Market Cap 169.29M
Revenue (ttm) 146.07M
Net Income (ttm) -196.04M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -134.21%
Debt to Equity Ratio -0.45
Volume 658,500
Avg Vol 1,004,854
Day's Range N/A - N/A
Shares Out 22.66M
Stochastic %K 33%
Beta 0.80
Analysts Strong Sell
Price Target $15.29

Company Profile

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compounds include XPOVIO in combination with bortezomib and dexamethasone for th...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 658 0600
Address:
85 Wells Avenue, 2nd Floor, Suite 210, Newton, United States
celebratelife
celebratelife May. 20 at 3:04 PM
$KPTI Paulson in his new suit? As usual he added zero value. Reshma practically handled the whole thing, and she could have done 100% fine without him but it cost us a lot of money to get him down there. You can be he's not the type who's economical on expenses. His new mantra of "financial discipline" after years of splurging our cash is disappointing to hear. All talk, no action. On his watch KPTI has been DESTROYED as he fed everyone everyday catered free lunches, and splurged in so many ways including huge donations of our money that we didn't have. He's had no sense of urgency for years as he burned hundreds of millions of our money and handed us delay after delay without a trace of responsibility or regret. Arrogant and entitled, Paulson is NOT fit to lead the company even one more day, with or without data. He is a disgrace to us long term shareholders and a gift to short sellers, scums, cockroaches, vultures, sharks who've sucked our assets years after year on this man's watch.
1 · Reply
laaarsas
laaarsas May. 20 at 10:39 AM
$KPTI Have you all did it???
0 · Reply
celebratelife
celebratelife May. 19 at 8:55 PM
0 · Reply
laaarsas
laaarsas May. 19 at 12:49 PM
$KPTI Did you all do it?
1 · Reply
mich1282
mich1282 May. 18 at 8:47 PM
$KPTI kind of wild this thing has taken a 21% hit since earnings with major data incoming and big tires accumulating
1 · Reply
laaarsas
laaarsas May. 17 at 4:02 PM
$KPTI I have called them. Still no answer. You have to call them. All of you.
0 · Reply
laaarsas
laaarsas May. 16 at 9:37 PM
$KPTI anyone got anything to say here?
0 · Reply
celebratelife
celebratelife May. 16 at 4:38 PM
$KPTI is on the verge of collapse with only a few months of cash left due to mismanagement and lack of financial discipline or sense of urgency for years. The Board is squarely responsible. Vote them out.
0 · Reply
hbkstockislife
hbkstockislife May. 16 at 1:45 PM
$KPTI can anyone let me know why this ASCO data I so important ..we already know the data correct like a month and half back ..just asking
2 · Reply
JFais
JFais May. 16 at 1:28 PM
Finishing up our weekly recap post: $KPTI double beat on Q1 report, "important presentation at ASCO", endometrial trial fully enrolled & on track for midyear readout $TMDX weakness due to trial delays & gross margin compression for several quarters (aggressively investing for future growth), temporary headwind from the Modernization Act Top 5 Holdings Channel: Feels like people starting to use AI for sharing portfolios, makes for really cool graphics helpful for idea generation (categorized by therapeutic area). Hat tip to @lfholt , @JoseRestonVA and @WassimLaroussi3 among several others (latter is cooking up a nifty tool for fund tracking if you haven't seen his feed lately)
2 · Reply
Latest News on KPTI
Karyopharm Therapeutics Slides: Corporate presentation

May 17, 2026, 7:00 AM EDT - 3 days ago

Karyopharm Therapeutics Slides: Corporate presentation


Karyopharm Therapeutics Q1 Earnings Call Highlights

May 14, 2026, 1:10 PM EDT - 6 days ago

Karyopharm Therapeutics Q1 Earnings Call Highlights


Karyopharm reports Q1 EPS ($1.24), consensus ($1.44)

2026-05-14T12:06:55.000Z - 6 days ago

Karyopharm reports Q1 EPS ($1.24), consensus ($1.44)


Karyopharm sees 2026 revenue $130M-$150M, consensus $137.49M

2026-05-14T12:04:59.000Z - 6 days ago

Karyopharm sees 2026 revenue $130M-$150M, consensus $137.49M


Karyopharm Therapeutics Earnings Call Transcript: Q1 2026

May 14, 2026, 8:00 AM EDT - 6 days ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2026


