Market Cap 412.52M
Revenue (ttm) 10.12M
Net Income (ttm) -220.66M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -2,180.43%
Debt to Equity Ratio 0.00
Volume 1,591,900
Avg Vol 3,179,046
Day's Range N/A - N/A
Shares Out 266.14M
Stochastic %K 85%
Beta 2.01
Analysts Strong Sell
Price Target $9.59

Company Profile

Autolus Therapeutics plc, a clinical-stage biopharmaceutical company, develops T cell therapies for the treatment of cancer and autoimmune diseases in United Kingdom and internationally. The company's clinical-stage programs include obecabtagene autoleucel (AUTO1), a CD19-targeting programmed T cell investigational therapy that is in Phase 1b/2 clinical trial for the treatment of adult ALL; AUTO1/22, which is in a Phase 1 clinical trial in pediatric patients with relapsed or refractory ALL; AUTO...

Industry: Biotechnology
Sector: Healthcare
Phone: 44 20 3829 6230
Address:
The Mediaworks, 191 Wood Lane White City, London, United Kingdom
XX1XX
XX1XX Dec. 8 at 4:07 AM
$AUTL Current lupus drugs suppress the immune system indefinitely and don’t cure the disease. CAR-T could offer: ✔ One-time treatment ✔ Long-lasting remission ✔ No ongoing medications This is the same type of breakthrough seen in cancer — but applied to a huge market: ~1.5M people in the U.S. have lupus Up to 70% have B-cell–driven disease Current drugs: $20$70K per year, lifelong CAR-T pricing: $350K+ one-time If this works, it’s a multi-billion-dollar category — far larger than leukemia.
0 · Reply
TricksterT
TricksterT Dec. 8 at 4:05 AM
$AUTL overnight trading is going wild. Should be interesting this week.
1 · Reply
Biotechs5454
Biotechs5454 Dec. 8 at 2:05 AM
$AUTL Is AUTL spreading itself too thin trying to tackle too much? I truly think their cash burn/risk of dilution is the biggest weight on the share price. Welcome other thoughts.
1 · Reply
Mden
Mden Dec. 8 at 12:08 AM
$AUTL will they report Phase 1 ALARIC trial in AL amyloidosis data in ASH?
0 · Reply
Michael_garic
Michael_garic Dec. 7 at 9:43 PM
$AUTL The "headlines" from ASH this weekend were dominated by Multiple Myeloma (Legend Biotech, J&J, etc.) and AML (new pills/combinations). Autolus stood out because it had one of the few high-profile "wins" in the ALL (Leukemia) category. The lack of a flashy, better pediatric CAR-T result from a big pharma competitors today appears to confirm AUTL taking a leadership role in relapsed B ALL. My opinion. Not advice.
0 · Reply
Michael_garic
Michael_garic Dec. 7 at 9:37 PM
$AUTL AUTL ASH update on pediatric trials Remission Rate (ORR): Validated at 95% (19 out of 20 patients responded). "best in class" Durability: Validated. The data explicitly states that "nearly 90% of responders had ongoing remission at the data cut-off." Safety: Validated as "consistent with adults," showing low rates of severe toxicity (Grade 3+ CRS/ICANS). Much better than the current standard treatment Kymriah. The safety data confirms the drug is gentle enough for kids. This keeps them on track for the estimated 2028 full pediatric approval , but the strength of this data might generate pressure for earlier access or compassionate use programs. It is considered a "late-breaking" or major update for the company this weekend.
1 · Reply
Mden
Mden Dec. 7 at 7:54 PM
$AUTL the limited in vivo car-t safety profile is not as good as obe-cel. Two out of three have grade 2 CRS, even with ticilizumab used. There is room for ex vivo car-t
2 · Reply
GeniusLoci
GeniusLoci Dec. 7 at 7:46 PM
$AUTL Previous sessions: Pocket Pivot followed by a MACD Bullish Centerline Cross
0 · Reply
dgbio
dgbio Dec. 7 at 6:21 PM
$AUTL Kelonia's abstract was published on November 24. It's very unlikely they will have new safety information on Tuesday. Kelonia is using CD3-targeted lentiviral vectors. I don't think hepatoxicity is a concern in this case. https://meetings-api.hematology.org/api/abstract/vmpreview/304572
1 · Reply
dgbio
dgbio Dec. 7 at 5:07 PM
$AUTL I don't think anyone is going to use untargeted AAV vectors for CAR-Ts.
1 · Reply
Latest News on AUTL
Why Is Autolus Therapeutics Stock Trading Higher On Tuesday?

