Market Cap 3.35B
Revenue (ttm) 0.00
Net Income (ttm) -208.02M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 2,278,400
Avg Vol 735,082
Day's Range N/A - N/A
Shares Out 77.59M
Stochastic %K 97%
Beta 3.15
Analysts Strong Sell
Price Target $56.71

Company Profile

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and S...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 651 5940
Address:
221 Crescent Street, Building 23 Suite 105, Waltham, United States
edvquye
edvquye Feb. 22 at 11:38 PM
0 · Reply
DailyAnalysis
DailyAnalysis Feb. 22 at 4:56 PM
Clinical breakthroughs sent $SYRE into a 1D parabolic move with RSI tagging 81. The 1W trend is dominant, but 4H and 30M CCI indicate extreme extension, making a STOCH cooling period likely. @DailyAnalysis
0 · Reply
DailyAnalysis
DailyAnalysis Feb. 21 at 8:26 PM
$SYRE 1W accumulation accelerates after positive trial data. 1D RSI is overbought, but 4H CCI and STOCH show sustained momentum. 30M volume confirms aggressive bidding as traders digest the narrowed Q4 fiscal loss. @DailyAnalysis
0 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Feb. 21 at 5:50 PM
$SYRE RSI: 80.94, MACD: 1.7168 Vol: 2.66, MA20: 34.45, MA50: 33.41 ⚪ HOLD - Sideways 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
UgoGreg
UgoGreg Feb. 20 at 9:38 PM
$SYRE https://youtu.be/nCPt9XhiRxk
0 · Reply
erevnon
erevnon Feb. 20 at 6:41 PM
Wells Fargo maintains Spyre Therapeutics $SYRE at Overweight and raises the price target from $40 to https://marketsblock.com/stock-upgrades-and-downgrades/
0 · Reply
inspector_gadget86
inspector_gadget86 Feb. 20 at 2:55 PM
$SYRE Reported $756.5 million in cash/marketable securities as of Dec 31, 2025, providing a runway into H2 2028
0 · Reply
Pika_Capital
Pika_Capital Feb. 20 at 2:51 PM
$SYRE beautiful action. One of the core positions
0 · Reply
StockConsultant
StockConsultant Feb. 19 at 2:13 PM
$SYRE Spyre Therapeutics stock, watch for a continuation breakout, target 41+ area at https://stockconsultant.com/?SYRE
0 · Reply
PatriciaWong158
PatriciaWong158 Feb. 18 at 1:32 PM
$SYRE Biotech microcap with funding uncertainty.
0 · Reply
Latest News on SYRE
Spyre Therapeutics Announces Grants of Inducement Awards

