Market Cap 1.85B
Revenue (ttm) 172.35M
Net Income (ttm) -285.42M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -165.60%
Debt to Equity Ratio 8.26
Volume 2,321,800
Avg Vol 1,647,552
Day's Range N/A - N/A
Shares Out 88.61M
Stochastic %K 40%
Beta 0.41
Analysts Strong Sell
Price Target $39.25

Company Profile

Syndax Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, develops therapies for the treatment of cancer. Its lead product candidate includes Revuforj (revumenib), a menin inhibitor for the treatment of relapsed or refractory R/R acute leukemia; and Niktimvo (axatilimab-csfr), a colony stimulating factor-1 receptor blocking antibody to treat chronic graft-versus-host disease. The company is also developing revumenib for the treatment of R/R acute myeloid leukemia (AML) with a n...

Industry: Biotechnology
Sector: Healthcare
Phone: 781 419 1400
Website: syndax.com
Address:
730 Third Avenue, 9th Floor, New York, United States
dgbio
dgbio May. 15 at 4:01 AM
$SNDX While the current focus is on axatilimab in GVHD and IPF, there are several active or planned investigator-sponsored axatilimab combo trials in oncology: • Combination with Nivolumab in Patients With Relapsed/​Refractory Classical Hodgkin Lymphoma (NAHL) •Combination With Olaparib in BRCA1/​2 and PALB2- Associated Metastatic HER2-negative Breast Cancer •Combined With Decitabine/​Venetoclax for the Treatment of TP53-mutated AML •Combined with Pembrolizumab and Radiation Therapy in TNBC •Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors •With or Without Azacitidine for the Treatment of Patients With Advanced Phase Myeloproliferative Neoplasms, Myeloproliferative Neoplasm/​Myelodysplastic Syndrome Overlap or High Risk Chronic Myelomonocytic Leukemia •Low Dose Oral CyclophoSphamide (s) to Potentiate Axatilimab + Retifanlimab in Treating Metastatic Triple Negative Breast Cancer
0 · Reply
Night_Owl_Biotech
Night_Owl_Biotech May. 14 at 2:23 AM
Commercial-stage oncology focused biopharma Year 4/FY29 & 5-year revenues for all such bios with market caps north of $1B & those who have reported Q126 sales & results of operations. Hence $LEGN & TLX have been excluded. $NVAX is also excluded because only 1 analyst provides NVAX estimates after FY28. We added gross margin multiples as well $SNDX trades @ the 2nd lowest multiple. Remember SNDX collaboration revenues, included in revenue estimates, are 25-30% of Niktimvo sales (per SNDX mgmt) where the value comes from SNDX's 50% share. Put simplest, SNDX analyst estimates do not reflect 50% of Niktimvo sales which means, in theory, SNDX's revenue multiples are overstated. $URGN has been on a tear. Does the relatively low multiple suggest there's more to come? Is this the year we finally get $IMCR data in melanoma? Remember KimmTrak may have peaked or is nearing 90% of peak at $400MM/year
1 · Reply
NVDAMillionaire
NVDAMillionaire May. 14 at 1:43 AM
$SNDX Really good write-up that perfectly summarizes SNDX's present situation. So if you want to bring your SNDX knowledge up to date or just discover SNDX, this is required reading. https://everyticker.com/quote/SNDX/analysis/syndax-pharmaceuticals-twin-first-in-class-approvals-fuel-a-rare-biotech-profitability-path-nasdaq-sndx
0 · Reply
Jarvis7424
Jarvis7424 May. 13 at 5:45 PM
$SNDX undervalued
0 · Reply
Valuetraderextraordinary
Valuetraderextraordinary May. 13 at 5:29 PM
$SNDX 24pc short!!!!!
0 · Reply
Valuetraderextraordinary
Valuetraderextraordinary May. 13 at 3:27 PM
$SNDX M&A target defo!
0 · Reply
Jarvis7424
Jarvis7424 May. 13 at 2:56 PM
$SNDX I’ll take a buyout at $37
0 · Reply
DonCorleone77
DonCorleone77 May. 13 at 11:36 AM
$SNDX Syndax price target lowered to $37 from $38 at UBS UBS lowered the firm's price target on Syndax to $37 from $38 and keeps a Buy rating on the shares.
0 · Reply
Quantumup
Quantumup May. 13 at 10:41 AM
Citizens on $KURA said, We reiterate our Market Outperform rating and price target of $24 for Kura Oncology based on a discounted EPS and revenue multiple analysis. $SNDX ABBV BMY RHHBY DSNKY PFE $RIGL Citizens added—Yesterday, Kura announced 1Q26 financial results, provided updates on the KOMZIFTI (ziftomenib, zifto) launch and discussed milestones for 2026. Of note, the registrational Phase 3 KOMET-017 trial is enrolling ahead of expectations, with the potential for top-line results for the intensive chemo combo as early as 2028. With signs pointing to a strong KOMZIFTI launch, the frontline AML trials fully funded, the FTI program progressing in the clinic, and a cash position of $580.8MM, we believe Kura shares represent an attractive investment opportunity, with ~59% downside (bear case of $4) and ~200% upside (bull case of $29).
1 · Reply
mulc
mulc May. 13 at 4:20 AM
$SNDX I was staying quiet, but i knew kura was gonna shit the bed…just tells you that excuses sndx made in general regarding q1 for entire sector were not made up out of thin air. Now how good do their revuforj result look after this bad Q1 results for kura?
1 · Reply
Latest News on SNDX
Syndax price target lowered to $37 from $38 at UBS

