Cardio Diagnostics Hldgs Inc (CDIO)

$1.83 -0.11 (-5.67%)
Market Cap 3.54M
Revenue (ttm) 30,000.00
Net Income (ttm) -8.38M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -27,933.33%
Debt to Equity Ratio 0.00
Volume 191,100
Avg Vol 465,014
Day's Range N/A - N/A
Shares Out 1.83M
Stochastic %K 6%
Beta 2.94
Analysts Sell
Price Target $8.00

Company Profile

Cardio Diagnostics Holdings, Inc. develops and commercializes epigenetics-based clinical tests for cardiovascular disease. The company offers Epi+Gen CHD, a three-year symptomatic coronary heart disease (CHD) risk assessment clinical blood test targeting CHD events, including heart attacks; PrecisionCHD, an integrated epigenetic-genetic clinical blood test for the detection of coronary heart disease; and Actionable Clinical Intelligence, a platform that offers new epigenetic and genetic insights...

Industry: Biotechnology
Sector: Healthcare
Phone: 855 226 9991
Website: cdio.ai
Address:
311 West Superior Street, Suite 444, Chicago, United States
Organized
Organized Jan. 14 at 2:21 AM
$CDIO
0 · Reply
Organized
Organized Jan. 14 at 2:21 AM
$CDIO
0 · Reply
VibraniumClaw
VibraniumClaw Jan. 14 at 2:00 AM
[{@CoralSharkie playing chess while others playing checkers 😮‍❄️ Different vision. Different execution. If you’re not paying attention, you’re behind. One follow = clarity… Real ones already know 💎 $PMW.X $BBAI $MGRX $CDIO ~ on watch as well.
0 · Reply
Redsox1975
Redsox1975 Jan. 13 at 10:54 PM
$CDIO same social media posts over and over from these scumbags at cardio such a fraud
0 · Reply
Trader1141
Trader1141 Jan. 13 at 10:23 PM
$CDIO fck you!!! Buying more!!
0 · Reply
Redsox1975
Redsox1975 Jan. 13 at 9:29 PM
$CDIO bankruptcy soon
0 · Reply
Redsox1975
Redsox1975 Jan. 13 at 8:56 PM
$CDIO timberrrrrr 1.50 tomorrow
0 · Reply
Trader1141
Trader1141 Jan. 13 at 8:17 PM
$CDIO when you least expect it
2 · Reply
Redsox1975
Redsox1975 Jan. 13 at 8:17 PM
$CDIO .06 stock
0 · Reply
Trader1141
Trader1141 Jan. 13 at 8:17 PM
$CDIO so when is the turnaround on this d@mn thing???
0 · Reply
Latest News on CDIO
Cardio Diagnostics, Aimil Ltd. and Dr. Lal PathLabs Limited Partner to Launch the PrecisionCHD™ Test in India

Jan 7, 2026, 6:25 AM EST - 6 days ago

Cardio Diagnostics, Aimil Ltd. and Dr. Lal PathLabs Limited Partner to Launch the PrecisionCHD™ Test in India

Cardio Diagnostics Holdings, Inc. and Southdale YMCA Announce New Heart Health Partnership to Serve the Edina, Minnesota Community

Jan 6, 2026, 8:35 AM EST - 7 days ago

Cardio Diagnostics Holdings, Inc. and Southdale YMCA Announce New Heart Health Partnership to Serve the Edina, Minnesota Community

Cardio Diagnostics Receives Final Gapfill Payment Rates for AI-Driven Cardiovascular Tests from the Centers for Medicare and Medicaid Services (CMS)

Dec 3, 2025, 8:35 AM EST - 5 weeks ago

Cardio Diagnostics Receives Final Gapfill Payment Rates for AI-Driven Cardiovascular Tests from the Centers for Medicare and Medicaid Services (CMS)

Cardio Diagnostics Holdings, Inc. to Present Data Demonstrating PrecisionCHD's Ability to Detect INOCA and MINOCA at the American Heart Association Scientific Sessions

Nov 5, 2025, 8:35 AM EST - 2 months ago

Cardio Diagnostics Holdings, Inc. to Present Data Demonstrating PrecisionCHD's Ability to Detect INOCA and MINOCA at the American Heart Association Scientific Sessions

Cardio Diagnostics Holdings, Inc. and YMCA of East Tennessee Partner to Bring Heart Health Education and Advanced Testing to East Tennessee Community

