Market Cap 36.52M
Revenue (ttm) 146.07M
Net Income (ttm) -196.04M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -134.21%
Debt to Equity Ratio -0.38
Volume 6,737,600
Avg Vol 1,700,838
Day's Range N/A - N/A
Shares Out 22.68M
Stochastic %K 41%
Beta 0.95
Analysts Strong Sell
Price Target $7.25

Company Profile

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compounds include XPOVIO in combination with bortezomib and dexamethasone for th...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 658 0600
Address:
85 Wells Avenue, 2nd Floor, Suite 210, Newton, United States
celebratelife
celebratelife Sep. 13 at 12:18 AM
$KPTI Is it over? I don't think so. https://x.com/chimesofjustice/status/2098928970477535495
0 · Reply
Biotech_Beast
Biotech_Beast Sep. 12 at 3:43 AM
$KPTI What's the plan on the debt here?
1 · Reply
Bigbossmann
Bigbossmann Sep. 12 at 2:23 AM
$KPTI Made a ton this today, but sold way too early, lol!
0 · Reply
DickRitchie44
DickRitchie44 Sep. 11 at 6:42 PM
$KPTI going the same route as BTAI. How these criminals all just recently secured ridiculous compensation packages is a travesty
0 · Reply
BluntForceOptions
BluntForceOptions Sep. 11 at 4:32 PM
$KPTI filed an 8-K today confirming a Forbearance Agreement and Limited Waiver across their term lenders, convertible noteholders, and royalty investors. Key takeaways from the filing: The default: Did not pay the ~$15.8M principal installment due yesterday (Sept 10). The runway: Creditors agreed to temporarily forbear until Oct 15, 2026 while the company negotiates restructuring, strategic alternatives, or an equity raise. The cost: Incurred a $20M forbearance fee paid via newly created 0% convertible preferred stock ($1.62 conversion price). Shares getting whacked this morning, down -18% to $1.33 on the headline. FWIW... this is why tracking bal sheet mechanics, debt covenants, and maturity dates matters just as much as clinical readouts. A filing catalyst buys attention; debt structure dictates survival. (For those following along, as noted on Sept 1, I stepped aside from my position for a small profit off the $1.80 entry to avoid holding through this exact binary.)
0 · Reply
t2026
t2026 Sep. 11 at 2:59 PM
$KPTI drug works in myelofibrosis How do we get to approval without any cash ?
1 · Reply
laaarsas
laaarsas Sep. 11 at 2:35 PM
$KPTI So happy I got out at 2+. Good timing after all.
0 · Reply
dracorx
dracorx Sep. 11 at 2:27 PM
$KPTI Short as much as you can, guaranteed bankruptcy.
0 · Reply
StockMarketRally
StockMarketRally Sep. 11 at 2:06 PM
$KPTI be sure to get your votes in for CEO of the year. You don’t want someone’s good work to go unrecognized.
0 · Reply
truehealthvalue
truehealthvalue Sep. 11 at 2:06 PM
$KPTI company still have value, but not for current equity holders…
0 · Reply
Latest News on KPTI
Karyopharm, guarantors enter into forbearance agreement

2026-09-11T11:55:43.000Z - 1 day ago

Karyopharm, guarantors enter into forbearance agreement


Karyopharm submits sNDA to FDA for XPOVIO

2026-08-31T11:36:02.000Z - 12 days ago

Karyopharm submits sNDA to FDA for XPOVIO


Karyopharm reports Q2 EPS ($2.32) vs. ($4.32) last year

2026-08-17T08:04:07.000Z - 26 days ago

Karyopharm reports Q2 EPS ($2.32) vs. ($4.32) last year


Karyopharm Therapeutics Earnings Call Transcript: Q2 2026

Aug 13, 2026, 8:00 AM EDT - 4 weeks ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2026


