Market Cap 45.78M
Revenue (ttm) 146.07M
Net Income (ttm) -196.04M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -134.21%
Debt to Equity Ratio -0.45
Volume 754,449
Avg Vol 1,415,654
Day's Range N/A - N/A
Shares Out 22.66M
Stochastic %K 5%
Beta 0.89
Analysts Strong Sell
Price Target $6.40

Company Profile

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compounds include XPOVIO in combination with bortezomib and dexamethasone for th...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 658 0600
Address:
85 Wells Avenue, 2nd Floor, Suite 210, Newton, United States
Spanish_guy
Spanish_guy Aug. 18 at 3:00 PM
$KPTI shorts are in trouble. Stock on the Minimum and any good news could explode It.
1 · Reply
GaryGherkins
GaryGherkins Aug. 18 at 12:45 PM
$KPTI management being super quiet with a material event coming up could be interesting, hope they have an atm in place
0 · Reply
Lowkeyoptions
Lowkeyoptions Aug. 18 at 11:01 AM
$KPTI funded until September theyll need to get the price up – Total Revenue was $33.4 Million, and U.S. XPOVIO® (selinexor) Net Product Revenue was $30.8 Million for the Second Quarter of 2026 – – Company Reaffirms Full-Year 2026 Total Revenue Guidance of $130 Million to $150 Million Including U.S. XPOVIO Net Product Revenue Guidance of $115 Million to $130 Million – The Company expects its existing liquidity, including cash, cash equivalents and investments, together with anticipated cash flow from net product revenue and license and other revenue, to fund its current operating plans into September 2026. https://www.prnewswire.com/news-releases/karyopharm-reports-second-quarter-2026-financial-results-and-highlights-continued-progress-toward-myelofibrosis-snda-submission-302850269.html
0 · Reply
Spanish_guy
Spanish_guy Aug. 18 at 12:09 AM
$KPTI they Will pump the stock for the Next offering. Must do, no?
0 · Reply
celebratelife
celebratelife Aug. 17 at 11:25 PM
$KPTI LATEST BULLSHITS RICHARD PAULSON & THE LOUSY KPTI BOARD HAVE FED INVESTORS https://x.com/chimesofjustice/status/2089493488429654316
0 · Reply
celebratelife
celebratelife Aug. 17 at 9:09 PM
$KPTI Richard Paulson and the evil Board that has empowered him, have fed investors BS for years, and made millions, destroyed KPTI. Shorts love'em.
0 · Reply
k3vl4r
k3vl4r Aug. 17 at 8:12 PM
K3vl4r AI outlook, Aug 17 Reading most bullish: $LX $DEXE $EEIQ $KPTI Leaning bearish: $NVNI $MOG $HTCO 1438/1656 tracked assets read bullish. Scenarios to research, not advice. https://app.k3vl4r.com/today #stocks #investing
0 · Reply
Lowkeyoptions
Lowkeyoptions Aug. 17 at 6:03 PM
$KPTI macd cross up
0 · Reply
Lowkeyoptions
Lowkeyoptions Aug. 17 at 1:10 PM
Lately these pharmas take a few days to recover. $TENX $KPTI like$CAPR now add $EYPT
0 · Reply
Coco63
Coco63 Aug. 17 at 12:24 PM
$IMMP The probability of a buyout by Merck is between 40% and 60%. The purchase price would likely range from €1.5 billion to €2 billion. I’m placing my bets for the end of the year. Immutep’s annual report, due next week, will provide an opportunity to update the status of ongoing clinical trials, and the stock could see a strong upward surge. $MRK $CAPR $GOSS $KPTI $MREO $NVO $LLY $NBIS $FAMI $DFSC $SPCX $XPON $SRPT $AAOI $AMZN $GYGY $NVDA $AAPL $IPST
0 · Reply
Latest News on KPTI
Karyopharm reports Q2 EPS ($2.32) vs. ($4.32) last year

2026-08-17T08:04:07.000Z - 1 day ago

Karyopharm reports Q2 EPS ($2.32) vs. ($4.32) last year


Karyopharm Therapeutics Earnings Call Transcript: Q2 2026

Aug 13, 2026, 8:00 AM EDT - 5 days ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2026


