Market Cap 127.96M
Revenue (ttm) 66.80M
Net Income (ttm) 8.57M
EPS (ttm) N/A
PE Ratio 9.42
Forward PE N/A
Profit Margin 12.83%
Debt to Equity Ratio 0.00
Volume 629,508
Avg Vol 1,106,288
Day's Range N/A - N/A
Shares Out 57.90M
Stochastic %K 42%
Beta 1.45
Analysts Sell
Price Target $4.50

Company Profile

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement...

Industry: Biotechnology
Sector: Healthcare
Phone: 857 242 1600
Address:
675 Massachusetts Avenue, 14th Floor, Cambridge, United States
MikeyMcDermott
MikeyMcDermott Jul. 2 at 9:27 PM
Apparently an FDA approval for a biotech shitco that owns 10% of a drug gets same reaction as a biotech shitco that owns 100% of its drug which gets a CRL. $SPRO vs $UNCY 3+ days after FDA
0 · Reply
BxxZ
BxxZ Jul. 2 at 8:46 PM
$SPRO $GSK How low can U go? (not Spro - actually GSK!!!) Fuj in fej - MUPM
0 · Reply
MikeyMcDermott
MikeyMcDermott Jul. 2 at 7:04 PM
No. The scientists in The People's Republic of Cambridge are killing this stock by not unlocking value. $SPRO
0 · Reply
GeneralGainz
GeneralGainz Jul. 2 at 6:40 PM
$SPRO This is WAY too low after getting FDA approval. Going to load another 10k shares from my $NFLX profits after earnings into this!
1 · Reply
Inc82
Inc82 Jul. 2 at 5:59 PM
$SPRO The shorts are killing this stock.
0 · Reply
Inc82
Inc82 Jul. 2 at 5:57 PM
$SPRO what a disaster!
0 · Reply
DDel
DDel Jul. 2 at 5:24 PM
$SPRO bought more, again. gsk for the win.
0 · Reply
Zalsalman
Zalsalman Jul. 2 at 3:37 PM
Hello $SPRO Is anyone from the company here? 👀 Why is everything so quiet?
1 · Reply
BxxZ
BxxZ Jul. 2 at 1:59 PM
$SPRO $GSK The stock market does not predict any tebi rights buy or RM being on the horizon!!! What they do predict is stubburn intention of the mgt. to go alone on their New Growth phase project - meaning new shares to be issued (up to 120m for measly 240-250m????) and dillution of current shareholders into oblivion (less than 1/3 rd of ownership) - all just for mgt's wish for their new journey!!! Well Esther - there is another path ; prepare Cost saving plan & make everybody apart from yourself (actually being only a shell also you could work part-time!!!) redundant. All U need is external accountancy&legal support!!! To much to ask being dependant only on GSK checks?! Doubt so!!! Makes far more sense than your alone fantasy growth story (current leadership is not up to it!!!)...... So, in case WS is correct do not dream of "yoir own story" and if there eis no discusion with GSK just do your job and reduce costs!!!!
3 · Reply
BxxZ
BxxZ Jul. 2 at 11:58 AM
$SPRO $GSK Seems Forrest is tired.... Better let him rest through summer to be fully "reffiled" in Sept/Oct. Lost opp's & tight dates do not matter. Procrastination is becoming his new "motto". 🤣🤣🤣
0 · Reply
Latest News on SPRO
Spero Therapeutics Transcript: AGM 2026