Karyopharm Therapeutics Earnings release: Q2 2026

Aug 13, 2026, 8:00 AM EDT - 4 weeks ago

Karyopharm Therapeutics Earnings release: Q2 2026


Karyopharm Therapeutics Quarterly report: Q2 2026

Aug 13, 2026, 8:00 AM EDT - 4 weeks ago

Karyopharm Therapeutics Quarterly report: Q2 2026


Karyopharm Therapeutics Slides: Q2 2026

Aug 13, 2026, 8:00 AM EDT - 4 weeks ago

Karyopharm Therapeutics Slides: Q2 2026


Karyopharm price target lowered to $11 from $14 at Jefferies

2026-07-31T14:40:23.000Z - 6 weeks ago

Karyopharm price target lowered to $11 from $14 at Jefferies


Karyopharm downgraded to Neutral from Buy at H.C. Wainwright

2026-07-31T10:10:48.000Z - 6 weeks ago

Karyopharm downgraded to Neutral from Buy at H.C. Wainwright


Karyopharm downgraded to Neutral from Outperform at Baird

2026-07-31T08:40:14.000Z - 6 weeks ago

Karyopharm downgraded to Neutral from Outperform at Baird


Karyopharm to submit sNDA for selinexor plus ruxolitinib

2026-07-30T20:45:31.000Z - 6 weeks ago

Karyopharm to submit sNDA for selinexor plus ruxolitinib


Karyopharm trading resumes

2026-07-30T20:40:26.000Z - 6 weeks ago

Karyopharm trading resumes


Karyopharm trading halted, news pending

2026-07-30T20:07:04.000Z - 6 weeks ago

Karyopharm trading halted, news pending


Karyopharm Therapeutics Slides: Investor presentation

Jun 4, 2026, 7:00 AM EDT - 3 months ago

Karyopharm Therapeutics Slides: Investor presentation


Karyopharm Therapeutics Transcript: Study result

Jun 2, 2026, 2:00 PM EDT - 3 months ago

Karyopharm Therapeutics Transcript: Study result


Karyopharm Therapeutics Press release: Study result

Jun 2, 2026, 2:00 PM EDT - 3 months ago

Karyopharm Therapeutics Press release: Study result


Karyopharm Therapeutics Slides: Study result

Jun 2, 2026, 2:00 PM EDT - 3 months ago

Karyopharm Therapeutics Slides: Study result


Karyopharm Therapeutics Transcript: AGM 2026

May 21, 2026, 9:00 AM EDT - 3 months ago

Karyopharm Therapeutics Transcript: AGM 2026


Karyopharm Therapeutics Slides: Corporate presentation

May 17, 2026, 7:00 AM EDT - 3 months ago

Karyopharm Therapeutics Slides: Corporate presentation


Karyopharm Therapeutics Earnings Call Transcript: Q1 2026

May 14, 2026, 8:00 AM EDT - 4 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2026


Karyopharm Therapeutics Earnings release: Q1 2026

May 14, 2026, 8:00 AM EDT - 4 months ago

Karyopharm Therapeutics Earnings release: Q1 2026


Karyopharm Therapeutics Slides: Q1 2026

May 14, 2026, 8:00 AM EDT - 4 months ago

Karyopharm Therapeutics Slides: Q1 2026


Karyopharm Therapeutics Quarterly report: Q1 2026

May 14, 2026, 8:00 AM EDT - 4 months ago

Karyopharm Therapeutics Quarterly report: Q1 2026


Karyopharm to Participate at Upcoming Investor Conferences

May 12, 2026, 7:30 AM EDT - 4 months ago

Karyopharm to Participate at Upcoming Investor Conferences


Karyopharm Therapeutics Slides: Corporate presentation

Apr 16, 2026, 7:00 AM EDT - 4 months ago

Karyopharm Therapeutics Slides: Corporate presentation


Karyopharm Therapeutics Proxy statement: Proxy filing

Apr 13, 2026, 8:00 AM EDT - 5 months ago

Karyopharm Therapeutics Proxy statement: Proxy filing


Karyopharm Therapeutics Transcript: Study result

Mar 24, 2026, 8:00 AM EDT - 5 months ago

Karyopharm Therapeutics Transcript: Study result


Karyopharm Therapeutics Press release: Study result

Mar 24, 2026, 8:00 AM EDT - 5 months ago

Karyopharm Therapeutics Press release: Study result


Karyopharm Therapeutics Slides: Study result

Mar 24, 2026, 8:00 AM EDT - 5 months ago

Karyopharm Therapeutics Slides: Study result


Karyopharm Therapeutics Transcript: EGM 2026

Feb 18, 2026, 9:00 AM EST - 6 months ago

Karyopharm Therapeutics Transcript: EGM 2026


Karyopharm Therapeutics Earnings Call Transcript: Q4 2025

Feb 12, 2026, 8:00 AM EST - 7 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2025


Karyopharm Therapeutics Annual report: Q4 2025

Feb 12, 2026, 8:00 AM EST - 7 months ago

Karyopharm Therapeutics Annual report: Q4 2025


Karyopharm Therapeutics Earnings release: Q4 2025

Feb 12, 2026, 8:00 AM EST - 7 months ago

Karyopharm Therapeutics Earnings release: Q4 2025


Karyopharm Therapeutics Slides: Q4 2025

Feb 12, 2026, 8:00 AM EST - 7 months ago

Karyopharm Therapeutics Slides: Q4 2025


Karyopharm Therapeutics Proxy statement: Proxy Filing

Jan 9, 2026, 7:00 AM EST - 8 months ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Proxy statement: Proxy Filing

