Market Cap 158.65M
Revenue (ttm) 66.80M
Net Income (ttm) 8.57M
EPS (ttm) N/A
PE Ratio 11.75
Forward PE N/A
Profit Margin 12.83%
Debt to Equity Ratio 0.00
Volume 1,129,200
Avg Vol 620,444
Day's Range N/A - N/A
Shares Out 57.90M
Stochastic %K 9%
Beta 1.45
Analysts Sell
Price Target $4.50

Company Profile

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement...

Industry: Biotechnology
Sector: Healthcare
Phone: 857 242 1600
Address:
675 Massachusetts Avenue, 14th Floor, Cambridge, United States
BxxZ
BxxZ Jun. 10 at 7:51 AM
$SPRO Well - being in this position and seing what is going on - ...... $GSK in these days & having exchanges with the fda since last dec. is now pretty much well aware of the labeling (which is key in tebi case) granted !!! Might be (it would also make sense due to risks of missuses!) fda was quite restrictive? This would/could change drastically the possibilities of the drug short/mid term (time of valid patents,!) CF of the drug...... & GSK will make sure to wait for comm.figures of few q's before making final move? We will know more on june 18th..... Well - may be a surprise at the conference today?
0 · Reply
zerodayrounder
zerodayrounder Jun. 10 at 1:12 AM
I know $GSK already has the license for $SPRO tebi and the bidding process for $NUVL was probably competitive but they are assuming PDUFA risk on 2 drugs in September and November 2026 as well. Seems like GSK should be quite comfortable with Tebi PDUFA in 8 days when they have been handling the whole process since December. Simplify and focus on maximizing gross/operating profits from tebi moving from R&D to commercial launch
0 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 9:49 PM
$GSK Luke Miels in response to a question in the Nuvalent Q&A, said there was financial discipline that left room for future accretive deals. $SPRO
1 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 9:42 PM
$GSK opening slide deck for $NUVL acquistion / acquisition philosophy: Maybe totally pollyannish since GSK already has the exclusive license but tebi late stage, will deliver near term revenue growth, canceling milestones/royalties will increase margins; simplify the relationship by owning 100% of tebi. $SPRO
0 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 5:34 PM
I know $GSK obviously way more diversified than $SPRO but I'd expect GSK to be taking some more selling pressure too if tebi and its blockbuster drug potential got denied by the FDA or bad label. If it is a $1 billion PYS drug, that would clip its 2031 revenue guidance it always references.
1 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 4:24 PM
The PDUFA traders like $UNCY over $SPRO I guess.
1 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 4:21 PM
maybe the miscalculation re $SPRO all along is $GSK doesn't mind cutting milestone/royalty checks. Seems odd to me if you can extinguish those payments on what is supposedly a potential blockbuster. I thought GSK would want full control of all its blockbusters and out-license non-blockbusters like it did with Lynavoy in March 2026. GSK has problem with $ANAB and the jemperli license ...
1 · Reply
sadie444
sadie444 Jun. 9 at 4:08 PM
$SPRO for those of you that are going negative you have to understand this is nothing to do with the company. This has to do with overall market conditions and has since last Friday. Today’s market downturn happened almost exactly after BOA announced, they were warning their customers to start taking profits as seven of the 10 warning signals had now been breached. As their analyst stated, there are still very good buys still, including within the S&P 500 and NASDAQ. But overall, those that have made significant gains both of them the magnificent 7 and the connected stocks are now taking profits bringing the markets back down.
1 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 3:47 PM
0 · Reply
Inc82
Inc82 Jun. 9 at 3:34 PM
$SPRO I am long, but this movement does not look good. Tell me if I am wrong?
1 · Reply
Latest News on SPRO
Spero Therapeutics Earnings release: Q1 2026

