape.
0 · Reply
StockConsultant
StockConsultant Feb. 4 at 12:11 AM
$IONS Ionis Pharmaceuticals stock, watch for a top of range breakout
0 · Reply
Latest News on IONS
Ionis to present at upcoming investor conferences

Feb 19, 2026, 7:05 AM EST - 4 days ago

Ionis to present at upcoming investor conferences


Ionis, Otsuka win EU nod for hereditary angioedema therapy

2026-01-21T14:17:01.000Z - 4 weeks ago

Ionis, Otsuka win EU nod for hereditary angioedema therapy


Ionis Pharmaceuticals (IONS) Gains EU Approval for Dawnzera

2026-01-21T12:33:27.000Z - 4 weeks ago

Ionis Pharmaceuticals (IONS) Gains EU Approval for Dawnzera


Ionis to present at 44th Annual J.P. Morgan Healthcare Conference

Tue, 06 Jan 2026 07:05:00 -0500 - 6 weeks ago

Ionis to present at 44th Annual J.P. Morgan Healthcare Conference


Ionis Pharmaceuticals (IONS) in Tweedy Browne Q3 2025

2025-11-15T17:00:32.000Z - 3 months ago

Ionis Pharmaceuticals (IONS) in Tweedy Browne Q3 2025


Biogen Completes Acquisition of Alcyone Therapeutics

Fri, 14 Nov 2025 16:05:00 -0500 - 3 months ago

Biogen Completes Acquisition of Alcyone Therapeutics


Ionis to present at upcoming investor conferences

Wed, 12 Nov 2025 16:00:00 -0500 - 3 months ago

Ionis to present at upcoming investor conferences


Ionis to hold third quarter 2025 financial results webcast

Oct 16, 2025, 7:05 AM EDT - 4 months ago

Ionis to hold third quarter 2025 financial results webcast


Ionis' brain disorder drug shows promise in clinical trial

Sep 22, 2025, 7:10 AM EDT - 5 months ago

Ionis' brain disorder drug shows promise in clinical trial


Ionis to host investors and analysts for Innovation Day 2025

Sep 8, 2025, 4:00 PM EDT - 5 months ago

Ionis to host investors and analysts for Innovation Day 2025


Is The 35% Rally In IONS Stock Just The Beginning?

Sep 3, 2025, 10:41 AM EDT - 6 months ago

Is The 35% Rally In IONS Stock Just The Beginning?