Dec 30, 2025, 7:00 AM EST - 8 months ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm to Participate in Baird's Biotech Discovery Series

Dec 8, 2025, 7:00 AM EST - 9 months ago

Karyopharm to Participate in Baird's Biotech Discovery Series


Karyopharm Therapeutics Earnings Call Transcript: Q3 2025

Nov 3, 2025, 8:00 AM EST - 10 months ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2025


Karyopharm Therapeutics Earnings release: Q3 2025

Nov 3, 2025, 8:00 AM EST - 10 months ago

Karyopharm Therapeutics Earnings release: Q3 2025


Karyopharm Therapeutics Quarterly report: Q3 2025

Nov 3, 2025, 8:00 AM EST - 10 months ago

Karyopharm Therapeutics Quarterly report: Q3 2025


Karyopharm Therapeutics Slides: Q3 2025

Nov 3, 2025, 8:00 AM EST - 10 months ago

Karyopharm Therapeutics Slides: Q3 2025


Karyopharm Therapeutics Earnings Call Transcript: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q2 2025


Karyopharm Therapeutics Quarterly report: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Quarterly report: Q2 2025


Karyopharm Therapeutics Earnings release: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Earnings release: Q2 2025


Karyopharm Therapeutics Slides: Q2 2025

Aug 11, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Slides: Q2 2025


Karyopharm Therapeutics Slides: FY 2025

Jun 5, 2025, 3:10 PM EDT - 1 year ago

Karyopharm Therapeutics Slides: FY 2025


Karyopharm Therapeutics Slides: Corporate Presentation

Jun 5, 2025, 7:00 AM EDT - 1 year ago

Karyopharm Therapeutics Slides: Corporate Presentation


Karyopharm Therapeutics Transcript: AGM 2025

May 28, 2025, 9:00 AM EDT - 1 year ago

Karyopharm Therapeutics Transcript: AGM 2025


Karyopharm Therapeutics Earnings Call Transcript: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q1 2025


Karyopharm Therapeutics Quarterly report: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Quarterly report: Q1 2025


Karyopharm Therapeutics Earnings release: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Earnings release: Q1 2025


Karyopharm Therapeutics Slides: Q1 2025

May 12, 2025, 4:30 PM EDT - 1 year ago

Karyopharm Therapeutics Slides: Q1 2025


Karyopharm Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Announces 1-for-15 Reverse Stock Split

Feb 24, 2025, 8:40 AM EST - 1 year ago

Karyopharm Announces 1-for-15 Reverse Stock Split


Karyopharm Therapeutics Earnings Call Transcript: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q4 2024


Karyopharm Therapeutics Annual report: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Annual report: Q4 2024


Karyopharm Therapeutics Earnings release: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings release: Q4 2024


Karyopharm Therapeutics Slides: Q4 2024

Feb 19, 2025, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Slides: Q4 2024


Karyopharm Therapeutics Proxy statement: Proxy Filing

Dec 16, 2024, 7:00 AM EST - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Proxy statement: Proxy Filing

Dec 5, 2024, 7:00 AM EST - 1 year ago

Karyopharm Therapeutics Proxy statement: Proxy Filing


Karyopharm Therapeutics Earnings Call Transcript: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings Call Transcript: Q3 2024


Karyopharm Therapeutics Quarterly report: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Quarterly report: Q3 2024


Karyopharm Therapeutics Earnings release: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Earnings release: Q3 2024