Jun 23, 2026, 9:00 AM EDT - 9 days ago

Spero Therapeutics Transcript: AGM 2026


GSK, Spero Therapeutics announce FDA approval of Utebzi

2026-06-17T15:17:18.000Z - 15 days ago

GSK, Spero Therapeutics announce FDA approval of Utebzi

GSK


Spero Therapeutics Earnings release: Q1 2026

May 13, 2026, 4:00 PM EDT - 7 weeks ago

Spero Therapeutics Earnings release: Q1 2026


Spero Therapeutics Quarterly report: Q1 2026

May 13, 2026, 4:00 PM EDT - 7 weeks ago

Spero Therapeutics Quarterly report: Q1 2026


Spero Therapeutics Proxy statement: Proxy filing

Apr 27, 2026, 8:00 AM EDT - 2 months ago

Spero Therapeutics Proxy statement: Proxy filing


Spero Therapeutics Proxy statement: Proxy filing

Apr 27, 2026, 8:00 AM EDT - 2 months ago

Spero Therapeutics Proxy statement: Proxy filing


Spero Therapeutics Proxy statement: Proxy filing

Apr 13, 2026, 8:00 AM EDT - 2 months ago

Spero Therapeutics Proxy statement: Proxy filing


Spero Therapeutics Earnings release: Q4 2025

Mar 26, 2026, 4:00 PM EDT - 3 months ago

Spero Therapeutics Earnings release: Q4 2025


Spero Therapeutics Annual report: Q4 2025

Mar 26, 2026, 4:00 PM EDT - 3 months ago

Spero Therapeutics Annual report: Q4 2025


Spero Therapeutics Earnings release: Q3 2025

Nov 13, 2025, 4:00 PM EST - 8 months ago

Spero Therapeutics Earnings release: Q3 2025


Spero Therapeutics Quarterly report: Q3 2025

Nov 13, 2025, 4:00 PM EST - 8 months ago

Spero Therapeutics Quarterly report: Q3 2025


Spero Therapeutics Earnings Call Transcript: Q2 2025

Aug 12, 2025, 4:30 PM EDT - 11 months ago

Spero Therapeutics Earnings Call Transcript: Q2 2025


Spero Therapeutics Quarterly report: Q2 2025

Aug 12, 2025, 4:30 PM EDT - 11 months ago

Spero Therapeutics Quarterly report: Q2 2025


Spero Therapeutics Earnings release: Q2 2025

Aug 12, 2025, 4:30 PM EDT - 11 months ago

Spero Therapeutics Earnings release: Q2 2025


Spero Therapeutics Slides: Corporate Presentation

Jun 16, 2025, 7:00 AM EDT - 1 year ago

Spero Therapeutics Slides: Corporate Presentation


Spero Therapeutics Earnings release: Q1 2025

May 13, 2025, 4:00 PM EDT - 1 year ago

Spero Therapeutics Earnings release: Q1 2025


Spero Therapeutics Quarterly report: Q1 2025

May 13, 2025, 4:00 PM EDT - 1 year ago

Spero Therapeutics Quarterly report: Q1 2025


Spero Therapeutics Proxy statement: Proxy Filing

Apr 28, 2025, 8:00 AM EDT - 1 year ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Proxy statement: Proxy Filing

Apr 28, 2025, 8:00 AM EDT - 1 year ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Earnings Call Transcript: Q4 2024

Mar 27, 2025, 4:30 PM EDT - 1 year ago

Spero Therapeutics Earnings Call Transcript: Q4 2024


Spero Therapeutics Annual report: Q4 2024

Mar 27, 2025, 4:30 PM EDT - 1 year ago

Spero Therapeutics Annual report: Q4 2024


Spero Therapeutics Earnings release: Q4 2024

Mar 27, 2025, 4:30 PM EDT - 1 year ago

Spero Therapeutics Earnings release: Q4 2024


Spero Therapeutics reports Q4 EPS (38c), consensus (31c)

2025-03-27T20:20:55.000Z - 1 year ago

Spero Therapeutics reports Q4 EPS (38c), consensus (31c)


Spero Therapeutics announces interim leadership changes

2025-01-10T12:31:40.000Z - 1 year ago

Spero Therapeutics announces interim leadership changes


Spero Therapeutics downgraded to Hold from Buy at TD Cowen

2024-11-18T12:41:28.000Z - 1 year ago

Spero Therapeutics downgraded to Hold from Buy at TD Cowen


Spero Therapeutics reports Q3 EPS (32c), consensus (36c)

2024-11-14T21:20:42.000Z - 1 year ago

Spero Therapeutics reports Q3 EPS (32c), consensus (36c)


Spero Therapeutics Earnings release: Q3 2024

Nov 14, 2024, 12:00 AM EST - 1 year ago

Spero Therapeutics Earnings release: Q3 2024


Spero Therapeutics Quarterly report: Q3 2024

Nov 14, 2024, 12:00 AM EST - 1 year ago

Spero Therapeutics Quarterly report: Q3 2024


Spero Therapeutics Earnings Call Transcript: Q2 2024

Aug 5, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings Call Transcript: Q2 2024


Spero Therapeutics Quarterly report: Q2 2024

Aug 5, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Quarterly report: Q2 2024


Spero Therapeutics Earnings release: Q2 2024

Aug 5, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings release: Q2 2024


Spero Therapeutics Quarterly report: Q1 2024

May 15, 2024, 4:00 PM EDT - 2 years ago

Spero Therapeutics Quarterly report: Q1 2024


Spero Therapeutics Earnings release: Q1 2024

May 15, 2024, 4:00 PM EDT - 2 years ago

Spero Therapeutics Earnings release: Q1 2024


Spero Therapeutics Proxy statement: Proxy Filing

Apr 16, 2024, 8:00 AM EDT - 2 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Proxy statement: Proxy Filing

Apr 16, 2024, 8:00 AM EDT - 2 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Registration statement: Registration Filing

Mar 15, 2024, 8:00 AM EDT - 2 years ago

Spero Therapeutics Registration statement: Registration Filing


Spero Therapeutics Earnings Call Transcript: Q4 2023

Mar 13, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings Call Transcript: Q4 2023