Karyopharm Therapeutics Earnings release: Q2 2026

Aug 13, 2026, 8:00 AM EDT - 5 days ago

Karyopharm Therapeutics Earnings release: Q2 2026


Karyopharm Therapeutics Quarterly report: Q2 2026

Aug 13, 2026, 8:00 AM EDT - 5 days ago

Karyopharm Therapeutics Quarterly report: Q2 2026


Karyopharm Therapeutics Slides: Q2 2026

Aug 13, 2026, 8:00 AM EDT - 5 days ago

Karyopharm Therapeutics Slides: Q2 2026


Karyopharm price target lowered to $11 from $14 at Jefferies

2026-07-31T14:40:23.000Z - 18 days ago

Karyopharm price target lowered to $11 from $14 at Jefferies


Karyopharm downgraded to Neutral from Buy at H.C. Wainwright

2026-07-31T10:10:48.000Z - 18 days ago

Karyopharm downgraded to Neutral from Buy at H.C. Wainwright


Karyopharm downgraded to Neutral from Outperform at Baird

2026-07-31T08:40:14.000Z - 18 days ago

Karyopharm downgraded to Neutral from Outperform at Baird


Karyopharm to submit sNDA for selinexor plus ruxolitinib

2026-07-30T20:45:31.000Z - 18 days ago

Karyopharm to submit sNDA for selinexor plus ruxolitinib


Karyopharm trading resumes

2026-07-30T20:40:26.000Z - 18 days ago

Karyopharm trading resumes


Karyopharm trading halted, news pending

2026-07-30T20:07:04.000Z - 18 days ago

Karyopharm trading halted, news pending


Karyopharm Therapeutics Slides: Investor presentation

Jun 4, 2026, 7:00 AM EDT - 2 months ago

Karyopharm Therapeutics Slides: Investor presentation


Karyopharm Therapeutics Transcript: Study result

Jun 2, 2026, 2:00 PM EDT - 2 months ago

Karyopharm Therapeutics Transcript: Study result


Karyopharm Therapeutics Press release: Study result

Jun 2, 2026, 2:00 PM EDT - 2 months ago

Karyopharm Therapeutics Press release: Study result


Karyopharm Therapeutics Slides: Study result

Jun 2, 2026, 2:00 PM EDT - 2 months ago

Karyopharm Therapeutics Slides: Study result


Karyopharm Therapeutics Transcript: AGM 2026

May 21, 2026, 9:00 AM EDT - 3 months ago

Karyopharm Therapeutics Transcript: AGM 2026


Karyopharm Therapeutics Slides: Corporate presentation

May 17, 2026, 7:00 AM EDT - 3 months ago

Karyopharm Therapeutics Slides: Corporate presentation


Karyopharm reports Q1 EPS ($1.24), consensus ($1.44)

2026-05-14T12:06:55.000Z - 3 months ago

Karyopharm reports Q1 EPS ($1.24), consensus ($1.44)


Karyopharm Therapeutics Earnings Call Transcript: Q1 2026

May 14, 2026, 8:00 AM EDT - 3 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2026


