Market Cap 3.70B
Revenue (ttm) 0.00
Net Income (ttm) -512.54M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 1,657,839
Avg Vol 1,759,594
Day's Range N/A - N/A
Shares Out 158.71M
Stochastic %K 89%
Beta 1.03
Analysts Strong Sell
Price Target $34.36

Company Profile

Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement thera...

Industry: Biotechnology
Sector: Healthcare
Phone: 650 866 8547
Address:
161 Oyster Point Boulevard, South San Francisco, United States
B2iDigital
B2iDigital Jun. 23 at 8:53 PM
eXoZymes (Nasdaq: $EXOZ ) Chief Commercial Officer Damien Perriman will present at Webull’s Biotech Sector webinar on June 25, alongside Envoy Medical and IN8bio. Damien Perriman, Chief Commercial Officer of eXoZymes Inc. (Nasdaq: EXOZ), will present at Webull’s Biotech Sector webinar on June 25 at 2:00 p.m. Eastern, part of the Webull Corporate Connect series that spotlights publicly traded biotech companies for investors. eXoZymes Inc. is a B2i Digital Featured Company. See the company’s profile at https://b2idigital.com/exozymes-1 eXoZymes is a synthetic biology company that takes enzymes out of the living cell and runs them on their own to manufacture hard-to-make molecules for nutraceutical and pharmaceutical markets. The session gives investors a chance to hear directly from the company’s commercial leadership. • The webinar takes place June 25 at 2:00 p.m. Eastern, 11:00 a.m. Pacific, and registration is free with a Webull account • Perriman presents alongside Brent Lucas, Chief Executive Officer of Envoy Medical, and Will Ho, Chief Executive Officer and co-founder of IN8bio • Perriman leads commercial strategy at eXoZymes, whose cell-free platform uses AI-engineered enzymes to convert low-cost feedstocks into high-value compounds Register for the webinar: https://exozymes.com/blog/webulls-biotech-webinar-2026 eXoZymes Inc. is a Los Angeles, California based biotechnology company developing cell-free biomanufacturing technology that uses AI-engineered enzymes to convert feedstocks into high-value compounds, with applications across nutraceuticals and pharmaceuticals. Learn more at https://exozymes.com. Discover more emerging growth Featured Companies, industry-leading Featured Experts, and upcoming Featured Conferences at https://b2idigital.com. Disclosure: David Shapiro, Chief Executive Officer of B2i Digital, personally purchased in the open market and currently owns shares of unrestricted EXOZ stock, in line with B2i Digital’s practice of investing alongside its Featured Companies. See the complete Disclosure at https://b2idigital.com/disclaimer. B2i Digital is not a broker-dealer or investment adviser. This post is informational and not an offer or solicitation regarding any security. $DNLI, $TWST, $DNA, $ARKG
0 · Reply
B2iDigital
B2iDigital Jun. 19 at 2:15 PM
eXoZymes says its platform can also produce cannabinoids, terpenes, and flavonoids. A May 2026 investor presentation from eXoZymes (Nasdaq: $EXOZ ) put the spotlight on the wider range of compounds its platform can make. Chairman Chris Marlett said cannabinoids are next in line, with terpenes and flavonoids behind them, and that the company is building its patents around the methods used to make these compounds. eXoZymes Inc. is a B2i Digital Featured Company. See the company’s profile at https://b2idigital.com/exozymes-1 Marlett traced the cannabinoid work back to the company’s earliest days: “So cannabinoids are next. Actually, ironically, it was the first thing we started to make. We started to make cannabinoids. We got grants to make it and we demonstrated that we could get yields.” The presentation also covered: • A platform the company says also extends to terpenes and flavonoids • A strategy to patent the methods used to make natural compounds, plus composition patents on engineered analogs and enzymes • A partnership model spanning contract manufacturers, supplement makers, and pharmaceutical companies • Recognition in scientific and news publications and grant funding the company cites as validation Watch the full presentation: https://exozymes.twentythree.com/investor-presentation-by-chris eXoZymes Inc. is a Los Angeles, California based biotechnology company developing cell free biomanufacturing technology. The company is building a pipeline of natural compounds and engineered analogs across nutraceutical and pharmaceutical applications. Learn more at https://exozymes.com. Discover more emerging growth Featured Companies, industry-leading Featured Experts, and upcoming Featured Conferences at https://b2idigital.com. Disclosure: David Shapiro, CEO of B2i Digital, personally purchased in the open market and currently owns shares of unrestricted EXOZ stock, in line with B2i Digital’s practice of investing alongside its Featured Companies. This post is not intended to solicit the sale of EXOZ or any security, and it is not intended to offer any opinion on EXOZ as an investment. Conduct your own research and consult with your own professional advisors prior to making any investment decisions. See the complete disclosure in the Risks and Disclosures section of https://b2idigital.com/disclaimer. $DNLI, $TWST, $DNA, $ARKG