Nov 25, 2025, 12:37 PM EST - 12 days ago

Why Is Autolus Therapeutics Stock Trading Higher On Tuesday?


Autolus Therapeutics plc (AUTL) Q2 2025 Earnings Call Transcript

Aug 12, 2025, 4:37 PM EDT - 4 months ago

Autolus Therapeutics plc (AUTL) Q2 2025 Earnings Call Transcript


Autolus Therapeutics plc (AUTL) Q1 2025 Earnings Call Transcript

May 11, 2025, 4:22 AM EDT - 7 months ago

Autolus Therapeutics plc (AUTL) Q1 2025 Earnings Call Transcript


XX1XX
XX1XX Dec. 8 at 4:07 AM
$AUTL Current lupus drugs suppress the immune system indefinitely and don’t cure the disease. CAR-T could offer: ✔ One-time treatment ✔ Long-lasting remission ✔ No ongoing medications This is the same type of breakthrough seen in cancer — but applied to a huge market: ~1.5M people in the U.S. have lupus Up to 70% have B-cell–driven disease Current drugs: $20$70K per year, lifelong CAR-T pricing: $350K+ one-time If this works, it’s a multi-billion-dollar category — far larger than leukemia.
0 · Reply
TricksterT
TricksterT Dec. 8 at 4:05 AM
$AUTL overnight trading is going wild. Should be interesting this week.
1 · Reply
Biotechs5454
Biotechs5454 Dec. 8 at 2:05 AM
$AUTL Is AUTL spreading itself too thin trying to tackle too much? I truly think their cash burn/risk of dilution is the biggest weight on the share price. Welcome other thoughts.
1 · Reply
Mden
Mden Dec. 8 at 12:08 AM
$AUTL will they report Phase 1 ALARIC trial in AL amyloidosis data in ASH?
0 · Reply
Michael_garic
Michael_garic Dec. 7 at 9:43 PM
$AUTL The "headlines" from ASH this weekend were dominated by Multiple Myeloma (Legend Biotech, J&J, etc.) and AML (new pills/combinations). Autolus stood out because it had one of the few high-profile "wins" in the ALL (Leukemia) category. The lack of a flashy, better pediatric CAR-T result from a big pharma competitors today appears to confirm AUTL taking a leadership role in relapsed B ALL. My opinion. Not advice.
0 · Reply
Michael_garic
Michael_garic Dec. 7 at 9:37 PM
$AUTL AUTL ASH update on pediatric trials Remission Rate (ORR): Validated at 95% (19 out of 20 patients responded). "best in class" Durability: Validated. The data explicitly states that "nearly 90% of responders had ongoing remission at the data cut-off." Safety: Validated as "consistent with adults," showing low rates of severe toxicity (Grade 3+ CRS/ICANS). Much better than the current standard treatment Kymriah. The safety data confirms the drug is gentle enough for kids. This keeps them on track for the estimated 2028 full pediatric approval , but the strength of this data might generate pressure for earlier access or compassionate use programs. It is considered a "late-breaking" or major update for the company this weekend.
1 · Reply
Mden
Mden Dec. 7 at 7:54 PM
$AUTL the limited in vivo car-t safety profile is not as good as obe-cel. Two out of three have grade 2 CRS, even with ticilizumab used. There is room for ex vivo car-t
2 · Reply
GeniusLoci
GeniusLoci Dec. 7 at 7:46 PM
$AUTL Previous sessions: Pocket Pivot followed by a MACD Bullish Centerline Cross
0 · Reply
dgbio
dgbio Dec. 7 at 6:21 PM
$AUTL Kelonia's abstract was published on November 24. It's very unlikely they will have new safety information on Tuesday. Kelonia is using CD3-targeted lentiviral vectors. I don't think hepatoxicity is a concern in this case. https://meetings-api.hematology.org/api/abstract/vmpreview/304572
1 · Reply
dgbio
dgbio Dec. 7 at 5:07 PM
$AUTL I don't think anyone is going to use untargeted AAV vectors for CAR-Ts.
1 · Reply
dgbio
dgbio Dec. 7 at 4:35 PM
$AUTL Cabaletta is not "chemo-free" at all, it's similar to Aucatzyl. Kelonia reports on the first three patients treated with anti-BCMA product. It's many years away from anything competing with Aucatzyl.
1 · Reply
Michael_garic
Michael_garic Dec. 7 at 4:31 PM