Oct 28, 2025, 8:35 AM EDT - 2 months ago

Cardio Diagnostics Holdings, Inc. and YMCA of East Tennessee Partner to Bring Heart Health Education and Advanced Testing to East Tennessee Community

Cardio Diagnostics Holdings, Inc. Expands Provider Network, Adding 15 New Provider Organizations From Across the United States

Oct 21, 2025, 8:35 AM EDT - 3 months ago

Cardio Diagnostics Holdings, Inc. Expands Provider Network, Adding 15 New Provider Organizations From Across the United States

Cardio Diagnostics Receives Gapfill Payment Rates for AI-Driven Cardiovascular Tests from the Centers for Medicare and Medicaid Services (CMS)

Jul 22, 2025, 8:31 AM EDT - 6 months ago

Cardio Diagnostics Receives Gapfill Payment Rates for AI-Driven Cardiovascular Tests from the Centers for Medicare and Medicaid Services (CMS)

Cardio Diagnostics Enters Into an Agreement with AGEPHA Pharma to Advance Precision Assessment and Management of Inflammation Associated with Coronary Heart Disease

Jul 8, 2025, 8:31 AM EDT - 6 months ago

Cardio Diagnostics Enters Into an Agreement with AGEPHA Pharma to Advance Precision Assessment and Management of Inflammation Associated with Coronary Heart Disease

Cardio Diagnostics Secures Japanese Patent for AI-Driven Cardiovascular Disease Detection Technology

Jun 10, 2025, 8:35 AM EDT - 7 months ago

Cardio Diagnostics Secures Japanese Patent for AI-Driven Cardiovascular Disease Detection Technology

Cardio Diagnostics Holdings, Inc. Regains Compliance with Nasdaq Minimum Bid Price

May 29, 2025, 8:35 AM EDT - 8 months ago

Cardio Diagnostics Holdings, Inc. Regains Compliance with Nasdaq Minimum Bid Price

Cardio Diagnostics Broadens Access to Precision Cardiovascular Care with New Practice Partnerships Across U.S. Mainland and Puerto Rico

May 20, 2025, 8:35 AM EDT - 8 months ago

Cardio Diagnostics Broadens Access to Precision Cardiovascular Care with New Practice Partnerships Across U.S. Mainland and Puerto Rico

Cardio Diagnostics Holdings, Inc. Announces 1-for-30 Reverse Stock Split

May 8, 2025, 8:35 AM EDT - 8 months ago

Cardio Diagnostics Holdings, Inc. Announces 1-for-30 Reverse Stock Split

Cardio Diagnostics Holdings, Inc. to Showcase Enhanced PrecisionCHD™, Actionable Clinical Intelligence™ and New Clinical Advancements at the American College of Cardiology's 74th Annual Scientific Session

Mar 26, 2025, 8:31 AM EDT - 10 months ago

Cardio Diagnostics Holdings, Inc. to Showcase Enhanced PrecisionCHD™, Actionable Clinical Intelligence™ and New Clinical Advancements at the American College of Cardiology's 74th Annual Scientific Session

Cardio Diagnostics Expands the Reach of its AI-Driven Precision Cardiovascular Medicine Tests by Partnering with Seven New Provider Organizations

Feb 4, 2025, 8:31 AM EST - 1 year ago

Cardio Diagnostics Expands the Reach of its AI-Driven Precision Cardiovascular Medicine Tests by Partnering with Seven New Provider Organizations

Cardio Diagnostics Holdings, Inc. Receives Final Medicare Pricing Determination from Centers for Medicare and Medicaid Services (CMS) for AI-Powered Cardiovascular Tests

Dec 16, 2024, 8:31 AM EST - 1 year ago

Cardio Diagnostics Holdings, Inc. Receives Final Medicare Pricing Determination from Centers for Medicare and Medicaid Services (CMS) for AI-Powered Cardiovascular Tests

Cardio Diagnostics Holdings, Inc. to Sponsor and Showcase AI-Powered Solutions at the FLAACOs Annual Conference

Nov 12, 2024, 8:31 AM EST - 1 year ago

Cardio Diagnostics Holdings, Inc. to Sponsor and Showcase AI-Powered Solutions at the FLAACOs Annual Conference

Cardio Diagnostics Holdings, Inc. Receives Preliminary Medicare Pricing from Centers for Medicare and Medicaid Services (CMS) for AI-Powered Cardiovascular Tests

Oct 1, 2024, 8:31 AM EDT - 1 year ago

Cardio Diagnostics Holdings, Inc. Receives Preliminary Medicare Pricing from Centers for Medicare and Medicaid Services (CMS) for AI-Powered Cardiovascular Tests

