Market Cap 6.43B
Revenue (ttm) 0.00
Net Income (ttm) -155.20M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 574,900
Avg Vol 1,196,392
Day's Range N/A - N/A
Shares Out 86.84M
Stochastic %K 70%
Beta 3.12
Analysts Strong Sell
Price Target $95.20

Company Profile

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 – anti-TL1A mAbs designed to bind to tumor necros...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 651 5940
Address:
Building 23, Suite 105 221 Crescent Street, Waltham, United States
CH_Expat
CH_Expat May. 22 at 6:19 PM
$SYRE @CDMO One in the guts for the long weekend.
2 · Reply
FennickTradings
FennickTradings May. 19 at 1:55 PM
$SYRE got the payout🔥
1 · Reply
MissFred
MissFred May. 18 at 4:03 PM
$SYRE Remember Aeglea Theraputics ? I$ do
0 · Reply
MissFred
MissFred May. 18 at 3:59 PM
0 · Reply
outlawinvestor1
outlawinvestor1 May. 16 at 10:04 AM
updated paragon family of extended life biologics. https://www.paragontherapeutics.com/ $APGE $SYRE $ORKA $JBIO $CBIO
0 · Reply
oaksapollo
oaksapollo May. 12 at 3:46 AM
$SYRE this is the most absurd valuation in biotech right now. Anyone can use YTE and do what they’re doing.
1 · Reply
chking09
chking09 May. 11 at 5:28 PM
$SYRE breakout?
0 · Reply
Quantumup
Quantumup May. 6 at 11:12 AM
Stifel y'day⬆️ $SYRE's PT to $107 (was $92), reit'd at Buy/said: Following best-in-class UC PoC data for SPY001 (α4β7), SYRE is well-positioned heading into additional PoC cohorts for SPY002 (TL1A) and SPY003 (IL-23p19) in mid-year/3Q26. $JNJ TAK APGE ABVX $ABBV Here's what else Stifel had to say: https://x.com/Quantumup1/status/2051982840607215753?s=20
0 · Reply
d_risk
d_risk May. 5 at 2:55 PM
$SYRE - Spyre Therapeutics Inc - 10Q - Updated Risk Factors 🚨 Peer Alert: Risk-factor words are +208.0% above peer average (36,855 vs 11,964 across 652 peers). SYRE’s 10-Q sharpens its downside: survival now explicitly hinges on new capital despite a large cash balance; it doubles down on going-concern, perpetual-loss, and no-revenue risks; concentrates dependence on four core programs and complex drug/device, biologics and CMC hurdles; and materially expands regulatory, IP, manufacturing, AI, talent, pricing, geopolitical and control‑weakness risks that could dilute shareholders, delay approvals and cripple commercialization. 🟢 Added 🟠 Removed https://d-risk.ai/SYRE/10-Q/2026-05-05
0 · Reply
Merlintrader
Merlintrader Apr. 30 at 11:10 PM
$SYRE Spyre Therapeutics 2026 (Nasdaq: $SYRE): When Great Clinical Data Matter More Than Promises https://www.merlintrader.com/spyre-therapeutics-may2026-deepdive/
0 · Reply
Latest News on SYRE
Spyre Therapeutics reports Q1 EPS (74c), consensus (65c)

2026-05-05T12:27:39.000Z - 18 days ago

Spyre Therapeutics reports Q1 EPS (74c), consensus (65c)


