Market Cap 1.28B
Revenue (ttm) 1.08M
Net Income (ttm) -71.80M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -6,648.15%
Debt to Equity Ratio 0.00
Volume 118,100
Avg Vol 318,682
Day's Range N/A - N/A
Shares Out 44.77M
Stochastic %K 63%
Beta 3.80
Analysts Strong Sell
Price Target $33.14

Company Profile

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; a...

Industry: Biotechnology
Sector: Healthcare
Phone: 650 338 3533
Address:
250 East Grand Avenue, South San Francisco, United States
IN0V8
IN0V8 Dec. 26 at 7:14 PM
$SEPN Watch Jonestrading initiates coverage with buy rating; PT $43
0 · Reply
RevelationRanger
RevelationRanger Dec. 26 at 12:31 PM
$SEPN Expectations are recalibrating toward pragmatic delivery instead of lofty projections. Efficiency initiatives must translate into measurable productivity. Evidence of repeatability is likely to change market tone. Upside remains tied to tangible progress, not assumptions.
0 · Reply
MementoMori2023
MementoMori2023 Dec. 24 at 8:10 PM
$GLUE $SEPN A week later, not too shabby.. OMER, GLUE, MLTX, SEPN pretty good calls
0 · Reply
JarvisFlow
JarvisFlow Dec. 23 at 2:09 PM
Jones Trading updates rating for Septerna ( $SEPN ) to Buy, target set at 43.
0 · Reply
Thestocktraderhubzee
Thestocktraderhubzee Dec. 19 at 12:30 PM
$SEPN Raymond James Initiates Coverage On Septerna with Strong Buy Rating, Announces Price Target of $38
0 · Reply
JarvisFlow
JarvisFlow Dec. 19 at 12:23 PM
Raymond James has updated their rating for Septerna ( $SEPN ) to Strong Buy with a price target of 38.
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CGRE
CGRE Dec. 17 at 6:37 PM
$SEPN https://www.marketbeat.com/instant-alerts/septerna-nasdaqsepn-coverage-initiated-at-truist-financial-2025-12-17/
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MementoMori2023
MementoMori2023 Dec. 16 at 1:57 PM
$OMER let me introduce you to $GLUE $SEPN , again cash from Novartis and a great pipeline with news around the corner.
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JarvisFlow
JarvisFlow Dec. 15 at 1:52 PM
Truist Securities updates rating for Septerna ( $SEPN ) to Buy, target set at 34.
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scotttrader213
scotttrader213 Dec. 1 at 12:51 PM
$SEPN $NVO Septerna, Inc. delivered a strong 3Q25, driven by partnership revenue from its transformative collaboration with Novo Nordisk.$SEPN going higher towards 35
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Latest News on SEPN
Septerna's Novo Partnership Begins To Transform The Story

