Market Cap 5.87B
Revenue (ttm) 0.00
Net Income (ttm) -155.20M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 1,463,500
Avg Vol 1,107,188
Day's Range N/A - N/A
Shares Out 78.78M
Stochastic %K 23%
Beta 2.93
Analysts Strong Sell
Price Target $90.13

Company Profile

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 – anti-TL1A mAbs designed to bind to tumor necros...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 651 5940
Address:
Building 23, Suite 105 221 Crescent Street, Waltham, United States
Merlintrader
Merlintrader Apr. 30 at 11:10 PM
$SYRE Spyre Therapeutics 2026 (Nasdaq: $SYRE): When Great Clinical Data Matter More Than Promises https://www.merlintrader.com/spyre-therapeutics-may2026-deepdive/
0 · Reply
draketdot
draketdot Apr. 30 at 10:19 PM
$SYRE 33% increase incoming?
0 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Apr. 30 at 7:49 PM
$SYRE RSI: 77.96, MACD: 6.7487 Vol: 9.71, MA20: 64.26, MA50: 51.55 ⚪ HOLD - Sideways 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
FennickTradings
FennickTradings Apr. 30 at 1:19 PM
$SYRE enough cash for cvr dividend payout😅
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RunnerSignals
RunnerSignals Apr. 29 at 8:10 PM
market warriors $TENB $HUM $CHGG $BIIB $SYRE reversed from red to strong green closes with 6–12% intraday swings and volume 1.2x–1.6x avg
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NeverFadeTheOracle
NeverFadeTheOracle Apr. 29 at 2:39 PM
1 · Reply
grandefappuccino
grandefappuccino Apr. 28 at 8:49 PM
$SYRE ready to run 5/5
0 · Reply
Avocado_smash
Avocado_smash Apr. 28 at 2:43 AM
$SYRE Structure and Trend strength up>
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 24 at 2:18 PM
$SYRE 68.8 is your friend.
2 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 23 at 6:50 PM
$SYRE Trim under 70
1 · Reply
Latest News on SYRE
Spyre Therapeutics Announces Grants of Inducement Awards

