Apr. 25 at 3:49 AM
$REPL
"RP1 combined with nivolumab provided deep and durable systemic responses in patients with anti–PD-1–failed melanoma, including those with poor prognostic factors. The safety profile was favorable, with mostly grade 1/2 adverse events."
"Tumor-infiltrating lymphocyte therapy (lifileucel) is the only US Food and Drug Administration (FDA)–approved therapy for melanoma in patients previously treated with anti–PD-1 therapy16,17 and provided an objective response rate (ORR) of 31.4%.18 However, nearly all patients experienced grade 3/4 treatment-emergent adverse events,18,19 and the treatment-related mortality rate was 7.5%."
https://ascopubs.org/doi/10.1200/JCO-25-01346