Market Cap 149.39M
Revenue (ttm) 66.80M
Net Income (ttm) 8.57M
EPS (ttm) N/A
PE Ratio 11.63
Forward PE N/A
Profit Margin 12.83%
Debt to Equity Ratio 0.00
Volume 322,800
Avg Vol 470,988
Day's Range N/A - N/A
Shares Out 57.90M
Stochastic %K 43%
Beta 1.43
Analysts Sell
Price Target $4.50

Company Profile

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement...

Industry: Biotechnology
Sector: Healthcare
Phone: 857 242 1600
Address:
675 Massachusetts Avenue, 14th Floor, Cambridge, United States
sandlot2025
sandlot2025 May. 20 at 5:07 AM
$SPRO how is this holding serve on such a huge revenue drop? The earnings were surprising against that but is it enough to move it on up?
0 · Reply
zerodayrounder
zerodayrounder May. 19 at 7:42 PM
$SPRO sour hour? only 4900 shares traded since 3PM EST? Odd. 🤔
0 · Reply
zerodayrounder
zerodayrounder May. 19 at 6:18 PM
$SPRO sitting just above the converged 20/50 day simple moving average and 9 day EMA. Perfect launch zone on news?
0 · Reply
mdboss
mdboss May. 19 at 5:29 PM
$SPRO Spero/Immunitas/GSK could be a match made in heaven. Could the timing be any more perfect for the splash of a big deal ahead of the ASCO Annual Meeting later next week and the anticipated approval of Tebi next month? If there is a parachute in our future, I hope it lands me in the Hamptons just in time for a fun summer beach season!
2 · Reply
stevie2times
stevie2times May. 19 at 8:27 AM
$SPRO 😂 The street can play games a lil longer,the reality is about to set in. $GSK is currently on the hook for $276M of the first $750M in sales in milestones alone ($101M first sale + $175M in sales) NOT EVEN COUNTING ROYALTIES. That's 37%!! GSK about to write a great big check, nothing gets in the way of Big Pharma margins.
1 · Reply
HahaYouSUCK
HahaYouSUCK May. 19 at 2:03 AM
0 · Reply
BxxZ
BxxZ May. 18 at 8:25 PM
$SPRO This is becoming ridiculous - A GSK charade !!!! $GSK no more plain talk - take action !!!
1 · Reply
DDel
DDel May. 18 at 6:51 PM
0 · Reply
BxxZ
BxxZ May. 18 at 4:54 PM
$SPRO Tebi is a no brainer - it is the fact trials were stopped due to efficacy of the drug & it would not come as a surprise if FDA approved the drug a mth in advance..... Happened with many drugs - and none was so evident to be approved as Tebi..... So - FDA - do your job 🤣 GSK - ???? (sleeping time is over!!!)
1 · Reply
zerodayrounder
zerodayrounder May. 18 at 2:39 PM
$SPRO moving some freight again. Already at 340k shares. Hopefully an indication that some actionable news will be disclosed publicly soon.
1 · Reply
Latest News on SPRO
Spero Therapeutics Earnings release: Q1 2026