$AUTL Physician sentiment at ASH Buy: The Safety Profile in Lupus (confirmed clean) and Real-World Ease of Use in B-ALL (ROCCA study). Sell: The Complexity. Doctors clearly prefer the "Off-the-Shelf" workflow (Fate/CRISPR) and are rooting for it to succeed so they can stop managing cell collection logistics. Bottom Line: Doctors view Autolus as the current "Best in Class" for safety and durability, but they view the process (chemo + cell collection) as a necessary evil that they hope to eventually replace.
1 · Reply
Michael_garic
Michael_garic Dec. 7 at 4:29 PM
$AUTL More feedback from ASH On the "In Vivo" Future (Kelonia/Cabaletta) Skepticism: While investors are panicked about "In Vivo" making factories obsolete, doctors are much more conservative. The sentiment at ASH is: "Show me 100 patients, not 3." Safety First: Physicians are still haunted by early gene therapy trials where patients died of liver failure. Until they see robust safety data from Kelonia (likely Tuesday), they are sticking with ex vivo (Autolus) because they know exactly what they are putting into the patient.
0 · Reply
Michael_garic
Michael_garic Dec. 7 at 4:28 PM
$AUTL On SubQ Blinatumomab: "The Immediate Threat" The loudest applause/buzz is actually for Subcutaneous Blinatumomab (Amgen), and this is a mixed bag for Autolus. The Sentiment: "This changes my clinic flow tomorrow." Doctors hate the continuous IV pump for Blinatumomab. The new SubQ injection makes Blinatumomab ridiculously easy to give. The Impact on Autolus: Physicians are saying they will likely use SubQ Blinatumomab earlier and more often. This means fewer patients might fail chemotherapy and reach the "desperate" stage where they need Autolus. However, for those who do fail Blinatumomab, Autolus remains the primary salvage option.
0 · Reply
Michael_garic
Michael_garic Dec. 7 at 4:27 PM
$AUTL On B-ALL (The ROCCA Real-World Study): "The 'User-Friendly' CAR-T" A major, under-the-radar win for Autolus this weekend was the presentation of the ROCCA Consortium data (Real-World Evidence). The Comparison: This study compared Autolus's Aucatzyl directly against Tecartus (Gilead) in real-world practice. The Verdict: Physicians are noting that Autolus had significantly less severe toxicity (Severe CRS: 0% vs. 6%; Severe ICANS: 6% vs. 32%) while maintaining similar efficacy. The Practice Shift: The sentiment among community oncologists is: "If efficacy is the same, why would I use the toxic one?" This data is effectively winning the argument that Autolus should be the standard of care for older or frailer patients who can't handle the ICU.
0 · Reply
Michael_garic
Michael_garic Dec. 7 at 4:25 PM
$AUTL AUTL feedback at ASH Rheumatologists are reacting positively to the safety profile but are hesitant about the process. The "Zero ICANS" Win: The fact that Autolus confirmed zero neurotoxicity (brain swelling) is the single most important talking point. Doctors are saying they would actually feel comfortable prescribing this to a young woman, whereas they are terrified of giving Yescarta (which has high neurotoxicity rates) to a non-cancer patient. While impressed by the cure rate, doctors are openly complaining about the lymphodepletion (chemotherapy) requirement. The sentiment is: "If I have to give my patient chemo to give them this cure, I will do it, but I am looking for the first company that lets me skip it." Doctors love the competition from the standpoint of no chemo and same day discharge but are worried about a long-term cure from in-vivo treatments. AUTL is a proven commodity.
0 · Reply
Michael_garic
Michael_garic Dec. 7 at 4:13 PM
$AUTL ASH LBA updates from Kelonia(in-vivo/chemo free) will be on Tues 7:30 AUTL protocol: Lupus patients who achieved "100% renal response" did not just get a T-cell infusion. They first spent ~3 days receiving chemotherapy to wipe out their existing immune system. The Consequence: This means the safety data Autolus is celebrating ("No Neurotoxicity") is only half the story. The patients still suffered the side effects of the chemotherapy itself, which often include: Temporary hair loss. Nausea and vomiting. Increased risk of infection (neutropenia). Fertility risks (Cyclophosphamide is toxic to ovaries/sperm). 3. The Commercial Reality For a 60-year-old Leukemia patient, chemotherapy is expected. For a 25-year-old woman with Lupus, avoiding chemotherapy is often the #1 priority. If Tuesday data shows "Chemo-Free" has issues it confirms that chemotherapy is necessary for everyone, meaning Autolus's "safer" neurotoxicity profile remains the best option on the market.
