Market Cap 324.62M
Revenue (ttm) 0.00
Net Income (ttm) -75.27M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 3,691,200
Avg Vol 2,450,076
Day's Range N/A - N/A
Shares Out 45.21M
Stochastic %K 2%
Beta 0.89
Analysts Sell
Price Target $5.75

Company Profile

Sionna Therapeutics, Inc., a clinical-stage biopharmaceutical company, researches and develops medicines for the treatment of cystic fibrosis (CF). It develops galicaftor (SION-2222), a transmembrane domain 1 (TMD1)-directed cystic fibrosis transmembrane conductance regulator (CFTR) that has completed Phase 2 trial; navocaftor (SION-3067), a potentiator that has completed Phase 2 trial; SION-109, an intracellular loop 4 directed CFTR corrector that has completed Phase 1 trial; SION-2851, a TMD1-...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 819 2020
Address:
21 Hickory Drive, Suite 500, Waltham, United States
Colonia
Colonia Sep. 18 at 7:09 PM
$SION any new news here? Q1 play?
0 · Reply
XQuise
XQuise Sep. 17 at 10:47 PM
$SION 🧘🏻🫡🤑thx
0 · Reply
AnalyticaInvestor
AnalyticaInvestor Sep. 16 at 10:15 AM
$WTI $EBS $SION Good morning, investors. AI infrastructure spending continues supporting power, electrical equipment, and semiconductor suppliers, but rising policy risks and restrictive interest rates are keeping broader risk appetite constrained. On the watchlist, $WTI is up more than 132% YTD as energy markets remain firm, while $IDHC is up 32% and $EBS remains under pressure following a 38% decline. Among gainers, $HLP surged 21% despite no company specific catalyst. On the downside, $DVLT fell 18% amid ongoing litigation concerns despite securing a new purchase order. Read the full Analytica Alpha 👇 https://analyticainvestor.beehiiv.com/p/markets-slip-as-10-yr-tops-5
0 · Reply
peterb030
peterb030 Sep. 15 at 2:37 PM
$TENX was also in $SION lets hope will come with a pr soon
0 · Reply
notreload_ai
notreload_ai Sep. 15 at 10:22 AM
$SION will start a Q1 2027 Phase 2a trial of SION-451 plus SION-2222 after a missed Trikafta add-on study. A 46% staff cut extends cash into 2H 2029. https://notreload.xyz/xy/sionna-advances-dual-cf-combo-after-august-trial-miss/
0 · Reply
topstockalerts
topstockalerts Sep. 15 at 12:50 AM
Sionna Therapeutics announced a major strategic restructuring that includes a 46% workforce reduction and a renewed focus on its dual SION-451 + SION-2222 combination. The company plans to advance the therapy into the Phase 2a AscenSION CF proof-of-concept study, expected to begin in the first quarter of 2027. At the same time, Sionna will discontinue SION-719 as an add-on therapy after the Phase 2a PreciSION CF trial failed to meet its primary endpoint for reducing sweat chloride. The workforce reduction is expected to generate about $6.4 million in restructuring charges, while cost-cutting measures are projected to extend the company’s cash runway into the second half of 2029. Sionna ended the second quarter with approximately $268 million in cash. Investor sentiment was further pressured by Raymond James, which downgraded the stock to Market Perform from Strong Buy, following a series of analyst downgrades after the August 10 clinical setback. $SION
0 · Reply
Ohsi
Ohsi Sep. 14 at 8:29 PM
$SION Color me surprised
0 · Reply
Dableinstocks
Dableinstocks Sep. 14 at 8:09 PM
$SION wow, there was news on the horizon. I finally called something right. 🤣
1 · Reply
glaucio
glaucio Sep. 14 at 3:42 PM
$SION looking tasty 😋
0 · Reply
Dableinstocks
Dableinstocks Sep. 14 at 2:02 PM
$SION moving up again today. I feel like someone knows something.
0 · Reply
Latest News on SION
Sionna Therapeutics Transcript: Study update