May 13, 2026, 4:00 PM EDT - 6 days ago

Spero Therapeutics Earnings release: Q1 2026


Spero Therapeutics Quarterly report: Q1 2026

May 13, 2026, 4:00 PM EDT - 6 days ago

Spero Therapeutics Quarterly report: Q1 2026


Spero Therapeutics Proxy statement: Proxy filing

Apr 27, 2026, 8:00 AM EDT - 22 days ago

Spero Therapeutics Proxy statement: Proxy filing


Spero Therapeutics Proxy statement: Proxy filing

Apr 27, 2026, 8:00 AM EDT - 22 days ago

Spero Therapeutics Proxy statement: Proxy filing


Spero Therapeutics Proxy statement: Proxy filing

Apr 13, 2026, 8:00 AM EDT - 5 weeks ago

Spero Therapeutics Proxy statement: Proxy filing


Spero Therapeutics Earnings release: Q4 2025

Mar 26, 2026, 4:00 PM EDT - 7 weeks ago

Spero Therapeutics Earnings release: Q4 2025


Spero Therapeutics Annual report: Q4 2025

Mar 26, 2026, 4:00 PM EDT - 7 weeks ago

Spero Therapeutics Annual report: Q4 2025


Spero Therapeutics Earnings release: Q3 2025

Nov 13, 2025, 4:00 PM EST - 6 months ago

Spero Therapeutics Earnings release: Q3 2025


Spero Therapeutics Quarterly report: Q3 2025

Nov 13, 2025, 4:00 PM EST - 6 months ago

Spero Therapeutics Quarterly report: Q3 2025


Spero Therapeutics Earnings Call Transcript: Q2 2025

Aug 12, 2025, 4:30 PM EDT - 10 months ago

Spero Therapeutics Earnings Call Transcript: Q2 2025


Spero Therapeutics Quarterly report: Q2 2025

Aug 12, 2025, 4:30 PM EDT - 10 months ago

Spero Therapeutics Quarterly report: Q2 2025


Spero Therapeutics Earnings release: Q2 2025

Aug 12, 2025, 4:30 PM EDT - 10 months ago

Spero Therapeutics Earnings release: Q2 2025


Spero Therapeutics Slides: Corporate Presentation

Jun 16, 2025, 7:00 AM EDT - 1 year ago

Spero Therapeutics Slides: Corporate Presentation


Spero Therapeutics Earnings release: Q1 2025

May 13, 2025, 4:00 PM EDT - 1 year ago

Spero Therapeutics Earnings release: Q1 2025


Spero Therapeutics Quarterly report: Q1 2025

May 13, 2025, 4:00 PM EDT - 1 year ago

Spero Therapeutics Quarterly report: Q1 2025


Spero Therapeutics Proxy statement: Proxy Filing

Apr 28, 2025, 8:00 AM EDT - 1 year ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Proxy statement: Proxy Filing

Apr 28, 2025, 8:00 AM EDT - 1 year ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Earnings Call Transcript: Q4 2024

Mar 27, 2025, 4:30 PM EDT - 1 year ago

Spero Therapeutics Earnings Call Transcript: Q4 2024


Spero Therapeutics Annual report: Q4 2024

Mar 27, 2025, 4:30 PM EDT - 1 year ago

Spero Therapeutics Annual report: Q4 2024


Spero Therapeutics Earnings release: Q4 2024

Mar 27, 2025, 4:30 PM EDT - 1 year ago

Spero Therapeutics Earnings release: Q4 2024


Spero Therapeutics reports Q4 EPS (38c), consensus (31c)

2025-03-27T20:20:55.000Z - 1 year ago

Spero Therapeutics reports Q4 EPS (38c), consensus (31c)


Spero Therapeutics announces interim leadership changes

2025-01-10T12:31:40.000Z - 1 year ago

Spero Therapeutics announces interim leadership changes


Spero Therapeutics downgraded to Hold from Buy at TD Cowen

2024-11-18T12:41:28.000Z - 1 year ago

Spero Therapeutics downgraded to Hold from Buy at TD Cowen


Spero Therapeutics reports Q3 EPS (32c), consensus (36c)

2024-11-14T21:20:42.000Z - 1 year ago

Spero Therapeutics reports Q3 EPS (32c), consensus (36c)


Spero Therapeutics Earnings release: Q3 2024

Nov 14, 2024, 12:00 AM EST - 1 year ago

Spero Therapeutics Earnings release: Q3 2024


Spero Therapeutics Quarterly report: Q3 2024

Nov 14, 2024, 12:00 AM EST - 1 year ago

Spero Therapeutics Quarterly report: Q3 2024


Spero Therapeutics Earnings Call Transcript: Q2 2024

Aug 5, 2024, 4:30 PM EDT - 1 year ago

Spero Therapeutics Earnings Call Transcript: Q2 2024


Spero Therapeutics Quarterly report: Q2 2024

Aug 5, 2024, 4:30 PM EDT - 1 year ago

Spero Therapeutics Quarterly report: Q2 2024


Spero Therapeutics Earnings release: Q2 2024

Aug 5, 2024, 4:30 PM EDT - 1 year ago

Spero Therapeutics Earnings release: Q2 2024


Spero Therapeutics Quarterly report: Q1 2024

May 15, 2024, 4:00 PM EDT - 2 years ago

Spero Therapeutics Quarterly report: Q1 2024


Spero Therapeutics Earnings release: Q1 2024

May 15, 2024, 4:00 PM EDT - 2 years ago

Spero Therapeutics Earnings release: Q1 2024


Spero Therapeutics Proxy statement: Proxy Filing

Apr 16, 2024, 8:00 AM EDT - 2 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Proxy statement: Proxy Filing