1 · Reply
Merlintrader
Merlintrader Jun. 19 at 3:39 AM
$RCKT Rocket Pharmaceuticals & Denali Therapeutics (Nasdaq: $RCKT / $DNLI): Priority Review Vouchers, Non-Dilutive Cash and Runway https://www.merlintrader.com/rocket-denali-priority-review-voucher-cash/
0 · Reply
buyslowsellfast
buyslowsellfast Jun. 17 at 7:21 PM
Sold $DNLI 23.00. Still hold core 2021 position. Bought a trading lot 26 mar 2025. Will buy back at least part of it on a dip.
0 · Reply
B2iDigital
B2iDigital Jun. 12 at 5:53 PM
eXoZymes names NCT, a compound tied to fat metabolism, as its lead molecule. NCT, a naturally occurring compound tied to how the body stores and burns fat, is the lead molecule for eXoZymes Inc. (NASDAQ: EXOZ). In a May 2026 investor presentation, Chairman Chris Marlett described how the company is pursuing it for markets such as obesity, type 2 diabetes, and fatty liver on both a nutraceutical and a pharmaceutical track. eXoZymes Inc. is a B2i Digital Featured Company. See the company’s profile at https://b2idigital.com/exozymes-1 On what NCT does in the body, Marlett said: “...we see NCT as sort of a master metabolic switch that activates this pathway that really ramps up mitochondrial metabolization of fats and energy in your body and really could address the root of how the body stores and burns stored fat.” Marlett also noted: • Early data the company says points to measurable metabolic effects tied to NCT • A planned over the counter nutraceutical path, with market entry targeted following GRAS work • A parallel pharmaceutical path built around more potent NCT analogs • Interest from pharmaceutical companies exploring complements to GLP-1 therapies, per the company Watch the full presentation: https://exozymes.twentythree.com/investor-presentation-by-chris eXoZymes Inc. is a Los Angeles, California based biotechnology company applying AI engineered enzymes to produce natural molecules at scale. Its lead molecule, NCT, is being pursued on both a nutraceutical and a pharmaceutical track. Learn more at https://exozymes.com. Discover more emerging growth Featured Companies, industry-leading Featured Experts, and upcoming Featured Conferences at https://b2idigital.com. Disclosure: David Shapiro, CEO of B2i Digital, personally purchased in the open market and currently owns shares of unrestricted EXOZ stock, in line with B2i Digital’s practice of investing alongside its Featured Companies. This post is not intended to solicit the sale of EXOZ or any security, and it is not intended to offer any opinion on EXOZ as an investment. Conduct your own research and consult with your own professional advisors prior to making any investment decisions. See the complete disclosure in the Risks and Disclosures section of https://b2idigital.com/disclaimer. $DNLI, $TWST, $DNA, $ARKG
1 · Reply
B2iDigital
B2iDigital Jun. 9 at 7:13 PM
eXoZymes (Nasdaq: $EXOZ ) announced the pricing of a public offering expected to generate approximately $5.3 million in gross proceeds, with funding intended to support development of its NCT program, continued R&D, and general corporate initiatives. For investors following eXoZymes, the announcement is significant because it provides additional capital to advance the company's AI-enabled exozyme platform and its efforts to scale production of high-value molecules for nutraceutical, pharmaceutical, and specialty chemical markets. eXoZymes is focused on using engineered enzymes operating outside living cells to manufacture complex molecules at commercial scale, an approach the company believes can overcome limitations associated with traditional biomanufacturing methods. Read the full announcement: https://exozymes.com/blog/fundraise-pricing-2026 eXoZymes is a B2i Digital Featured Company. See the company’s profile at https://b2idigital.com/exozymes-1. Disclosure: This post is for informational purposes only and does not constitute investment advice, an offer to sell, or a solicitation to purchase EXOZ or any other security. David Shapiro, CEO of B2i Digital, personally purchased shares of unrestricted EXOZ stock in the open market as part of B2i Digital's practice of investing alongside its Featured Companies. Investors should conduct their own due diligence and consult qualified financial and professional advisors before making any investment decisions. $DNLI, $TWST, $DNA, $ARKG
1 · Reply
B2iDigital
B2iDigital Jun. 5 at 6:03 PM