RalphMBB
RalphMBB Feb. 19 at 12:14 AM
$IONS Wish I had bought more back in July. I checked and it was 23.5% of my portfolio. It has been my second best performer of '25. Great company and much valued innovatove medicines in development.
0 · Reply
Dr_Stoxx
Dr_Stoxx Feb. 18 at 4:25 PM
$IONS: long swing hold for me and I'll be dumping before the ER, but it does look primed here.
0 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Feb. 18 at 9:57 AM
$IONS RSI: 47.71, MACD: 0.6553 Vol: 2.17, MA20: 82.52, MA50: 80.88 🔴 SELL - Downtrend 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
Fingerlickengood
Fingerlickengood Feb. 9 at 3:07 PM
$CDXS $IONS https://biz.chosun.com/en/en-science/2026/02/09/Z5RDWXQNSJDCREPPUK2VFBPFPU/
1 · Reply
johnnygogogo
johnnygogogo Feb. 5 at 11:23 PM
$IONS hey kiddos, Arrowhead is already taking market share. “And patients switching from Olezarsen” @skeezbag
1 · Reply
Fingerlickengood
Fingerlickengood Feb. 5 at 6:35 PM
$CDXS $IONS This is interesting! https://www.investing.com/news/insider-trading-news/ionis-pharma-ceo-monia-sells-52-million-in-shares-93CH-4480511
4 · Reply
Joe_Mama
Joe_Mama Feb. 5 at 3:08 PM
$IONS Target reached. Looks like she wants more …
0 · Reply
SuperGreenToday
SuperGreenToday Feb. 5 at 12:10 PM
$IONS Share Price: $84.92 Contract Selected: Jul 17, 2026 $85 Calls Buy Zone: $9.13 – $11.27 Target Zone: $15.69 – $19.18 Potential Upside: 62% ROI Time to Expiration: 161 Days | Updates via https://fxcapta.com/stockinfo/
0 · Reply
NodeNoble
NodeNoble Feb. 4 at 11:06 AM
$IONS faces competitive and commercial challenges for its later-generation RNA therapies in a crowded landscape.
0 · Reply
StockConsultant
StockConsultant Feb. 4 at 12:11 AM
$IONS Ionis Pharmaceuticals stock, watch for a top of range breakout
0 · Reply
Night_Owl_Biotech
Night_Owl_Biotech Feb. 2 at 2:17 AM
As shown on the attached graph, $KALV FY26 - FY35 analyst consensus revenue estimates are consistent with the 10-year revenue forecasts prepared by the managements of 3 peer commercial-stage bios (CTIC, KDMN & SRRA) that were acquired for enterprise values ranging from $1.7B to $1.9B within 15 months of FDA approval. Based on KALV's Q325 10Q, Sebetralstat generates competitive gross margins (91%). Our simple question, if analysts forecast Sebetralstat to generate the same sales at roughly the same gross margins, does that suggest KALV would be worth the same ($1.7 to $1.9B) if KALV is ever acquired? This is not investment advice. New drugs are generally worth some multiple and/or NPV of projected sales, so we're simply trying to understand the upside if KALV is ever acquired (i.e. competing HAE therapies). Per Seeking Alpha, KALV's market cap is ~$800MM where cash more or less = debt (so EV is about the same) $IONS $THTX $XBI $IBB NOTE: SRRA was acquired before PDUFA
1 · Reply
SuperGreenToday
SuperGreenToday Jan. 29 at 4:38 AM
$IONS Share Price: $81.94 Contract Selected: Jul 17, 2026 $80 Calls Buy Zone: $9.78 – $12.08 Target Zone: $18.58 – $22.70 Potential Upside: 79% ROI Time to Expiration: 169 Days | Updates via https://fxcapta.com/stockinfo/
0 · Reply
Dr_Stoxx
Dr_Stoxx Jan. 28 at 7:27 PM
$IONS not bad here. I've been holding a remnant from our last trade (hit our raised stop).
0 · Reply
StockConsultant
StockConsultant Jan. 28 at 1:48 PM
$IONS Ionis Pharmaceuticals stock watch for a narrow range breakout
0 · Reply
Dr_Stoxx
Dr_Stoxx Jan. 26 at 7:51 PM
$IONS our old friend...still just sitting there...a little up, a little down...
0 · Reply
Merlintrader
Merlintrader Jan. 23 at 2:17 PM
$IONS https://www.merlintrader.com/ions-ionis-pharmaceuticals/
0 · Reply
ZacksResearch
ZacksResearch Jan. 22 at 5:43 PM
EU green light for $IONS — Dawnzera just expanded its reach 🇪🇺💥 Ionis secured EU approval for Dawnzera in hereditary angioedema, following FDA clearance in the United States in August last year — regulatory momentum on both sides of the Atlantic. See what this approval means for the story 👉 https://www.zacks.com/stock/news/2821375/ionis-dawnzera-gets-eu-approval-for-hereditary-angioedema?cid=sm-stocktwits-2-2821375-teaser-30058&ADID=SYND_STOCKTWITS_TWEET_2_2821375_TEASER_30058
0 · Reply
ZacksResearch
ZacksResearch Jan. 22 at 4:43 PM
$IONS gains EU approval for Dawnzera—what's next for the stock? 🚀 The European Commission's nod for Dawnzera, backed by strong Phase III data, grants Ionis a $15M milestone and tiered royalties up to 30% on sales. Shares are up 2.5% on the news and have surged 130.5% over the past year against the industry's 3.3% fall. Discover the impact of this approval on IONS here 👉 https://www.zacks.com/stock/news/2821375/ionis-dawnzera-gets-eu-approval-for-hereditary-angioedema?cid=sm-stocktwits-2-2821375-body-30057&ADID=SYND_STOCKTWITS_TWEET_2_2821375_BODY_30057
0 · Reply
Dr_Stoxx
Dr_Stoxx Jan. 22 at 2:59 PM
$IONS STOPPED US OUT LAST WEEK IN THE LIVE TRADING ROOM BUT IT'S BACK AND LOOKING GOOD HERE.
0 · Reply
Greenamay
Greenamay Jan. 21 at 3:30 PM
$IONS https://stocks.apple.com/AOI5oTv1FQwm3Vu9wXf4qYg
0 · Reply
johnnygogogo
johnnygogogo Jan. 20 at 4:11 PM
$ARWR on what date in the future will Arrowhead have a larger mkt cap than $IONS ? And what future date will they be larger than $ALNY ? Serious and unserious answers welcome.
3 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Jan. 16 at 11:37 PM
$IONS RSI: 39.47, MACD: -0.0102 Vol: 1.65, MA20: 79.79, MA50: 78.26 🟢 BUY - Uptrend + healthy RSI 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply