Market Cap 154.57M
Revenue (ttm) 66.80M
Net Income (ttm) 8.57M
EPS (ttm) N/A
PE Ratio 22.25
Forward PE N/A
Profit Margin 12.83%
Debt to Equity Ratio 0.00
Volume 828,400
Avg Vol 380,394
Day's Range N/A - N/A
Shares Out 57.89M
Stochastic %K 13%
Beta 1.45
Analysts Sell
Price Target $4.50

Company Profile

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which is in Phase 3 development; and SPR720, a novel product candi...

Industry: Biotechnology
Sector: Healthcare
Phone: 857 242 1600
Address:
675 Massachusetts Avenue, 14th Floor, Cambridge, United States
buyandsold
buyandsold Apr. 30 at 5:09 AM
$SPRO GSK does not have to pay a different amount for the company pre or post pdufa. It is the same amount they are prepared to pay either way. If $SPRO does not want that amount they will just pay milestones and royalties with no issue. $7
0 · Reply
rubraquercus
rubraquercus Apr. 29 at 7:50 PM
$SPRO The quants and algos help them get out and a few scaredy pants freak the F out and post stupid shite. GSK loves us, enough said....add if you can is my only advice. Duh...
1 · Reply
GardnerJ
GardnerJ Apr. 29 at 7:32 PM
$SPRO They sure do mention “exploring opportunities to grow portfolio of clinical-stage product candidates “ a lot in the annual report. I can’t see any reason I would vote to give them that opportunity, especially when I have no idea what the candidate is and the fact the majority of their candidates went nowhere. Please just sell or pay me a 100% of my initial investment every year for the next 10-15 years.
1 · Reply
Inc82
Inc82 Apr. 29 at 5:46 PM
$SPRO It looks like we are going back to $2.00
2 · Reply
zerodayrounder
zerodayrounder Apr. 29 at 2:55 PM
$SPRO not sure why $GSK would wait until this summer if they have like 90%+ confidence in approval AND are likely starting to have labeling discussions with FDA about now. Would be weird to pay $5+ extra dollars per share ($300 million+) if you can accept some risk ahead of PDUFA and lock in a price. GSK certainly needs some good news -- getting absolutely blasted and their stock chart is broken now.
2 · Reply
BxxZ
BxxZ Apr. 29 at 2:33 PM
$SPRO 1h of trading with abnormal vol (a bit over 320k avg. - today 293k ?!) and we're down ???? Ups.....
0 · Reply
buyandsold
buyandsold Apr. 29 at 1:59 PM
$SPRO Rational acquirers typically wait until after the FDA decision to avoid paying for approval risk. The June 18, 2026 PDUFA date is just weeks away. GSK has every incentive to let that date pass before considering a buyout — if approved, they negotiate from a position of clarity; if rejected, the question becomes moot.
2 · Reply
buyandsold
buyandsold Apr. 29 at 1:58 PM
$SPRO The window for an acquisition being economically compelling for GSK would be early in the commercial ramp, before it becomes clear just how big the royalty stream will be.
1 · Reply
HahaYouSUCK
HahaYouSUCK Apr. 29 at 12:38 PM
1 · Reply
mdboss
mdboss Apr. 29 at 7:35 AM
$SPRO Tebipenem was highlighted as a top-tier pipeline priority in GSK's Q1 2026 earnings report, recognized as one of two major product approvals expected this year. The report emphasized its role in the 2026 value strategy, confirmed its June 18, 2026, PDUFA date, and framed it as a key competitive advantage in the Specialty Medicines segment.
2 · Reply
Latest News on SPRO
Spero Therapeutics Earnings Call Transcript: Q2 2025

Aug 12, 2025, 4:30 PM EDT - 9 months ago

Spero Therapeutics Earnings Call Transcript: Q2 2025


Spero Therapeutics Earnings Call Transcript: Q4 2024

Mar 27, 2025, 4:30 PM EDT - 1 year ago

Spero Therapeutics Earnings Call Transcript: Q4 2024


Spero Therapeutics Earnings Call Transcript: Q2 2024

Aug 5, 2024, 4:30 PM EDT - 1 year ago

Spero Therapeutics Earnings Call Transcript: Q2 2024


Spero Therapeutics Earnings Call Transcript: Q4 2023

Mar 13, 2024, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings Call Transcript: Q4 2023