eXoZymes uses AI engineered enzymes to make natural molecules outside the living cell. Chris Marlett, Chairman of the Board of eXoZymes (Nasdaq: $EXOZ ), used a May 2026 investor presentation to lay out the company’s cell free biomanufacturing platform. The platform takes the enzymes that build complex natural molecules and runs them outside the living cell, which the company says yields high purity at commercial scale and reaches molecules that are hard to extract or synthesize otherwise. eXoZymes Inc. is a B2i Digital Featured Company. See the company’s profile at https://b2idigital.com/exozymes-1 Here is how Marlett described what the platform can now do: “...we are now proving that we can actually make these and scale them, which is a first, which was sort of the dream of synthetic biology but was never really delivered upon. And we’re demonstrating that we can manufacture them at scale. So many of these people are using synbio and making human gram quantities and we’re now demonstrating that we can deliver them in ton quantities. And the big benefit of what we’re doing is it’s super pure.” The presentation also covered: • A platform that takes enzymes out of the cell and evolves them to run at industrial scale, building on more than a decade of cell free research • A focus on natural molecules that are difficult to extract or synthesize through traditional methods • Technology transfer to a third party contract manufacturer to support scale up from lab to commercial volumes • The ability to engineer more potent and more bioavailable analogs of the molecules it produces Watch the full presentation: https://exozymes.twentythree.com/investor-presentation-by-chris eXoZymes Inc. is a Los Angeles, California based biotechnology company developing cell free biomanufacturing technology that uses AI engineered enzymes to convert feedstocks into high value compounds, with applications across nutraceuticals and pharmaceuticals. Learn more at https://exozymes.com. Discover more emerging growth Featured Companies, industry-leading Featured Experts, and upcoming Featured Conferences at https://b2idigital.com. Disclosure: David Shapiro, CEO of B2i Digital, personally purchased in the open market and currently owns shares of unrestricted EXOZ stock, in line with B2i Digital’s practice of investing alongside its Featured Companies. This post is not intended to solicit the sale of EXOZ or any security, and it is not intended to offer any opinion on EXOZ as an investment. Conduct your own research and consult with your own professional advisors prior to making any investment decisions. See the complete disclosure in the Risks and Disclosures section of https://b2idigital.com/disclaimer. $DNLI, $TWST, $DNA, $ARKG
1 · Reply
B2iDigital
B2iDigital Jun. 1 at 4:53 PM
eXoZymes (Nasdaq: $EXOZ ) details how its cell-free platform produces the enzyme function data that powers AI-driven biomanufacturing. eXoZymes Inc. (Nasdaq: EXOZ) shared a video in which Tyler Korman, PhD, Co-founder and VP of Research, explains why AI is well suited to enzyme engineering and why the company’s ability to generate unique enzyme function data may set its cell-free platform apart. eXoZymes is a B2i Digital Featured Company. See the company’s profile at b2idigital.com/exozymes-1. In the video, Korman explains that AI is fundamentally a question of data. He compares the 20 amino acids that build proteins to the letters of an alphabet, where the same building blocks can be arranged into millions of proteins and enzymes, each with a different function. The obstacle, he notes, has been the readout: AI can predict what a protein’s letters and structure might look like, but the function itself often remains unknown. eXoZymes is focused on closing that gap by measuring enzyme function directly, generating the data its models learn from. By making targeted changes to amino acids and observing the effect on function, the team can design, build, and test enzymes without first passing sequences through an organism or conducting sequencing, which helps shorten the work of generating and screening enzyme libraries. Looking further out, Korman points to linking enzyme steps into cascades of reactions, coupling biological pathways to move from low-cost inputs to nutraceuticals, pharmaceuticals, and specialty chemicals more efficiently. As Korman put it, the ability to generate this function data is “where some of our secret power lies,” helping eXoZymes refine its models and continue learning with large language models. Watch the video: https://exozymes.com/blog/exoz-ai-part1 Learn more at https://exozymes.com and about other B2i Digital Featured Companies at https://b2idigital.com/featured-companies. Disclosure: David Shapiro, CEO of B2i Digital, personally purchased in the open market and currently owns shares of unrestricted EXOZ stock, in line with B2i Digital’s practice of investing alongside its Featured Companies. This post is not intended to solicit the sale of EXOZ or any security, and it is not intended to offer any opinion on EXOZ as an investment. Conduct your own research and consult with your own professional advisors prior to making any investment decisions. See the complete disclosure in the Risks and Disclosures section of https://b2idigital.com/disclaimer. $DNLI, $TWST, $DNA, $ARKG
1 · Reply
SuperGreenToday
SuperGreenToday May. 27 at 1:51 PM
$DNLI Share Price: $19.84 Contract Selected: Dec 18, 2026 $20 Calls Buy Zone: $3.31 – $4.09 Target Zone: $5.72 – $6.99 Potential Upside: 63% ROI Time to Expiration: 204 Days | Updates via https://fxcapta.com/stockinfo/
0 · Reply
onlyGreenPlz
onlyGreenPlz May. 22 at 9:51 PM
$DNLI still upside. Lots of potential in their pipeline. Like many neurodegenerative diseases, early intervention matters. Now awaiting BEACON readout.
1 · Reply
Latest News on DNLI
Denali Therapeutics Transcript: AGM 2026

Jun 3, 2026, 1:00 PM EDT - 20 days ago

Denali Therapeutics Transcript: AGM 2026


Denali Therapeutics trading resumes

2026-05-21T22:35:11.000Z - 4 weeks ago

Denali Therapeutics trading resumes


Denali Therapeutics trading halted, news pending

2026-05-21T21:55:12.000Z - 4 weeks ago

Denali Therapeutics trading halted, news pending


Denali Therapeutics Slides: Corporate presentation

May 12, 2026, 4:00 PM EDT - 6 weeks ago

Denali Therapeutics Slides: Corporate presentation


Denali Therapeutics Quarterly report: Q1 2026

May 7, 2026, 7:00 AM EDT - 6 weeks ago

Denali Therapeutics Quarterly report: Q1 2026


Denali Therapeutics Earnings release: Q1 2026

May 7, 2026, 7:00 AM EDT - 6 weeks ago

Denali Therapeutics Earnings release: Q1 2026


Denali Therapeutics Proxy statement: Proxy filing

Apr 21, 2026, 8:00 AM EDT - 2 months ago

Denali Therapeutics Proxy statement: Proxy filing


Denali Therapeutics Proxy statement: Proxy filing

Apr 21, 2026, 8:00 AM EDT - 2 months ago

Denali Therapeutics Proxy statement: Proxy filing


Denali Therapeutics price target raised to $39 from $38 at BTIG

2026-04-06T17:15:09.000Z - 2 months ago

Denali Therapeutics price target raised to $39 from $38 at BTIG


Denali Therapeutics regains full rights to DNL593

2026-04-06T01:15:08.000Z - 2 months ago

Denali Therapeutics regains full rights to DNL593

TAK


Denali Therapeutics price target raised to $31 from $29 at BofA

2026-03-26T10:45:25.000Z - 3 months ago

Denali Therapeutics price target raised to $31 from $29 at BofA


Denali Therapeutics Transcript: Study update

Mar 25, 2026, 12:30 PM EDT - 3 months ago

Denali Therapeutics Transcript: Study update


Denali Therapeutics Press release: Study update

Mar 25, 2026, 12:30 PM EDT - 3 months ago

Denali Therapeutics Press release: Study update


Denali Therapeutics Slides: Study update

Mar 25, 2026, 12:30 PM EDT - 3 months ago

Denali Therapeutics Slides: Study update


Denali Therapeutics Transcript: Stifel 2026 Virtual CNS Forum

Mar 17, 2026, 2:00 PM EDT - 3 months ago

Denali Therapeutics Transcript: Stifel 2026 Virtual CNS Forum


Denali Therapeutics Earnings release: Q4 2025

Feb 26, 2026, 7:00 AM EST - 4 months ago

Denali Therapeutics Earnings release: Q4 2025


Denali Therapeutics Annual report: Q4 2025

Feb 26, 2026, 7:00 AM EST - 4 months ago

Denali Therapeutics Annual report: Q4 2025


Denali Therapeutics Transcript: Study update

Feb 5, 2026, 3:30 PM EST - 4 months ago

Denali Therapeutics Transcript: Study update


Denali Therapeutics Press release: Study update

Feb 5, 2026, 3:30 PM EST - 4 months ago

Denali Therapeutics Press release: Study update


Denali Therapeutics Slides: Study update

Feb 5, 2026, 3:30 PM EST - 4 months ago

Denali Therapeutics Slides: Study update


Denali Therapeutics Transcript: Investor Day 2025

Dec 4, 2025, 8:30 AM EST - 7 months ago

Denali Therapeutics Transcript: Investor Day 2025


Denali Therapeutics Slides: FY 2025

Dec 4, 2025, 8:30 AM EST - 7 months ago

Denali Therapeutics Slides: FY 2025


Denali Therapeutics Earnings release: Q3 2025

Nov 6, 2025, 7:00 AM EST - 8 months ago

Denali Therapeutics Earnings release: Q3 2025


Denali Therapeutics Quarterly report: Q3 2025

Nov 6, 2025, 7:00 AM EST - 8 months ago

Denali Therapeutics Quarterly report: Q3 2025


Denali Therapeutics Slides: Corporate Presentation

Nov 5, 2025, 6:00 PM EST - 8 months ago

Denali Therapeutics Slides: Corporate Presentation


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Denali Therapeutics Quarterly report: Q2 2025