Feb 6, 2026, 4:01 PM EST - 16 days ago

Spyre Therapeutics Announces Grants of Inducement Awards


Spyre Therapeutics: Validated Targets, Optimized Delivery

Jan 1, 2026, 4:36 AM EST - 7 weeks ago

Spyre Therapeutics: Validated Targets, Optimized Delivery


Intelligent Development Could Make Spyre Therapeutics Best In Show

Sep 18, 2025, 10:34 PM EDT - 5 months ago

Intelligent Development Could Make Spyre Therapeutics Best In Show


Spyre Therapeutics: Targeting The Future Of IBD Treatment

Mar 4, 2025, 4:51 AM EST - 1 year ago

Spyre Therapeutics: Targeting The Future Of IBD Treatment


Spyre Therapeutics Added to the Nasdaq Biotechnology Index

Dec 18, 2024, 8:00 AM EST - 1 year ago

Spyre Therapeutics Added to the Nasdaq Biotechnology Index


edvquye
edvquye Feb. 22 at 11:38 PM
0 · Reply
DailyAnalysis
DailyAnalysis Feb. 22 at 4:56 PM
Clinical breakthroughs sent $SYRE into a 1D parabolic move with RSI tagging 81. The 1W trend is dominant, but 4H and 30M CCI indicate extreme extension, making a STOCH cooling period likely. @DailyAnalysis
0 · Reply
DailyAnalysis
DailyAnalysis Feb. 21 at 8:26 PM
$SYRE 1W accumulation accelerates after positive trial data. 1D RSI is overbought, but 4H CCI and STOCH show sustained momentum. 30M volume confirms aggressive bidding as traders digest the narrowed Q4 fiscal loss. @DailyAnalysis
0 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Feb. 21 at 5:50 PM
$SYRE RSI: 80.94, MACD: 1.7168 Vol: 2.66, MA20: 34.45, MA50: 33.41 ⚪ HOLD - Sideways 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
UgoGreg
UgoGreg Feb. 20 at 9:38 PM
$SYRE https://youtu.be/nCPt9XhiRxk
0 · Reply
erevnon
erevnon Feb. 20 at 6:41 PM
Wells Fargo maintains Spyre Therapeutics $SYRE at Overweight and raises the price target from $40 to https://marketsblock.com/stock-upgrades-and-downgrades/
0 · Reply
inspector_gadget86
inspector_gadget86 Feb. 20 at 2:55 PM
$SYRE Reported $756.5 million in cash/marketable securities as of Dec 31, 2025, providing a runway into H2 2028
0 · Reply
Pika_Capital
Pika_Capital Feb. 20 at 2:51 PM
$SYRE beautiful action. One of the core positions
0 · Reply
StockConsultant
StockConsultant Feb. 19 at 2:13 PM
$SYRE Spyre Therapeutics stock, watch for a continuation breakout, target 41+ area at https://stockconsultant.com/?SYRE
0 · Reply
PatriciaWong158
PatriciaWong158 Feb. 18 at 1:32 PM
$SYRE Biotech microcap with funding uncertainty.
0 · Reply
ortega1963
ortega1963 Feb. 13 at 2:37 PM
$SYRE Breaking out
0 · Reply
ortega1963
ortega1963 Feb. 13 at 2:32 PM
$SYRE long
0 · Reply
StockConsultant
StockConsultant Feb. 13 at 1:22 PM
$SYRE Spyre Therapeutics stock, watch for a top of range breakout at https://stockconsultant.com/?SYRE
1 · Reply
OphirMedia
OphirMedia Feb. 13 at 2:15 AM
Checking the pulse on these names for the Friday close: $IRWD $SYRE $WOLF $APH $TTE. ​We’ve got a mix of high-growth biotech momentum, AI infrastructure, and a massive turnaround play. ​1️⃣ Is $IRWD really the best 'Fallen Angel' play right now? 2️⃣ Can $SYRE sustain this biotech run? 3️⃣ $WOLF vs. $APH – which one dominates the tech rotation?
0 · Reply
ortega1963
ortega1963 Feb. 10 at 2:08 PM
$SYRE Triangle
0 · Reply
SyndicateSigma
SyndicateSigma Feb. 4 at 9:45 AM
$SYRE biotech, synthetic biology platform
0 · Reply
BillionerOfKing
BillionerOfKing Jan. 27 at 4:55 PM
$SYRE Current Stock Price: $32.73 Contracts to trade: $35 SYRE Feb 20 2026 Call Entry: $1.80 Exit: $3.13 ROI: 74% Hold ~25 days Shared as daily free alerts and for educational purposes only. https://dailypickai.com/freealerts
0 · Reply
FennickTradings
FennickTradings Jan. 13 at 7:46 PM
$SYRE when new dividend for cvr holders?
0 · Reply
edvquye
edvquye Jan. 13 at 5:59 AM
$SYRE looks good
0 · Reply
biolover
biolover Jan. 7 at 1:24 AM
$VKTX Looks like $LLY is looking for IBD combination. If their interest in $ABVX is real , it will not serve them alone. 13-19% clinical remission will not compete with the upcoming long interval combinations ( $SYRE ) I was expecting them to look for Jak inh but $VTYX is an alternative. If LLy completes acquisition of two IBD biotechs expec JNJ and ABBV to move big on GLP1. I don’t see an outstanding JNJ management or board , but it is not a brainer at this point.
1 · Reply
CompressionCaptain
CompressionCaptain Dec. 26 at 2:08 PM
$SYRE Market structure is quietly punishing unfocused strategies. Governance alignment should reduce uncertainty over time. Demonstrated durability would lengthen investor time horizons. Durable value creation requires execution to catch up with vision.
1 · Reply
biolover
biolover Dec. 22 at 5:04 PM
$VKTX not static. No complacency. That what matters. Good delivery on trials and moving with amylin po and sc soon. 2809 is irrelevant long term. Although they will likely advance it in 2026. VK Will have a portfolio that stands up to $LLY by 2027-2028 time. Not all institutions see medical facts as they are before phase 3 data . Poeple who followed obesity recall institutions were loaded with $NVO to $650 B MC when early data were clearly inferior to Lilly and we were posting daily on that. It is a patience game. Like Pfizer and others that proved lack of understanding of obesity data and trends , I am concerned about $LLY lack of understanding of IBD trajectory . It is moving towards combination of Sc drugs given q 3-6 months like from $SYRE and not po vs sc. ABBV and JNJ who have the most skin in game know that and this is why not very keen on ABVX
0 · Reply