Nov. 25 at 4:41 PM
Silexion Therapeutics shares rose Tuesday after the company reported successful completion of toxicology studies for its cancer therapy SIL204, showing no systemic organ toxicity in two species. The positive results keep the biotech on track to begin a Phase 2/3 trial for locally advanced pancreatic cancer in Q2 2026, with regulatory filings underway in Israel and Germany. SIL204, an RNA-silencing therapy targeting mutated KRAS oncogenes, demonstrated strong preclinical activity, including tumor growth inhibition and systemic antitumor effects in pancreatic cancer models. CEO Ilan Hadar said the findings support the company’s planned trial timeline and noted that Silexion has secured its CRO partner and is advancing regulatory submissions.
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