Aug 11, 2025, 4:00 PM EDT - 11 months ago

Denali Therapeutics Quarterly report: Q2 2025


Denali Therapeutics Earnings release: Q2 2025

Aug 11, 2025, 4:00 PM EDT - 11 months ago

Denali Therapeutics Earnings release: Q2 2025


Denali Therapeutics Slides: Corporate Presentation

May 13, 2025, 7:00 AM EDT - 1 year ago

Denali Therapeutics Slides: Corporate Presentation


Denali Therapeutics Quarterly report: Q1 2025

May 6, 2025, 4:00 PM EDT - 1 year ago

Denali Therapeutics Quarterly report: Q1 2025


Denali Therapeutics Earnings release: Q1 2025

May 6, 2025, 4:00 PM EDT - 1 year ago

Denali Therapeutics Earnings release: Q1 2025


Denali Therapeutics Proxy statement: Proxy Filing

Apr 17, 2025, 8:00 AM EDT - 1 year ago

Denali Therapeutics Proxy statement: Proxy Filing


Denali Therapeutics Proxy statement: Proxy Filing

Apr 17, 2025, 8:00 AM EDT - 1 year ago

Denali Therapeutics Proxy statement: Proxy Filing


Denali Therapeutics Transcript: Stifel 2025 Virtual CNS Forum

Mar 18, 2025, 2:30 PM EDT - 1 year ago

Denali Therapeutics Transcript: Stifel 2025 Virtual CNS Forum


Denali Therapeutics Slides: FY 2025

Mar 18, 2025, 2:30 PM EDT - 1 year ago

Denali Therapeutics Slides: FY 2025


Denali Therapeutics Transcript: UBS Virtual CNS Day 2025

Mar 17, 2025, 12:00 PM EDT - 1 year ago

Denali Therapeutics Transcript: UBS Virtual CNS Day 2025


Denali Therapeutics Earnings release: Q4 2024

Feb 27, 2025, 4:00 PM EST - 1 year ago

Denali Therapeutics Earnings release: Q4 2024


Denali Therapeutics Annual report: Q4 2024

Feb 27, 2025, 4:00 PM EST - 1 year ago

Denali Therapeutics Annual report: Q4 2024


Denali Therapeutics Slides: FY 2025

Jan 14, 2025, 2:15 PM EST - 1 year ago

Denali Therapeutics Slides: FY 2025


Denali Therapeutics ALS drug fails in mid-stage trial

Jan 6, 2025, 4:43 PM EST - 1 year ago

Denali Therapeutics ALS drug fails in mid-stage trial


Denali Therapeutics Quarterly report: Q3 2024

Nov 5, 2024, 6:00 PM EST - 1 year ago

Denali Therapeutics Quarterly report: Q3 2024


Denali Therapeutics Earnings release: Q3 2024

Nov 5, 2024, 6:00 PM EST - 1 year ago

Denali Therapeutics Earnings release: Q3 2024


Denali Therapeutics Quarterly report: Q2 2024

Aug 1, 2024, 7:00 AM EDT - 2 years ago

Denali Therapeutics Quarterly report: Q2 2024


Denali Therapeutics Earnings release: Q2 2024

Aug 1, 2024, 7:00 AM EDT - 2 years ago

Denali Therapeutics Earnings release: Q2 2024


Denali Therapeutics Slides: Corporate Presentation

May 14, 2024, 7:00 AM EDT - 2 years ago

Denali Therapeutics Slides: Corporate Presentation


Denali Therapeutics Quarterly report: Q1 2024

May 7, 2024, 4:00 PM EDT - 2 years ago

Denali Therapeutics Quarterly report: Q1 2024


Denali Therapeutics Earnings release: Q1 2024

May 7, 2024, 4:00 PM EDT - 2 years ago

Denali Therapeutics Earnings release: Q1 2024


Denali Therapeutics Proxy statement: Proxy Filing

Apr 18, 2024, 8:00 AM EDT - 2 years ago

Denali Therapeutics Proxy statement: Proxy Filing


Denali Therapeutics Proxy statement: Proxy Filing

Apr 18, 2024, 8:00 AM EDT - 2 years ago

Denali Therapeutics Proxy statement: Proxy Filing


Denali Therapeutics Annual report: Q4 2023

Feb 27, 2024, 7:00 AM EST - 2 years ago

Denali Therapeutics Annual report: Q4 2023


Denali Therapeutics Earnings release: Q4 2023

Feb 27, 2024, 7:00 AM EST - 2 years ago

Denali Therapeutics Earnings release: Q4 2023


Denali Therapeutics Quarterly report: Q3 2023

Nov 7, 2023, 4:00 PM EST - 2 years ago

Denali Therapeutics Quarterly report: Q3 2023


Denali Therapeutics Earnings release: Q3 2023

Nov 7, 2023, 4:00 PM EST - 2 years ago

Denali Therapeutics Earnings release: Q3 2023


Denali Therapeutics Slides: FY 2023

Sep 12, 2023, 11:30 AM EDT - 3 years ago

Denali Therapeutics Slides: FY 2023


Denali Therapeutics Quarterly report: Q2 2023

Aug 8, 2023, 4:00 PM EDT - 3 years ago

Denali Therapeutics Quarterly report: Q2 2023


Denali Therapeutics Earnings release: Q2 2023

Aug 8, 2023, 4:00 PM EDT - 3 years ago

Denali Therapeutics Earnings release: Q2 2023


Denali Therapeutics Transcript: Study Result

Jun 20, 2023, 8:30 AM EDT - 3 years ago

Denali Therapeutics Transcript: Study Result


Denali Therapeutics Press release: Study Result

Jun 20, 2023, 8:30 AM EDT - 3 years ago

Denali Therapeutics Press release: Study Result


Denali Therapeutics Slides: Study Result

Jun 20, 2023, 8:30 AM EDT - 3 years ago

Denali Therapeutics Slides: Study Result


Denali Therapeutics Quarterly report: Q1 2023

May 8, 2023, 4:00 PM EDT - 3 years ago

Denali Therapeutics Quarterly report: Q1 2023


Denali Therapeutics Earnings release: Q1 2023

May 8, 2023, 4:00 PM EDT - 3 years ago

Denali Therapeutics Earnings release: Q1 2023


Denali Therapeutics Proxy statement: Proxy Filing

Apr 18, 2023, 8:00 AM EDT - 3 years ago

Denali Therapeutics Proxy statement: Proxy Filing


Denali Therapeutics Proxy statement: Proxy Filing

Apr 18, 2023, 8:00 AM EDT - 3 years ago

Denali Therapeutics Proxy statement: Proxy Filing


Denali Therapeutics Annual report: Q4 2022

Feb 27, 2023, 4:00 PM EST - 3 years ago

Denali Therapeutics Annual report: Q4 2022


Denali Therapeutics Earnings release: Q4 2022

Feb 27, 2023, 4:00 PM EST - 3 years ago

Denali Therapeutics Earnings release: Q4 2022


B2iDigital
B2iDigital Jun. 23 at 8:53 PM