Karyopharm Therapeutics Earnings release: Q1 2026

May 14, 2026, 8:00 AM EDT - 6 days ago

Karyopharm Therapeutics Earnings release: Q1 2026


Karyopharm Therapeutics Slides: Q1 2026

May 14, 2026, 8:00 AM EDT - 6 days ago

Karyopharm Therapeutics Slides: Q1 2026


Karyopharm Therapeutics Quarterly report: Q1 2026

May 14, 2026, 8:00 AM EDT - 6 days ago

Karyopharm Therapeutics Quarterly report: Q1 2026


Karyopharm to Participate at Upcoming Investor Conferences

May 12, 2026, 7:30 AM EDT - 8 days ago

Karyopharm to Participate at Upcoming Investor Conferences


Karyopharm files $400M mixed securities shelf

2026-05-04T20:43:12.000Z - 16 days ago

Karyopharm files $400M mixed securities shelf


Karyopharm Therapeutics Slides: Corporate presentation

Apr 16, 2026, 7:00 AM EDT - 4 weeks ago

Karyopharm Therapeutics Slides: Corporate presentation


Karyopharm Therapeutics Proxy statement: Proxy filing

Apr 13, 2026, 8:00 AM EDT - 5 weeks ago

Karyopharm Therapeutics Proxy statement: Proxy filing


Karyopharm price target lowered to $15 from $21 at Baird

2026-03-25T11:26:32.000Z - 2 months ago

Karyopharm price target lowered to $15 from $21 at Baird


Karyopharm Therapeutics Transcript: Study result

Mar 24, 2026, 8:00 AM EDT - 2 months ago

Karyopharm Therapeutics Transcript: Study result


Karyopharm Therapeutics Press release: Study result

Mar 24, 2026, 8:00 AM EDT - 2 months ago

Karyopharm Therapeutics Press release: Study result


Karyopharm Therapeutics Slides: Study result

Mar 24, 2026, 8:00 AM EDT - 2 months ago

Karyopharm Therapeutics Slides: Study result


Karyopharm announces $30M private placement

2026-03-24T11:05:33.000Z - 2 months ago

Karyopharm announces $30M private placement


Karyopharm initiated with a Buy at Rodman & Renshaw

2026-03-09T20:20:12.000Z - 2 months ago

Karyopharm initiated with a Buy at Rodman & Renshaw


Karyopharm Therapeutics Transcript: EGM 2026

Feb 18, 2026, 9:00 AM EST - 3 months ago

Karyopharm Therapeutics Transcript: EGM 2026


Karyopharm Therapeutics Earnings Call Transcript: Q4 2025

Feb 12, 2026, 8:00 AM EST - 3 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2025


Karyopharm Therapeutics Annual report: Q4 2025

Feb 12, 2026, 8:00 AM EST - 3 months ago

Karyopharm Therapeutics Annual report: Q4 2025


Karyopharm Therapeutics Earnings release: Q4 2025

Feb 12, 2026, 8:00 AM EST - 3 months ago

Karyopharm Therapeutics Earnings release: Q4 2025


Karyopharm Therapeutics Slides: Q4 2025

Feb 12, 2026, 8:00 AM EST - 3 months ago

Karyopharm Therapeutics Slides: Q4 2025


Karyopharm reports Q4 EPS ($5.71) vs. ($3.67) last year

2026-02-12T12:46:18.000Z - 3 months ago

Karyopharm reports Q4 EPS ($5.71) vs. ($3.67) last year


Karyopharm initiated with an Overweight at Cantor Fitzgerald

2026-02-05T10:10:10.000Z - 3 months ago

Karyopharm initiated with an Overweight at Cantor Fitzgerald


Karyopharm sees FY25 revenue $145M, consensus $147.83M

2026-01-12T12:17:22.000Z - 4 months ago

Karyopharm sees FY25 revenue $145M, consensus $147.83M


Karyopharm Therapeutics Proxy statement: Proxy Filing

Jan 9, 2026, 7:00 AM EST - 4 months ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Proxy statement: Proxy Filing

Dec 30, 2025, 7:00 AM EST - 5 months ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm to Participate in Baird's Biotech Discovery Series

Dec 8, 2025, 7:00 AM EST - 5 months ago

Karyopharm to Participate in Baird's Biotech Discovery Series


Karyopharm price target lowered to $19 from $30 at RBC Capital

2025-11-04T14:50:10.000Z - 7 months ago

Karyopharm price target lowered to $19 from $30 at RBC Capital


Karyopharm Therapeutics Earnings Call Transcript: Q3 2025

Nov 3, 2025, 8:00 AM EST - 7 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2025


