Market Cap 7.78B
Revenue (ttm) 0.00
Net Income (ttm) -155.20M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 1,054,100
Avg Vol 1,261,070
Day's Range N/A - N/A
Shares Out 87.94M
Stochastic %K 12%
Beta 2.99
Analysts Strong Sell
Price Target $120.67

Company Profile

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 – anti-TL1A mAbs designed to bind to tumor necros...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 651 5940
Address:
Building 23, Suite 105 221 Crescent Street, Waltham, United States
Merlintrader
Merlintrader Sep. 3 at 5:19 PM
Spyre Therapeutics ($SYRE) Stock Hub 2026: Two Positive Phase 2 Readouts Down, Can SPY003 Make It Three In September? https://www.merlintrader.com/spyre-therapeutics-syre-stock-hub/
0 · Reply
Quantumup
Quantumup Aug. 28 at 5:08 PM
Guggenheim (a/o 8/26) reit'd Top Pick $SYRE at Buy-$130 after Spyre announced topline results for the Ph II SKYWAY-RA program where the magnitude of effect didn't meet SYRE's internal bar to justify prioritizing the SPY072 monoTx. PTGX - $JNJ $ABVX ABBV MRK TVRD Here's what Guggenheim said in its note: https://x.com/Quantumup1/status/2093385178164908159?s=20
0 · Reply
Biotech_Beast
Biotech_Beast Aug. 27 at 4:12 PM
$SYRE In September, SYRE will report 12 week data from ulcerative colitis patients treated with SPY003, an anti IL-23. $ABBV's Skyrizi already has pretty convenient dosing, so it might be hard to differentiate the agent much there. Then there is data in Q4'26 from SPY072 in PsA and axSpA. https://seekingalpha.com/article/4940789-spyre-therapeutics-catalyst-rich-period-but-easiest-money-may-have-been-made
0 · Reply
eienek
eienek Aug. 26 at 7:19 PM
$SYRE I’m actually surprised SYRE is still holding around $93. It’s a ~$8B clinical-stage biotech with no approved drugs or commercial revenue, its valuation already assumes substantial success from the pipeline, and the latest RA results weren’t strong enough for the company to advance SPY072 as monotherapy. After such a massive run-up, I expected a much sharper correction.
1 · Reply
StockMarketToday247
StockMarketToday247 Aug. 26 at 6:57 PM
$BHVN $SYRE $GOVX — three biotech situations, one capital-markets lesson: balance-sheet strength changes what management can afford to do. $BHVN is licensing Kv7 to SK for $400M of near-term cash, plus milestones/royalties, while shifting future costs and certain obligations off its balance sheet. $SYRE had statistically significant RA findings but decided the magnitude was not good enough to prioritize the program. It had ~$1.145B of cash/investments at June 30. That is what optionality looks like: it can afford to stop funding “good enough.” $GOVX had ~$3.14M of June cash and runway only into September. It gets ~$3.65M from exercising 5.7M warrants at $0.64, but issues ~11.4M new 5-year warrants in return. The signal I’m watching isn’t simply dilution. It’s negotiating leverage. Cash lets you wait. Assets give you financing options. Weak balance sheets make liquidity expensive. That’s where I’ve got my eyes today. https://insidersonly.beehiiv.com/p/the-best-biotech-asset-may-be-the-ability-to-say-no
0 · Reply
runitback349
runitback349 Aug. 26 at 5:41 PM
$SYRE piggy going much lower
0 · Reply
Merlintrader
Merlintrader Aug. 26 at 1:22 PM
$SYRE Spyre Therapeutics Stock Hub 2026: SPY072 hit its primary endpoint in rheumatoid arthritis on August 25 and Spyre still declined to advance it as a monotherapy. The only placebo-controlled dataset it has published. Every IBD number is open-label. Free Biotech Catalyst Calendar on Merlintrader. https://www.merlintrader.com/spyre-therapeutics-syre-stock-hub/?utm_source=stocktwits&utm_medium=social&utm_campaign=spyre-therapeutics-syre-stock-hub
0 · Reply
briefingcom
briefingcom Aug. 26 at 12:05 PM
$SYRE: Spyre (-11.3%) announces topline results from rheumatoid arthritis sub-study; magnitude of effect did not meet target.
0 · Reply
anachartanalyst
anachartanalyst Aug. 26 at 10:01 AM
$SYRE https://anachart.com/wp-content/uploads/2026/08/1787738470_soc-img.jpg
0 · Reply
Cache_Money
Cache_Money Aug. 26 at 12:51 AM
$SYRE Oh too bad, SKYWAY RA data wasn’t strong enough to continue on to a phase 3. Strange that there wasn’t a clear dose-response for most of the readouts but it’s not terribly surprising that TL1A in RA didn’t quite reach the efficacy seen with TNFs. SKYLINE and SKYLIGHT combo readouts are going to be the key game-changers so just sitting tight here.
1 · Reply
Latest News on SYRE
Spyre Therapeutics falls -13.2%

