Market Cap 7.02B
Revenue (ttm) 0.00
Net Income (ttm) -155.20M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 958,700
Avg Vol 1,229,904
Day's Range N/A - N/A
Shares Out 86.84M
Stochastic %K 77%
Beta 3.05
Analysts Strong Sell
Price Target $96.07

Company Profile

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 – anti-TL1A mAbs designed to bind to tumor necros...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 651 5940
Address:
Building 23, Suite 105 221 Crescent Street, Waltham, United States
BreakoutsHappen
BreakoutsHappen Jun. 15 at 9:05 AM
0 · Reply
oaksapollo
oaksapollo Jun. 13 at 1:56 AM
$SYRE $7B cap, absolute insanity. Years from commercialization, loaded with clinical execution risk, fierce competition, and sure to dilute significantly between now and any potential approval. No idea why anyone wants to own this. If options ever become more liquid I will be making bearish bets on a regular basis.
1 · Reply
SoxFan666
SoxFan666 Jun. 9 at 3:18 PM
$SYRE been real busy and just checked my Schwab account: i got a divy for 8k on 5/15. is this real?
0 · Reply
mnzg
mnzg Jun. 8 at 3:16 PM
$SYRE i had 25268 agle shares back in 22-23 and i have not been following it since then but i just checked my account and it says i have dividend (not credited into my account yet) but we should also be getting 1 SYRE share for 25 AGLE shares right ? Can someone who knows about this help to understand please ? Many thanks in advanve
2 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Jun. 4 at 3:07 PM
$SYRE Never left
1 · Reply
StockConsultant
StockConsultant Jun. 4 at 1:48 PM
$SYRE Spyre Therapeutics stock, watch for a bull flag breakout at https://stockconsultant.com/?SYRE Breakout trade WATCH for possible breakout above 78.45 Target: 91.89, 19.2% Stop: 71.78 Loss: 6.9% P/L ratio: 2.8 : 1 - Good BULLISH [Timing] Strong bullish 3 day candlestick pattern with Extreme 3 day accumulation. [Timing] Extreme bullish 1 day moneyflow [Timing] breakout watch above 78.45, no resistance in area just above. BEARISH [Positioning] 1 Day Price change strong up, may pause [Positioning] Intermediate trend possibly bearish, Uptrend turned sideways, may continue or pullback. [Positioning] at resistance
0 · Reply
Quantumup
Quantumup Jun. 4 at 11:35 AM
Deutsche Bank⬆️ $SYRE's PT to $115 (was $102) and reiterated Buy. $JNJ ABBV TAK APGE $ABVX Here's what Deutsche Bank said in its note: https://x.com/Quantumup1/status/2062497861581844711?s=20
0 · Reply
anachartanalyst
anachartanalyst Jun. 4 at 10:02 AM
$SYRE https://anachart.com/wp-content/uploads/2026/06/1780567272_soc-img.jpg
0 · Reply
SuperGreenToday
SuperGreenToday Jun. 3 at 8:03 AM
$SYRE Share Price: $69.22 Contract Selected: Nov 20, 2026 $70 Calls Buy Zone: $14.54 – $17.96 Target Zone: $26.22 – $32.04 Potential Upside: 70% ROI Time to Expiration: 169 Days | Updates via https://fxcapta.com/stockinfo/
0 · Reply
ImadogImaMut
ImadogImaMut Jun. 1 at 5:07 PM
$SYRE I’ve had this on my list Well today my friends today 🏎️☮️
0 · Reply
Latest News on SYRE
Spyre Therapeutics Announces Grants of Inducement Awards

Jun 5, 2026, 4:01 PM EDT - 9 days ago

Spyre Therapeutics Announces Grants of Inducement Awards


Spyre Therapeutics Slides: Corporate presentation

Jun 2, 2026, 7:00 AM EDT - 12 days ago

Spyre Therapeutics Slides: Corporate presentation


Spyre Therapeutics management to meet with BTIG

2026-05-27T19:00:13.000Z - 18 days ago

Spyre Therapeutics management to meet with BTIG


Spyre Therapeutics Transcript: AGM 2026

May 27, 2026, 12:00 PM EDT - 18 days ago

Spyre Therapeutics Transcript: AGM 2026


Spyre Therapeutics reports Q1 EPS (74c), consensus (65c)

2026-05-05T12:27:39.000Z - 5 weeks ago

Spyre Therapeutics reports Q1 EPS (74c), consensus (65c)