Karyopharm Therapeutics Earnings release: Q3 2025

Nov 3, 2025, 8:00 AM EST - 7 months ago

Karyopharm Therapeutics Earnings release: Q3 2025


Karyopharm Therapeutics Quarterly report: Q3 2025

Nov 3, 2025, 8:00 AM EST - 7 months ago

Karyopharm Therapeutics Quarterly report: Q3 2025


Karyopharm Therapeutics Slides: Q3 2025

Nov 3, 2025, 8:00 AM EST - 7 months ago

Karyopharm Therapeutics Slides: Q3 2025


Karyopharm Therapeutics Earnings Call Transcript: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 10 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2025


Karyopharm Therapeutics Quarterly report: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 10 months ago

Karyopharm Therapeutics Quarterly report: Q2 2025


Karyopharm Therapeutics Earnings release: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 10 months ago

Karyopharm Therapeutics Earnings release: Q2 2025


Karyopharm Therapeutics Slides: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 10 months ago

Karyopharm Therapeutics Slides: Q2 2025


Karyopharm Therapeutics Slides: FY 2025

Jun 5, 2025, 3:10 PM EDT - 1 year ago

Karyopharm Therapeutics Slides: FY 2025


Karyopharm Therapeutics Slides: Corporate Presentation

Jun 5, 2025, 7:00 AM EDT - 1 year ago

Karyopharm Therapeutics Slides: Corporate Presentation


Karyopharm Therapeutics Transcript: AGM 2025

May 28, 2025, 9:00 AM EDT - 1 year ago

Karyopharm Therapeutics Transcript: AGM 2025


Karyopharm Therapeutics Earnings Call Transcript: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2025


Karyopharm Therapeutics Quarterly report: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Quarterly report: Q1 2025


Karyopharm Therapeutics Earnings release: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Earnings release: Q1 2025


Karyopharm Therapeutics Slides: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Slides: Q1 2025


Karyopharm Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Announces 1-for-15 Reverse Stock Split

Feb 24, 2025, 8:40 AM EST - 1 year ago

Karyopharm Announces 1-for-15 Reverse Stock Split


Karyopharm Therapeutics Earnings Call Transcript: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2024


Karyopharm Therapeutics Annual report: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Annual report: Q4 2024


Karyopharm Therapeutics Earnings release: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings release: Q4 2024


Karyopharm Therapeutics Slides: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Slides: Q4 2024


Karyopharm Therapeutics Proxy statement: Proxy Filing

Dec 16, 2024, 7:00 AM EST - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Proxy statement: Proxy Filing

Dec 5, 2024, 7:00 AM EST - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Earnings Call Transcript: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2024


Karyopharm Therapeutics Quarterly report: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Quarterly report: Q3 2024


Karyopharm Therapeutics Earnings release: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings release: Q3 2024


Karyopharm Therapeutics Slides: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Slides: Q3 2024


Karyopharm Therapeutics Transcript: Study Update

Oct 31, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Transcript: Study Update


Karyopharm Therapeutics Press release: Study Update

Oct 31, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Press release: Study Update


Karyopharm Therapeutics Slides: Study Update

Oct 31, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Slides: Study Update


Karyopharm Therapeutics Earnings Call Transcript: Q2 2024

Aug 6, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2024


Karyopharm Therapeutics Quarterly report: Q2 2024

Aug 6, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Quarterly report: Q2 2024


Karyopharm Therapeutics Earnings release: Q2 2024

Aug 6, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Earnings release: Q2 2024