Cardio Diagnostics Holdings Inc. Launches CDIO.AI, A Redesigned Website Enhancing User Experience and Highlighting Our AI-Driven Cardiovascular Solutions

Jul 29, 2024, 8:45 AM EDT - 1 year ago

Cardio Diagnostics Holdings Inc. Launches CDIO.AI, A Redesigned Website Enhancing User Experience and Highlighting Our AI-Driven Cardiovascular Solutions

Cardio Diagnostics Announces Its Epi+Gen CHD Heart Attack Risk Assessment Test is Now Available at Meijer Supercenter in McHenry, Illinois

Jun 27, 2024, 8:31 AM EDT - 1 year ago

Cardio Diagnostics Announces Its Epi+Gen CHD Heart Attack Risk Assessment Test is Now Available at Meijer Supercenter in McHenry, Illinois

Cardio Diagnostics Announces It's Exhibiting at the 2024 Onsite Employee Health Clinics Forum

Jun 25, 2024, 8:31 AM EDT - 1 year ago

Cardio Diagnostics Announces It's Exhibiting at the 2024 Onsite Employee Health Clinics Forum

Cardio Diagnostics Holdings, Inc. Achieves SOC 2 Type I Compliance Certification for Security and Confidentiality

Jun 10, 2024, 8:31 AM EDT - 1 year ago

Cardio Diagnostics Holdings, Inc. Achieves SOC 2 Type I Compliance Certification for Security and Confidentiality

Cardio Diagnostics to Participate in the Centers for Medicare and Medicaid Services' (CMS) Clinical Laboratory Fee Schedule (CLFS) Annual Meeting to Secure Medicare Payment for Its Innovative Tests

May 21, 2024, 8:31 AM EDT - 1 year ago

Cardio Diagnostics to Participate in the Centers for Medicare and Medicaid Services' (CMS) Clinical Laboratory Fee Schedule (CLFS) Annual Meeting to Secure Medicare Payment for Its Innovative Tests

Cardio Diagnostics Holdings, Inc. Announces the Availability of Its Clinical Tests at Family Medicine Specialists' Retail Healthcare Clinic at Walmart Supercenter in Round Lake Beach, Illinois, That Offers Walk-In Appointments Seven Days a Week

May 13, 2024, 8:31 AM EDT - 1 year ago

Cardio Diagnostics Holdings, Inc. Announces the Availability of Its Clinical Tests at Family Medicine Specialists' Retail Healthcare Clinic at Walmart Supercenter in Round Lake Beach, Illinois, That Offers Walk-In Appointments Seven Days a Week

Cardio Diagnostics Announces Publication of Study Showing That its PrecisionCHD™ Test Could Save Health Insurers Over $113 Million Annually

Apr 29, 2024, 8:31 AM EDT - 1 year ago

Cardio Diagnostics Announces Publication of Study Showing That its PrecisionCHD™ Test Could Save Health Insurers Over $113 Million Annually

Exponential Health Partners with Cardio Diagnostics to Elevate Cardiovascular Disease Prevention in Michigan

Apr 9, 2024, 8:31 AM EDT - 1 year ago

Exponential Health Partners with Cardio Diagnostics to Elevate Cardiovascular Disease Prevention in Michigan

Cardio Diagnostics Holdings, Inc. Enters Into a Nationwide Telehealth Agreement with Navierre

Apr 4, 2024, 8:31 AM EDT - 1 year ago

Cardio Diagnostics Holdings, Inc. Enters Into a Nationwide Telehealth Agreement with Navierre

Cardio Diagnostics Holdings, Inc. to Showcase HeartRisk and Actionable Clinical Intelligence Version 3 at the American College of Cardiology's 73rd Annual Scientific Session

Mar 14, 2024, 8:31 AM EDT - 1 year ago

Cardio Diagnostics Holdings, Inc. to Showcase HeartRisk and Actionable Clinical Intelligence Version 3 at the American College of Cardiology's 73rd Annual Scientific Session

Cardio Diagnostics Holdings, Inc. Announces Issuance of Second U.S. Patent for Compositions and Methods for Detecting Predisposition to Cardiovascular Disease

Mar 5, 2024, 8:31 AM EST - 2 years ago

Cardio Diagnostics Holdings, Inc. Announces Issuance of Second U.S. Patent for Compositions and Methods for Detecting Predisposition to Cardiovascular Disease