May 13, 2026, 4:00 PM EDT - 27 days ago

Spero Therapeutics Earnings release: Q1 2026


Spero Therapeutics Quarterly report: Q1 2026

May 13, 2026, 4:00 PM EDT - 27 days ago

Spero Therapeutics Quarterly report: Q1 2026


Spero Therapeutics Proxy statement: Proxy filing

Apr 27, 2026, 8:00 AM EDT - 6 weeks ago

Spero Therapeutics Proxy statement: Proxy filing


Spero Therapeutics Proxy statement: Proxy filing

Apr 27, 2026, 8:00 AM EDT - 6 weeks ago

Spero Therapeutics Proxy statement: Proxy filing


Spero Therapeutics Proxy statement: Proxy filing

Apr 13, 2026, 8:00 AM EDT - 2 months ago

Spero Therapeutics Proxy statement: Proxy filing


Spero Therapeutics Earnings release: Q4 2025

Mar 26, 2026, 4:00 PM EDT - 2 months ago

Spero Therapeutics Earnings release: Q4 2025


Spero Therapeutics Annual report: Q4 2025

Mar 26, 2026, 4:00 PM EDT - 2 months ago

Spero Therapeutics Annual report: Q4 2025


Spero Therapeutics Earnings release: Q3 2025

Nov 13, 2025, 4:00 PM EST - 7 months ago

Spero Therapeutics Earnings release: Q3 2025


Spero Therapeutics Quarterly report: Q3 2025

Nov 13, 2025, 4:00 PM EST - 7 months ago

Spero Therapeutics Quarterly report: Q3 2025


Spero Therapeutics Earnings Call Transcript: Q2 2025

Aug 12, 2025, 4:30 PM EDT - 10 months ago

Spero Therapeutics Earnings Call Transcript: Q2 2025


Spero Therapeutics Quarterly report: Q2 2025

Aug 12, 2025, 4:30 PM EDT - 10 months ago

Spero Therapeutics Quarterly report: Q2 2025


Spero Therapeutics Earnings release: Q2 2025

Aug 12, 2025, 4:30 PM EDT - 10 months ago

Spero Therapeutics Earnings release: Q2 2025


Spero Therapeutics Slides: Corporate Presentation

Jun 16, 2025, 7:00 AM EDT - 1 year ago

Spero Therapeutics Slides: Corporate Presentation


Spero Therapeutics Earnings release: Q1 2025

May 13, 2025, 4:00 PM EDT - 1 year ago

Spero Therapeutics Earnings release: Q1 2025


Spero Therapeutics Quarterly report: Q1 2025

May 13, 2025, 4:00 PM EDT - 1 year ago

Spero Therapeutics Quarterly report: Q1 2025


Spero Therapeutics Proxy statement: Proxy Filing

Apr 28, 2025, 8:00 AM EDT - 1 year ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Proxy statement: Proxy Filing

Apr 28, 2025, 8:00 AM EDT - 1 year ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Earnings Call Transcript: Q4 2024

Mar 27, 2025, 4:30 PM EDT - 1 year ago

Spero Therapeutics Earnings Call Transcript: Q4 2024


Spero Therapeutics Annual report: Q4 2024

Mar 27, 2025, 4:30 PM EDT - 1 year ago

Spero Therapeutics Annual report: Q4 2024


Spero Therapeutics Earnings release: Q4 2024

Mar 27, 2025, 4:30 PM EDT - 1 year ago

Spero Therapeutics Earnings release: Q4 2024


Spero Therapeutics reports Q4 EPS (38c), consensus (31c)

2025-03-27T20:20:55.000Z - 1 year ago

Spero Therapeutics reports Q4 EPS (38c), consensus (31c)


Spero Therapeutics announces interim leadership changes

2025-01-10T12:31:40.000Z - 1 year ago

Spero Therapeutics announces interim leadership changes


Spero Therapeutics downgraded to Hold from Buy at TD Cowen

2024-11-18T12:41:28.000Z - 1 year ago

Spero Therapeutics downgraded to Hold from Buy at TD Cowen


Spero Therapeutics reports Q3 EPS (32c), consensus (36c)

2024-11-14T21:20:42.000Z - 1 year ago

Spero Therapeutics reports Q3 EPS (32c), consensus (36c)


Spero Therapeutics Earnings release: Q3 2024

Nov 14, 2024, 12:00 AM EST - 1 year ago

Spero Therapeutics Earnings release: Q3 2024


Spero Therapeutics Quarterly report: Q3 2024

Nov 14, 2024, 12:00 AM EST - 1 year ago

Spero Therapeutics Quarterly report: Q3 2024


Spero Therapeutics Earnings Call Transcript: Q2 2024

Aug 5, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings Call Transcript: Q2 2024


Spero Therapeutics Quarterly report: Q2 2024

Aug 5, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Quarterly report: Q2 2024


Spero Therapeutics Earnings release: Q2 2024

Aug 5, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings release: Q2 2024


Spero Therapeutics Quarterly report: Q1 2024

May 15, 2024, 4:00 PM EDT - 2 years ago

Spero Therapeutics Quarterly report: Q1 2024


Spero Therapeutics Earnings release: Q1 2024

May 15, 2024, 4:00 PM EDT - 2 years ago

Spero Therapeutics Earnings release: Q1 2024


Spero Therapeutics Proxy statement: Proxy Filing

Apr 16, 2024, 8:00 AM EDT - 2 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Proxy statement: Proxy Filing

