300bigboys
Nov 13, 4:32 PM
$WVE Overall, I’d view today’s WVE-007 update as more positive than negative, particularly when evaluated for its potential to improve body composition rather than compete directly with things like Zepbound.
Wave demonstrated strong, dose-dependent Activin E suppression of 82%, 84%, and 88% at 240 mg, 400 mg, and 600 mg, respectively, with encouraging durability and safety. Importantly, earlier 240 mg results showed 14.3% less visceral fat, 5.3% less total fat, and 2.4% more lean mass relative to placebo at six months, despite only 0.9% overall weight reduction.
Today’s announcement confirms that body-composition benefits persisted through one year in that cohort. The 600 mg group showed less impressive total-fat reduction, but participants also had lower baseline adiposity. Wave believes patients with greater adiposity may respond more strongly, which its ongoing Phase 2a trial will test.
less bad visceral fat & smaller waist circumference, though not as much total fat
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