Cardio Diagnostics Holdings, Inc. Expands HeartRisk™ Platform Offering to Diverse Markets in Conjunction with Nationwide Rollout

Feb 15, 2024, 8:46 AM EST - 2 years ago

Cardio Diagnostics Holdings, Inc. Expands HeartRisk™ Platform Offering to Diverse Markets in Conjunction with Nationwide Rollout

Cardio Diagnostics Holdings, Inc. Expands Partnership with Family Medicine Specialists to Bring Its Specialty Cardiology Tests to Select Walmart Supercenters

Feb 7, 2024, 8:31 AM EST - 2 years ago

Cardio Diagnostics Holdings, Inc. Expands Partnership with Family Medicine Specialists to Bring Its Specialty Cardiology Tests to Select Walmart Supercenters

Houston-Based resTOR Longevity Clinic to Offer Cardio Diagnostics' AI-Driven Epigenetic-Genetic Heart Disease Tests

Feb 5, 2024, 8:31 AM EST - 2 years ago

Houston-Based resTOR Longevity Clinic to Offer Cardio Diagnostics' AI-Driven Epigenetic-Genetic Heart Disease Tests

Cardio Diagnostics Holdings, Inc. Accelerates Cardiac Care Innovation with Appointment of Dr. Vimal Ramjee as Strategic Advisor

Jan 24, 2024, 8:31 AM EST - 2 years ago

Cardio Diagnostics Holdings, Inc. Accelerates Cardiac Care Innovation with Appointment of Dr. Vimal Ramjee as Strategic Advisor

Cardio Diagnostics Holdings, Inc. Announces the Grant of a Patent in India

Jan 8, 2024, 8:31 AM EST - 2 years ago

Cardio Diagnostics Holdings, Inc. Announces the Grant of a Patent in India

CORRECTING and REPLACING Cardio Diagnostics Holdings, Inc. Unveils Groundbreaking Employer Cardiovascular Disease Risk Intelligence Platform, HeartRisk™

Jan 4, 2024, 11:36 AM EST - 2 years ago

CORRECTING and REPLACING Cardio Diagnostics Holdings, Inc. Unveils Groundbreaking Employer Cardiovascular Disease Risk Intelligence Platform, HeartRisk™

Cardio Diagnostics Holdings, Inc. Unveils Groundbreaking Employer Cardiovascular Disease Risk Intelligence Platform, HeartRisk™

Jan 4, 2024, 8:31 AM EST - 2 years ago

Cardio Diagnostics Holdings, Inc. Unveils Groundbreaking Employer Cardiovascular Disease Risk Intelligence Platform, HeartRisk™

American Medical Association (AMA) Grants Cardio Diagnostics a Dedicated CPT PLA Reimbursement Code for Epi+Gen CHD, an AI-powered Test for Assessing the Probability of a Heart Attack or Coronary Heart Disease Event

Jan 3, 2024, 8:31 AM EST - 2 years ago

American Medical Association (AMA) Grants Cardio Diagnostics a Dedicated CPT PLA Reimbursement Code for Epi+Gen CHD, an AI-powered Test for Assessing the Probability of a Heart Attack or Coronary Heart Disease Event

American Medical Association (AMA) Grants Cardio Diagnostics Holdings, Inc.'s AI-Powered Coronary Heart Disease Detection Test, PrecisionCHD, a Dedicated CPT PLA Reimbursement Code

Jan 2, 2024, 8:31 AM EST - 2 years ago

American Medical Association (AMA) Grants Cardio Diagnostics Holdings, Inc.'s AI-Powered Coronary Heart Disease Detection Test, PrecisionCHD, a Dedicated CPT PLA Reimbursement Code

Cardio Diagnostics Holdings, Inc. Appoints Biotechnology Investor, Executive & Serial Entrepreneur Paul Burton to its Board of Directors

Dec 21, 2023, 9:21 AM EST - 2 years ago

Cardio Diagnostics Holdings, Inc. Appoints Biotechnology Investor, Executive & Serial Entrepreneur Paul Burton to its Board of Directors

Cardio Diagnostics Holdings, Inc. Regains Nasdaq Minimum Bid Price Requirement

Dec 6, 2023, 8:31 AM EST - 2 years ago

Cardio Diagnostics Holdings, Inc. Regains Nasdaq Minimum Bid Price Requirement

CORRECTING and REPLACING Cardio Diagnostics Holdings, Inc. Convenes Cardiovascular Care & Risk Roundtable at the 42nd Annual J.P. Morgan Healthcare Conference