Karyopharm Therapeutics Earnings release: Q1 2026

May 14, 2026, 8:00 AM EDT - 3 months ago

Karyopharm Therapeutics Earnings release: Q1 2026


Karyopharm Therapeutics Slides: Q1 2026

May 14, 2026, 8:00 AM EDT - 3 months ago

Karyopharm Therapeutics Slides: Q1 2026


Karyopharm Therapeutics Quarterly report: Q1 2026

May 14, 2026, 8:00 AM EDT - 3 months ago

Karyopharm Therapeutics Quarterly report: Q1 2026


Karyopharm to Participate at Upcoming Investor Conferences

May 12, 2026, 7:30 AM EDT - 3 months ago

Karyopharm to Participate at Upcoming Investor Conferences


Karyopharm Therapeutics Slides: Corporate presentation

Apr 16, 2026, 7:00 AM EDT - 4 months ago

Karyopharm Therapeutics Slides: Corporate presentation


Karyopharm Therapeutics Proxy statement: Proxy filing

Apr 13, 2026, 8:00 AM EDT - 4 months ago

Karyopharm Therapeutics Proxy statement: Proxy filing


Karyopharm Therapeutics Transcript: Study result

Mar 24, 2026, 8:00 AM EDT - 5 months ago

Karyopharm Therapeutics Transcript: Study result


Karyopharm Therapeutics Press release: Study result

Mar 24, 2026, 8:00 AM EDT - 5 months ago

Karyopharm Therapeutics Press release: Study result


Karyopharm Therapeutics Slides: Study result

Mar 24, 2026, 8:00 AM EDT - 5 months ago

Karyopharm Therapeutics Slides: Study result


Karyopharm Therapeutics Transcript: EGM 2026

Feb 18, 2026, 9:00 AM EST - 6 months ago

Karyopharm Therapeutics Transcript: EGM 2026


Karyopharm Therapeutics Earnings Call Transcript: Q4 2025

Feb 12, 2026, 8:00 AM EST - 6 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2025


Karyopharm Therapeutics Annual report: Q4 2025

Feb 12, 2026, 8:00 AM EST - 6 months ago

Karyopharm Therapeutics Annual report: Q4 2025


Karyopharm Therapeutics Earnings release: Q4 2025

Feb 12, 2026, 8:00 AM EST - 6 months ago

Karyopharm Therapeutics Earnings release: Q4 2025


Karyopharm Therapeutics Slides: Q4 2025

Feb 12, 2026, 8:00 AM EST - 6 months ago

Karyopharm Therapeutics Slides: Q4 2025


Karyopharm Therapeutics Proxy statement: Proxy Filing

Jan 9, 2026, 7:00 AM EST - 7 months ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Proxy statement: Proxy Filing

Dec 30, 2025, 7:00 AM EST - 8 months ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm to Participate in Baird's Biotech Discovery Series

Dec 8, 2025, 7:00 AM EST - 9 months ago

Karyopharm to Participate in Baird's Biotech Discovery Series


Karyopharm Therapeutics Earnings Call Transcript: Q3 2025

Nov 3, 2025, 8:00 AM EST - 10 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2025


Karyopharm Therapeutics Earnings release: Q3 2025

Nov 3, 2025, 8:00 AM EST - 10 months ago

Karyopharm Therapeutics Earnings release: Q3 2025


Karyopharm Therapeutics Quarterly report: Q3 2025

Nov 3, 2025, 8:00 AM EST - 10 months ago

Karyopharm Therapeutics Quarterly report: Q3 2025


Karyopharm Therapeutics Slides: Q3 2025

Nov 3, 2025, 8:00 AM EST - 10 months ago

Karyopharm Therapeutics Slides: Q3 2025


Karyopharm Therapeutics Earnings Call Transcript: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2025


Karyopharm Therapeutics Quarterly report: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Quarterly report: Q2 2025


Karyopharm Therapeutics Earnings release: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Earnings release: Q2 2025


Karyopharm Therapeutics Slides: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Slides: Q2 2025


Karyopharm Therapeutics Slides: FY 2025

Jun 5, 2025, 3:10 PM EDT - 1 year ago

Karyopharm Therapeutics Slides: FY 2025


Karyopharm Therapeutics Slides: Corporate Presentation

Jun 5, 2025, 7:00 AM EDT - 1 year ago

Karyopharm Therapeutics Slides: Corporate Presentation


Karyopharm Therapeutics Transcript: AGM 2025

May 28, 2025, 9:00 AM EDT - 1 year ago

Karyopharm Therapeutics Transcript: AGM 2025


Karyopharm Therapeutics Earnings Call Transcript: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2025


Karyopharm Therapeutics Quarterly report: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Quarterly report: Q1 2025


Karyopharm Therapeutics Earnings release: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Earnings release: Q1 2025


Karyopharm Therapeutics Slides: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Slides: Q1 2025


Karyopharm Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Announces 1-for-15 Reverse Stock Split