eXoZymes (Nasdaq: $EXOZ ) Chief Commercial Officer Damien Perriman will present at Webull’s Biotech Sector webinar on June 25, alongside Envoy Medical and IN8bio. Damien Perriman, Chief Commercial Officer of eXoZymes Inc. (Nasdaq: EXOZ), will present at Webull’s Biotech Sector webinar on June 25 at 2:00 p.m. Eastern, part of the Webull Corporate Connect series that spotlights publicly traded biotech companies for investors. eXoZymes Inc. is a B2i Digital Featured Company. See the company’s profile at https://b2idigital.com/exozymes-1 eXoZymes is a synthetic biology company that takes enzymes out of the living cell and runs them on their own to manufacture hard-to-make molecules for nutraceutical and pharmaceutical markets. The session gives investors a chance to hear directly from the company’s commercial leadership. • The webinar takes place June 25 at 2:00 p.m. Eastern, 11:00 a.m. Pacific, and registration is free with a Webull account • Perriman presents alongside Brent Lucas, Chief Executive Officer of Envoy Medical, and Will Ho, Chief Executive Officer and co-founder of IN8bio • Perriman leads commercial strategy at eXoZymes, whose cell-free platform uses AI-engineered enzymes to convert low-cost feedstocks into high-value compounds Register for the webinar: https://exozymes.com/blog/webulls-biotech-webinar-2026 eXoZymes Inc. is a Los Angeles, California based biotechnology company developing cell-free biomanufacturing technology that uses AI-engineered enzymes to convert feedstocks into high-value compounds, with applications across nutraceuticals and pharmaceuticals. Learn more at https://exozymes.com. Discover more emerging growth Featured Companies, industry-leading Featured Experts, and upcoming Featured Conferences at https://b2idigital.com. Disclosure: David Shapiro, Chief Executive Officer of B2i Digital, personally purchased in the open market and currently owns shares of unrestricted EXOZ stock, in line with B2i Digital’s practice of investing alongside its Featured Companies. See the complete Disclosure at https://b2idigital.com/disclaimer. B2i Digital is not a broker-dealer or investment adviser. This post is informational and not an offer or solicitation regarding any security. $DNLI, $TWST, $DNA, $ARKG
0 · Reply
B2iDigital
B2iDigital Jun. 19 at 2:15 PM
eXoZymes says its platform can also produce cannabinoids, terpenes, and flavonoids. A May 2026 investor presentation from eXoZymes (Nasdaq: $EXOZ ) put the spotlight on the wider range of compounds its platform can make. Chairman Chris Marlett said cannabinoids are next in line, with terpenes and flavonoids behind them, and that the company is building its patents around the methods used to make these compounds. eXoZymes Inc. is a B2i Digital Featured Company. See the company’s profile at https://b2idigital.com/exozymes-1 Marlett traced the cannabinoid work back to the company’s earliest days: “So cannabinoids are next. Actually, ironically, it was the first thing we started to make. We started to make cannabinoids. We got grants to make it and we demonstrated that we could get yields.” The presentation also covered: • A platform the company says also extends to terpenes and flavonoids • A strategy to patent the methods used to make natural compounds, plus composition patents on engineered analogs and enzymes • A partnership model spanning contract manufacturers, supplement makers, and pharmaceutical companies • Recognition in scientific and news publications and grant funding the company cites as validation Watch the full presentation: https://exozymes.twentythree.com/investor-presentation-by-chris eXoZymes Inc. is a Los Angeles, California based biotechnology company developing cell free biomanufacturing technology. The company is building a pipeline of natural compounds and engineered analogs across nutraceutical and pharmaceutical applications. Learn more at https://exozymes.com. Discover more emerging growth Featured Companies, industry-leading Featured Experts, and upcoming Featured Conferences at https://b2idigital.com. Disclosure: David Shapiro, CEO of B2i Digital, personally purchased in the open market and currently owns shares of unrestricted EXOZ stock, in line with B2i Digital’s practice of investing alongside its Featured Companies. This post is not intended to solicit the sale of EXOZ or any security, and it is not intended to offer any opinion on EXOZ as an investment. Conduct your own research and consult with your own professional advisors prior to making any investment decisions. See the complete disclosure in the Risks and Disclosures section of https://b2idigital.com/disclaimer. $DNLI, $TWST, $DNA, $ARKG
1 · Reply
Merlintrader
Merlintrader Jun. 19 at 3:39 AM
$RCKT Rocket Pharmaceuticals & Denali Therapeutics (Nasdaq: $RCKT / $DNLI): Priority Review Vouchers, Non-Dilutive Cash and Runway https://www.merlintrader.com/rocket-denali-priority-review-voucher-cash/
0 · Reply
buyslowsellfast
buyslowsellfast Jun. 17 at 7:21 PM
Sold $DNLI 23.00. Still hold core 2021 position. Bought a trading lot 26 mar 2025. Will buy back at least part of it on a dip.
0 · Reply
B2iDigital
B2iDigital Jun. 12 at 5:53 PM
eXoZymes names NCT, a compound tied to fat metabolism, as its lead molecule. NCT, a naturally occurring compound tied to how the body stores and burns fat, is the lead molecule for eXoZymes Inc. (NASDAQ: EXOZ). In a May 2026 investor presentation, Chairman Chris Marlett described how the company is pursuing it for markets such as obesity, type 2 diabetes, and fatty liver on both a nutraceutical and a pharmaceutical track. eXoZymes Inc. is a B2i Digital Featured Company. See the company’s profile at https://b2idigital.com/exozymes-1 On what NCT does in the body, Marlett said: “...we see NCT as sort of a master metabolic switch that activates this pathway that really ramps up mitochondrial metabolization of fats and energy in your body and really could address the root of how the body stores and burns stored fat.” Marlett also noted: • Early data the company says points to measurable metabolic effects tied to NCT • A planned over the counter nutraceutical path, with market entry targeted following GRAS work • A parallel pharmaceutical path built around more potent NCT analogs • Interest from pharmaceutical companies exploring complements to GLP-1 therapies, per the company Watch the full presentation: https://exozymes.twentythree.com/investor-presentation-by-chris eXoZymes Inc. is a Los Angeles, California based biotechnology company applying AI engineered enzymes to produce natural molecules at scale. Its lead molecule, NCT, is being pursued on both a nutraceutical and a pharmaceutical track. Learn more at https://exozymes.com. Discover more emerging growth Featured Companies, industry-leading Featured Experts, and upcoming Featured Conferences at https://b2idigital.com. Disclosure: David Shapiro, CEO of B2i Digital, personally purchased in the open market and currently owns shares of unrestricted EXOZ stock, in line with B2i Digital’s practice of investing alongside its Featured Companies. This post is not intended to solicit the sale of EXOZ or any security, and it is not intended to offer any opinion on EXOZ as an investment. Conduct your own research and consult with your own professional advisors prior to making any investment decisions. See the complete disclosure in the Risks and Disclosures section of https://b2idigital.com/disclaimer. $DNLI, $TWST, $DNA, $ARKG