2026-08-26T16:05:24.000Z - 8 days ago

Spyre Therapeutics falls -13.2%


Spyre Therapeutics falls -11.6%

2026-08-26T14:05:27.000Z - 8 days ago

Spyre Therapeutics falls -11.6%


Spyre Therapeutics Announces Grants of Inducement Awards

Aug 7, 2026, 4:05 PM EDT - 27 days ago

Spyre Therapeutics Announces Grants of Inducement Awards


Spyre Therapeutics reports Q2 EPS (36c), consensus (75c)

2026-08-04T20:21:51.000Z - 4 weeks ago

Spyre Therapeutics reports Q2 EPS (36c), consensus (75c)


Spyre Therapeutics Quarterly report: Q2 2026

Aug 4, 2026, 7:00 AM EDT - 4 weeks ago

Spyre Therapeutics Quarterly report: Q2 2026


Spyre Therapeutics Earnings release: Q2 2026

Aug 4, 2026, 7:00 AM EDT - 4 weeks ago

Spyre Therapeutics Earnings release: Q2 2026


Spyre Therapeutics files automatic mixed securities shelf

2026-06-26T20:10:16.000Z - 2 months ago

Spyre Therapeutics files automatic mixed securities shelf


Spyre Therapeutics Slides: Corporate presentation

Jun 2, 2026, 7:00 AM EDT - 3 months ago

Spyre Therapeutics Slides: Corporate presentation


Spyre Therapeutics Transcript: AGM 2026

May 27, 2026, 12:00 PM EDT - 3 months ago

Spyre Therapeutics Transcript: AGM 2026


Spyre Therapeutics Quarterly report: Q1 2026

May 5, 2026, 7:00 AM EDT - 4 months ago

Spyre Therapeutics Quarterly report: Q1 2026


Spyre Therapeutics Earnings release: Q1 2026

May 5, 2026, 7:00 AM EDT - 4 months ago

Spyre Therapeutics Earnings release: Q1 2026


Spyre Therapeutics Transcript: Study result

Apr 13, 2026, 8:00 AM EDT - 4 months ago

Spyre Therapeutics Transcript: Study result


Spyre Therapeutics Press release: Study result

Apr 13, 2026, 8:00 AM EDT - 4 months ago

Spyre Therapeutics Press release: Study result


Spyre Therapeutics Slides: Study result

Apr 13, 2026, 8:00 AM EDT - 4 months ago

Spyre Therapeutics Slides: Study result


Spyre Therapeutics Proxy statement: Proxy filing

Apr 10, 2026, 8:00 AM EDT - 4 months ago

Spyre Therapeutics Proxy statement: Proxy filing


Spyre Therapeutics Proxy statement: Proxy filing

Apr 10, 2026, 8:00 AM EDT - 4 months ago

Spyre Therapeutics Proxy statement: Proxy filing


Spyre Therapeutics Earnings release: Q4 2025

Feb 19, 2026, 7:00 AM EST - 6 months ago

Spyre Therapeutics Earnings release: Q4 2025


Spyre Therapeutics Annual report: Q4 2025

Feb 19, 2026, 7:00 AM EST - 6 months ago

Spyre Therapeutics Annual report: Q4 2025


Spyre Therapeutics Registration statement: Registration Filing

Feb 19, 2026, 7:00 AM EST - 6 months ago

Spyre Therapeutics Registration statement: Registration Filing


Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference

Nov 11, 2025, 8:40 AM EST - 9 months ago

Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference


Spyre Therapeutics Slides: Corporate Presentation

Nov 9, 2025, 6:00 PM EST - 9 months ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Earnings release: Q3 2025