Spyre Therapeutics Quarterly report: Q1 2026

May 5, 2026, 7:00 AM EDT - 18 days ago

Spyre Therapeutics Quarterly report: Q1 2026


Spyre Therapeutics Earnings release: Q1 2026

May 5, 2026, 7:00 AM EDT - 18 days ago

Spyre Therapeutics Earnings release: Q1 2026


Spyre Therapeutics Announces Grants of Inducement Awards

May 1, 2026, 4:28 PM EDT - 22 days ago

Spyre Therapeutics Announces Grants of Inducement Awards


Spyre Therapeutics 6.5M share Secondary priced at $62.00

2026-04-15T09:50:13.000Z - 5 weeks ago

Spyre Therapeutics 6.5M share Secondary priced at $62.00


Spyre Therapeutics announces $300M offering of common stock

2026-04-13T20:50:45.000Z - 5 weeks ago

Spyre Therapeutics announces $300M offering of common stock


Spyre Therapeutics Transcript: Study result

Apr 13, 2026, 8:00 AM EDT - 5 weeks ago

Spyre Therapeutics Transcript: Study result


Spyre Therapeutics Press release: Study result

Apr 13, 2026, 8:00 AM EDT - 5 weeks ago

Spyre Therapeutics Press release: Study result


Spyre Therapeutics Slides: Study result

Apr 13, 2026, 8:00 AM EDT - 5 weeks ago

Spyre Therapeutics Slides: Study result


Spyre Therapeutics Proxy statement: Proxy filing

Apr 10, 2026, 8:00 AM EDT - 6 weeks ago

Spyre Therapeutics Proxy statement: Proxy filing


Spyre Therapeutics Proxy statement: Proxy filing

Apr 10, 2026, 8:00 AM EDT - 6 weeks ago

Spyre Therapeutics Proxy statement: Proxy filing


Spyre Therapeutics Earnings release: Q4 2025

Feb 19, 2026, 7:00 AM EST - 3 months ago

Spyre Therapeutics Earnings release: Q4 2025


Spyre Therapeutics Annual report: Q4 2025

Feb 19, 2026, 7:00 AM EST - 3 months ago

Spyre Therapeutics Annual report: Q4 2025


Spyre Therapeutics Registration statement: Registration Filing

Feb 19, 2026, 7:00 AM EST - 3 months ago

Spyre Therapeutics Registration statement: Registration Filing


Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference

Nov 11, 2025, 8:40 AM EST - 6 months ago

Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference


Spyre Therapeutics Slides: Corporate Presentation

Nov 9, 2025, 6:00 PM EST - 6 months ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Earnings release: Q3 2025

Nov 4, 2025, 7:00 AM EST - 7 months ago

Spyre Therapeutics Earnings release: Q3 2025


Spyre Therapeutics Quarterly report: Q3 2025

Nov 4, 2025, 7:00 AM EST - 7 months ago

Spyre Therapeutics Quarterly report: Q3 2025


Spyre Therapeutics Earnings release: Q2 2025

Aug 5, 2025, 7:00 AM EDT - 10 months ago

Spyre Therapeutics Earnings release: Q2 2025


Spyre Therapeutics Quarterly report: Q2 2025

Aug 5, 2025, 7:00 AM EDT - 10 months ago

Spyre Therapeutics Quarterly report: Q2 2025


Spyre Therapeutics Transcript: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Transcript: Status Update


Spyre Therapeutics Press release: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Press release: Status Update


Spyre Therapeutics Slides: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Slides: Status Update


Spyre Therapeutics Slides: Corporate Presentation

Jun 17, 2025, 7:00 AM EDT - 1 year ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Earnings release: Q1 2025

May 8, 2025, 4:00 PM EDT - 1 year ago

Spyre Therapeutics Earnings release: Q1 2025


Spyre Therapeutics Quarterly report: Q1 2025

May 8, 2025, 4:00 PM EDT - 1 year ago

Spyre Therapeutics Quarterly report: Q1 2025


Spyre Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Proxy statement: Proxy Filing


Spyre Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Proxy statement: Proxy Filing


Spyre Therapeutics Earnings release: Q4 2024

Feb 27, 2025, 9:30 AM EST - 1 year ago

Spyre Therapeutics Earnings release: Q4 2024


Spyre Therapeutics Annual report: Q4 2024

Feb 27, 2025, 9:30 AM EST - 1 year ago

Spyre Therapeutics Annual report: Q4 2024


Spyre Therapeutics Slides: Corporate Presentation

Jan 13, 2025, 7:00 AM EST - 1 year ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Added to the Nasdaq Biotechnology Index