May 1, 2026, 4:28 PM EDT - 10 hours ago

Spyre Therapeutics Announces Grants of Inducement Awards


Spyre Therapeutics Transcript: Study result

Apr 13, 2026, 8:00 AM EDT - 18 days ago

Spyre Therapeutics Transcript: Study result


Spyre Therapeutics Announces Grants of Inducement Awards

Apr 3, 2026, 4:01 PM EDT - 4 weeks ago

Spyre Therapeutics Announces Grants of Inducement Awards


Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference

Nov 11, 2025, 8:40 AM EST - 6 months ago

Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference


Spyre Therapeutics Transcript: Status Update

Jun 17, 2025, 8:00 AM EDT - 11 months ago

Spyre Therapeutics Transcript: Status Update


Spyre Therapeutics Added to the Nasdaq Biotechnology Index

Dec 18, 2024, 8:00 AM EST - 1 year ago

Spyre Therapeutics Added to the Nasdaq Biotechnology Index


Spyre Therapeutics Transcript: Study Result

Nov 12, 2024, 8:00 AM EST - 1 year ago

Spyre Therapeutics Transcript: Study Result


Spyre Therapeutics Transcript: M&A Announcement

Jun 22, 2023, 9:00 AM EDT - 3 years ago

Spyre Therapeutics Transcript: M&A Announcement


Merlintrader
Merlintrader Apr. 30 at 11:10 PM
$SYRE Spyre Therapeutics 2026 (Nasdaq: $SYRE): When Great Clinical Data Matter More Than Promises https://www.merlintrader.com/spyre-therapeutics-may2026-deepdive/
0 · Reply
draketdot
draketdot Apr. 30 at 10:19 PM
$SYRE 33% increase incoming?
0 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Apr. 30 at 7:49 PM
$SYRE RSI: 77.96, MACD: 6.7487 Vol: 9.71, MA20: 64.26, MA50: 51.55 ⚪ HOLD - Sideways 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
FennickTradings
FennickTradings Apr. 30 at 1:19 PM
$SYRE enough cash for cvr dividend payout😅
0 · Reply
RunnerSignals
RunnerSignals Apr. 29 at 8:10 PM
market warriors $TENB $HUM $CHGG $BIIB $SYRE reversed from red to strong green closes with 6–12% intraday swings and volume 1.2x–1.6x avg
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 29 at 2:39 PM
1 · Reply
grandefappuccino
grandefappuccino Apr. 28 at 8:49 PM
$SYRE ready to run 5/5
0 · Reply
Avocado_smash
Avocado_smash Apr. 28 at 2:43 AM
$SYRE Structure and Trend strength up>
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 24 at 2:18 PM
$SYRE 68.8 is your friend.
2 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 23 at 6:50 PM
$SYRE Trim under 70
1 · Reply
BottomFisher_
BottomFisher_ Apr. 20 at 2:01 PM
$LLY continues to aggressively expand its oncology footprint — multiple myeloma alone represents a ~$40B+ global market opportunity, and the company is clearly signaling intent to compete at the highest level of treatment innovation. The strategic angle here is platform expansion: if their in vivo / next-gen biologics approach continues to progress, it doesn’t just stay in late-line settings — it potentially moves into earlier treatment lines, which is where the real revenue scale sits. This is no longer a single-market story. Lilly is positioning across multiple large therapeutic areas, with oncology first, and potential spillover into IBD next ($SYRE watchlist relevance). For context, $JNJ and $ABBV remain dominant incumbents in oncology and immunology respectively, but the competitive pressure is increasing as Lilly scales pipeline ambition across multiple $100B+ markets (obesity, oncology, immunology).
1 · Reply
BottomFisher_
BottomFisher_ Apr. 19 at 4:03 PM
$SYRE — This is one of the cleanest multi-year catalyst setups in biotech right now, and the market is NOT fully pricing it in yet. Pipeline is stacked with shots on goal: 2026 kicks off with external validation — JnJ’s DUET data (UC/CD) on guselkumab + golimumab could reset sentiment across the entire class. Mid-2026 we get SPY002 (SKYLINE UC) open-label readout — early efficacy signals = momentum trigger. SPY072 is the real sleeper here: • Q3’26 → RA topline • Q4’26 → PsA + axSpA data drops That’s THREE major readouts in back half of 2026 alone. And don’t forget — 2027 brings full placebo-controlled induction data in UC, which is where real valuation re-rating happens. This isn’t a one-event trade. It’s a rolling catalyst machine. Biotech traders know: staggered data = sustained volatility + multiple entry points. Eyes on positioning BEFORE the crowd catches on.
1 · Reply
Avocado_smash
Avocado_smash Apr. 15 at 1:11 PM
$SYRE Strong Offering! 🚀🚀🚀🚀🚀🚀🚀🚀🚀
0 · Reply
Pika_Capital
Pika_Capital Apr. 15 at 1:10 PM
$SYRE $400M raised at $62. Power move. They got tons of cash now
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DonCorleone77
DonCorleone77 Apr. 15 at 10:30 AM
$SYRE Spyre Therapeutics 6.5M share Secondary priced at $62.00 The deal size was increased to $403M in common stock from $300M in common stock. Jefferies, Goldman Sachs, Evercore ISI and Guggenheim acted as joint book running managers for the offering.
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AlertsAndNews
AlertsAndNews Apr. 15 at 2:46 AM
$SYRE offering here Spyre Therapeutics Announces Pricing of Upsized $403.0 Million Public Offering of Common Stock "today announced the pricing of its previously announced underwritten public offering of 6,500,000 shares of its common stock at a price to the public of $62.00 per share. The gross proceeds to the Company from this offering are expected to be approximately $403.0 million"
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Stocks_and_Stacks
Stocks_and_Stacks Apr. 14 at 4:14 AM
🚀 Bulls charging hard on April 13 amid renewed US-Iran peace talk hopes! 🐂📈 First off 😎 who’s all up late studying charts and getting ready for tomorrow? Our group just received two new banger alerts that have serious 100-200% run potential. Eyes sharp, bulls! Huge congrats to everyone riding these top 5 movers today – resilience and catalysts delivered big green! $RVMD +41% – Revolution Medicines soaring on positive new clinical trial results in oncology. $XNDU +28% – Xanadu Quantum Technologies lifting on quantum computing buzz and sector momentum. $CAR +24% – Avis Budget Group jumping amid strong rental demand and sector rotation. $SYRE +23% – Spyre Therapeutics climbing on biotech pipeline momentum. $RCT +90%+ (earlier surge) – RedCloud Holdings exploding on a major $30M Saudi licensing deal for its RAID engine. Epic day stacking wins despite the headlines, bulls… 💪 Who else is celebrating big gains? Drop your winners below. #TopMovers #BullMarket #Stocks #BangerAlerts
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deweyeggbert
deweyeggbert Apr. 14 at 1:47 AM
$SYRE big dilution dip coming. Institutions will use that dip to acquire shares on the cheap. I'm in with puts and maybe go long when the dust settles.
1 · Reply
mikesterz7
mikesterz7 Apr. 14 at 1:18 AM
$SYRE Spyre is looking forward to developing the drug as a single treatment, as well as in combination with its investigational antibodies SPY002 or SPY003.
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MiamiDreamin
MiamiDreamin Apr. 14 at 1:14 AM
$SYRE 300m offer?
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topstockalerts
topstockalerts Apr. 14 at 1:12 AM
Spyre Therapeutics announced a $300 million underwritten public offering of its common stock, with all shares being sold by the company. Underwriters will also have a 30-day option to purchase up to an additional $45 million in shares at the offering price, less underwriting discounts. The biotech firm said the offering is subject to market conditions and other customary closing terms. Jefferies, Goldman Sachs, Evercore ISI, and Guggenheim Securities are serving as joint book-running managers, with LifeSci Capital acting as passive bookrunner. The announcement followed a 23.26% surge in Spyre’s shares during regular trading after the company reported positive induction results from its SKYLINE trial of SPY001 in patients with moderate to severe ulcerative colitis. Spyre is focused on developing antibody-based therapies for inflammatory bowel disease and other immune-mediated conditions. $SYRE
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