Spero Therapeutics Annual report: Q4 2023

Mar 13, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Annual report: Q4 2023


Spero Therapeutics Earnings release: Q4 2023

Mar 13, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings release: Q4 2023


Spero Therapeutics Provides Corporate Update and 2024 Outlook

Jan 5, 2024, 8:05 AM EST - 2 years ago

Spero Therapeutics Provides Corporate Update and 2024 Outlook


Spero Therapeutics Earnings Call Transcript: Q3 2023

Nov 13, 2023, 4:30 PM EST - 2 years ago

Spero Therapeutics Earnings Call Transcript: Q3 2023


Spero Therapeutics Quarterly report: Q3 2023

Nov 13, 2023, 4:30 PM EST - 2 years ago

Spero Therapeutics Quarterly report: Q3 2023


Spero Therapeutics Earnings release: Q3 2023

Nov 13, 2023, 4:30 PM EST - 2 years ago

Spero Therapeutics Earnings release: Q3 2023


Spero Therapeutics Slides: Investor Presentation

Nov 1, 2023, 7:45 AM EDT - 2 years ago

Spero Therapeutics Slides: Investor Presentation


Spero Therapeutics Proxy statement: Proxy Filing

Sep 1, 2023, 8:00 AM EDT - 3 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Proxy statement: Proxy Filing

Aug 22, 2023, 8:00 AM EDT - 3 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Earnings Call Transcript: Q2 2023

Aug 10, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings Call Transcript: Q2 2023


Spero Therapeutics Quarterly report: Q2 2023

Aug 10, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Quarterly report: Q2 2023


Spero Therapeutics Earnings release: Q2 2023

Aug 10, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings release: Q2 2023


Spero Therapeutics Earnings Call Transcript: Q1 2023

May 11, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings Call Transcript: Q1 2023


Spero Therapeutics Quarterly report: Q1 2023

May 11, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Quarterly report: Q1 2023


Spero Therapeutics Earnings release: Q1 2023

May 11, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings release: Q1 2023


