Aug. 27 at 12:12 PM
$AUPH "Meta-Analysis Supports Combination Therapy for Lupus Nephritis"
- meta-analysis found that VCS + MPAA resulted in 281.38 more complete renal responses per 1000 patients vs belimumab (145.02), obinutuzumab (134.23) and tacrolimus (168.03)
- with respect to safety outcomes, CTX, LEF, and TAC + MPAA were associated with higher infection risks compared with MMF alone. VCS and OBI combinations showed more modest infection increases (less than 100 extra cases), with uncertain effects on severe infections
- “These findings support the growing body of evidence favoring these combinations as potential first-line therapies”
https://www.renalandurologynews.com/news/lupus-nephritis-combination-therapy-meta-analysis-risk/
https://www.kireports.org/article/S2468-0249(25)00419-X/pdf