Market Cap 193.87M
Revenue (ttm) 146.07M
Net Income (ttm) -196.04M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -134.21%
Debt to Equity Ratio -0.40
Volume 264,600
Avg Vol 1,056,588
Day's Range N/A - N/A
Shares Out 22.54M
Stochastic %K 19%
Beta 0.40
Analysts Strong Sell
Price Target $14.57

Company Profile

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compounds include XPOVIO in combination with bortezomib and dexamethasone for th...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 658 0600
Address:
85 Wells Avenue, 2nd Floor, Suite 210, Newton, United States
laaarsas
laaarsas Apr. 30 at 7:32 AM
$KPTI Donkey of the day! Still no response about BICR PFS :))))
0 · Reply
laaarsas
laaarsas Apr. 29 at 7:07 AM
$KPTI Donkey of the day
0 · Reply
celebratelife
celebratelife Apr. 28 at 10:48 PM
$KPTI Every month useless CEO Richard Paulson is paid over $100K, and useless GC Mike Mano over $50K no matte what on top of huge comps. - not to mention the useless Board. They got it made, always at our cost.
0 · Reply
laaarsas
laaarsas Apr. 28 at 7:47 AM
$KPTI Donkey of the day
0 · Reply
anachartanalyst
anachartanalyst Apr. 27 at 6:02 PM
$KPTI https://anachart.com/wp-content/uploads/ana_temp/1777312922_soc-img.jpg
0 · Reply
laaarsas
laaarsas Apr. 27 at 1:01 PM
$KPTI Soon gonna sell all my stock. RA Capital got fooled.
0 · Reply
laaarsas
laaarsas Apr. 27 at 12:28 PM
0 · Reply
SnoopDawg
SnoopDawg Apr. 27 at 11:04 AM
$KPTI piper sandler to 16 from 8.
0 · Reply
celebratelife
celebratelife Apr. 25 at 6:48 PM
$KPTI It seems shorts have made hundreds of millions on this lousy Board and CEO's watch, at the cost of shareholders, and this lousy Board and CEO don't give a damn and even if they did they're too incompetent to deal with it - with a General Counsel like Mike Mano and dork of a CEO like Richard Paulson. Shorts want more. Interest keeps rising, and Paulson, Mano, Greene and the rest of the lousy Board still don't give a shit because they're gotten paid millions anyway, and keep getting fat paychecks no matter what happens as long as they get the company going so they can continue getting their fucking fat pay checks and even god damn bonuses that they don't deserve -- and conveniently for them, their fucking bonuses are not tied to shareholder value / stock performance, like it is in many good companies. Karyopharm governance sucks and has always only enriched the insiders and likes of Dempseys of the world to whom these value destroyers even donate our money that we don't have.
0 · Reply
StockMarketRally
StockMarketRally Apr. 24 at 2:26 PM
$KPTI sold out after holding since 2018. I may be wrong, but I have faith in just about any other stock (and management team) at this point relative to Karyopharm. I have better chances of doubling my money elsewhere and then much more long term. I know it’s not an airport and I don’t need to announce my departure. Almost 10 years of this. My $100,000 should have been $200,000 with a market index not $4,000 with Karyopharm
3 · Reply
Latest News on KPTI
Karyopharm Therapeutics Transcript: Study result

Mar 24, 2026, 8:00 AM EDT - 5 weeks ago

Karyopharm Therapeutics Transcript: Study result


Karyopharm Therapeutics Transcript: EGM 2026

Feb 18, 2026, 9:00 AM EST - 2 months ago

Karyopharm Therapeutics Transcript: EGM 2026


Karyopharm Therapeutics Earnings Call Transcript: Q4 2025

Feb 12, 2026, 8:00 AM EST - 2 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2025


Karyopharm to Participate in Baird's Biotech Discovery Series

Dec 8, 2025, 7:00 AM EST - 5 months ago

Karyopharm to Participate in Baird's Biotech Discovery Series


Karyopharm Therapeutics Earnings Call Transcript: Q3 2025

Nov 3, 2025, 8:00 AM EST - 6 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2025


Karyopharm Therapeutics Earnings Call Transcript: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 9 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2025


Karyopharm Therapeutics Transcript: AGM 2025

May 28, 2025, 9:00 AM EDT - 1 year ago

Karyopharm Therapeutics Transcript: AGM 2025


Karyopharm Therapeutics Earnings Call Transcript: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2025