Apr 16, 2024, 8:00 AM EDT - 2 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Registration statement: Registration Filing

Mar 15, 2024, 8:00 AM EDT - 2 years ago

Spero Therapeutics Registration statement: Registration Filing


Spero Therapeutics Earnings Call Transcript: Q4 2023

Mar 13, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings Call Transcript: Q4 2023


Spero Therapeutics Annual report: Q4 2023

Mar 13, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Annual report: Q4 2023


Spero Therapeutics Earnings release: Q4 2023

Mar 13, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings release: Q4 2023


Spero Therapeutics Provides Corporate Update and 2024 Outlook

Jan 5, 2024, 8:05 AM EST - 2 years ago

Spero Therapeutics Provides Corporate Update and 2024 Outlook


Spero Therapeutics Earnings Call Transcript: Q3 2023

Nov 13, 2023, 4:30 PM EST - 2 years ago

Spero Therapeutics Earnings Call Transcript: Q3 2023


Spero Therapeutics Quarterly report: Q3 2023

Nov 13, 2023, 4:30 PM EST - 2 years ago

Spero Therapeutics Quarterly report: Q3 2023


Spero Therapeutics Earnings release: Q3 2023

Nov 13, 2023, 4:30 PM EST - 2 years ago

Spero Therapeutics Earnings release: Q3 2023


Spero Therapeutics Slides: Investor Presentation

Nov 1, 2023, 7:45 AM EDT - 2 years ago

Spero Therapeutics Slides: Investor Presentation


Spero Therapeutics Proxy statement: Proxy Filing

Sep 1, 2023, 8:00 AM EDT - 2 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Proxy statement: Proxy Filing

Aug 22, 2023, 8:00 AM EDT - 2 years ago

Spero Therapeutics Proxy statement: Proxy Filing


Spero Therapeutics Earnings Call Transcript: Q2 2023

Aug 10, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings Call Transcript: Q2 2023


Spero Therapeutics Quarterly report: Q2 2023

Aug 10, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Quarterly report: Q2 2023


Spero Therapeutics Earnings release: Q2 2023

Aug 10, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings release: Q2 2023


Spero Therapeutics Earnings Call Transcript: Q1 2023

May 11, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings Call Transcript: Q1 2023


Spero Therapeutics Quarterly report: Q1 2023

May 11, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Quarterly report: Q1 2023


Spero Therapeutics Earnings release: Q1 2023

May 11, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings release: Q1 2023