Spero Therapeutics to Present at Upcoming Investor Conference

Apr 26, 2023, 8:05 AM EDT - 3 years ago

Spero Therapeutics to Present at Upcoming Investor Conference


MikeyMcDermott
MikeyMcDermott Jul. 2 at 9:27 PM
Apparently an FDA approval for a biotech shitco that owns 10% of a drug gets same reaction as a biotech shitco that owns 100% of its drug which gets a CRL. $SPRO vs $UNCY 3+ days after FDA
0 · Reply
BxxZ
BxxZ Jul. 2 at 8:46 PM
$SPRO $GSK How low can U go? (not Spro - actually GSK!!!) Fuj in fej - MUPM
0 · Reply
MikeyMcDermott
MikeyMcDermott Jul. 2 at 7:04 PM
No. The scientists in The People's Republic of Cambridge are killing this stock by not unlocking value. $SPRO
0 · Reply
GeneralGainz
GeneralGainz Jul. 2 at 6:40 PM
$SPRO This is WAY too low after getting FDA approval. Going to load another 10k shares from my $NFLX profits after earnings into this!
1 · Reply
Inc82
Inc82 Jul. 2 at 5:59 PM
$SPRO The shorts are killing this stock.
0 · Reply
Inc82
Inc82 Jul. 2 at 5:57 PM
$SPRO what a disaster!
0 · Reply
DDel
DDel Jul. 2 at 5:24 PM
$SPRO bought more, again. gsk for the win.
0 · Reply
Zalsalman
Zalsalman Jul. 2 at 3:37 PM
Hello $SPRO Is anyone from the company here? 👀 Why is everything so quiet?
1 · Reply
BxxZ
BxxZ Jul. 2 at 1:59 PM
$SPRO $GSK The stock market does not predict any tebi rights buy or RM being on the horizon!!! What they do predict is stubburn intention of the mgt. to go alone on their New Growth phase project - meaning new shares to be issued (up to 120m for measly 240-250m????) and dillution of current shareholders into oblivion (less than 1/3 rd of ownership) - all just for mgt's wish for their new journey!!! Well Esther - there is another path ; prepare Cost saving plan & make everybody apart from yourself (actually being only a shell also you could work part-time!!!) redundant. All U need is external accountancy&legal support!!! To much to ask being dependant only on GSK checks?! Doubt so!!! Makes far more sense than your alone fantasy growth story (current leadership is not up to it!!!)...... So, in case WS is correct do not dream of "yoir own story" and if there eis no discusion with GSK just do your job and reduce costs!!!!
3 · Reply
BxxZ
BxxZ Jul. 2 at 11:58 AM
$SPRO $GSK Seems Forrest is tired.... Better let him rest through summer to be fully "reffiled" in Sept/Oct. Lost opp's & tight dates do not matter. Procrastination is becoming his new "motto". 🤣🤣🤣
0 · Reply
MikeyMcDermott
MikeyMcDermott Jul. 1 at 11:54 PM
Hope $SPRO doesnt sell for 40 cents on the dollar like the Celts did with Jaylen Brown
1 · Reply
MikeyMcDermott
MikeyMcDermott Jul. 1 at 9:50 PM
fwiw, the $CYCN and Korsana Biosciences reverse merger deal was executed on April 1, 2026. Is there something special about first day of new quarter or these reverse merger deals? Either something about SEC reporting / clean break for a new quarter or confirmation bias cc $SPRO $GSK
0 · Reply
Inc82
Inc82 Jul. 1 at 7:42 PM
$SPRO MMs playing with this stock. Buying and selling to each other.
0 · Reply
MikeyMcDermott
MikeyMcDermott Jul. 1 at 7:20 PM
$SPRO I'd have to put my CPA hat back on -- been a long time, but I do wonder if signing on June 30 vs July 1 creates a material difference for SPRO Q2 financial reporting. My guess is it does -- would have to reclassify tebi as asset held for sale and probably recast the income statement with discontinued operations etc. If they signed on July 1, it would just be a subsequent event and all the accounting could be done intra-quarter I would imagine -- and deal would close between July 1 and Sept 1, and could deal with reverse merge piece on Q3 report / fresh state accounting in mid November. cc $GSK
1 · Reply
BxxZ
BxxZ Jul. 1 at 6:56 PM
$SPRO $GSK Tic-tac, tic-tac..... one would say..... Working in super (duper) slow mode has never been efficient !!! Let us see the "materpiece" !!! 🤣🤣🤣 (no vacation for U)
0 · Reply
MikeyMcDermott
MikeyMcDermott Jul. 1 at 6:13 PM
$SPRO kings of snatching defeat from the jaws of victory
0 · Reply
MikeyMcDermott
MikeyMcDermott Jul. 1 at 4:08 PM
$SPRO would be a great way for $GSK to muck up their deal flow in Cambridge, MA for strong-arming SPRO over 50-100 million or whatever on a blockbuster they absolutely need to control 100%. why would they sell their 16% for 18 million dollars? and still be on the hook for 326 milion milestones and potentially large royalties and have zero control over the fate over Spero but most importantly the tebi rights it doesn't own but should control? that makes no sense to me I don't know KROS but the "greenmail" appears like an activist hedge fund that was involved similarly, I hope Esther and SPRO board never find work again in biotech if they snatch defeat from the jaws of victory where are the bankers getting this across the finish line so they collect their fees? there is always a leak -- look what they did on the GSK / Nuvalent deal to force the action clown show
1 · Reply
buyandsold
buyandsold Jul. 1 at 3:54 PM
$SPRO All right there's been enough speculation about blue skies. What's the worst possible scenario from this point? There are always things that surprise me in the markets, permutations that I didn't even know existed, so I'm interested in those with more experience chiming in here. I had never heard of greenmail until the nasty people at KROS introduced me to it. For me the worst I can think is that GSK just starts unwinding their position in the open market and the company continues with its burn rate.
1 · Reply
Biostock
Biostock Jul. 1 at 2:30 PM
$VWAV Autonomous Defense Technologies $OSS $RCAT $ONDS $SPRO
0 · Reply
MikeyMcDermott
MikeyMcDermott Jul. 1 at 1:11 AM
0 · Reply
MikeyMcDermott
MikeyMcDermott Jul. 1 at 12:48 AM
$SPRO I can't believe I'm explaining this again but here it goes: $GSK expects first commercial sale by end of 2026 -- I'm estimating between Oct 1 and Nov 1, let's call it October 15. On that day, GSK will owe $51 million to SPRO and $25 million on the one year anniversary. I expect GSK wants to own all the rights by then to avoid (1) all the milestones/royalties and (2) any future contract dispute with Spero or financial buyer of the remaining tebi rights. There is a 30 day minimum Hood Scott Rodino wait period on any acquisition over $150 million-ish; sale of tebi rights qualifies. GSK couldn't close deal for probably 6-8 weeks -- announcing tomorrow takes us to Sept 1. About a month before 1st commercial sale. Next, I believe the only growth pivot for Spero is by (1) monetizing tebi rights for UPFRONT cash and (2) using the 120 million shares to reverse merge with a private biotech. Reverse mergers take 4 months. That takes you to November 1. That company needs the $$$ for trials.
1 · Reply
Bigos
Bigos Jun. 30 at 10:26 PM
$SPRO What "timelines" are you referring to, and why do you think they "suggest" that a deal needs to be done before summer break is finished?
0 · Reply