Karyopharm Therapeutics Slides: Q2 2024

Aug 6, 2024, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Slides: Q2 2024


celebratelife
celebratelife May. 20 at 3:04 PM
$KPTI Paulson in his new suit? As usual he added zero value. Reshma practically handled the whole thing, and she could have done 100% fine without him but it cost us a lot of money to get him down there. You can be he's not the type who's economical on expenses. His new mantra of "financial discipline" after years of splurging our cash is disappointing to hear. All talk, no action. On his watch KPTI has been DESTROYED as he fed everyone everyday catered free lunches, and splurged in so many ways including huge donations of our money that we didn't have. He's had no sense of urgency for years as he burned hundreds of millions of our money and handed us delay after delay without a trace of responsibility or regret. Arrogant and entitled, Paulson is NOT fit to lead the company even one more day, with or without data. He is a disgrace to us long term shareholders and a gift to short sellers, scums, cockroaches, vultures, sharks who've sucked our assets years after year on this man's watch.
1 · Reply
laaarsas
laaarsas May. 20 at 10:39 AM
$KPTI Have you all did it???
0 · Reply
celebratelife
celebratelife May. 19 at 8:55 PM
0 · Reply
laaarsas
laaarsas May. 19 at 12:49 PM
$KPTI Did you all do it?
1 · Reply
mich1282
mich1282 May. 18 at 8:47 PM
$KPTI kind of wild this thing has taken a 21% hit since earnings with major data incoming and big tires accumulating
1 · Reply
laaarsas
laaarsas May. 17 at 4:02 PM
$KPTI I have called them. Still no answer. You have to call them. All of you.
0 · Reply
laaarsas
laaarsas May. 16 at 9:37 PM
$KPTI anyone got anything to say here?
0 · Reply
celebratelife
celebratelife May. 16 at 4:38 PM
$KPTI is on the verge of collapse with only a few months of cash left due to mismanagement and lack of financial discipline or sense of urgency for years. The Board is squarely responsible. Vote them out.
0 · Reply
hbkstockislife
hbkstockislife May. 16 at 1:45 PM
$KPTI can anyone let me know why this ASCO data I so important ..we already know the data correct like a month and half back ..just asking
2 · Reply
JFais
JFais May. 16 at 1:28 PM
Finishing up our weekly recap post: $KPTI double beat on Q1 report, "important presentation at ASCO", endometrial trial fully enrolled & on track for midyear readout $TMDX weakness due to trial delays & gross margin compression for several quarters (aggressively investing for future growth), temporary headwind from the Modernization Act Top 5 Holdings Channel: Feels like people starting to use AI for sharing portfolios, makes for really cool graphics helpful for idea generation (categorized by therapeutic area). Hat tip to @lfholt , @JoseRestonVA and @WassimLaroussi3 among several others (latter is cooking up a nifty tool for fund tracking if you haven't seen his feed lately)
2 · Reply
celebratelife
celebratelife May. 15 at 4:41 PM
$KPTI AS LONG AS RICHARD PARTY PAULSON IS CEO KPT IS DOOMED. FIRE HIS THAT ARROGANT ENTITLED INCOMPETENT VALUE DESTROYER'S ASS AND KPT WILL TAKE OFF. This shows two big blocks over 100k dumped today.
0 · Reply
elmono
elmono May. 15 at 4:25 PM
$KPTI shorters heaven today…..🙏 for all cheapies
1 · Reply
laaarsas
laaarsas May. 15 at 3:43 PM
$KPTI Here we go. People start to realise BICR PFS is shit.
1 · Reply
laaarsas
laaarsas May. 15 at 12:53 PM
$KPTI Fifty days. For 50 days the company has refused to respond. Has anything like this ever happened before?
0 · Reply
laaarsas
laaarsas May. 15 at 11:54 AM
$KPTI Where is it?
1 · Reply
MarketBeat
MarketBeat May. 14 at 5:10 PM
https://marketbeat.com/a/8654805/ $KPTI Karyopharm Therapeutics Q1 Earnings Call Highlights
0 · Reply
laaarsas
laaarsas May. 14 at 4:11 PM
$KPTI Why the fuck did they not adress the BICR PFS in SIENDO? Honestly
0 · Reply
DeadManJoaquin
DeadManJoaquin May. 14 at 3:15 PM
$KPTI I've 2000 $2.50 calls expiring tomorrow. Was a tense hold for awhile. Whew
0 · Reply
Merlintrader
Merlintrader May. 14 at 2:33 PM
$RGNX Three Biotech Earnings Reports, Three Different Catalyst Stories: Gene Therapy, Autoimmune Cell Therapy and Oncology in Focus — $RGNX, $CABA, $KPTI https://www.merlintrader.com/three-biotech-earnings-rgnx-caba-kpti-may2026/
0 · Reply
steven1x
steven1x May. 14 at 2:17 PM
$KPTI any changes in OS?
0 · Reply
EarningsInsider
EarningsInsider May. 14 at 1:31 PM
https://www.marketbeat.com/earnings/reports/2026-5-14-karyopharm-therapeutics-inc-stock/ $KPTI Karyopharm Therapeutics Earnings Transcript
0 · Reply
steven1x
steven1x May. 14 at 1:23 PM
$KPTI https://api-gw-prd.stocktwits.com/earnings-api/v1/documents/63dffb36-1f4d-4a12-99b6-9ea3485acce8/slides.pdf
1 · Reply