Apr 16, 2024, 8:00 AM EDT - 2 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Registration statement: Registration Filing

Mar 15, 2024, 8:00 AM EDT - 2 years ago

Spero Therapeutics Registration statement: Registration Filing


Spero Therapeutics Earnings Call Transcript: Q4 2023

Mar 13, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings Call Transcript: Q4 2023


Spero Therapeutics Annual report: Q4 2023

Mar 13, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Annual report: Q4 2023


Spero Therapeutics Earnings release: Q4 2023

Mar 13, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings release: Q4 2023


Spero Therapeutics Provides Corporate Update and 2024 Outlook

Jan 5, 2024, 8:05 AM EST - 2 years ago

Spero Therapeutics Provides Corporate Update and 2024 Outlook


Spero Therapeutics Earnings Call Transcript: Q3 2023

Nov 13, 2023, 4:30 PM EST - 2 years ago

Spero Therapeutics Earnings Call Transcript: Q3 2023


Spero Therapeutics Quarterly report: Q3 2023

Nov 13, 2023, 4:30 PM EST - 2 years ago

Spero Therapeutics Quarterly report: Q3 2023


Spero Therapeutics Earnings release: Q3 2023

Nov 13, 2023, 4:30 PM EST - 2 years ago

Spero Therapeutics Earnings release: Q3 2023


Spero Therapeutics Slides: Investor Presentation

Nov 1, 2023, 7:45 AM EDT - 2 years ago

Spero Therapeutics Slides: Investor Presentation


Spero Therapeutics Proxy statement: Proxy Filing

Sep 1, 2023, 8:00 AM EDT - 3 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Proxy statement: Proxy Filing

Aug 22, 2023, 8:00 AM EDT - 3 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Earnings Call Transcript: Q2 2023

Aug 10, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings Call Transcript: Q2 2023


Spero Therapeutics Quarterly report: Q2 2023

Aug 10, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Quarterly report: Q2 2023


Spero Therapeutics Earnings release: Q2 2023

Aug 10, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings release: Q2 2023


Spero Therapeutics Earnings Call Transcript: Q1 2023

May 11, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings Call Transcript: Q1 2023


Spero Therapeutics Quarterly report: Q1 2023

May 11, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Quarterly report: Q1 2023


Spero Therapeutics Earnings release: Q1 2023

May 11, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings release: Q1 2023


