Sep. 4 at 11:28 AM
$ANVS NfL (Neurofilament Light) Trajectory in AD vs. PD
NfL measures active neuroaxonal destruction. Tracking the annual rate of change (%/year) is a key prognostic tool for disease progression.
Annual Progression Rates:
• Healthy Controls: ~2%–3.9%/yr (normal age-related axonal decay).
• Alzheimer's (
$AD): ~7%–15%+/yr. Levels accelerate up to a decade pre-diagnosis and surge during MCI-to-dementia conversion.
• Parkinson's (
$PD - Cognitively Normal): ~2%–4%/yr. Minimal elevation over normal aging due to localized subcortical damage.
• Parkinson's (
$PDD / Atypical): ~6%–10%+/yr. Spikes significantly once cognitive impairment sets in or in aggressive phenotypes (MSA/PSP).
Remember, buntanetap , did not slow down, did not halt, but decreased NFL and TAU
