prismmarketview
Oct 6, 1:38 PM
$KRRO: first cohort dosed in ANCHOR, Phase 1/2 trial of KRRO-121 (RNA-editing oligonucleotide) for hyperammonemia in UCDs
→ Single 2 mg/kg dose in healthy volunteers, currently enrolling in Australia
→ Phase 1: up to 50 healthy volunteers, placebo-controlled (SAD up to 30, MAD up to 20)
→ Phase 2: up to 15 UCD patients across all genotypes, subject to regulatory approval
→ Patient dosing 1H 2027, interim readout 2H 2027
Caveats: dosing only, no clinical results. Preclinical ammonia data not yet shown in humans. Safety and activity are the next tests.
$KRRO #Biotech #RareDisease
https://prismmarketview.com/korro-bio-begins-human-testing-of-rna-editing-therapy-for-urea-cycle-disorders/
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