Spero Therapeutics to Present at Upcoming Investor Conference

Apr 26, 2023, 8:05 AM EDT - 3 years ago

Spero Therapeutics to Present at Upcoming Investor Conference


BxxZ
BxxZ Jun. 10 at 7:51 AM
$SPRO Well - being in this position and seing what is going on - ...... $GSK in these days & having exchanges with the fda since last dec. is now pretty much well aware of the labeling (which is key in tebi case) granted !!! Might be (it would also make sense due to risks of missuses!) fda was quite restrictive? This would/could change drastically the possibilities of the drug short/mid term (time of valid patents,!) CF of the drug...... & GSK will make sure to wait for comm.figures of few q's before making final move? We will know more on june 18th..... Well - may be a surprise at the conference today?
0 · Reply
zerodayrounder
zerodayrounder Jun. 10 at 1:12 AM
I know $GSK already has the license for $SPRO tebi and the bidding process for $NUVL was probably competitive but they are assuming PDUFA risk on 2 drugs in September and November 2026 as well. Seems like GSK should be quite comfortable with Tebi PDUFA in 8 days when they have been handling the whole process since December. Simplify and focus on maximizing gross/operating profits from tebi moving from R&D to commercial launch
0 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 9:49 PM
$GSK Luke Miels in response to a question in the Nuvalent Q&A, said there was financial discipline that left room for future accretive deals. $SPRO
1 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 9:42 PM
$GSK opening slide deck for $NUVL acquistion / acquisition philosophy: Maybe totally pollyannish since GSK already has the exclusive license but tebi late stage, will deliver near term revenue growth, canceling milestones/royalties will increase margins; simplify the relationship by owning 100% of tebi. $SPRO
0 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 5:34 PM
I know $GSK obviously way more diversified than $SPRO but I'd expect GSK to be taking some more selling pressure too if tebi and its blockbuster drug potential got denied by the FDA or bad label. If it is a $1 billion PYS drug, that would clip its 2031 revenue guidance it always references.
1 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 4:24 PM
The PDUFA traders like $UNCY over $SPRO I guess.
1 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 4:21 PM
maybe the miscalculation re $SPRO all along is $GSK doesn't mind cutting milestone/royalty checks. Seems odd to me if you can extinguish those payments on what is supposedly a potential blockbuster. I thought GSK would want full control of all its blockbusters and out-license non-blockbusters like it did with Lynavoy in March 2026. GSK has problem with $ANAB and the jemperli license ...
1 · Reply
sadie444
sadie444 Jun. 9 at 4:08 PM
$SPRO for those of you that are going negative you have to understand this is nothing to do with the company. This has to do with overall market conditions and has since last Friday. Today’s market downturn happened almost exactly after BOA announced, they were warning their customers to start taking profits as seven of the 10 warning signals had now been breached. As their analyst stated, there are still very good buys still, including within the S&P 500 and NASDAQ. But overall, those that have made significant gains both of them the magnificent 7 and the connected stocks are now taking profits bringing the markets back down.
1 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 3:47 PM
0 · Reply
Inc82
Inc82 Jun. 9 at 3:34 PM
$SPRO I am long, but this movement does not look good. Tell me if I am wrong?
1 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 3:22 PM
$SPRO what a surprise, tapping the rising 50 day. Several down days in a row to support, then pull a $NUVL? NUVL certainly wasn't looking too hot -- I guess the market didn't like its data at ASCO but $GSK did.
0 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 3:17 PM
$SPRO I still don't think FDA approval will move the needle on SPRO given what I've harped on before: (1) uncertain royalty stream (2) no control over destiny (3) risk of bad capital allocation (4) no team in place. I would think $GSK has multiple corporate development teams -- one in oncology and one for its infectious disease portfolio. Would be cool if CEO Luke Miels could walk into Citi fireside chat tomorrow and talk about (1) Nuvalent late stage cancer drugs + adding to 2027 revs/operating profit and 2029 EPS and (2) taking full control of tebi (a potential blockbuster) a week before FDA which sales would start very soon and save at least $51 million highly probable milestone in next 3 months plus whatever revenue milestones/royalties tebi would achieve in 2027. Seems like it could get done for $500 million. Not sure how SPRO would walk away from that to be honest. $500 million would be enough to fund reverse merger w/ another synergistic oncology play for GSK to get a toehold in?
0 · Reply
BxxZ
BxxZ Jun. 9 at 2:58 PM
$SPRO $GSK If we are lucky - may be they announce - "THE SECOND DEAL!!!" just afzer market closure ...... At the end - WHY NOT!!! - they know everything to the core of it and beyond - and - as I hear - also the "stars/planets" today are well aligned .... 🤣🤣🤣
1 · Reply
BxxZ
BxxZ Jun. 9 at 2:44 PM
$SPRO $GSK Well - with recent news on >10B acquisition I strongly doubt there will be some significant happening within next mth (or 2!!!)..... Strongly hope I am wrong and they nonetheless finally do "the move"....
0 · Reply
Inc82
Inc82 Jun. 9 at 2:41 PM
$SPRO going back to $2.20
1 · Reply
DiamondHandZeus
DiamondHandZeus Jun. 9 at 1:57 PM
$SPRO SPRO 9 days away from approval — who is ready to welcome the PDUFA bois in to pump this stock?
1 · Reply
BxxZ
BxxZ Jun. 9 at 10:03 AM
$SPRO wouldn't be surprised if they decided to drive this down harsh ...... $GSK ....... ?
2 · Reply
zerodayrounder
zerodayrounder Jun. 9 at 2:34 AM
False alarm -- $GSK in talks to buy $NUVL for $9 billion. cc $SPRO
1 · Reply
zerodayrounder
zerodayrounder Jun. 8 at 11:26 PM
Another inconsequential fact leading to confirmation bias: $GSK always issues "transaction in own shares" 6-K disclosures before 1030AM EST related to its buyback program. (It is now each Monday -- weekly -- vs everyday before (LSE rules changed in late Feb 2026)) Today the 6-K crossed at 4:08PM EST. Maybe compliance team was busy. cc $SPRO
1 · Reply
Inc82
Inc82 Jun. 8 at 7:23 PM
$SPRO when is this going to end?
1 · Reply
sadie444
sadie444 Jun. 8 at 6:25 PM
$SPRO While much of the market is up today, the biotech indices including the XBI are down, indicating the sector is continuing to get sold as a whole out of fear of the Fed raising rates.
1 · Reply
zerodayrounder
zerodayrounder Jun. 8 at 5:56 PM
$SPRO so a HIGHLY probable $51 million first commercial sale milestone is due in ~3 months... $GSK save yourself 3 cents EPS in Q3 ALONE by putting up $600 - $700 million TODAY!
0 · Reply