Karyopharm Announces 1-for-15 Reverse Stock Split

Feb 24, 2025, 8:40 AM EST - 1 year ago

Karyopharm Announces 1-for-15 Reverse Stock Split


Karyopharm Therapeutics Earnings Call Transcript: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2024


Karyopharm Therapeutics Earnings Call Transcript: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2024


Karyopharm Therapeutics Transcript: Study Update

Oct 31, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Transcript: Study Update


Karyopharm to Participate at Upcoming Investor Conferences

Sep 3, 2024, 7:00 AM EDT - 1 year ago

Karyopharm to Participate at Upcoming Investor Conferences


Karyopharm Therapeutics Earnings Call Transcript: Q2 2024

Aug 6, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2024


Karyopharm Therapeutics Transcript: AGM 2024

May 29, 2024, 9:00 AM EDT - 2 years ago

Karyopharm Therapeutics Transcript: AGM 2024


Karyopharm Therapeutics Earnings Call Transcript: Q1 2024

May 8, 2024, 8:00 AM EDT - 2 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2024


Karyopharm Therapeutics Earnings Call Transcript: Q4 2023

Feb 29, 2024, 8:00 AM EST - 2 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2023


Karyopharm Therapeutics Earnings Call Transcript: Q3 2023

Nov 2, 2023, 8:00 AM EDT - 2 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2023


Karyopharm Therapeutics Earnings Call Transcript: Q2 2023

Aug 2, 2023, 8:00 AM EDT - 2 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2023


Karyopharm Therapeutics Earnings Call Transcript: Q1 2023

May 4, 2023, 8:00 AM EDT - 3 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2023


Karyopharm Therapeutics Transcript: Investor Update

Apr 18, 2023, 4:30 PM EDT - 3 years ago

Karyopharm Therapeutics Transcript: Investor Update


Karyopharm Therapeutics Earnings Call Transcript: Q4 2022

Feb 15, 2023, 8:00 AM EST - 3 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2022


Karyopharm Therapeutics Transcript: Study Update

Dec 12, 2022, 8:30 AM EST - 3 years ago

Karyopharm Therapeutics Transcript: Study Update


Karyopharm Therapeutics Earnings Call Transcript: Q3 2022

Nov 3, 2022, 8:00 AM EDT - 3 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2022


Karyopharm Therapeutics Earnings Call Transcript: Q2 2022

Aug 4, 2022, 5:51 AM EDT - 4 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2022


Karyopharm Therapeutics Earnings Call Transcript: Q1 2022

May 5, 2022, 6:57 AM EDT - 4 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2022


Karyopharm Therapeutics Transcript: Study Result

Mar 17, 2022, 4:30 PM EDT - 4 years ago

Karyopharm Therapeutics Transcript: Study Result


Karyopharm Therapeutics Earnings Call Transcript: Q4 2021

Feb 8, 2022, 3:47 AM EST - 4 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2021


Karyopharm Therapeutics Transcript: Investor Day 2021

Dec 7, 2021, 7:00 PM EST - 4 years ago

Karyopharm Therapeutics Transcript: Investor Day 2021


Karyopharm Therapeutics Earnings Call Transcript: Q3 2021

Nov 2, 2021, 8:00 PM EDT - 4 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2021


Karyopharm Therapeutics Earnings Call Transcript: Q2 2021

Aug 5, 2021, 5:49 PM EDT - 5 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2021


Karyopharm Therapeutics Transcript: AGM 2021

May 21, 2021, 9:00 AM EDT - 5 years ago

Karyopharm Therapeutics Transcript: AGM 2021


Karyopharm Therapeutics Earnings Call Transcript: Q1 2021

May 2, 2021, 7:04 PM EDT - 5 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2021


Karyopharm Therapeutics Earnings Call Transcript: Q4 2020

Feb 11, 2021, 8:30 AM EST - 5 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2020


Karyopharm Therapeutics Transcript: FDA Announcement

Dec 18, 2020, 1:00 PM EST - 5 years ago

Karyopharm Therapeutics Transcript: FDA Announcement


Karyopharm Therapeutics Transcript: ASH 2020

Dec 8, 2020, 1:00 PM EST - 5 years ago

Karyopharm Therapeutics Transcript: ASH 2020


Karyopharm Therapeutics Transcript: Study Update

Nov 20, 2020, 12:00 PM EST - 5 years ago

Karyopharm Therapeutics Transcript: Study Update


Karyopharm Therapeutics Earnings Call Transcript: Q3 2020

Nov 2, 2020, 4:30 PM EST - 5 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2020