Spero Therapeutics Provides Corporate Update and 2024 Outlook

Jan 5, 2024, 8:05 AM EST - 2 years ago

Spero Therapeutics Provides Corporate Update and 2024 Outlook


Spero Therapeutics Earnings Call Transcript: Q3 2023

Nov 13, 2023, 4:30 PM EST - 2 years ago

Spero Therapeutics Earnings Call Transcript: Q3 2023


Spero Therapeutics Earnings Call Transcript: Q2 2023

Aug 10, 2023, 4:30 PM EDT - 2 years ago

Spero Therapeutics Earnings Call Transcript: Q2 2023


Spero Therapeutics Earnings Call Transcript: Q1 2023

May 11, 2023, 4:30 PM EDT - 3 years ago

Spero Therapeutics Earnings Call Transcript: Q1 2023


Spero Therapeutics to Present at Upcoming Investor Conference

Apr 26, 2023, 8:05 AM EDT - 3 years ago

Spero Therapeutics to Present at Upcoming Investor Conference


Spero Therapeutics Earnings Call Transcript: Q4 2022

Mar 30, 2023, 3:30 PM EDT - 3 years ago

Spero Therapeutics Earnings Call Transcript: Q4 2022


Spero Therapeutics Earnings Call Transcript: Q3 2022

Nov 14, 2022, 4:30 PM EST - 3 years ago

Spero Therapeutics Earnings Call Transcript: Q3 2022


buyandsold
buyandsold Apr. 30 at 5:09 AM
$SPRO GSK does not have to pay a different amount for the company pre or post pdufa. It is the same amount they are prepared to pay either way. If $SPRO does not want that amount they will just pay milestones and royalties with no issue. $7
0 · Reply
rubraquercus
rubraquercus Apr. 29 at 7:50 PM
$SPRO The quants and algos help them get out and a few scaredy pants freak the F out and post stupid shite. GSK loves us, enough said....add if you can is my only advice. Duh...
1 · Reply
GardnerJ
GardnerJ Apr. 29 at 7:32 PM
$SPRO They sure do mention “exploring opportunities to grow portfolio of clinical-stage product candidates “ a lot in the annual report. I can’t see any reason I would vote to give them that opportunity, especially when I have no idea what the candidate is and the fact the majority of their candidates went nowhere. Please just sell or pay me a 100% of my initial investment every year for the next 10-15 years.
1 · Reply
Inc82
Inc82 Apr. 29 at 5:46 PM
$SPRO It looks like we are going back to $2.00
2 · Reply
zerodayrounder
zerodayrounder Apr. 29 at 2:55 PM
$SPRO not sure why $GSK would wait until this summer if they have like 90%+ confidence in approval AND are likely starting to have labeling discussions with FDA about now. Would be weird to pay $5+ extra dollars per share ($300 million+) if you can accept some risk ahead of PDUFA and lock in a price. GSK certainly needs some good news -- getting absolutely blasted and their stock chart is broken now.
2 · Reply
BxxZ
BxxZ Apr. 29 at 2:33 PM
$SPRO 1h of trading with abnormal vol (a bit over 320k avg. - today 293k ?!) and we're down ???? Ups.....
0 · Reply
buyandsold
buyandsold Apr. 29 at 1:59 PM
$SPRO Rational acquirers typically wait until after the FDA decision to avoid paying for approval risk. The June 18, 2026 PDUFA date is just weeks away. GSK has every incentive to let that date pass before considering a buyout — if approved, they negotiate from a position of clarity; if rejected, the question becomes moot.
2 · Reply
buyandsold
buyandsold Apr. 29 at 1:58 PM
$SPRO The window for an acquisition being economically compelling for GSK would be early in the commercial ramp, before it becomes clear just how big the royalty stream will be.
1 · Reply
HahaYouSUCK
HahaYouSUCK Apr. 29 at 12:38 PM
1 · Reply
mdboss
mdboss Apr. 29 at 7:35 AM
$SPRO Tebipenem was highlighted as a top-tier pipeline priority in GSK's Q1 2026 earnings report, recognized as one of two major product approvals expected this year. The report emphasized its role in the 2026 value strategy, confirmed its June 18, 2026, PDUFA date, and framed it as a key competitive advantage in the Specialty Medicines segment.
2 · Reply
BxxZ
BxxZ Apr. 28 at 8:25 PM
$SPRO Unbelivable end - don't U think ?! So AI run algoritmic sh%t..... Come on GSK - will U show some balls !!!
1 · Reply
zerodayrounder
zerodayrounder Apr. 28 at 7:57 PM