Spero Therapeutics to Present at Upcoming Investor Conference

Apr 26, 2023, 8:05 AM EDT - 3 years ago

Spero Therapeutics to Present at Upcoming Investor Conference


sandlot2025
sandlot2025 May. 20 at 5:07 AM
$SPRO how is this holding serve on such a huge revenue drop? The earnings were surprising against that but is it enough to move it on up?
0 · Reply
zerodayrounder
zerodayrounder May. 19 at 7:42 PM
$SPRO sour hour? only 4900 shares traded since 3PM EST? Odd. 🤔
0 · Reply
zerodayrounder
zerodayrounder May. 19 at 6:18 PM
$SPRO sitting just above the converged 20/50 day simple moving average and 9 day EMA. Perfect launch zone on news?
0 · Reply
mdboss
mdboss May. 19 at 5:29 PM
$SPRO Spero/Immunitas/GSK could be a match made in heaven. Could the timing be any more perfect for the splash of a big deal ahead of the ASCO Annual Meeting later next week and the anticipated approval of Tebi next month? If there is a parachute in our future, I hope it lands me in the Hamptons just in time for a fun summer beach season!
2 · Reply
stevie2times
stevie2times May. 19 at 8:27 AM
$SPRO 😂 The street can play games a lil longer,the reality is about to set in. $GSK is currently on the hook for $276M of the first $750M in sales in milestones alone ($101M first sale + $175M in sales) NOT EVEN COUNTING ROYALTIES. That's 37%!! GSK about to write a great big check, nothing gets in the way of Big Pharma margins.
1 · Reply
HahaYouSUCK
HahaYouSUCK May. 19 at 2:03 AM
0 · Reply
BxxZ
BxxZ May. 18 at 8:25 PM
$SPRO This is becoming ridiculous - A GSK charade !!!! $GSK no more plain talk - take action !!!
1 · Reply
DDel
DDel May. 18 at 6:51 PM
0 · Reply
BxxZ
BxxZ May. 18 at 4:54 PM
$SPRO Tebi is a no brainer - it is the fact trials were stopped due to efficacy of the drug & it would not come as a surprise if FDA approved the drug a mth in advance..... Happened with many drugs - and none was so evident to be approved as Tebi..... So - FDA - do your job 🤣 GSK - ???? (sleeping time is over!!!)
1 · Reply
zerodayrounder
zerodayrounder May. 18 at 2:39 PM
$SPRO moving some freight again. Already at 340k shares. Hopefully an indication that some actionable news will be disclosed publicly soon.
1 · Reply
RunningRobert1
RunningRobert1 May. 18 at 11:59 AM
$SPRO Spero Therapeutics SPRO Q1 2026 Summary 15May2026 https://youtu.be/e2MFcqJe7iI Full steam ahead until the PDUFA, the question is how much can it pop before approval or are we trading sideways till then?
0 · Reply
stevie2times
stevie2times May. 17 at 12:51 AM
$SPRO The phone is ringing for those Royals daily. GSK is def front row seat,But' they are definitely not bidding vs themselves!! $6B annual space w the only pill form & QUIDP taking the patent out until 2041 😏
1 · Reply
zerodayrounder
zerodayrounder May. 16 at 11:43 PM
ps I don't think $GSK gave any more granular detail other than estimating tebipenem peak annual sales as greater than 2 billion pounds (or $2.7 billion) Maybe @mdboss is right that Tebi can be $5 billion peak sales drug and we are just assuming 2.7b given the open ended way GSK estimated peak sales I guess we will see when the final buyout price for $SPRO remaining Tebi rights is announced The royalties get huge on incremental sales over 2.7 billion vs baseline of 200 million royalties we've been assuming based on 2.7bln (low double digits % over 1 billion annual sales)
0 · Reply
zerodayrounder
zerodayrounder May. 16 at 11:13 PM
$SPRO there is no buy out coming. I expect a "buzzer beater" deal from $GSK to acquire tebi rights ahead of FDA approval like they did on an out-license with AlfaSigma in March 2026 for a non-core drug lynavoy. GSK received $300MLN upfront, $100MLN on FDA approval and ongoing royalties from Alfa. The deal was signed about 2 weeks before FDA approved lynavoy. Read the tea leaves: there will be a buyout of the remaining Tebi rights SPRO owns, crystallizing the value upfront on agreed upon NPV analysis (i.e., add up all royalties + milestones less SPRO royalties owed to Meiji) with anticipated growth in Tebi re $2.7bln + peak sales out to 2041 & discounted back to PV. Anyone hoping for a buyout of SPRO equity will be disappointed. My hope is market is caught off guard by the news, we get a power gap to $10+ zone depending on tebi valuation and squeeze higher due to 13k call options losing delta hedge & excitement on reverse merger target causing rush of buying. Have a game plan.
2 · Reply
buyandsold
buyandsold May. 16 at 5:57 PM
How could a buyout be mutually beneficial to $SPRO management and GSK but still screw shareholders? I can't easily think of a scenario. Can anyone?
1 · Reply
zerodayrounder
zerodayrounder May. 15 at 7:24 PM
$SPRO highest volume week since October 20 2025/IDWeek presentation. Yesterday price action huge bullish engulfing candle covering all prices since April 27. I think the 40 cent range maybe the widest (minus gaps, post 2022 CRL melt down)
1 · Reply
mdboss
mdboss May. 15 at 2:42 PM
$SPRO I would imagine that Ankit can't wait to see Tebi get to the finish line. The possibility of a "next phase" with a hot to trot cancer drug is simply MINDBLOWING. The licensing agreement with Boehringer Ingelheim and Immunitas was likely a prerequisite to what happens next.
1 · Reply
CharlieeMungerTWITS
CharlieeMungerTWITS May. 15 at 2:10 PM
0 · Reply
buyandsold
buyandsold May. 15 at 1:55 PM
$SPRO $12 Is the number
3 · Reply
BxxZ
BxxZ May. 15 at 11:25 AM
$SPRO $GSK So pathetic - ......
0 · Reply
BxxZ
BxxZ May. 15 at 10:24 AM
$SPRO $GSK Show some balls finally - it is time.... We can clearly see those Spro "snowballs" (Board&mgt) are just following Ur wishes!!!
0 · Reply
Homepayment
Homepayment May. 15 at 4:19 AM
0 · Reply