Karyopharm Therapeutics Earnings Call Transcript: Q2 2020

Aug 4, 2020, 8:30 AM EDT - 6 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2020


Karyopharm Therapeutics Transcript: FDA Announcement

Jun 22, 2020, 12:30 PM EDT - 6 years ago

Karyopharm Therapeutics Transcript: FDA Announcement


Karyopharm Therapeutics Transcript: Study Result

May 29, 2020, 1:00 PM EDT - 6 years ago

Karyopharm Therapeutics Transcript: Study Result


Karyopharm Therapeutics Transcript: AGM 2020

May 21, 2020, 2:00 PM EDT - 6 years ago

Karyopharm Therapeutics Transcript: AGM 2020


Karyopharm Therapeutics Earnings Call Transcript: Q1 2020

May 5, 2020, 8:30 AM EDT - 6 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2020


Karyopharm Therapeutics Transcript: Study Update

Apr 7, 2020, 8:30 AM EDT - 6 years ago

Karyopharm Therapeutics Transcript: Study Update


Karyopharm Therapeutics Transcript: Study Result

Mar 2, 2020, 8:30 AM EST - 6 years ago

Karyopharm Therapeutics Transcript: Study Result


Karyopharm Therapeutics Earnings Call Transcript: Q4 2019

Feb 13, 2020, 8:30 AM EST - 6 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2019


Karyopharm Therapeutics Earnings Call Transcript: Q3 2019

Nov 4, 2019, 8:30 AM EST - 7 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2019


Karyopharm Therapeutics Earnings Call Transcript: Q2 2019

Aug 6, 2019, 8:30 AM EDT - 7 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2019


Karyopharm Therapeutics Transcript: FDA Announcement

Jul 3, 2019, 1:30 PM EDT - 7 years ago

Karyopharm Therapeutics Transcript: FDA Announcement


Karyopharm Therapeutics Earnings Call Transcript: Q1 2019

May 9, 2019, 8:30 AM EDT - 7 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2019


Karyopharm Therapeutics Earnings Call Transcript: Q4 2018

Feb 28, 2019, 8:30 AM EST - 7 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2018


Karyopharm Therapeutics Earnings Call Transcript: Q3 2018

Nov 8, 2018, 8:30 AM EST - 8 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2018


Karyopharm Therapeutics Transcript: Study Result

Sep 14, 2018, 8:00 AM EDT - 8 years ago

Karyopharm Therapeutics Transcript: Study Result


Karyopharm Therapeutics Earnings Call Transcript: Q2 2018

Aug 7, 2018, 8:30 AM EDT - 8 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2018


Karyopharm Therapeutics Earnings Call Transcript: Q1 2018

May 10, 2018, 8:30 AM EDT - 8 years ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2018


