Nov. 13 at 8:24 AM
$TBPH Alright team, need your help breaking this down.
I'm seeing a lot of positive noise around the Q3 earnings, the big cash pile (
$333M), and the stable YUPELRI revenue. Great.
But the real story here is the Ampreloxetine Phase 3 (CYPRESS) data in Q1 2026, right?
My question: The previous trial (0170) officially failed. But I see they showed strong data (OR 0.28) in the MSA patient subgroup. Is the current CYPRESS trial just a "clean" repeat on only that group? Is this really considered "de-risked"?
And what about the competition? The incumbents (Northera/Midodrine) are carrying a Black Box Warning for supine hypertension. I read
$TBPH doesn't have this safety issue. Is that the real clinical differentiation?
Bottom line: If the science is strong, there's no dilution risk, and the competition is weak – why is the market sleeping on this? What am I missing?
Seriously looking for the Bear Case here. Explain it to me.