Spyre Therapeutics Quarterly report: Q1 2026

May 5, 2026, 7:00 AM EDT - 5 weeks ago

Spyre Therapeutics Quarterly report: Q1 2026


Spyre Therapeutics Earnings release: Q1 2026

May 5, 2026, 7:00 AM EDT - 5 weeks ago

Spyre Therapeutics Earnings release: Q1 2026


Spyre Therapeutics 6.5M share Secondary priced at $62.00

2026-04-15T09:50:13.000Z - 2 months ago

Spyre Therapeutics 6.5M share Secondary priced at $62.00


Spyre Therapeutics price target raised to $90 from $65 at Baird

2026-04-14T11:44:26.000Z - 2 months ago

Spyre Therapeutics price target raised to $90 from $65 at Baird


Spyre Therapeutics announces $300M offering of common stock

2026-04-13T20:50:45.000Z - 2 months ago

Spyre Therapeutics announces $300M offering of common stock


Spyre Therapeutics initiated with a Strong Buy at Raymond James

2026-04-13T20:12:35.000Z - 2 months ago

Spyre Therapeutics initiated with a Strong Buy at Raymond James


Spyre Therapeutics Transcript: Study result

Apr 13, 2026, 8:00 AM EDT - 2 months ago

Spyre Therapeutics Transcript: Study result


Spyre Therapeutics Press release: Study result

Apr 13, 2026, 8:00 AM EDT - 2 months ago

Spyre Therapeutics Press release: Study result


Spyre Therapeutics Slides: Study result

Apr 13, 2026, 8:00 AM EDT - 2 months ago

Spyre Therapeutics Slides: Study result


Spyre Therapeutics Proxy statement: Proxy filing

Apr 10, 2026, 8:00 AM EDT - 2 months ago

Spyre Therapeutics Proxy statement: Proxy filing


Spyre Therapeutics Proxy statement: Proxy filing

Apr 10, 2026, 8:00 AM EDT - 2 months ago

Spyre Therapeutics Proxy statement: Proxy filing


Spyre Therapeutics Earnings release: Q4 2025

Feb 19, 2026, 7:00 AM EST - 4 months ago

Spyre Therapeutics Earnings release: Q4 2025


Spyre Therapeutics Annual report: Q4 2025

Feb 19, 2026, 7:00 AM EST - 4 months ago

Spyre Therapeutics Annual report: Q4 2025


Spyre Therapeutics Registration statement: Registration Filing

Feb 19, 2026, 7:00 AM EST - 4 months ago

Spyre Therapeutics Registration statement: Registration Filing


Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference

Nov 11, 2025, 8:40 AM EST - 7 months ago

Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference


Spyre Therapeutics Slides: Corporate Presentation

Nov 9, 2025, 6:00 PM EST - 7 months ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Earnings release: Q3 2025

Nov 4, 2025, 7:00 AM EST - 7 months ago

Spyre Therapeutics Earnings release: Q3 2025


Spyre Therapeutics Quarterly report: Q3 2025

Nov 4, 2025, 7:00 AM EST - 7 months ago

Spyre Therapeutics Quarterly report: Q3 2025


Spyre Therapeutics Earnings release: Q2 2025

Aug 5, 2025, 7:00 AM EDT - 11 months ago

Spyre Therapeutics Earnings release: Q2 2025


Spyre Therapeutics Quarterly report: Q2 2025

Aug 5, 2025, 7:00 AM EDT - 11 months ago

Spyre Therapeutics Quarterly report: Q2 2025


Spyre Therapeutics Transcript: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Transcript: Status Update


Spyre Therapeutics Press release: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Press release: Status Update


Spyre Therapeutics Slides: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Slides: Status Update


Spyre Therapeutics Slides: Corporate Presentation

Jun 17, 2025, 7:00 AM EDT - 1 year ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Earnings release: Q1 2025

May 8, 2025, 4:00 PM EDT - 1 year ago

Spyre Therapeutics Earnings release: Q1 2025


Spyre Therapeutics Quarterly report: Q1 2025

May 8, 2025, 4:00 PM EDT - 1 year ago

Spyre Therapeutics Quarterly report: Q1 2025


Spyre Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Proxy statement: Proxy Filing


Spyre Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Proxy statement: Proxy Filing


Spyre Therapeutics Earnings release: Q4 2024

Feb 27, 2025, 9:30 AM EST - 1 year ago

Spyre Therapeutics Earnings release: Q4 2024


Spyre Therapeutics Annual report: Q4 2024

Feb 27, 2025, 9:30 AM EST - 1 year ago

Spyre Therapeutics Annual report: Q4 2024


Spyre Therapeutics Slides: Corporate Presentation

Jan 13, 2025, 7:00 AM EST - 1 year ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Added to the Nasdaq Biotechnology Index