Sep 14, 2026, 4:30 PM EDT - 4 days ago

Sionna Therapeutics Transcript: Study update


Sionna Therapeutics Press release: Study update

Sep 14, 2026, 4:30 PM EDT - 4 days ago

Sionna Therapeutics Press release: Study update


Sionna Therapeutics Slides: Study update

Sep 14, 2026, 4:30 PM EDT - 4 days ago

Sionna Therapeutics Slides: Study update


Sionna Therapeutics to reduce workforce by 46%

2026-09-14T20:05:19.000Z - 4 days ago

Sionna Therapeutics to reduce workforce by 46%


Sionna Therapeutics rises 15.9%

2026-08-11T16:05:27.000Z - 5 weeks ago

Sionna Therapeutics rises 15.9%


Sionna Therapeutics rises 14.0%

2026-08-11T14:05:30.000Z - 5 weeks ago

Sionna Therapeutics rises 14.0%


Sionna Therapeutics downgraded to Neutral from Buy at BTIG

2026-08-10T19:20:28.000Z - 5 weeks ago

Sionna Therapeutics downgraded to Neutral from Buy at BTIG


Sionna Therapeutics falls -92.0%

2026-08-10T16:06:38.000Z - 5 weeks ago

Sionna Therapeutics falls -92.0%


Why Sionna Therapeutics Stock Is Crashing 92% to a Record Low

Aug 10, 2026, 12:01 PM EDT - 5 weeks ago

Why Sionna Therapeutics Stock Is Crashing 92% to a Record Low


Sionna Therapeutics Transcript: Study result

Aug 10, 2026, 8:00 AM EDT - 5 weeks ago

Sionna Therapeutics Transcript: Study result


Sionna Therapeutics Press release: Study result

Aug 10, 2026, 8:00 AM EDT - 5 weeks ago

Sionna Therapeutics Press release: Study result


Sionna Therapeutics Slides: Study result

Aug 10, 2026, 8:00 AM EDT - 5 weeks ago

Sionna Therapeutics Slides: Study result


Sionna Therapeutics Slides: Corporate presentation

Aug 6, 2026, 9:00 AM EDT - 6 weeks ago

Sionna Therapeutics Slides: Corporate presentation


Sionna Therapeutics Earnings release: Q2 2026

Aug 6, 2026, 7:00 AM EDT - 6 weeks ago

Sionna Therapeutics Earnings release: Q2 2026


Sionna Therapeutics Quarterly report: Q2 2026

Aug 6, 2026, 7:00 AM EDT - 6 weeks ago

Sionna Therapeutics Quarterly report: Q2 2026


Sionna Therapeutics Reports First Quarter 2026 Financial Results

May 12, 2026, 7:00 AM EDT - 4 months ago

Sionna Therapeutics Reports First Quarter 2026 Financial Results


Sionna Therapeutics Earnings release: Q1 2026

May 12, 2026, 7:00 AM EDT - 4 months ago

Sionna Therapeutics Earnings release: Q1 2026


Sionna Therapeutics Quarterly report: Q1 2026

May 12, 2026, 7:00 AM EDT - 4 months ago

Sionna Therapeutics Quarterly report: Q1 2026


Sionna Therapeutics Slides: Corporate presentation

May 12, 2026, 7:00 AM EDT - 4 months ago

Sionna Therapeutics Slides: Corporate presentation


Sionna Therapeutics Proxy statement: Proxy filing

Apr 27, 2026, 8:00 AM EDT - 4 months ago

Sionna Therapeutics Proxy statement: Proxy filing


Sionna Therapeutics Proxy statement: Proxy filing

Apr 27, 2026, 8:00 AM EDT - 4 months ago

Sionna Therapeutics Proxy statement: Proxy filing


Sionna Therapeutics Annual report: Q4 2025

Mar 2, 2026, 7:00 AM EST - 6 months ago

Sionna Therapeutics Annual report: Q4 2025


Sionna Therapeutics Earnings release: Q4 2025

Mar 2, 2026, 7:00 AM EST - 6 months ago

Sionna Therapeutics Earnings release: Q4 2025


Sionna Therapeutics Slides: Corporate presentation

Mar 2, 2026, 7:00 AM EST - 6 months ago

Sionna Therapeutics Slides: Corporate presentation


Sionna Therapeutics Slides: Corporate presentation