laaarsas
laaarsas Apr. 30 at 7:32 AM
$KPTI Donkey of the day! Still no response about BICR PFS :))))
0 · Reply
laaarsas
laaarsas Apr. 29 at 7:07 AM
$KPTI Donkey of the day
0 · Reply
celebratelife
celebratelife Apr. 28 at 10:48 PM
$KPTI Every month useless CEO Richard Paulson is paid over $100K, and useless GC Mike Mano over $50K no matte what on top of huge comps. - not to mention the useless Board. They got it made, always at our cost.
0 · Reply
laaarsas
laaarsas Apr. 28 at 7:47 AM
$KPTI Donkey of the day
0 · Reply
anachartanalyst
anachartanalyst Apr. 27 at 6:02 PM
$KPTI https://anachart.com/wp-content/uploads/ana_temp/1777312922_soc-img.jpg
0 · Reply
laaarsas
laaarsas Apr. 27 at 1:01 PM
$KPTI Soon gonna sell all my stock. RA Capital got fooled.
0 · Reply
laaarsas
laaarsas Apr. 27 at 12:28 PM
0 · Reply
SnoopDawg
SnoopDawg Apr. 27 at 11:04 AM
$KPTI piper sandler to 16 from 8.
0 · Reply
celebratelife
celebratelife Apr. 25 at 6:48 PM
$KPTI It seems shorts have made hundreds of millions on this lousy Board and CEO's watch, at the cost of shareholders, and this lousy Board and CEO don't give a damn and even if they did they're too incompetent to deal with it - with a General Counsel like Mike Mano and dork of a CEO like Richard Paulson. Shorts want more. Interest keeps rising, and Paulson, Mano, Greene and the rest of the lousy Board still don't give a shit because they're gotten paid millions anyway, and keep getting fat paychecks no matter what happens as long as they get the company going so they can continue getting their fucking fat pay checks and even god damn bonuses that they don't deserve -- and conveniently for them, their fucking bonuses are not tied to shareholder value / stock performance, like it is in many good companies. Karyopharm governance sucks and has always only enriched the insiders and likes of Dempseys of the world to whom these value destroyers even donate our money that we don't have.
0 · Reply
StockMarketRally
StockMarketRally Apr. 24 at 2:26 PM
$KPTI sold out after holding since 2018. I may be wrong, but I have faith in just about any other stock (and management team) at this point relative to Karyopharm. I have better chances of doubling my money elsewhere and then much more long term. I know it’s not an airport and I don’t need to announce my departure. Almost 10 years of this. My $100,000 should have been $200,000 with a market index not $4,000 with Karyopharm
3 · Reply
laaarsas
laaarsas Apr. 23 at 10:09 PM
$KPTI Still in donkey territory
0 · Reply
SuperGreenToday
SuperGreenToday Apr. 23 at 12:58 AM
$KPTI Share Price: $9.55 Contract Selected: Aug 21, 2026 $10 Calls Buy Zone: $0.51 – $0.63 Target Zone: $0.88 – $1.07 Potential Upside: 62% ROI Time to Expiration: 120 Days | Updates via https://fxcapta.com/stockinfo/
1 · Reply
celebratelife
celebratelife Apr. 22 at 9:28 PM
$KPTI Richard Paulson is celebrating the stock is back above 9. He forgot he caused a 1 for 15 RS by mismanagement/splurging. So $9=$0.6
0 · Reply
DeadManJoaquin
DeadManJoaquin Apr. 22 at 3:10 PM
$KPTI STACKING cash on this one. Busted ATM
0 · Reply
Watson66
Watson66 Apr. 22 at 2:30 PM
$KPTI shorts are trying hard. A great sign their party might be coming to an end 🤡
1 · Reply
laaarsas
laaarsas Apr. 22 at 2:21 PM
$KPTI Sold some and moved to other options. Company can’t be trusted. Watch out.
0 · Reply
laaarsas
laaarsas Apr. 22 at 9:47 AM
$KPTI Call them!! Email them! Demand the data! Truthful shareholders deserve to know! Unite!!!
0 · Reply
laaarsas
laaarsas Apr. 22 at 6:23 AM
$KPTI Still no reply regarding BICR PFS in SIENDO. It’s beyond me how the risk of biggest upcoming value driver is completely ignored by everyone on this board. And g-dd-mn company never replies to emails!! Such a joke! WARNING. THEY ARE DUCKING THE MOST IMPORTANT QUESTION REGARDING MOST IMPORTANT UPCOMING VALUE DRIVER!!! HUGE RED FLAG!! Contact management and demand an answer!!
0 · Reply
InkaTwits
InkaTwits Apr. 21 at 3:37 PM
$KPTI 🥱
0 · Reply
DoctrBenway
DoctrBenway Apr. 21 at 2:36 PM
$KPTI https://investors.karyopharm.com/2026-04-21-Karyopharms-Phase-3-SENTRY-Trial-in-Myelofibrosis-Selected-for-Late-Breaking-Oral-Presentation-at-ASCO-2026-Annual-Meeting
0 · Reply
pennylotto
pennylotto Apr. 21 at 2:22 PM
$KPTI In my "lottery money" portfolio, this stock is the most troublesome. Nothing about it makes sense. I might dump it and buy $MGN for sh!ts and giggles. 🤑
0 · Reply
laaarsas
laaarsas Apr. 21 at 7:28 AM
$KPTI seems like donkey KPTI sheep has muted me. But I was totally right about SENTRY outcome. What if I’m right that selective reporting of PFS from SIENDO is a huge problem? Go figure.
0 · Reply