Market Cap 1.04B
Revenue (ttm) 1.08M
Net Income (ttm) -71.80M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -6,648.15%
Debt to Equity Ratio 0.00
Volume 1,521,700
Avg Vol 315,010
Day's Range N/A - N/A
Shares Out 44.77M
Stochastic %K 89%
Beta N/A
Analysts Strong Sell
Price Target $27.75

Company Profile

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; a...

Industry: Biotechnology
Sector: Healthcare
Phone: 650 338 3533
Address:
250 East Grand Avenue, South San Francisco, United States
StockScanners
StockScanners Nov. 15 at 4:09 AM
$SEPN keep watch if this holds above 21.40
0 · Reply
meganJuarez77
meganJuarez77 Nov. 14 at 7:34 PM
$SEPN I’m stacking NXXT now because earnings could arrive today and the multiple is too low for this growth and funds want the reprice before it happens and Geode has about 314,454 ≈ $0.63M while Vanguard has 1,049,265 ≈ $2.10M
1 · Reply
GJ_Rockabilt
GJ_Rockabilt Nov. 14 at 5:50 PM
$SEPN It's NOT a Squeeze.
0 · Reply
LabPsycho
LabPsycho Nov. 14 at 5:36 PM
$SEPN @GothamGirl Worth repeating in part because of the use of 'buttresses'
0 · Reply
GothamGirl
GothamGirl Nov. 14 at 2:14 PM
$SEPN $SGMO Worth repeating...
1 · Reply
JarvisFlow
JarvisFlow Nov. 14 at 1:49 PM
Wells Fargo has updated their rating for Septerna ( $SEPN ) to Overweight with a price target of 28.
0 · Reply
Dan8406
Dan8406 Nov. 11 at 3:12 PM
$SEPN https://www.gurufocus.com/news/3201242/hc-wainwright-co-raises-price-target-for-sepn-to-3000-sepn-stock-news
0 · Reply
JarvisFlow
JarvisFlow Nov. 11 at 12:43 PM
HC Wainwright & Co. has updated their rating for Septerna ( $SEPN ) to Buy with a price target of 30.
0 · Reply
ChessGM
ChessGM Nov. 10 at 10:09 PM
$SEPN Bullish (8.2) Looking good for tomorrow. In the latest analysis of Septerna, Inc. (SEPN), the company exhibits strong momentum, reflected by a significant 53% increase in share price over the past month and nearly doubling its value in the last quarter. The recent appointment of Dr. Keith Gottesdiener to the board has generated optimism due to his extensive experience in drug development. This strategic leadership change is expected to enhance the company's focus on G protein-coupled receptor (GPCR) drug discovery, a promising area within biotechnology. Financially, Septerna's P/E ratio remains competitive within the biotech sector, and while specific EPS growth figures are not disclosed, the upward price movement suggests positive investor sentiment regarding future earnings. Revenue forecasts appear to be optimistic, although current trends in earnings estimate revisions indicate some caution. Comparatively, SEPN is performing well against industry peers, bolstered by insider buying activity that has increased by 219%, signaling confidence from those closest to the company. Looking ahead, Septerna is set to report earnings in the near future. Analysts are closely monitoring these upcoming results, given the historical performance of the company, which has shown volatility but also potential for significant upside. The consensus among analysts is cautiously optimistic, with estimates suggesting a modest increase in revenue driven by ongoing clinical trials and potential product advancements. The impact of these earnings reports could be substantial, particularly if the company can demonstrate progress in its drug pipeline and articulate a clear growth strategy. In terms of sector performance, the biotechnology sector has shown resilience, with many companies experiencing robust growth driven by innovation and increased market demand for new therapies. As SEPN operates within this dynamic environment, its recent developments and strategic initiatives position it favorably for continued growth amidst sector-wide advancements.
0 · Reply
d_risk
d_risk Nov. 10 at 4:35 PM
$SEPN - Septerna, Inc. - 10Q - Updated Risk Factors SEPN flags heightened risks from broader U.S. agency disruptions, new macroeconomic and geopolitical threats, expanded healthcare and drug pricing reforms, rapid U.S. policy shifts, and sweeping tax law changes that could hit approvals, pricing, and cash flow. #Healthcare #U.S.PolicyShifts #GeopoliticalRisk #MacroeconomicRisk #DrugPricingReform 🟢 Added 🟠 Removed https://d-risk.ai/SEPN/10-Q/2025-11-10
0 · Reply
Latest News on SEPN
Septerna to Participate in Upcoming Investor Conferences

