Market Cap 4.02B
Revenue (ttm) 0.00
Net Income (ttm) -155.20M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 496,568
Avg Vol 778,252
Day's Range N/A - N/A
Shares Out 78.54M
Stochastic %K 73%
Beta 2.93
Analysts Strong Sell
Price Target $60.78

Company Profile

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 – anti-TL1A mAbs designed to bind to tumor necros...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 651 5940
Address:
Building 23, Suite 105 221 Crescent Street, Waltham, United States
NasdaqPulse
NasdaqPulse Apr. 9 at 12:52 PM
Heads Up Traders 👉Click to view @NasdaqPulse for timely updates amid the volatility. $ORKA & $SYRE are coming for $ABBV’s Skyrizi in Psoriasis & IBD respectively. Crazy market shifts as bio funds reallocate—up BIG last year, but both still YEARS away from phase 3. On the flip side, $VKTX is going head-to-head with $LLY’s Tirzepatide in obesity, already deep into phase 3. But here's the kicker: Most competing obesity drugs are falling short, and there’s a massive misunderstanding about how effective these treatments really are. Could be a major misstep from $VKTX CEO, possibly talking their stock down. In a market full of hype, watch the fundamentals and stay ahead of the curve. The next big move is coming.
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lozzamozza
lozzamozza Apr. 2 at 5:04 PM
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NeverFadeTheOracle
NeverFadeTheOracle Apr. 2 at 4:47 PM
$SYRE Adding with a close above 46.80 IBD play and not talking about Investors Business Daily $XBI
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NeverFadeTheOracle
NeverFadeTheOracle Mar. 31 at 11:40 PM
$SYRE Another biotech looking to add On weakness
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DwigtMcDichael
DwigtMcDichael Mar. 31 at 4:44 PM
$SYRE 500m J&J $$. This was unexpected but very welcomed!
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ajb_2010
ajb_2010 Mar. 31 at 4:44 PM
$SPY nice cluster of biotech names hitting 52 highs today $XBI remains range bound $SYRE at 52 highs
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MorganHoratio
MorganHoratio Mar. 31 at 1:10 PM
$SYRE Big biotech read-through most are sleeping on: BTIG just reiterated Buy / $70 PT after $RPRX + $JNJ teamed up on JNJ-4804 (dual IL-23 + TNF approach). That’s not just noise — it validates the combo therapy thesis in IBD, exactly where $SYRE is positioning. Why it matters: Big Pharma doubling down on multi-pathway biology Direct sympathy to $SYRE’s SPY120/130/230 combo platform DUET data from $JNJ later this year = potential sentiment catalyst Pipeline timeline: 2Q26: SPY001 (anti-CD47) PoC readout 2026: SPY002 (TL1A) + SPY003 (IL-23) data follow 2027: Full Phase 2 combo data (SKYLINE) Underrated angle: TL1A is part of the TNF superfamily — historically validated pathways = higher probability setups. If TNF worked, TL1A could be next. More shots on goal: 3Q26: SPY072 (RA) 4Q26: axSpA + PsA data Translation: This isn’t a single binary biotech — it’s a platform bet with multiple catalysts lined up. Market hasn’t fully priced this in yet. Stay alert.
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Quantumup
Quantumup Mar. 31 at 11:41 AM
BTIG reiterated $SYRE Buy-$70 after $RPRX announced a co-funding agreement w/ $JNJ for the devt of JNJ-4804 (co-antibody of remfya+golimumab [IL-23+TNF]). Here's what BTIG had to say in its note: https://x.com/Quantumup1/status/2038944109151261006?s=20
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ortega1963
ortega1963 Mar. 24 at 12:13 PM
$SYRE watching this stock
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DwigtMcDichael
DwigtMcDichael Mar. 16 at 4:53 PM
$SYRE I like when my bios have news. This one is loaded all year
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Latest News on SYRE
Spyre Therapeutics Announces Grants of Inducement Awards

Apr 3, 2026, 4:01 PM EDT - 7 days ago

Spyre Therapeutics Announces Grants of Inducement Awards


Spyre Therapeutics Added to the Nasdaq Biotechnology Index

Dec 18, 2024, 8:00 AM EST - 1 year ago

Spyre Therapeutics Added to the Nasdaq Biotechnology Index


NasdaqPulse
NasdaqPulse Apr. 9 at 12:52 PM
Heads Up Traders 👉Click to view @NasdaqPulse for timely updates amid the volatility. $ORKA & $SYRE are coming for $ABBV’s Skyrizi in Psoriasis & IBD respectively. Crazy market shifts as bio funds reallocate—up BIG last year, but both still YEARS away from phase 3. On the flip side, $VKTX is going head-to-head with $LLY’s Tirzepatide in obesity, already deep into phase 3. But here's the kicker: Most competing obesity drugs are falling short, and there’s a massive misunderstanding about how effective these treatments really are. Could be a major misstep from $VKTX CEO, possibly talking their stock down. In a market full of hype, watch the fundamentals and stay ahead of the curve. The next big move is coming.
0 · Reply
lozzamozza
lozzamozza Apr. 2 at 5:04 PM
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 2 at 4:47 PM
$SYRE Adding with a close above 46.80 IBD play and not talking about Investors Business Daily $XBI
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Mar. 31 at 11:40 PM
$SYRE Another biotech looking to add On weakness
0 · Reply
DwigtMcDichael
DwigtMcDichael Mar. 31 at 4:44 PM
$SYRE 500m J&J $$. This was unexpected but very welcomed!
0 · Reply
ajb_2010
ajb_2010 Mar. 31 at 4:44 PM
$SPY nice cluster of biotech names hitting 52 highs today $XBI remains range bound $SYRE at 52 highs
0 · Reply
MorganHoratio
MorganHoratio Mar. 31 at 1:10 PM
$SYRE Big biotech read-through most are sleeping on: BTIG just reiterated Buy / $70 PT after $RPRX + $JNJ teamed up on JNJ-4804 (dual IL-23 + TNF approach). That’s not just noise — it validates the combo therapy thesis in IBD, exactly where $SYRE is positioning. Why it matters: Big Pharma doubling down on multi-pathway biology Direct sympathy to $SYRE’s SPY120/130/230 combo platform DUET data from $JNJ later this year = potential sentiment catalyst Pipeline timeline: 2Q26: SPY001 (anti-CD47) PoC readout 2026: SPY002 (TL1A) + SPY003 (IL-23) data follow 2027: Full Phase 2 combo data (SKYLINE) Underrated angle: TL1A is part of the TNF superfamily — historically validated pathways = higher probability setups. If TNF worked, TL1A could be next. More shots on goal: 3Q26: SPY072 (RA) 4Q26: axSpA + PsA data Translation: This isn’t a single binary biotech — it’s a platform bet with multiple catalysts lined up. Market hasn’t fully priced this in yet. Stay alert.
0 · Reply
Quantumup
Quantumup Mar. 31 at 11:41 AM
BTIG reiterated $SYRE Buy-$70 after $RPRX announced a co-funding agreement w/ $JNJ for the devt of JNJ-4804 (co-antibody of remfya+golimumab [IL-23+TNF]). Here's what BTIG had to say in its note: https://x.com/Quantumup1/status/2038944109151261006?s=20
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ortega1963
ortega1963 Mar. 24 at 12:13 PM
$SYRE watching this stock
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DwigtMcDichael
DwigtMcDichael Mar. 16 at 4:53 PM
$SYRE I like when my bios have news. This one is loaded all year
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SmartMoneyTradez
SmartMoneyTradez Mar. 15 at 8:00 PM
$SYRE https://www.marketbeat.com/stocks/NASDAQ/SYRE/institutional-ownership/
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BillionerOfKing
BillionerOfKing Mar. 10 at 3:11 PM
$SYRE Current Stock Price: $41.97 Contracts to trade: $40.0 SYRE Mar 20 2026 Call Entry: $1.10 Exit: $1.94 ROI: 77% Hold ~22 days Shared as daily free alerts and for educational purposes only. https://dailypickai.com/freealerts
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BioTechHealthX
BioTechHealthX Mar. 1 at 3:17 PM
$SYRE Spyre Therapeutics (NASDAQ: SYRE) has surged nearly 63% over the past year, crushing the S&P 500. With a $757 million cash runway, six Phase 2 readouts ahead, and growing institutional backing, investors are watching closely to see if this inflammatory bowel disease biotech is just getting started. https://biotechhealthx.com/biotech-news/should-you-now-start-buying-spyre-therapeutics-syre-shares/
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StocktwitsEarnings
StocktwitsEarnings Feb. 27 at 7:00 PM
$SYRE Q4 '25 Earnings Results & Recap Spyre Therapeutics reported a net loss of $155.2M for the year ended December 31, 2025, with R&D expenses increasing 5% to $171.7M and G&A expenses rising 5% to $47.9M.
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DailyAnalysis
DailyAnalysis Feb. 24 at 6:29 PM
Clinical breakthroughs sent $SYRE into a 1D parabolic move with RSI tagging 81. The 1W trend is dominant, but 4H and 30M CCI indicate extreme extension, making a STOCH cooling period likely. @DailyAnalysis
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DailyAnalysis
DailyAnalysis Feb. 23 at 3:37 PM
Clinical breakthroughs sent $SYRE into a 1D parabolic move with RSI tagging 81. The 1W trend is dominant, but 4H and 30M CCI indicate extreme extension, making a STOCH cooling period likely. @DailyAnalysis
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edvquye
edvquye Feb. 22 at 11:38 PM
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DailyAnalysis
DailyAnalysis Feb. 22 at 4:56 PM
Clinical breakthroughs sent $SYRE into a 1D parabolic move with RSI tagging 81. The 1W trend is dominant, but 4H and 30M CCI indicate extreme extension, making a STOCH cooling period likely. @DailyAnalysis
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DailyAnalysis
DailyAnalysis Feb. 21 at 8:26 PM
$SYRE 1W accumulation accelerates after positive trial data. 1D RSI is overbought, but 4H CCI and STOCH show sustained momentum. 30M volume confirms aggressive bidding as traders digest the narrowed Q4 fiscal loss. @DailyAnalysis
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OfficialStocktwitsUser
OfficialStocktwitsUser Feb. 21 at 5:50 PM
$SYRE RSI: 80.94, MACD: 1.7168 Vol: 2.66, MA20: 34.45, MA50: 33.41 ⚪ HOLD - Sideways 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
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erevnon
erevnon Feb. 20 at 6:41 PM
Wells Fargo maintains Spyre Therapeutics $SYRE at Overweight and raises the price target from $40 to https://marketsblock.com/stock-upgrades-and-downgrades/
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inspector_gadget86
inspector_gadget86 Feb. 20 at 2:55 PM
$SYRE Reported $756.5 million in cash/marketable securities as of Dec 31, 2025, providing a runway into H2 2028
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