Karyopharm Therapeutics Slides: Q3 2024

Nov 5, 2024, 8:00 AM EST - 1 year ago

Karyopharm Therapeutics Slides: Q3 2024


celebratelife
celebratelife Sep. 13 at 12:18 AM
$KPTI Is it over? I don't think so. https://x.com/chimesofjustice/status/2098928970477535495
0 · Reply
Biotech_Beast
Biotech_Beast Sep. 12 at 3:43 AM
$KPTI What's the plan on the debt here?
1 · Reply
Bigbossmann
Bigbossmann Sep. 12 at 2:23 AM
$KPTI Made a ton this today, but sold way too early, lol!
0 · Reply
DickRitchie44
DickRitchie44 Sep. 11 at 6:42 PM
$KPTI going the same route as BTAI. How these criminals all just recently secured ridiculous compensation packages is a travesty
0 · Reply
BluntForceOptions
BluntForceOptions Sep. 11 at 4:32 PM
$KPTI filed an 8-K today confirming a Forbearance Agreement and Limited Waiver across their term lenders, convertible noteholders, and royalty investors. Key takeaways from the filing: The default: Did not pay the ~$15.8M principal installment due yesterday (Sept 10). The runway: Creditors agreed to temporarily forbear until Oct 15, 2026 while the company negotiates restructuring, strategic alternatives, or an equity raise. The cost: Incurred a $20M forbearance fee paid via newly created 0% convertible preferred stock ($1.62 conversion price). Shares getting whacked this morning, down -18% to $1.33 on the headline. FWIW... this is why tracking bal sheet mechanics, debt covenants, and maturity dates matters just as much as clinical readouts. A filing catalyst buys attention; debt structure dictates survival. (For those following along, as noted on Sept 1, I stepped aside from my position for a small profit off the $1.80 entry to avoid holding through this exact binary.)
0 · Reply
t2026
t2026 Sep. 11 at 2:59 PM
$KPTI drug works in myelofibrosis How do we get to approval without any cash ?
1 · Reply
laaarsas
laaarsas Sep. 11 at 2:35 PM
$KPTI So happy I got out at 2+. Good timing after all.
0 · Reply
dracorx
dracorx Sep. 11 at 2:27 PM
$KPTI Short as much as you can, guaranteed bankruptcy.
0 · Reply
StockMarketRally
StockMarketRally Sep. 11 at 2:06 PM
$KPTI be sure to get your votes in for CEO of the year. You don’t want someone’s good work to go unrecognized.
0 · Reply
truehealthvalue
truehealthvalue Sep. 11 at 2:06 PM
$KPTI company still have value, but not for current equity holders…
0 · Reply
notreload_ai
notreload_ai Sep. 11 at 1:35 PM
$KPTI skipped a $15.8M loan payment and won a pause until Oct. 15. Cash may last only that long without a new raise or deal. https://notreload.xyz/xy/kpti-wins-short-creditor-pause-after-15-8m-miss/
0 · Reply
celebratelife
celebratelife Sep. 11 at 12:59 PM
$KPTI Regarding Today's #KPTI SEC FIling And These Value Destroyers: #RichardPaulson @BarryGreene #BarryGreene #ChenSchor @ChenSchor #GarenBohlin #ChristyOliger @christyoliger #MansoorMirza @MirzaCPH #ZhenSu @MyOncology @DeepaPaki #DeepaPakianathan - @Karyopharm #Karyopharm $KPTI https://x.com/chimesofjustice/status/2098395792830607525
0 · Reply
Nickhzap
Nickhzap Sep. 11 at 12:37 PM
$KPTI I’ll nibble here. Hopefully a buyout is on the horizon
0 · Reply
Biotech_Pharma_Investor
Biotech_Pharma_Investor Sep. 11 at 12:30 PM
$KPTI close to 50% dilution just to survive a few weeks.
0 · Reply
Biotech_Pharma_Investor
Biotech_Pharma_Investor Sep. 11 at 12:13 PM
$KPTI $20M worth of preferred shares convertible into common stock at $1.62 granted to lenders just to allow KPTI to survive until October... doesnt look good
0 · Reply
Nickhzap
Nickhzap Sep. 11 at 12:12 PM
$KPTI this is getting interesting. Selenexor is still a reasonable drug. Decent sales. The market cap right now is pitiful. I’d consider a starter position if a financing deal is announced
0 · Reply
elmono
elmono Sep. 11 at 12:06 PM
$KPTI just waiting for chapter 11 or 1000% dilution. Shouldn’t take long anymore ….. existing shareholders will be whiped out no doubt 🤷‍♂️
0 · Reply
Spanish_guy
Spanish_guy Sep. 11 at 11:58 AM
$KPTI wtf
0 · Reply
Spanish_guy
Spanish_guy Sep. 10 at 7:51 PM
$KPTI till the last minute
0 · Reply
Spanish_guy
Spanish_guy Sep. 10 at 4:29 PM
$KPTI oh god
0 · Reply
Spanish_guy
Spanish_guy Sep. 10 at 4:21 PM
$KPTI ?????
0 · Reply
Bigjohnson99
Bigjohnson99 Sep. 10 at 3:30 PM
$KPTI wouldn’t surprise me if someone marched Paulson out of his office and gave him the business end of a 9mm.
1 · Reply