2026-05-13T12:20:45.000Z - 1 day ago

Syndax price target lowered to $37 from $38 at UBS


Syndax reports 12 Revuforj abstracts accepted for EHA

2026-05-12T18:34:41.000Z - 2 days ago

Syndax reports 12 Revuforj abstracts accepted for EHA


Syndax price target raised to $46 from $45 at Stifel

2026-05-04T10:54:25.000Z - 11 days ago

Syndax price target raised to $46 from $45 at Stifel


Syndax price target lowered to $37 from $40 at Jefferies

2026-05-01T19:25:20.000Z - 13 days ago

Syndax price target lowered to $37 from $40 at Jefferies


Syndax price target raised to $37 from $35 at Barclays

2026-05-01T09:40:18.000Z - 14 days ago

Syndax price target raised to $37 from $35 at Barclays


Syndax Pharmaceuticals Earnings Call Transcript: Q1 2026

Apr 30, 2026, 4:30 PM EDT - 14 days ago

Syndax Pharmaceuticals Earnings Call Transcript: Q1 2026


Syndax price target raised to $34 from $28 at Goldman Sachs

2026-03-31T11:13:38.000Z - 6 weeks ago

Syndax price target raised to $34 from $28 at Goldman Sachs


Syndax price target lowered to $43 from $45 at Mizuho

2026-03-31T11:08:14.000Z - 6 weeks ago

Syndax price target lowered to $43 from $45 at Mizuho


Syndax assumed with a Buy at Jefferies

2026-03-30T13:08:09.000Z - 6 weeks ago

Syndax assumed with a Buy at Jefferies

KURA


Syndax price target raised to $45 from $33 at JPMorgan

2026-03-09T11:11:49.000Z - 2 months ago

Syndax price target raised to $45 from $33 at JPMorgan


Syndax price target raised to $57 from $51 at Citi

2026-03-02T11:59:34.000Z - 2 months ago

Syndax price target raised to $57 from $51 at Citi


Syndax reports Q4 EPS (78c), consensus (58c)

2026-02-26T21:39:29.000Z - 2 months ago

Syndax reports Q4 EPS (78c), consensus (58c)