Feb 24, 2025, 8:40 AM EST - 1 year ago

Karyopharm Announces 1-for-15 Reverse Stock Split


Karyopharm Therapeutics Earnings Call Transcript: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2024


Karyopharm Therapeutics Annual report: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Annual report: Q4 2024


Karyopharm Therapeutics Earnings release: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings release: Q4 2024


Karyopharm Therapeutics Slides: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Slides: Q4 2024


Karyopharm Therapeutics Proxy statement: Proxy Filing

Dec 16, 2024, 7:00 AM EST - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Proxy statement: Proxy Filing

Dec 5, 2024, 7:00 AM EST - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Earnings Call Transcript: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2024


Karyopharm Therapeutics Quarterly report: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Quarterly report: Q3 2024


Karyopharm Therapeutics Earnings release: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings release: Q3 2024


Karyopharm Therapeutics Slides: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Slides: Q3 2024


Karyopharm Therapeutics Transcript: Study Update

Oct 31, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Transcript: Study Update


Karyopharm Therapeutics Press release: Study Update

Oct 31, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Press release: Study Update


Karyopharm Therapeutics Slides: Study Update

Oct 31, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Slides: Study Update


Spanish_guy
Spanish_guy Aug. 18 at 3:00 PM
$KPTI shorts are in trouble. Stock on the Minimum and any good news could explode It.
1 · Reply
GaryGherkins
GaryGherkins Aug. 18 at 12:45 PM
$KPTI management being super quiet with a material event coming up could be interesting, hope they have an atm in place
0 · Reply
Lowkeyoptions
Lowkeyoptions Aug. 18 at 11:01 AM
$KPTI funded until September theyll need to get the price up – Total Revenue was $33.4 Million, and U.S. XPOVIO® (selinexor) Net Product Revenue was $30.8 Million for the Second Quarter of 2026 – – Company Reaffirms Full-Year 2026 Total Revenue Guidance of $130 Million to $150 Million Including U.S. XPOVIO Net Product Revenue Guidance of $115 Million to $130 Million – The Company expects its existing liquidity, including cash, cash equivalents and investments, together with anticipated cash flow from net product revenue and license and other revenue, to fund its current operating plans into September 2026. https://www.prnewswire.com/news-releases/karyopharm-reports-second-quarter-2026-financial-results-and-highlights-continued-progress-toward-myelofibrosis-snda-submission-302850269.html
0 · Reply
Spanish_guy
Spanish_guy Aug. 18 at 12:09 AM
$KPTI they Will pump the stock for the Next offering. Must do, no?
0 · Reply
celebratelife
celebratelife Aug. 17 at 11:25 PM
$KPTI LATEST BULLSHITS RICHARD PAULSON & THE LOUSY KPTI BOARD HAVE FED INVESTORS https://x.com/chimesofjustice/status/2089493488429654316
0 · Reply
celebratelife
celebratelife Aug. 17 at 9:09 PM
$KPTI Richard Paulson and the evil Board that has empowered him, have fed investors BS for years, and made millions, destroyed KPTI. Shorts love'em.
0 · Reply
k3vl4r
k3vl4r Aug. 17 at 8:12 PM
K3vl4r AI outlook, Aug 17 Reading most bullish: $LX $DEXE $EEIQ $KPTI Leaning bearish: $NVNI $MOG $HTCO 1438/1656 tracked assets read bullish. Scenarios to research, not advice. https://app.k3vl4r.com/today #stocks #investing
0 · Reply
Lowkeyoptions
Lowkeyoptions Aug. 17 at 6:03 PM
$KPTI macd cross up
0 · Reply
Lowkeyoptions
Lowkeyoptions Aug. 17 at 1:10 PM
Lately these pharmas take a few days to recover. $TENX $KPTI like$CAPR now add $EYPT
0 · Reply
Coco63
Coco63 Aug. 17 at 12:24 PM