Dec 18, 2024, 8:00 AM EST - 1 year ago

Spyre Therapeutics Added to the Nasdaq Biotechnology Index


CH_Expat
CH_Expat May. 22 at 6:19 PM
$SYRE @CDMO One in the guts for the long weekend.
2 · Reply
FennickTradings
FennickTradings May. 19 at 1:55 PM
$SYRE got the payout🔥
1 · Reply
MissFred
MissFred May. 18 at 4:03 PM
$SYRE Remember Aeglea Theraputics ? I$ do
0 · Reply
MissFred
MissFred May. 18 at 3:59 PM
0 · Reply
outlawinvestor1
outlawinvestor1 May. 16 at 10:04 AM
updated paragon family of extended life biologics. https://www.paragontherapeutics.com/ $APGE $SYRE $ORKA $JBIO $CBIO
0 · Reply
oaksapollo
oaksapollo May. 12 at 3:46 AM
$SYRE this is the most absurd valuation in biotech right now. Anyone can use YTE and do what they’re doing.
1 · Reply
chking09
chking09 May. 11 at 5:28 PM
$SYRE breakout?
0 · Reply
Quantumup
Quantumup May. 6 at 11:12 AM
Stifel y'day⬆️ $SYRE's PT to $107 (was $92), reit'd at Buy/said: Following best-in-class UC PoC data for SPY001 (α4β7), SYRE is well-positioned heading into additional PoC cohorts for SPY002 (TL1A) and SPY003 (IL-23p19) in mid-year/3Q26. $JNJ TAK APGE ABVX $ABBV Here's what else Stifel had to say: https://x.com/Quantumup1/status/2051982840607215753?s=20
0 · Reply
d_risk
d_risk May. 5 at 2:55 PM
$SYRE - Spyre Therapeutics Inc - 10Q - Updated Risk Factors 🚨 Peer Alert: Risk-factor words are +208.0% above peer average (36,855 vs 11,964 across 652 peers). SYRE’s 10-Q sharpens its downside: survival now explicitly hinges on new capital despite a large cash balance; it doubles down on going-concern, perpetual-loss, and no-revenue risks; concentrates dependence on four core programs and complex drug/device, biologics and CMC hurdles; and materially expands regulatory, IP, manufacturing, AI, talent, pricing, geopolitical and control‑weakness risks that could dilute shareholders, delay approvals and cripple commercialization. 🟢 Added 🟠 Removed https://d-risk.ai/SYRE/10-Q/2026-05-05
0 · Reply
Merlintrader
Merlintrader Apr. 30 at 11:10 PM
$SYRE Spyre Therapeutics 2026 (Nasdaq: $SYRE): When Great Clinical Data Matter More Than Promises https://www.merlintrader.com/spyre-therapeutics-may2026-deepdive/
0 · Reply
draketdot
draketdot Apr. 30 at 10:19 PM
$SYRE 33% increase incoming?
0 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Apr. 30 at 7:49 PM
$SYRE RSI: 77.96, MACD: 6.7487 Vol: 9.71, MA20: 64.26, MA50: 51.55 ⚪ HOLD - Sideways 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
FennickTradings
FennickTradings Apr. 30 at 1:19 PM
$SYRE enough cash for cvr dividend payout😅
0 · Reply
RunnerSignals
RunnerSignals Apr. 29 at 8:10 PM
market warriors $TENB $HUM $CHGG $BIIB $SYRE reversed from red to strong green closes with 6–12% intraday swings and volume 1.2x–1.6x avg
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 29 at 2:39 PM
1 · Reply
grandefappuccino
grandefappuccino Apr. 28 at 8:49 PM
$SYRE ready to run 5/5
0 · Reply
Avocado_smash
Avocado_smash Apr. 28 at 2:43 AM
$SYRE Structure and Trend strength up>
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 24 at 2:18 PM
$SYRE 68.8 is your friend.
2 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 23 at 6:50 PM
$SYRE Trim under 70
1 · Reply
Avocado_smash
Avocado_smash Apr. 15 at 1:11 PM
$SYRE Strong Offering! 🚀🚀🚀🚀🚀🚀🚀🚀🚀
0 · Reply
Pika_Capital
Pika_Capital Apr. 15 at 1:10 PM
$SYRE $400M raised at $62. Power move. They got tons of cash now
0 · Reply