Syndax Pharmaceuticals Earnings Call Transcript: Q4 2025

Feb 26, 2026, 4:30 PM EST - 2 months ago

Syndax Pharmaceuticals Earnings Call Transcript: Q4 2025


Syndax Announces Participation in March Investor Conferences

Feb 23, 2026, 7:00 AM EST - 2 months ago

Syndax Announces Participation in March Investor Conferences


Syndax price target raised to $28 from $27 at BofA

2026-02-03T12:36:57.000Z - 3 months ago

Syndax price target raised to $28 from $27 at BofA


Syndax announces expected milestones for 2026

2026-01-12T12:05:54.000Z - 4 months ago

Syndax announces expected milestones for 2026


Syndax Pharmaceuticals Transcript: Investor Update

Dec 8, 2025, 7:00 AM EST - 5 months ago

Syndax Pharmaceuticals Transcript: Investor Update


Syndax price target raised to $35 from $22 at Barclays

2025-11-24T11:35:26.000Z - 6 months ago

Syndax price target raised to $35 from $22 at Barclays


Syndax price target lowered to $33 from $40 at JPMorgan

2025-11-12T12:36:22.000Z - 6 months ago

Syndax price target lowered to $33 from $40 at JPMorgan


Syndax price target raised to $38 from $35 at UBS

2025-11-04T12:42:02.000Z - 6 months ago

Syndax price target raised to $38 from $35 at UBS


Syndax Pharmaceuticals Earnings Call Transcript: Q3 2025

Nov 3, 2025, 4:30 PM EST - 6 months ago

Syndax Pharmaceuticals Earnings Call Transcript: Q3 2025


Syndax Announces Participation in November Investor Conferences

Oct 30, 2025, 7:00 AM EDT - 7 months ago

Syndax Announces Participation in November Investor Conferences


Syndax Pharmaceuticals Transcript: Study Update

Oct 24, 2025, 2:30 PM EDT - 7 months ago

Syndax Pharmaceuticals Transcript: Study Update


Syndax Announces Participation in September Investor Conferences

Aug 26, 2025, 7:00 AM EDT - 9 months ago

Syndax Announces Participation in September Investor Conferences


Syndax Pharmaceuticals Earnings Call Transcript: Q2 2025

Aug 4, 2025, 4:30 PM EDT - 10 months ago

Syndax Pharmaceuticals Earnings Call Transcript: Q2 2025


Syndax Announces Participation in June Investor Conferences

May 29, 2025, 7:00 AM EDT - 1 year ago

Syndax Announces Participation in June Investor Conferences


Syndax Announces Participation in May Investor Conferences

May 8, 2025, 7:00 AM EDT - 1 year ago

Syndax Announces Participation in May Investor Conferences


Syndax Pharmaceuticals Earnings Call Transcript: Q1 2025

May 5, 2025, 4:30 PM EDT - 1 year ago

Syndax Pharmaceuticals Earnings Call Transcript: Q1 2025


Syndax Pharmaceuticals Earnings Call Transcript: Q4 2024

Mar 3, 2025, 8:00 AM EST - 1 year ago

Syndax Pharmaceuticals Earnings Call Transcript: Q4 2024


Syndax Pharmaceuticals Transcript: Status Update

Dec 9, 2024, 10:00 AM EST - 1 year ago

Syndax Pharmaceuticals Transcript: Status Update


US FDA approves Syndax's blood cancer drug

Nov 15, 2024, 6:26 PM EST - 1 year ago

US FDA approves Syndax's blood cancer drug


Syndax Pharmaceuticals Transcript: FDA Announcement

Nov 15, 2024, 6:00 PM EST - 1 year ago

Syndax Pharmaceuticals Transcript: FDA Announcement


Syndax Pharmaceuticals Earnings Call Transcript: Q3 2024

Nov 5, 2024, 4:30 PM EST - 1 year ago

Syndax Pharmaceuticals Earnings Call Transcript: Q3 2024


dgbio
dgbio May. 15 at 4:01 AM
$SNDX While the current focus is on axatilimab in GVHD and IPF, there are several active or planned investigator-sponsored axatilimab combo trials in oncology: • Combination with Nivolumab in Patients With Relapsed/​Refractory Classical Hodgkin Lymphoma (NAHL) •Combination With Olaparib in BRCA1/​2 and PALB2- Associated Metastatic HER2-negative Breast Cancer •Combined With Decitabine/​Venetoclax for the Treatment of TP53-mutated AML •Combined with Pembrolizumab and Radiation Therapy in TNBC •Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors •With or Without Azacitidine for the Treatment of Patients With Advanced Phase Myeloproliferative Neoplasms, Myeloproliferative Neoplasm/​Myelodysplastic Syndrome Overlap or High Risk Chronic Myelomonocytic Leukemia •Low Dose Oral CyclophoSphamide (s) to Potentiate Axatilimab + Retifanlimab in Treating Metastatic Triple Negative Breast Cancer
0 · Reply
Night_Owl_Biotech
Night_Owl_Biotech May. 14 at 2:23 AM