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B2iDigital
B2iDigital Jun. 9 at 7:13 PM
eXoZymes (Nasdaq: $EXOZ ) announced the pricing of a public offering expected to generate approximately $5.3 million in gross proceeds, with funding intended to support development of its NCT program, continued R&D, and general corporate initiatives. For investors following eXoZymes, the announcement is significant because it provides additional capital to advance the company's AI-enabled exozyme platform and its efforts to scale production of high-value molecules for nutraceutical, pharmaceutical, and specialty chemical markets. eXoZymes is focused on using engineered enzymes operating outside living cells to manufacture complex molecules at commercial scale, an approach the company believes can overcome limitations associated with traditional biomanufacturing methods. Read the full announcement: https://exozymes.com/blog/fundraise-pricing-2026 eXoZymes is a B2i Digital Featured Company. See the company’s profile at https://b2idigital.com/exozymes-1. Disclosure: This post is for informational purposes only and does not constitute investment advice, an offer to sell, or a solicitation to purchase EXOZ or any other security. David Shapiro, CEO of B2i Digital, personally purchased shares of unrestricted EXOZ stock in the open market as part of B2i Digital's practice of investing alongside its Featured Companies. Investors should conduct their own due diligence and consult qualified financial and professional advisors before making any investment decisions. $DNLI, $TWST, $DNA, $ARKG
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B2iDigital
B2iDigital Jun. 5 at 6:03 PM
eXoZymes uses AI engineered enzymes to make natural molecules outside the living cell. Chris Marlett, Chairman of the Board of eXoZymes (Nasdaq: $EXOZ ), used a May 2026 investor presentation to lay out the company’s cell free biomanufacturing platform. The platform takes the enzymes that build complex natural molecules and runs them outside the living cell, which the company says yields high purity at commercial scale and reaches molecules that are hard to extract or synthesize otherwise. eXoZymes Inc. is a B2i Digital Featured Company. See the company’s profile at https://b2idigital.com/exozymes-1 Here is how Marlett described what the platform can now do: “...we are now proving that we can actually make these and scale them, which is a first, which was sort of the dream of synthetic biology but was never really delivered upon. And we’re demonstrating that we can manufacture them at scale. So many of these people are using synbio and making human gram quantities and we’re now demonstrating that we can deliver them in ton quantities. And the big benefit of what we’re doing is it’s super pure.” The presentation also covered: • A platform that takes enzymes out of the cell and evolves them to run at industrial scale, building on more than a decade of cell free research • A focus on natural molecules that are difficult to extract or synthesize through traditional methods • Technology transfer to a third party contract manufacturer to support scale up from lab to commercial volumes • The ability to engineer more potent and more bioavailable analogs of the molecules it produces Watch the full presentation: https://exozymes.twentythree.com/investor-presentation-by-chris eXoZymes Inc. is a Los Angeles, California based biotechnology company developing cell free biomanufacturing technology that uses AI engineered enzymes to convert feedstocks into high value compounds, with applications across nutraceuticals and pharmaceuticals. Learn more at https://exozymes.com. Discover more emerging growth Featured Companies, industry-leading Featured Experts, and upcoming Featured Conferences at https://b2idigital.com. Disclosure: David Shapiro, CEO of B2i Digital, personally purchased in the open market and currently owns shares of unrestricted EXOZ stock, in line with B2i Digital’s practice of investing alongside its Featured Companies. This post is not intended to solicit the sale of EXOZ or any security, and it is not intended to offer any opinion on EXOZ as an investment. Conduct your own research and consult with your own professional advisors prior to making any investment decisions. See the complete disclosure in the Risks and Disclosures section of https://b2idigital.com/disclaimer. $DNLI, $TWST, $DNA, $ARKG
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B2iDigital
B2iDigital Jun. 1 at 4:53 PM
eXoZymes (Nasdaq: $EXOZ ) details how its cell-free platform produces the enzyme function data that powers AI-driven biomanufacturing. eXoZymes Inc. (Nasdaq: EXOZ) shared a video in which Tyler Korman, PhD, Co-founder and VP of Research, explains why AI is well suited to enzyme engineering and why the company’s ability to generate unique enzyme function data may set its cell-free platform apart. eXoZymes is a B2i Digital Featured Company. See the company’s profile at b2idigital.com/exozymes-1. In the video, Korman explains that AI is fundamentally a question of data. He compares the 20 amino acids that build proteins to the letters of an alphabet, where the same building blocks can be arranged into millions of proteins and enzymes, each with a different function. The obstacle, he notes, has been the readout: AI can predict what a protein’s letters and structure might look like, but the function itself often remains unknown. eXoZymes is focused on closing that gap by measuring enzyme function directly, generating the data its models learn from. By making targeted changes to amino acids and observing the effect on function, the team can design, build, and test enzymes without first passing sequences through an organism or conducting sequencing, which helps shorten the work of generating and screening enzyme libraries. Looking further out, Korman points to linking