Jan 7, 2026, 7:00 AM EST - 8 months ago

Sionna Therapeutics Slides: Corporate presentation


Sionna Therapeutics Transcript: Stifel 2025 Healthcare Conference

Nov 12, 2025, 8:00 AM EST - 10 months ago

Sionna Therapeutics Transcript: Stifel 2025 Healthcare Conference


Sionna Therapeutics Reports Third Quarter 2025 Financial Results

Nov 5, 2025, 7:00 AM EST - 10 months ago

Sionna Therapeutics Reports Third Quarter 2025 Financial Results


Sionna Therapeutics Quarterly report: Q3 2025

Nov 5, 2025, 7:00 AM EST - 10 months ago

Sionna Therapeutics Quarterly report: Q3 2025


Sionna Therapeutics Earnings release: Q3 2025

Nov 5, 2025, 7:00 AM EST - 10 months ago

Sionna Therapeutics Earnings release: Q3 2025


Sionna Therapeutics Slides: Corporate Presentation

Oct 20, 2025, 6:00 PM EDT - 11 months ago

Sionna Therapeutics Slides: Corporate Presentation


Sionna Therapeutics Quarterly report: Q2 2025

Aug 11, 2025, 7:00 AM EDT - 1 year ago

Sionna Therapeutics Quarterly report: Q2 2025


Sionna Therapeutics Earnings release: Q2 2025

Aug 11, 2025, 7:00 AM EDT - 1 year ago

Sionna Therapeutics Earnings release: Q2 2025


Sionna Therapeutics Transcript: Study Update

Jun 4, 2025, 8:00 AM EDT - 1 year ago

Sionna Therapeutics Transcript: Study Update


Sionna Therapeutics Press release: Study Update

Jun 4, 2025, 8:00 AM EDT - 1 year ago

Sionna Therapeutics Press release: Study Update


Sionna Therapeutics Slides: Study Update

Jun 4, 2025, 8:00 AM EDT - 1 year ago

Sionna Therapeutics Slides: Study Update


Sionna Therapeutics Quarterly report: Q1 2025

May 12, 2025, 7:00 AM EDT - 1 year ago

Sionna Therapeutics Quarterly report: Q1 2025


Sionna Therapeutics Earnings release: Q1 2025

May 12, 2025, 7:00 AM EDT - 1 year ago

Sionna Therapeutics Earnings release: Q1 2025


Sionna Therapeutics Proxy statement: Proxy Filing

Apr 29, 2025, 8:00 AM EDT - 1 year ago

Sionna Therapeutics Proxy statement: Proxy Filing


Sionna Therapeutics Proxy statement: Proxy Filing

Apr 29, 2025, 8:00 AM EDT - 1 year ago

Sionna Therapeutics Proxy statement: Proxy Filing


Sionna Therapeutics Earnings release: Q4 2024

Mar 20, 2025, 8:00 AM EDT - 1 year ago

Sionna Therapeutics Earnings release: Q4 2024


Sionna Therapeutics Annual report: Q4 2024

Mar 20, 2025, 8:00 AM EDT - 1 year ago

Sionna Therapeutics Annual report: Q4 2024


Sionna Therapeutics Prices Upsized Initial Public Offering

Feb 6, 2025, 7:51 PM EST - 1 year ago

Sionna Therapeutics Prices Upsized Initial Public Offering


Colonia
Colonia Sep. 18 at 7:09 PM
$SION any new news here? Q1 play?
0 · Reply
XQuise
XQuise Sep. 17 at 10:47 PM
$SION 🧘🏻🫡🤑thx
0 · Reply
AnalyticaInvestor
AnalyticaInvestor Sep. 16 at 10:15 AM
$WTI $EBS $SION Good morning, investors. AI infrastructure spending continues supporting power, electrical equipment, and semiconductor suppliers, but rising policy risks and restrictive interest rates are keeping broader risk appetite constrained. On the watchlist, $WTI is up more than 132% YTD as energy markets remain firm, while $IDHC is up 32% and $EBS remains under pressure following a 38% decline. Among gainers, $HLP surged 21% despite no company specific catalyst. On the downside, $DVLT fell 18% amid ongoing litigation concerns despite securing a new purchase order. Read the full Analytica Alpha 👇 https://analyticainvestor.beehiiv.com/p/markets-slip-as-10-yr-tops-5