0 · Reply
Michael_garic
Michael_garic Dec. 7 at 3:53 PM
$AUTL ASH Kelonia Therapeutics (Tuesday Presenter): The "Tuesday Risk" for Autolus is likely Kelonia, who is scheduled to present in the 7:30 - 9:00 AM session. The Threat: Kelonia is presenting data on KLN-1010, their in vivo CAR-T. The Connection: Like Cabaletta’s "Chemo-Free" hope, Kelonia’s goal is to remove the heavy chemo/hospitalization burden entirely by using an injectable gene therapy. If Kelonia shows safety/efficacy: It hurts Autolus (implies the future is "factory-free"). If Kelonia shows toxicity (liver issues): It helps Autolus (confirms the "safe" factory approach is still King). Cabaletta Bio: While they may not be presenting live Tuesday, their stock will likely move in sympathy with Kelonia's data. If the "In Vivo / Low Chemo" narrative gets hot on Tuesday morning, CABA stock often rises with it.
0 · Reply
chelfen
chelfen Dec. 7 at 3:08 PM
$AUTL thanks, good stuff
0 · Reply
Michael_garic
Michael_garic Dec. 7 at 2:50 PM
$AUTL Update from ASH part 3 The Science: "Memory" Predicts Success (Abstract 4429) In a translational science presentation, Autolus revealed why their manufacturing process works better for some patients than others. The Finding: They identified that high levels of Central Memory T-cells (Tcm) in the final drug product are the strongest independent predictor of Overall Survival. Why it matters: This sounds technical, but it is a commercial weapon. Autolus uses this data to claim their manufacturing process (which is designed to preserve Tcm phenotype) is superior to "generic" CAR-T processes that burn out the cells. It effectively markets their "complex" manufacturing as a feature, not a bug.
0 · Reply
Michael_garic
Michael_garic Dec. 7 at 2:49 PM
$AUTL update from ASH part 2 The Defense: Long-Term B-ALL Survival (FELIX Study) Autolus presented updated long-term follow-up data (approx. 3 years) from the pivotal FELIX study in Relapsed/Refractory B-ALL. The Data: The "Cure" Rate: Approximately 38% to 40% of responders remain in remission without needing a subsequent stem cell transplant. Median Overall Survival (OS): 15.6 months (in a population that historically survives <6 months). Event-Free Survival (EFS): The data shows a "plateau" on the curve, suggesting that if a patient stays in remission past the 2-year mark, they are likely cured. Why it matters: This cements Aucatzyl (obe-cel) as a definitive therapy. It proves that for ~40% of patients, this is a "one-and-done" cure, validating the drug's $500K+ price tag to insurers.
1 · Reply
Michael_garic
Michael_garic Dec. 7 at 2:48 PM
$AUTL update from ASH At the 2025 ASH Annual Meeting, Autolus Therapeutics focused on defending its core B-ALL franchise with long-term data while pivoting aggressively to the "next big thing": Autoimmune Disease (Lupus). Here are the specific readouts and key data points Autolus presented: 1. The Headline: Lupus (SLE) Data (Abstract 302) This was the most critical update for the company's future growth. They presented the first substantial look at obe-cel in patients with Refractory Systemic Lupus Erythematosus (SLE) from the Phase 1 CARLYSLE study. The Data: Efficacy: Deep B-cell depletion was observed in all treated patients. Clinical benefit (reduction in SLEDAI scores) was seen in 100% of patients, with 50% achieving a complete renal response (reversal of kidney damage). Safety (The "Moat"): This was the big win. There were no cases of ICANS (neurotoxicity) and no high-grade (Grade ≥3) CRS. Why it matters: Safety is the #1 barrier in treating Lupus
1 · Reply