Nov 4, 2025, 7:00 AM EST - 10 months ago

Spyre Therapeutics Earnings release: Q3 2025


Spyre Therapeutics Quarterly report: Q3 2025

Nov 4, 2025, 7:00 AM EST - 10 months ago

Spyre Therapeutics Quarterly report: Q3 2025


Spyre Therapeutics Earnings release: Q2 2025

Aug 5, 2025, 7:00 AM EDT - 1 year ago

Spyre Therapeutics Earnings release: Q2 2025


Spyre Therapeutics Quarterly report: Q2 2025

Aug 5, 2025, 7:00 AM EDT - 1 year ago

Spyre Therapeutics Quarterly report: Q2 2025


Spyre Therapeutics Transcript: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Transcript: Status Update


Spyre Therapeutics Press release: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Press release: Status Update


Spyre Therapeutics Slides: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Slides: Status Update


Spyre Therapeutics Slides: Corporate Presentation

Jun 17, 2025, 7:00 AM EDT - 1 year ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Earnings release: Q1 2025

May 8, 2025, 4:00 PM EDT - 1 year ago

Spyre Therapeutics Earnings release: Q1 2025


Spyre Therapeutics Quarterly report: Q1 2025

May 8, 2025, 4:00 PM EDT - 1 year ago

Spyre Therapeutics Quarterly report: Q1 2025


Spyre Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Proxy statement: Proxy Filing


Spyre Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Proxy statement: Proxy Filing


Spyre Therapeutics Earnings release: Q4 2024

Feb 27, 2025, 9:30 AM EST - 1 year ago

Spyre Therapeutics Earnings release: Q4 2024


Spyre Therapeutics Annual report: Q4 2024

Feb 27, 2025, 9:30 AM EST - 1 year ago

Spyre Therapeutics Annual report: Q4 2024


Spyre Therapeutics Slides: Corporate Presentation

Jan 13, 2025, 7:00 AM EST - 1 year ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Added to the Nasdaq Biotechnology Index