$IMMP The probability of a buyout by Merck is between 40% and 60%. The purchase price would likely range from €1.5 billion to €2 billion. I’m placing my bets for the end of the year. Immutep’s annual report, due next week, will provide an opportunity to update the status of ongoing clinical trials, and the stock could see a strong upward surge. $MRK $CAPR $GOSS $KPTI $MREO $NVO $LLY $NBIS $FAMI $DFSC $SPCX $XPON $SRPT $AAOI $AMZN $GYGY $NVDA $AAPL $IPST
0 · Reply
Lowkeyoptions
Lowkeyoptions Aug. 17 at 10:52 AM
$KPTI resubmittance planned for August which is 2/3 through Karyopharm Plans to Submit sNDA for Selinexor Plus Ruxolitinib in Myelofibrosis Under Accelerated Approval Pathway https://www.prnewswire.com/news-releases/karyopharm-plans-to-submit-snda-for-selinexor-plus-ruxolitinib-in-myelofibrosis-under-accelerated-approval-pathway-302839315.html
0 · Reply
Lowkeyoptions
Lowkeyoptions Aug. 17 at 3:00 AM
$CAPR on the go again. I wonder when $TENX $KPTI will have it's run sc 13gs were heavy showing 20 million shares outstanding 37 million The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 and 11 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 37,423,917 shares of Common Stock outstanding as of July 28, 2026, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on July 31, 2026. Neither Perceptive Advisors nor Mr. Edelman directly holds any shares of Common Stock. The Master Fund directly holds 1,700,000 shares of Common Stock. Perceptive Advisors serves as the investment manager of the Master Fund and may be deemed to beneficially own the securities directly held by the Master Fund. Mr. Edelman is the managing member of Perceptive Advisors and may be deemed to beneficially own the securities directly held by the Master Fund.
0 · Reply
celebratelife
celebratelife Aug. 16 at 11:06 PM
$KPTI CEO RICHARD A. PAULSON COMPENSATION VS. PERFORMANCE https://x.com/chimesofjustice/status/2089126419246801031
0 · Reply
celebratelife
celebratelife Aug. 16 at 10:30 PM
0 · Reply
Love_whams
Love_whams Aug. 15 at 7:52 PM
$KPTI this going to pop 🌟i feel it NFA
0 · Reply
celebratelife
celebratelife Aug. 14 at 10:33 PM
$KPTI Richard Paulson's movie theatre at his $7 million mansion, per publicly available picture. His address is not tied to this link, though it's public information. https://photos.zillowstatic.com/fp/5f0664e971ab5c0dfdd0247fdcbc0c96-cc_ft_384.webp
0 · Reply
celebratelife
celebratelife Aug. 14 at 10:30 PM
$KPTI Paulson's wines, per publicly available picture. His address is not tied to this link, though it's public information. https://photos.zillowstatic.com/fp/c9a641b6c1a8339cd751c6f87c954cbb-cc_ft_768.webp
0 · Reply
celebratelife
celebratelife Aug. 14 at 9:15 PM
$KPTI Two letters today to the Board: https://x.com/chimesofjustice/status/2088373419154739412 and https://x.com/chimesofjustice/status/2088373318403359101
0 · Reply
celebratelife
celebratelife Aug. 14 at 9:15 PM
$KPTI Two letters today to the Board: https://x.com/chimesofjustice/status/2088373419154739412 and https://x.com/chimesofjustice/status/2088373318403359101. .
0 · Reply
celebratelife
celebratelife Aug. 14 at 9:03 PM
$KPTI Note to the Board of Directors following the transcript "correction" of Paulson's fucking speech.
0 · Reply
celebratelife
celebratelife Aug. 14 at 7:58 PM
$KPTI Richard Party Paulson: correction of call transcript
0 · Reply
Honeysuckle4384
Honeysuckle4384 Aug. 14 at 6:40 PM
$KPTI Deal is already done in framework. Waiting on closing of regulatory filing risk. The July upfront executive cash retention (while they were already under retention) with severance offset and change of control vesting is verbiage that is used mostly for M&A and when a framework is already in place. The company knew there was a pathway to FDA approval by this time and anyone that was interested in the MF program was likely at the table. Centerview has been here for a year. As soon as there is alignment with the FDA on the submission it gets filed and deal announced after IMO. If they were going to raise money they would have done that by now.
0 · Reply