from $GSK Q4 report 2 major product approvals expected -- bepirovirsen PDUFA date set today for October 26, 2026 --- partner $IONS $12B market cap too big to acquire tebipenem is next June 18.. with $SPRO $160 million market cap out of the readouts -- jemperli (contract dispute with $ANAB) one would think GSK would want to fully own blockbusters
0 · Reply
BxxZ
BxxZ Apr. 28 at 6:59 PM
$SPRO Lets see what GSK will present tommorrow at their q1 - and challenge the wording (about tebi!) vs.previous ones..... A lot of things do not add up here - one of them being also complete silence from Spro mgt. - after cancellation of all other programmes one would expect complete overhaul of its staff - something to be prepared (also discused with SH?, not only Board!) & introduced Asap! With tebi becoming only valuable asset (&us collecting royalties only!), depending fully on a partner, one would expect reduction of staff to max.3-5 people..... And what we get is silence& even abolishment of presenting the data on "normal" AGM (online as before & with q&a!) .....
1 · Reply
zerodayrounder
zerodayrounder Apr. 28 at 5:50 PM
$SPRO traded 937k, 750k and 1M shares on Feb 4-5-6. Likely had to do with $GSK disclosing June 18 as PDUFA date on Feb 4 earnings. So if GSK has very positive comments on tebi -- SPRO should react -- and maybe GSK runs risk of letting the price get away from them? Or do they lock in a price and are free to talk about a fully owned asset. Or they just don't mention anything at all and analysts worry about the 2031 guidance? Interesting situation with SPRO trading low volume and sitting on the 20 day MA and ~30 cents under potential breakout level.
1 · Reply
zerodayrounder
zerodayrounder Apr. 28 at 4:56 PM
looks like $GSK puts $SPRO assets inside same Tesaro subsidiary as $ANAB GSK also buys stuff from this list -- Bellus Health, Affinax, etc Book a win and have a positive partner story to tell on earnings call -- 100% ownership of blockbuster tebipenem offsetting the problems with ANAB contract/license dispute.
1 · Reply
zerodayrounder
zerodayrounder Apr. 28 at 4:19 PM
$SPRO also you have to wonder if $GSK wants to wrap up a SPRO deal to avoid a partner dispute like $ANAB over one of its identified blockbuster drugs that makes up big portion of 2031 guidance. ** acquiring SPRO would also be accretive to operating margins by avoiding 200mln/yr in royalties.
1 · Reply
zerodayrounder
zerodayrounder Apr. 28 at 2:51 PM
$SPRO I do find it odd behavior to (1) not hold an earnings call since May 2025; (2) indicate you will no longer update cash runway guidance (current guidance uses $40.3M year end cash balance and doesn't contemplate any further milestones even the $25 mln received in February); (3) request a share authorization for 240 mln common shares and 10 mln preferred shares when you currently have 120 mln authorized and only 57 mln o/s (and 12 mln more committed to the stock incentive plan -- the 2026 stock incentive plan doesn't add new shares, just retains shares available from 2017 plan and extends its expiration). And then go completely silent on social until last week w/ images suggesting neither the CEO/CFO or corporate counsel attended -- which is kind of weird for a company of about 20 employees (key tebi clinician left in February). I suppose you could still have dual track: $GSK tender offer w/ no shareholder vote and AGM planned June 23 post PDUFA just in case.
1 · Reply
rubraquercus
rubraquercus Apr. 28 at 2:13 PM
$SPRO added the dip
0 · Reply
CharlieeMungerTWITS
CharlieeMungerTWITS Apr. 28 at 10:40 AM
$SPRO If you’re trading this, the real drivers are: * PDUFA outcome (June 18) * Commercial potential of tebipenem * GSK’s strategic priorities post-approval (not before) LOAD UP before retail sniffs it out
1 · Reply
CharlieeMungerTWITS
CharlieeMungerTWITS Apr. 27 at 7:44 PM
$ARVN $SPRO $CELC Come on my little babies, we are ready PDUFA
0 · Reply
BxxZ
BxxZ Apr. 27 at 7:38 PM
$SPRO As expected - no merger 🤣.... Instead heavy shorting 🧐 GSK does not seem to care - no matter their q1 results on wednesday..... Seems nobody will put pressure - will it last through may?
0 · Reply
Willdowdell
Willdowdell Apr. 27 at 5:38 AM
$SPRO are there other potential uses for Tebi? Does the royalty agreement cover them as well?
1 · Reply