Dec 18, 2024, 8:00 AM EST - 1 year ago

Spyre Therapeutics Added to the Nasdaq Biotechnology Index


BreakoutsHappen
BreakoutsHappen Jun. 15 at 9:05 AM
0 · Reply
oaksapollo
oaksapollo Jun. 13 at 1:56 AM
$SYRE $7B cap, absolute insanity. Years from commercialization, loaded with clinical execution risk, fierce competition, and sure to dilute significantly between now and any potential approval. No idea why anyone wants to own this. If options ever become more liquid I will be making bearish bets on a regular basis.
1 · Reply
SoxFan666
SoxFan666 Jun. 9 at 3:18 PM
$SYRE been real busy and just checked my Schwab account: i got a divy for 8k on 5/15. is this real?
0 · Reply
mnzg
mnzg Jun. 8 at 3:16 PM
$SYRE i had 25268 agle shares back in 22-23 and i have not been following it since then but i just checked my account and it says i have dividend (not credited into my account yet) but we should also be getting 1 SYRE share for 25 AGLE shares right ? Can someone who knows about this help to understand please ? Many thanks in advanve
2 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Jun. 4 at 3:07 PM
$SYRE Never left
1 · Reply
StockConsultant
StockConsultant Jun. 4 at 1:48 PM
$SYRE Spyre Therapeutics stock, watch for a bull flag breakout at https://stockconsultant.com/?SYRE Breakout trade WATCH for possible breakout above 78.45 Target: 91.89, 19.2% Stop: 71.78 Loss: 6.9% P/L ratio: 2.8 : 1 - Good BULLISH [Timing] Strong bullish 3 day candlestick pattern with Extreme 3 day accumulation. [Timing] Extreme bullish 1 day moneyflow [Timing] breakout watch above 78.45, no resistance in area just above. BEARISH [Positioning] 1 Day Price change strong up, may pause [Positioning] Intermediate trend possibly bearish, Uptrend turned sideways, may continue or pullback. [Positioning] at resistance
0 · Reply
Quantumup
Quantumup Jun. 4 at 11:35 AM
Deutsche Bank⬆️ $SYRE's PT to $115 (was $102) and reiterated Buy. $JNJ ABBV TAK APGE $ABVX Here's what Deutsche Bank said in its note: https://x.com/Quantumup1/status/2062497861581844711?s=20
0 · Reply
anachartanalyst
anachartanalyst Jun. 4 at 10:02 AM
$SYRE https://anachart.com/wp-content/uploads/2026/06/1780567272_soc-img.jpg
0 · Reply
SuperGreenToday
SuperGreenToday Jun. 3 at 8:03 AM
$SYRE Share Price: $69.22 Contract Selected: Nov 20, 2026 $70 Calls Buy Zone: $14.54 – $17.96 Target Zone: $26.22 – $32.04 Potential Upside: 70% ROI Time to Expiration: 169 Days | Updates via https://fxcapta.com/stockinfo/
0 · Reply
ImadogImaMut
ImadogImaMut Jun. 1 at 5:07 PM
$SYRE I’ve had this on my list Well today my friends today 🏎️☮️
0 · Reply
CH_Expat
CH_Expat May. 22 at 6:19 PM
$SYRE @CDMO One in the guts for the long weekend.
2 · Reply
FennickTradings
FennickTradings May. 19 at 1:55 PM
$SYRE got the payout🔥
1 · Reply
MissFred
MissFred May. 18 at 4:03 PM
$SYRE Remember Aeglea Theraputics ? I$ do
0 · Reply
MissFred
MissFred May. 18 at 3:59 PM
0 · Reply
outlawinvestor1
outlawinvestor1 May. 16 at 10:04 AM
updated paragon family of extended life biologics. https://www.paragontherapeutics.com/ $APGE $SYRE $ORKA $JBIO $CBIO
1 · Reply
oaksapollo
oaksapollo May. 12 at 3:46 AM
$SYRE this is the most absurd valuation in biotech right now. Anyone can use YTE and do what they’re doing.
1 · Reply
chking09
chking09 May. 11 at 5:28 PM
$SYRE breakout?
0 · Reply
Quantumup
Quantumup May. 6 at 11:12 AM
Stifel y'day⬆️ $SYRE's PT to $107 (was $92), reit'd at Buy/said: Following best-in-class UC PoC data for SPY001 (α4β7), SYRE is well-positioned heading into additional PoC cohorts for SPY002 (TL1A) and SPY003 (IL-23p19) in mid-year/3Q26. $JNJ TAK APGE ABVX $ABBV Here's what else Stifel had to say: https://x.com/Quantumup1/status/2051982840607215753?s=20
0 · Reply
d_risk
d_risk May. 5 at 2:55 PM
$SYRE - Spyre Therapeutics Inc - 10Q - Updated Risk Factors 🚨 Peer Alert: Risk-factor words are +208.0% above peer average (36,855 vs 11,964 across 652 peers). SYRE’s 10-Q sharpens its downside: survival now explicitly hinges on new capital despite a large cash balance; it doubles down on going-concern, perpetual-loss, and no-revenue risks; concentrates dependence on four core programs and complex drug/device, biologics and CMC hurdles; and materially expands regulatory, IP, manufacturing, AI, talent, pricing, geopolitical and control‑weakness risks that could dilute shareholders, delay approvals and cripple commercialization. 🟢 Added 🟠 Removed https://d-risk.ai/SYRE/10-Q/2026-05-05
0 · Reply
Merlintrader
Merlintrader Apr. 30 at 11:10 PM
$SYRE Spyre Therapeutics 2026 (Nasdaq: $SYRE): When Great Clinical Data Matter More Than Promises https://www.merlintrader.com/spyre-therapeutics-may2026-deepdive/
0 · Reply
draketdot
draketdot Apr. 30 at 10:19 PM
$SYRE 33% increase incoming?
0 · Reply