Dec 18, 2024, 8:00 AM EST - 1 year ago

Spyre Therapeutics Added to the Nasdaq Biotechnology Index


Merlintrader
Merlintrader Sep. 3 at 5:19 PM
Spyre Therapeutics ($SYRE) Stock Hub 2026: Two Positive Phase 2 Readouts Down, Can SPY003 Make It Three In September? https://www.merlintrader.com/spyre-therapeutics-syre-stock-hub/
0 · Reply
Quantumup
Quantumup Aug. 28 at 5:08 PM
Guggenheim (a/o 8/26) reit'd Top Pick $SYRE at Buy-$130 after Spyre announced topline results for the Ph II SKYWAY-RA program where the magnitude of effect didn't meet SYRE's internal bar to justify prioritizing the SPY072 monoTx. PTGX - $JNJ $ABVX ABBV MRK TVRD Here's what Guggenheim said in its note: https://x.com/Quantumup1/status/2093385178164908159?s=20
0 · Reply
Biotech_Beast
Biotech_Beast Aug. 27 at 4:12 PM
$SYRE In September, SYRE will report 12 week data from ulcerative colitis patients treated with SPY003, an anti IL-23. $ABBV's Skyrizi already has pretty convenient dosing, so it might be hard to differentiate the agent much there. Then there is data in Q4'26 from SPY072 in PsA and axSpA. https://seekingalpha.com/article/4940789-spyre-therapeutics-catalyst-rich-period-but-easiest-money-may-have-been-made
0 · Reply
eienek
eienek Aug. 26 at 7:19 PM
$SYRE I’m actually surprised SYRE is still holding around $93. It’s a ~$8B clinical-stage biotech with no approved drugs or commercial revenue, its valuation already assumes substantial success from the pipeline, and the latest RA results weren’t strong enough for the company to advance SPY072 as monotherapy. After such a massive run-up, I expected a much sharper correction.
1 · Reply
StockMarketToday247
StockMarketToday247 Aug. 26 at 6:57 PM
$BHVN $SYRE $GOVX — three biotech situations, one capital-markets lesson: balance-sheet strength changes what management can afford to do. $BHVN is licensing Kv7 to SK for $400M of near-term cash, plus milestones/royalties, while shifting future costs and certain obligations off its balance sheet. $SYRE had statistically significant RA findings but decided the magnitude was not good enough to prioritize the program. It had ~$1.145B of cash/investments at June 30. That is what optionality looks like: it can afford to stop funding “good enough.” $GOVX had ~$3.14M of June cash and runway only into September. It gets ~$3.65M from exercising 5.7M warrants at $0.64, but issues ~11.4M new 5-year warrants in return. The signal I’m watching isn’t simply dilution. It’s negotiating leverage. Cash lets you wait. Assets give you financing options. Weak balance sheets make liquidity expensive. That’s where I’ve got my eyes today. https://insidersonly.beehiiv.com/p/the-best-biotech-asset-may-be-the-ability-to-say-no
0 · Reply
runitback349
runitback349 Aug. 26 at 5:41 PM
$SYRE piggy going much lower
0 · Reply
Merlintrader
Merlintrader Aug. 26 at 1:22 PM
$SYRE Spyre Therapeutics Stock Hub 2026: SPY072 hit its primary endpoint in rheumatoid arthritis on August 25 and Spyre still declined to advance it as a monotherapy. The only placebo-controlled dataset it has published. Every IBD number is open-label. Free Biotech Catalyst Calendar on Merlintrader. https://www.merlintrader.com/spyre-therapeutics-syre-stock-hub/?utm_source=stocktwits&utm_medium=social&utm_campaign=spyre-therapeutics-syre-stock-hub
0 · Reply
briefingcom
briefingcom Aug. 26 at 12:05 PM
$SYRE: Spyre (-11.3%) announces topline results from rheumatoid arthritis sub-study; magnitude of effect did not meet target.
0 · Reply
anachartanalyst
anachartanalyst Aug. 26 at 10:01 AM
$SYRE https://anachart.com/wp-content/uploads/2026/08/1787738470_soc-img.jpg
0 · Reply
Cache_Money
Cache_Money Aug. 26 at 12:51 AM
$SYRE Oh too bad, SKYWAY RA data wasn’t strong enough to continue on to a phase 3. Strange that there wasn’t a clear dose-response for most of the readouts but it’s not terribly surprising that TL1A in RA didn’t quite reach the efficacy seen with TNFs. SKYLINE and SKYLIGHT combo readouts are going to be the key game-changers so just sitting tight here.
1 · Reply
DonCorleone77
DonCorleone77 Aug. 26 at 12:28 AM
$ZM $ELMD $BOX $SYRE PRE-MARKET MOVERS: Currently Higher After Earnings: - Semtech (SMTC) up 4.1% - HEICO Corporation (HEI) up 2.4% Currently Lower After Earnings: - Qfin Holdings (QFIN) down 13.0% - Intuit (INTU) down 10.2% - nCino (NCNO) down 3.9% - Zoom Communications (ZM) down 5.0% - Electromed (ELMD) down 3.2% - Box (BOX) down 1.1% Currently Also Lower: - Spyre Therapeutics (SYRE) down 7.8% after results from RA sub-study of SKYWAY basket trial.