Commercial-stage oncology focused biopharma Year 4/FY29 & 5-year revenues for all such bios with market caps north of $1B & those who have reported Q126 sales & results of operations. Hence $LEGN & TLX have been excluded. $NVAX is also excluded because only 1 analyst provides NVAX estimates after FY28. We added gross margin multiples as well $SNDX trades @ the 2nd lowest multiple. Remember SNDX collaboration revenues, included in revenue estimates, are 25-30% of Niktimvo sales (per SNDX mgmt) where the value comes from SNDX's 50% share. Put simplest, SNDX analyst estimates do not reflect 50% of Niktimvo sales which means, in theory, SNDX's revenue multiples are overstated. $URGN has been on a tear. Does the relatively low multiple suggest there's more to come? Is this the year we finally get $IMCR data in melanoma? Remember KimmTrak may have peaked or is nearing 90% of peak at $400MM/year
1 · Reply
NVDAMillionaire
NVDAMillionaire May. 14 at 1:43 AM
$SNDX Really good write-up that perfectly summarizes SNDX's present situation. So if you want to bring your SNDX knowledge up to date or just discover SNDX, this is required reading. https://everyticker.com/quote/SNDX/analysis/syndax-pharmaceuticals-twin-first-in-class-approvals-fuel-a-rare-biotech-profitability-path-nasdaq-sndx
0 · Reply
Jarvis7424
Jarvis7424 May. 13 at 5:45 PM
$SNDX undervalued
0 · Reply
Valuetraderextraordinary
Valuetraderextraordinary May. 13 at 5:29 PM
$SNDX 24pc short!!!!!
0 · Reply
Valuetraderextraordinary
Valuetraderextraordinary May. 13 at 3:27 PM
$SNDX M&A target defo!
0 · Reply
Jarvis7424
Jarvis7424 May. 13 at 2:56 PM
$SNDX I’ll take a buyout at $37
0 · Reply
DonCorleone77
DonCorleone77 May. 13 at 11:36 AM
$SNDX Syndax price target lowered to $37 from $38 at UBS UBS lowered the firm's price target on Syndax to $37 from $38 and keeps a Buy rating on the shares.
0 · Reply
Quantumup
Quantumup May. 13 at 10:41 AM
Citizens on $KURA said, We reiterate our Market Outperform rating and price target of $24 for Kura Oncology based on a discounted EPS and revenue multiple analysis. $SNDX ABBV BMY RHHBY DSNKY PFE $RIGL Citizens added—Yesterday, Kura announced 1Q26 financial results, provided updates on the KOMZIFTI (ziftomenib, zifto) launch and discussed milestones for 2026. Of note, the registrational Phase 3 KOMET-017 trial is enrolling ahead of expectations, with the potential for top-line results for the intensive chemo combo as early as 2028. With signs pointing to a strong KOMZIFTI launch, the frontline AML trials fully funded, the FTI program progressing in the clinic, and a cash position of $580.8MM, we believe Kura shares represent an attractive investment opportunity, with ~59% downside (bear case of $4) and ~200% upside (bull case of $29).
1 · Reply
mulc
mulc May. 13 at 4:20 AM
$SNDX I was staying quiet, but i knew kura was gonna shit the bed…just tells you that excuses sndx made in general regarding q1 for entire sector were not made up out of thin air. Now how good do their revuforj result look after this bad Q1 results for kura?
1 · Reply
dgbio
dgbio May. 13 at 3:51 AM
$SNDX Frontline menin inhibitor + intensive chemo, KMT2A and NPM1, Kura vs Syndax: →CRc 93% vs 92% →MRD- 83% vs 83%, both assessed locally, Syndax does not mention methods, Kura mentions several including flow cytometry and NGS. →QTc Prolongation, Grade 3 4% vs 4% in DLT evaluable, 3% in total. I don't see how Kura can claim any superiority.
2 · Reply
Night_Owl_Biotech
Night_Owl_Biotech May. 13 at 2:58 AM
$INCY 3/31/2026 net cash/debt is 2.24X higher than $SNDX 5/12/26 market cap. INCY disclosed their risk-free interest rate on their cash at year end was 4.1%. Ignoring the obvious synergy Revuforj revenues adds to soften the Jakafi patent cliff, INCY's cash hoarde may start to become a meaningful drag on ROE & ROA. Does KURA's Q126 revenues make a INCY/SNDX transaction more or less likely? We suspect, all things considered, more likely but WTF do we know. This is not investment advice.
0 · Reply
dgbio
dgbio May. 13 at 1:55 AM
$SNDX Reading EHA abstracts. NPM1 is complex with many co-mutations occuring. This is post-hoc look on efficacy in different co-mutations. Very high CR+CRh in some. https://library.ehaweb.org/eha/2026/eha-2026/4207502/james.s.blachly.efficacy.of.revumenib.in.acute.myeloid.leukemia.harboring.html