Nov 25, 2025, 2:58 AM EST - 4 weeks ago

Septerna's Novo Partnership Begins To Transform The Story


Septerna to Participate in Upcoming Investor Conferences

Nov 3, 2025, 8:00 AM EST - 7 weeks ago

Septerna to Participate in Upcoming Investor Conferences


Septerna to Present at Jefferies Global Healthcare Conference

May 29, 2025, 8:00 AM EDT - 7 months ago

Septerna to Present at Jefferies Global Healthcare Conference


Septerna to Present at TD Cowen 45th Annual Health Care Conference

Feb 26, 2025, 8:00 AM EST - 10 months ago

Septerna to Present at TD Cowen 45th Annual Health Care Conference


Septerna Prices Upsized Initial Public Offering

Oct 24, 2024, 9:47 PM EDT - 1 year ago

Septerna Prices Upsized Initial Public Offering


Biotech Septerna aims to raise up to $186 million in US IPO

Oct 21, 2024, 6:26 AM EDT - 1 year ago

Biotech Septerna aims to raise up to $186 million in US IPO


IN0V8
IN0V8 Dec. 26 at 7:14 PM
$SEPN Watch Jonestrading initiates coverage with buy rating; PT $43
0 · Reply
RevelationRanger
RevelationRanger Dec. 26 at 12:31 PM
$SEPN Expectations are recalibrating toward pragmatic delivery instead of lofty projections. Efficiency initiatives must translate into measurable productivity. Evidence of repeatability is likely to change market tone. Upside remains tied to tangible progress, not assumptions.
0 · Reply
MementoMori2023
MementoMori2023 Dec. 24 at 8:10 PM
$GLUE $SEPN A week later, not too shabby.. OMER, GLUE, MLTX, SEPN pretty good calls
0 · Reply
JarvisFlow
JarvisFlow Dec. 23 at 2:09 PM
Jones Trading updates rating for Septerna ( $SEPN ) to Buy, target set at 43.
0 · Reply
Thestocktraderhubzee
Thestocktraderhubzee Dec. 19 at 12:30 PM
$SEPN Raymond James Initiates Coverage On Septerna with Strong Buy Rating, Announces Price Target of $38
0 · Reply
JarvisFlow
JarvisFlow Dec. 19 at 12:23 PM
Raymond James has updated their rating for Septerna ( $SEPN ) to Strong Buy with a price target of 38.
0 · Reply
CGRE
CGRE Dec. 17 at 6:37 PM
$SEPN https://www.marketbeat.com/instant-alerts/septerna-nasdaqsepn-coverage-initiated-at-truist-financial-2025-12-17/
0 · Reply
MementoMori2023
MementoMori2023 Dec. 16 at 1:57 PM
$OMER let me introduce you to $GLUE $SEPN , again cash from Novartis and a great pipeline with news around the corner.
0 · Reply
JarvisFlow
JarvisFlow Dec. 15 at 1:52 PM
Truist Securities updates rating for Septerna ( $SEPN ) to Buy, target set at 34.
0 · Reply
scotttrader213
scotttrader213 Dec. 1 at 12:51 PM
$SEPN $NVO Septerna, Inc. delivered a strong 3Q25, driven by partnership revenue from its transformative collaboration with Novo Nordisk.$SEPN going higher towards 35
0 · Reply
KittyCat888
KittyCat888 Nov. 26 at 8:57 PM
$SEPN This one was a winner for me! Long swing at 10.29. Definitely will have this on my watch list again. Gl all who are in this!
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GJ_Rockabilt
GJ_Rockabilt Nov. 21 at 8:37 PM
$SEPN I don't think this is ready for a Breakout, yet. In fact, I believe it's Overbought with Price divided by Sales at over 46. Three would be nice. I'll stick with my $LFWD Rewalk Robotics, thank you.
1 · Reply
StockScanners
StockScanners Nov. 20 at 2:30 AM
$SEPN keep watch if this holds above 22.25
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Eylonc2004
Eylonc2004 Nov. 17 at 10:05 AM
$SEPN Why did this stock go up yesterday?
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StockScanners
StockScanners Nov. 15 at 4:09 AM
$SEPN keep watch if this holds above 21.40
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GJ_Rockabilt
GJ_Rockabilt Nov. 14 at 5:50 PM
$SEPN It's NOT a Squeeze.
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LabPsycho
LabPsycho Nov. 14 at 5:36 PM
$SEPN @GothamGirl Worth repeating in part because of the use of 'buttresses'
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GothamGirl
GothamGirl Nov. 14 at 2:14 PM
$SEPN $SGMO Worth repeating...
1 · Reply
JarvisFlow
JarvisFlow Nov. 14 at 1:49 PM
Wells Fargo has updated their rating for Septerna ( $SEPN ) to Overweight with a price target of 28.
0 · Reply
Dan8406
Dan8406 Nov. 11 at 3:12 PM
$SEPN https://www.gurufocus.com/news/3201242/hc-wainwright-co-raises-price-target-for-sepn-to-3000-sepn-stock-news
0 · Reply
JarvisFlow
JarvisFlow Nov. 11 at 12:43 PM
HC Wainwright & Co. has updated their rating for Septerna ( $SEPN ) to Buy with a price target of 30.
0 · Reply
ChessGM
ChessGM Nov. 10 at 10:09 PM
$SEPN Bullish (8.2) Looking good for tomorrow. In the latest analysis of Septerna, Inc. (SEPN), the company exhibits strong momentum, reflected by a significant 53% increase in share price over the past month and nearly doubling its value in the last quarter. The recent appointment of Dr. Keith Gottesdiener to the board has generated optimism due to his extensive experience in drug development. This strategic leadership change is expected to enhance the company's focus on G protein-coupled receptor (GPCR) drug discovery, a promising area within biotechnology. Financially, Septerna's P/E ratio remains competitive within the biotech sector, and while specific EPS growth figures are not disclosed, the upward price movement suggests positive investor sentiment regarding future earnings. Revenue forecasts appear to be optimistic, although current trends in earnings estimate revisions indicate some caution. Comparatively, SEPN is performing well against industry peers, bolstered by insider buying activity that has increased by 219%, signaling confidence from those closest to the company. Looking ahead, Septerna is set to report earnings in the near future. Analysts are closely monitoring these upcoming results, given the historical performance of the company, which has shown volatility but also potential for significant upside. The consensus among analysts is cautiously optimistic, with estimates suggesting a modest increase in revenue driven by ongoing clinical trials and potential product advancements. The impact of these earnings reports could be substantial, particularly if the company can demonstrate progress in its drug pipeline and articulate a clear growth strategy. In terms of sector performance, the biotechnology sector has shown resilience, with many companies experiencing robust growth driven by innovation and increased market demand for new therapies. As SEPN operates within this dynamic environment, its recent developments and strategic initiatives position it favorably for continued growth amidst sector-wide advancements.
0 · Reply