Feb. 21 at 9:29 AM
$CRBU Great call at Citi conference.
Key insights:
- FDA alignment & financing will be done in H1
- Phase 3 start in H2, data readout in 2028
- Regarding possible deals to finance phase 3, Rachel plans to bring CB10 to the US alone while seeking for partnerships outside US (after readout)
- She did not mention CB11 in this context notably
- CB10 Phase 3 will focus on 2L with double ineligibility for autologous / stem cell transplant. Only 25% of patients receive autologous therapy today, and the targeted patients stand for 60% of the rest. This means 45% of patient populations, exceeding today`s market share of all autologous therapies
- Phase 3 success probability is very high, as CB10 will be compared to bispecifics / immunotherapy regimes without curative character and low PFS
My summary: CB11 will be out licensed to Pfizer in H1 (Pfizer ROFN until June) to finance phase 3 study. Next step: FDA alignment announcement. This is going to skyrocket!
https://kvgo.com/citi/caribou-biosciences-february-2026