0 · Reply
dgbio
dgbio May. 13 at 1:42 AM
$SNDX Reading EHA abstracts. This is great. R/R setting, revumenib oral combo with decitabine and venetoclax. CR/CRh of 60% vs 21-23% revumenib mono. Median DOR CR/CRh Not Reached (KMT2A) and 10 months (NPM1) vs 6 and 4 months for mono respectively. 42 pts with R/R AML were enrolled. The median age was 40 years (range, 12–82), including 5 adolescents (12%). Seventeen pts (40%) had KMT2Ar, 16 (38%) NPM1mt, and 9 (21%) NUP98r. Pts were heavily pretreated (median 2 prior lines, range 1–5); →The CR/CRh rate was 60% (25 pts), with CR in 43% (18 pts), CRh in 17% (7 pts), CRi in 10% (4 pts), CRp in 2% (1 pt), MLFS in 14% (6 pts), and PR in 2% (1 pt). →MRD negativity by MFC in responders was 64% (24/37), and 80% (20/25) in those with CR/CRh. →QTc prolongation grade ≥3 occurred in 2 pts (5%) https://library.ehaweb.org/eha/2026/eha-2026/4207483/branko.cuglievan.phase1.2studyof.theall-oral.combination.html
0 · Reply
Hawksssss
Hawksssss May. 12 at 11:48 PM
$SNDX Kura only got 6 million in sales in the second quarter after launch. Not so good. That should get rid of one of the major concerns for us
0 · Reply
dgbio
dgbio May. 12 at 10:00 PM
$SNDX Reading EHA abstracts. Frontline Revumenib + Intensive chemo. Two dose levels (DL) of revumenib were evaluated (DL1: 110 mg/220 mg ± strong CYP3A4 inhibitor [CYP3A4i]; DL2: 160 mg/270 mg ± strong CYP3A4i) in combination with cytarabine plus daunorubicin or idarubicin. KMT2Ar was detected in 92% (12/13) of pts in DL1 and 39% (7/18) in DL2; NPM1m was detected in 8% (1/13) of pts in DL1 and 56% (10/18) in DL2. →ORR was 100% (12/12) in DL1 and 92.9% (13/14) in DL2; →CRc rate was 100% (12/12) and 85.7% (12/14); →CR rate was 91.7% (11/12) and 78.6% (11/14), respectively. →MRD−CR was achieved in 100% (8/8) of tested pts in DL1 and 70.0% (7/10) in DL2. →No pt developed differentiation syndrome →Two pts in DL1 (6% of all pts) experienced any-grade QTcF prolongation (1 case of grade 3). https://library.ehaweb.org/eha/2026/eha-2026/4207477/ibrahim.aldoss.revumenib.2B.intensive.chemotherapy.for.newly.diagnosed.acute.html
0 · Reply
dgbio
dgbio May. 12 at 9:33 PM
$SNDX Reading EHA abstracts. Revumenib maintenance therapy post-transplant: median duration of treatment - 28 weeks, median RFS and OS - Not Reached, estimated OS at 12 months - 91%, discontinuation rate - 5%, QTc prolongation Grade 3 and higher - none, QTc prolongation Grade 2 - 5%. https://library.ehaweb.org/eha/2026/eha-2026/4208183/andrius.uenka.revumenib.therapy.post.hematopoietic.stem.cell.transplant.for.html
0 · Reply
dgbio
dgbio May. 12 at 9:16 PM
$SNDX Reading EHA abstracts: 'We identify a previously unrecognized mechanism of MENIN inhibitor resistance in KMT2A::MLLT3 AML mediated by ZEB1, which supports H9M-independent survival. MiR-204 negatively regulates ZEB1 and can be pharmacologically reactivated with hypomethylating agents, thereby restoring sensitivity to MENIN inhibition and providing a mechanistic rationale for combination therapy'. https://library.ehaweb.org/eha/2026/eha-2026/4206672/liam.macphee.zeb1.defines.a.targetable.menin-inhibitor.escape.program.in.kmt2a.html
0 · Reply
dgbio
dgbio May. 12 at 8:55 PM
$SNDX Kura reports only 6m revenue for Komzifti vs estimated 15m revenue for Revuforj in NPM1.
0 · Reply
Burning_Cash
Burning_Cash May. 12 at 8:22 PM
$SNDX At least KURA didn’t hit it out of the park. Maybe we’ll recover somewhat tomorrow. Don’t see anything to suggest the option guy(s) will be making bank, though.
1 · Reply
Night_Owl_Biotech
Night_Owl_Biotech May. 12 at 6:16 PM
$SNDX investors should go to the KURA page here on StockTwits. A user named Massimo or the like published an excerpt from a KURA presentation to be made in 1 month. Ziftomenib's CRc rates are north of 90%. At a minimum, that's going to get some attention. @outlawinvestor1 also posted a good comparison of the 2 drugs 1 day does not make a trend but shame on SNDX for not selling to Incyte when they could have.
8 · Reply
Burning_Cash
Burning_Cash May. 12 at 6:03 PM
$SNDX Or maybe not… 😅
0 · Reply