Nov 3, 2025, 8:00 AM EST - 13 days ago

Septerna to Participate in Upcoming Investor Conferences


Septerna to Present at Jefferies Global Healthcare Conference

May 29, 2025, 8:00 AM EDT - 6 months ago

Septerna to Present at Jefferies Global Healthcare Conference


Septerna Prices Upsized Initial Public Offering

Oct 24, 2024, 9:47 PM EDT - 1 year ago

Septerna Prices Upsized Initial Public Offering


Biotech Septerna aims to raise up to $186 million in US IPO

Oct 21, 2024, 6:26 AM EDT - 1 year ago

Biotech Septerna aims to raise up to $186 million in US IPO


StockScanners
StockScanners Nov. 15 at 4:09 AM
$SEPN keep watch if this holds above 21.40
0 · Reply
meganJuarez77
meganJuarez77 Nov. 14 at 7:34 PM
$SEPN I’m stacking NXXT now because earnings could arrive today and the multiple is too low for this growth and funds want the reprice before it happens and Geode has about 314,454 ≈ $0.63M while Vanguard has 1,049,265 ≈ $2.10M
1 · Reply
GJ_Rockabilt
GJ_Rockabilt Nov. 14 at 5:50 PM
$SEPN It's NOT a Squeeze.
0 · Reply
LabPsycho
LabPsycho Nov. 14 at 5:36 PM
$SEPN @GothamGirl Worth repeating in part because of the use of 'buttresses'
0 · Reply
GothamGirl
GothamGirl Nov. 14 at 2:14 PM
$SEPN $SGMO Worth repeating...
1 · Reply
JarvisFlow
JarvisFlow Nov. 14 at 1:49 PM
Wells Fargo has updated their rating for Septerna ( $SEPN ) to Overweight with a price target of 28.
0 · Reply
Dan8406
Dan8406 Nov. 11 at 3:12 PM
$SEPN https://www.gurufocus.com/news/3201242/hc-wainwright-co-raises-price-target-for-sepn-to-3000-sepn-stock-news
0 · Reply
JarvisFlow
JarvisFlow Nov. 11 at 12:43 PM
HC Wainwright & Co. has updated their rating for Septerna ( $SEPN ) to Buy with a price target of 30.
0 · Reply
ChessGM
ChessGM Nov. 10 at 10:09 PM
$SEPN Bullish (8.2) Looking good for tomorrow. In the latest analysis of Septerna, Inc. (SEPN), the company exhibits strong momentum, reflected by a significant 53% increase in share price over the past month and nearly doubling its value in the last quarter. The recent appointment of Dr. Keith Gottesdiener to the board has generated optimism due to his extensive experience in drug development. This strategic leadership change is expected to enhance the company's focus on G protein-coupled receptor (GPCR) drug discovery, a promising area within biotechnology. Financially, Septerna's P/E ratio remains competitive within the biotech sector, and while specific EPS growth figures are not disclosed, the upward price movement suggests positive investor sentiment regarding future earnings. Revenue forecasts appear to be optimistic, although current trends in earnings estimate revisions indicate some caution. Comparatively, SEPN is performing well against industry peers, bolstered by insider buying activity that has increased by 219%, signaling confidence from those closest to the company. Looking ahead, Septerna is set to report earnings in the near future. Analysts are closely monitoring these upcoming results, given the historical performance of the company, which has shown volatility but also potential for significant upside. The consensus among analysts is cautiously optimistic, with estimates suggesting a modest increase in revenue driven by ongoing clinical trials and potential product advancements. The impact of these earnings reports could be substantial, particularly if the company can demonstrate progress in its drug pipeline and articulate a clear growth strategy. In terms of sector performance, the biotechnology sector has shown resilience, with many companies experiencing robust growth driven by innovation and increased market demand for new therapies. As SEPN operates within this dynamic environment, its recent developments and strategic initiatives position it favorably for continued growth amidst sector-wide advancements.
0 · Reply
d_risk
d_risk Nov. 10 at 4:35 PM
$SEPN - Septerna, Inc. - 10Q - Updated Risk Factors SEPN flags heightened risks from broader U.S. agency disruptions, new macroeconomic and geopolitical threats, expanded healthcare and drug pricing reforms, rapid U.S. policy shifts, and sweeping tax law changes that could hit approvals, pricing, and cash flow. #Healthcare #U.S.PolicyShifts #GeopoliticalRisk #MacroeconomicRisk #DrugPricingReform 🟢 Added 🟠 Removed https://d-risk.ai/SEPN/10-Q/2025-11-10
0 · Reply
MementoMori2023
MementoMori2023 Oct. 22 at 6:50 PM
$GLUE be patience, let me introduce you to $SEPN , similar deal with Novartis, took a few months but went up 150%, GLUE has some much room, both do actually.
0 · Reply
SocioCobb
SocioCobb Oct. 17 at 1:16 AM
$SEPN All of my bangers check at least 4 of my 6 boxes. 1st box is always an open market S4.
0 · Reply
BillRayValentine
BillRayValentine Oct. 13 at 4:10 PM
$SEPN Pulled out (pause) most of my position. Letting the rest ride. Adding on any nice dip (5% or better) I bid this trade goodbye @ a 72.48% gain at this moment. 🙏🏿👊🏿✊🏿🥳🎉🤑
0 · Reply
USA_toinfinity_andbeyond
USA_toinfinity_andbeyond Oct. 8 at 3:50 PM
$SEPN I'm out. Good luck bulls!
0 · Reply
USA_toinfinity_andbeyond
USA_toinfinity_andbeyond Oct. 5 at 3:14 PM
$SEPN is doing great!
0 · Reply
BillRayValentine
BillRayValentine Sep. 29 at 4:31 PM
$SEPN What Studd of a stock. Let's Phuking Go!! Check the date..😎🤑🙏🏿✊🏿🤑🤑🙏🏿 Cuey celebration gif...
0 · Reply
GfromTn
GfromTn Sep. 21 at 11:47 PM
$SEPN we are positioned very well and we have a tremendously strong team so this week looking for $18 and 22-28 eoy
0 · Reply
222short222
222short222 Sep. 19 at 12:32 PM
0 · Reply
Trader1141
Trader1141 Sep. 19 at 10:53 AM
$SEPN another $ATMV 😍
0 · Reply
BillRayValentine
BillRayValentine Sep. 18 at 2:59 PM
$SEPN Beautiful 😍👍🏿🙏🏿🤑
0 · Reply
BillRayValentine
BillRayValentine Sep. 15 at 7:55 PM
$SEPN This thing is a Horse. I'm still ridin. Gonna ride right into $16 plus. 🙏🏿🦾😎
0 · Reply
GfromTn
GfromTn Sep. 12 at 12:30 PM
$SEPN $15 break and end of this year we will see $20’s this one is only getting better and better been holding and will continue to hold for when this runs
0 · Reply