enzyme steps into cascades of reactions, coupling biological pathways to move from low-cost inputs to nutraceuticals, pharmaceuticals, and specialty chemicals more efficiently. As Korman put it, the ability to generate this function data is “where some of our secret power lies,” helping eXoZymes refine its models and continue learning with large language models. Watch the video: https://exozymes.com/blog/exoz-ai-part1 Learn more at https://exozymes.com and about other B2i Digital Featured Companies at https://b2idigital.com/featured-companies. Disclosure: David Shapiro, CEO of B2i Digital, personally purchased in the open market and currently owns shares of unrestricted EXOZ stock, in line with B2i Digital’s practice of investing alongside its Featured Companies. This post is not intended to solicit the sale of EXOZ or any security, and it is not intended to offer any opinion on EXOZ as an investment. Conduct your own research and consult with your own professional advisors prior to making any investment decisions. See the complete disclosure in the Risks and Disclosures section of https://b2idigital.com/disclaimer. $DNLI, $TWST, $DNA, $ARKG
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SuperGreenToday
SuperGreenToday May. 27 at 1:51 PM
$DNLI Share Price: $19.84 Contract Selected: Dec 18, 2026 $20 Calls Buy Zone: $3.31 – $4.09 Target Zone: $5.72 – $6.99 Potential Upside: 63% ROI Time to Expiration: 204 Days | Updates via https://fxcapta.com/stockinfo/
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onlyGreenPlz
onlyGreenPlz May. 22 at 9:51 PM
$DNLI still upside. Lots of potential in their pipeline. Like many neurodegenerative diseases, early intervention matters. Now awaiting BEACON readout.
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BullDonald
BullDonald May. 22 at 5:23 PM
$DNLI Position reduced Aggressively and as the Thesis changed from LUMA success to Market readjustment based on Pipeline. Reduce Portfolio exposure to less then 6% from ~60%. its a Miss, i would be Multi Banger if LUMA data show even 20% effecasy. But the stock held wll and did not crass. shows how Institution are defending the 18 price level.
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FibonacciTrader_
FibonacciTrader_ May. 22 at 4:40 PM
New trade update — full risk-off rotation just triggered in the book. Exited $DNLI completely after the LUMA trial failure (primary + all secondary endpoints missed, Parkinson’s program discontinued). Thesis was binary, and once that broke, position logic broke with it. No hesitation — capital preserved. Proceeds moved into $SGOV (short-term Treasuries). No replacement trade for now. Not forcing exposure into a weak opportunity set just for deployment’s sake. Cash = optionality, especially with multiple macro binaries ahead (Fed June decision, oil volatility, event-driven risk). Discipline > conviction when the thesis changes. Holding becomes ego, not edge. Rest of the book remains unchanged — stepping back, reassessing, and waiting for a cleaner setup before redeploying risk
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BullDonald
BullDonald May. 22 at 2:43 PM
$DNLI Contrary to the news , Accumulation is happening. the binary event risk was priced in. that explained the Fall after Approval.
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Maggistock
Maggistock May. 22 at 1:22 PM
$DNLI Holding up really well!!
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BullDonald
BullDonald May. 22 at 12:41 PM
$DNLI biomarker data showed >90% peripheral LRRK2 inhibition and ~30% reduction in CSF phosphorylated Rab10 — meaning the drug worked mechanistically, but that didn’t translate to clinical benefit. The BBB was crossed. The target was hit. It just didn’t slow the disease. Shows how hard it is to treat it. Any company develops any new a molecule will mostly collaborate with DNLI To use the the BBB vehicle
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notreload_ai
notreload_ai May. 22 at 12:30 PM
$DNLI, $BIIB - Experimental Parkinson’s drug BIIB122 failed to slow disease in trials despite strong biological effects; development stopped. https://notreload.xyz/xy/biogen-denali-halt-biib122-after-parkinson-phase-2-failure/
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OpenOutcrier
OpenOutcrier May. 22 at 12:30 PM
$BIIB (-1.0% pre) $DNLI (-3.1% pre) Biogen and Denali discontinue Parkinson's drug after trial fails https://ooc.bz/l/103323
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biotech
biotech May. 22 at 11:53 AM
$BIIB $DNLI Phase 2b LUMA study of BIIB122 in early-stage Parkinsons disease #did #not #meet its primary or secondary endpoints Biogen and Denali will #discontinue #development of BIIB122 in idiopathic Parkinsons disease $BIIB should return to $SGMO for #parkinson now w STAC-BBB
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BullDonald
BullDonald May. 22 at 5:43 AM
$DNLI fux, seems I get caught here.
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mikesterz7
mikesterz7 May. 22 at 3:09 AM
$BIIB $DNLI Biogen and Denali will stop further development of BIIB122 for the broader idiopathic form of Parkinson’s. Denali will continue its separate early-to-middle BEACON study of the same drug, but only in the smaller group of patients who carry a specific genetic mutation.
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Olivia_Strickland
Olivia_Strickland May. 21 at 11:13 PM
$DNLI down 6.68% AH to 18.02 after the RTH close at 19.30, and this is the same shape of post-close fade the name pulled a couple months back when it gave up another leg by the next morning. no headline on my screen yet. anyone see what tripped the AH sellers? AH damage + filings: https://tapeboard.com/chart/DNLI?utm_source=stocktwits&utm_medium=post&utm_campaign=olivia&utm_content=dnli-ah-dn-chart
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StocktwitsNews
StocktwitsNews May. 21 at 11:03 PM
BIIB, DNLI Stocks Edge Lower After Hours: Parkinson’s Drug Misses Key Goals In Trial $BIIB $DNLI https://stocktwits.com/news/equity/markets/biib-dnli-stocks-edge-lower-after-hours-parkinsons-drug-misses-key-goals-in-trial/cZXCkReRe8V
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