0 · Reply
topstockalerts
topstockalerts Aug. 25 at 8:44 PM
Spyre Therapeutics shares fell sharply after hours Tuesday after the company reported preliminary Phase 2 SKYWAY rheumatoid arthritis data for SPY072. While both doses produced statistically significant benefits versus placebo on certain measures, the effect size did not meet Spyre’s internal threshold to prioritize SPY072 as a monotherapy for rheumatoid arthritis. The low dose significantly improved the primary endpoint, with a DAS28-CRP change of -1.9 versus -1.3 for placebo at week 12. The high dose achieved a 63% ACR20 response rate versus 43% for placebo, while the low dose produced a 38% ACR50 response rate versus 19%. SPY072 was well tolerated, with adverse events reported in 27% of treated patients versus 36% for placebo, mostly mild or moderate. Spyre said the results support the potential of its TL1A antibodies in autoimmune diseases and combination therapies. The 143-patient trial included 48 patients on the high dose, 48 on the low dose and 47 on placebo. $SYRE
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Dragan7
Dragan7 Aug. 25 at 8:39 PM
$SYRE "What's Next for Spyre's Pipeline? The company is reminding investors that the drug isn't entirely dead, as several upcoming milestones remain on track:Q4 2026: Topline data for SPY072 targeting psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). Late 2027 / Early 2028: Combination data evaluating SPY072 with IL-17A/F for hidradenitis suppurativa (HS)
1 · Reply
Tea_n_crumpet_enjoyer
Tea_n_crumpet_enjoyer Aug. 25 at 8:32 PM
$SYRE 9.4 billion market cap with no commercialisation ??? And a failed phase 2 …
1 · Reply
notreload_ai
notreload_ai Aug. 25 at 8:28 PM
$SYRE RA drug showed benefits and good safety, but results weren’t strong enough to justify developing it as a stand-alone treatment. https://notreload.xyz/xy/spyre-spy072-ra-data-misses-investor-monotherapy-expectations/
0 · Reply
oaksapollo
oaksapollo Aug. 25 at 8:25 PM
$SYRE I warned you guys. This is just the start of the story unraveling (no position, just a spectator).
0 · Reply
STACKD0E
STACKD0E Aug. 25 at 8:21 PM
0 · Reply
Parobolicbatman
Parobolicbatman Aug. 25 at 8:18 PM
$SYRE down on good news?
2 · Reply
Stocktwits
Stocktwits Aug. 25 at 8:12 PM
$SYRE down 19% after hours:
0 · Reply
DonCorleone77
DonCorleone77 Aug. 25 at 8:05 PM
$SYRE Spyre Therapeutics announces results from RA sub-study of SKYWAY basket trial Spyre Therapeutics announced results from the RA sub-study of its Phase 2 SKYWAY basket trial evaluating SPY072 in rheumatic diseases. Both doses of SPY072 demonstrated statistically significant benefits compared to placebo on one or more of the primary, key secondary, and exploratory endpoints. SPY072 was well tolerated, with a safety profile consistent with the TL1A class. The results provide proof-of-mechanism for TL1A in RA and support its potential in other autoimmune diseases and as a combination component, but did not meet the Company's internal bar to prioritize advancement of SPY072 in RA. SPY072 Low Dose demonstrated a statistically significant benefit compared to placebo on the primary endpoint at Week 12. Nominally significant improvements versus placebo were observed on the secondary endpoint with High Dose and on the exploratory endpoint with Low Dose. Results were generally comparable between advanced-therapy-naive and advanced-therapy-experienced sub-groups. Both doses of SPY072 achieved target drug concentrations and provided complete and durable suppression of free TL1A through Week 12, suggesting complete target engagement. SPY072 was well tolerated with a safety profile consistent with the TL1A class. Rates of adverse events were comparable between active and placebo and generally mild or moderate. One Serious TEAE occurred on each arm, none deemed drug-related. One death occurred in a participant receiving placebo. The most common TEAEs were infections and infestations, occurring in 14% of SPY072-treated participants and 15% of placebo-treated participants.
0 · Reply
Quantumup
Quantumup Aug. 25 at 10:52 AM
Piper Sandler🏁 $AGMB and said -- We are initiating coverage on AgomAb Therapeutics with an OW rating and $60 PT, where ontunisertib (GI-restricted oral ALK5 inhibitor) is poised for success in fibrostenotic Crohn's disease (FSCD). $SYRE $ABVX PALI ABBV JNJ PLRX PFE BMY LLY MRK TAK Here's what Piper Sandler went on to say in its initiation report: https://x.com/Quantumup1/status/2092203258173436408?s=20
0 · Reply