0 · Reply
peterb030
peterb030 Sep. 15 at 2:37 PM
$TENX was also in $SION lets hope will come with a pr soon
0 · Reply
notreload_ai
notreload_ai Sep. 15 at 10:22 AM
$SION will start a Q1 2027 Phase 2a trial of SION-451 plus SION-2222 after a missed Trikafta add-on study. A 46% staff cut extends cash into 2H 2029. https://notreload.xyz/xy/sionna-advances-dual-cf-combo-after-august-trial-miss/
0 · Reply
topstockalerts
topstockalerts Sep. 15 at 12:50 AM
Sionna Therapeutics announced a major strategic restructuring that includes a 46% workforce reduction and a renewed focus on its dual SION-451 + SION-2222 combination. The company plans to advance the therapy into the Phase 2a AscenSION CF proof-of-concept study, expected to begin in the first quarter of 2027. At the same time, Sionna will discontinue SION-719 as an add-on therapy after the Phase 2a PreciSION CF trial failed to meet its primary endpoint for reducing sweat chloride. The workforce reduction is expected to generate about $6.4 million in restructuring charges, while cost-cutting measures are projected to extend the company’s cash runway into the second half of 2029. Sionna ended the second quarter with approximately $268 million in cash. Investor sentiment was further pressured by Raymond James, which downgraded the stock to Market Perform from Strong Buy, following a series of analyst downgrades after the August 10 clinical setback. $SION
0 · Reply
Ohsi
Ohsi Sep. 14 at 8:29 PM
$SION Color me surprised
0 · Reply
Dableinstocks
Dableinstocks Sep. 14 at 8:09 PM
$SION wow, there was news on the horizon. I finally called something right. 🤣
1 · Reply
glaucio
glaucio Sep. 14 at 3:42 PM
$SION looking tasty 😋
0 · Reply
Dableinstocks
Dableinstocks Sep. 14 at 2:02 PM
$SION moving up again today. I feel like someone knows something.
0 · Reply
MingChoo
MingChoo Sep. 13 at 1:05 PM
$SION Next up9
0 · Reply
pal123
pal123 Sep. 11 at 6:48 PM
0 · Reply
fantastex
fantastex Sep. 11 at 1:33 PM
$SION 8+ today smelling some buyout offer soon
0 · Reply
fantastex
fantastex Sep. 10 at 8:04 PM
$SION 9 Tomorrow?
1 · Reply
fantastex
fantastex Sep. 10 at 7:55 PM
$SION running hard
1 · Reply
AshLim1
AshLim1 Sep. 8 at 7:39 PM
$SION Been good to me no doubt but had to sell today in need of funds,however I did place a bit into SMR was I wrong answers on a post card was fun being amongst these 600 odd few left early I noticed is what it is, but I will come back to SION 😉 soon still watching
0 · Reply
topstockalerts
topstockalerts Sep. 8 at 12:00 AM
$SION I’m starting to think this story has another chapter.
1 · Reply
JFais
JFais Sep. 7 at 11:56 AM
$IONS $SION $RARE $TENX some of the more recent ones that came to mind, feel free to add others
2 · Reply
DylanGFM
DylanGFM Sep. 7 at 1:54 AM
$SION this is the only one I can find right now that is down 50% on the month but up 10% on the week
0 · Reply
EvCe
EvCe Sep. 4 at 4:37 PM
$SION steady horse 💲💲💲
0 · Reply
fantastex
fantastex Sep. 4 at 1:53 PM
$SION 20% pump anytime . Now its Just time for call killers....
0 · Reply
MrEd916
MrEd916 Sep. 3 at 8:00 PM
$SION Looks like no one thinks she's gonna pop again in the morning tomorrow
0 · Reply