Dec 4, 2023, 5:38 PM EST - 2 years ago

CORRECTING and REPLACING Cardio Diagnostics Holdings, Inc. Convenes Cardiovascular Care & Risk Roundtable at the 42nd Annual J.P. Morgan Healthcare Conference

Cardio Diagnostics Holdings, Inc's Convenes Cardiovascular Care & Risk Roundtable at the 42nd Annual J.P. Morgan Healthcare Conference

Dec 4, 2023, 8:31 AM EST - 2 years ago

Cardio Diagnostics Holdings, Inc's Convenes Cardiovascular Care & Risk Roundtable at the 42nd Annual J.P. Morgan Healthcare Conference

American Medical Association is Reviewing Cardio Diagnostics Holdings, Inc's Integrated Epigenetic-Genetic Cardiovascular Medicine Tests for CPT PLA Codes

Nov 28, 2023, 8:31 AM EST - 2 years ago

American Medical Association is Reviewing Cardio Diagnostics Holdings, Inc's Integrated Epigenetic-Genetic Cardiovascular Medicine Tests for CPT PLA Codes

Cardio Diagnostics Holdings, Inc. Announces Breakthrough in Coronary Heart Disease Detection with PrecisionCHD Test, Published in the Journal of the American Heart Association

Nov 20, 2023, 8:31 AM EST - 2 years ago

Cardio Diagnostics Holdings, Inc. Announces Breakthrough in Coronary Heart Disease Detection with PrecisionCHD Test, Published in the Journal of the American Heart Association

Family Medicine Specialists Selects Cardio Diagnostics' Epigenetic-Genetic Tests for Assessing Heart Attack Risk for its BlueCross BlueShield Patients

Nov 7, 2023, 9:01 AM EST - 2 years ago

Family Medicine Specialists Selects Cardio Diagnostics' Epigenetic-Genetic Tests for Assessing Heart Attack Risk for its BlueCross BlueShield Patients

Cardio Diagnostics Holdings, Inc Receives Innovative Technology Contract from Vizient for Its Novel AI-Driven Precision Heart Disease Tests – Epi+Gen CHD & PrecisionCHD

Oct 31, 2023, 9:01 AM EDT - 2 years ago

Cardio Diagnostics Holdings, Inc Receives Innovative Technology Contract from Vizient for Its Novel AI-Driven Precision Heart Disease Tests – Epi+Gen CHD & PrecisionCHD

Cardio Diagnostics Holdings, Inc and Aimil Ltd Join Forces to Introduce Cardiovascular Epigenetic Technologies to India

Oct 17, 2023, 9:01 AM EDT - 2 years ago

Cardio Diagnostics Holdings, Inc and Aimil Ltd Join Forces to Introduce Cardiovascular Epigenetic Technologies to India

Cardio Diagnostics Holdings, Inc Launches New Lab and Fulfillment Center, Paving Way for Expanded Testing Capacity, Reduced Costs, Reduced Turnaround Time and Improved Margins

Oct 12, 2023, 8:30 AM EDT - 2 years ago

Cardio Diagnostics Holdings, Inc Launches New Lab and Fulfillment Center, Paving Way for Expanded Testing Capacity, Reduced Costs, Reduced Turnaround Time and Improved Margins

Cardio Diagnostics Publishes Novel and Scalable Pathways to Enhance Global Coronary Heart Disease Care through Precision Epigenetics in Epigenomics

Sep 20, 2023, 9:01 AM EDT - 2 years ago

Cardio Diagnostics Publishes Novel and Scalable Pathways to Enhance Global Coronary Heart Disease Care through Precision Epigenetics in Epigenomics

Cardio Diagnostics Holdings, Inc. and Truckers Health Network Enter Into a Strategic Collaboration to Accelerate Cardiovascular Health Initiatives in the Trucking Industry

Sep 7, 2023, 9:01 AM EDT - 2 years ago

Cardio Diagnostics Holdings, Inc. and Truckers Health Network Enter Into a Strategic Collaboration to Accelerate Cardiovascular Health Initiatives in the Trucking Industry

Cardio Diagnostics Holdings, Inc Partners with Ascension Borgess Hospital's Heart Attack Prevention Clinic on Coronary Artery Disease Study

Sep 6, 2023, 9:16 AM EDT - 2 years ago

Cardio Diagnostics Holdings, Inc Partners with Ascension Borgess Hospital's Heart Attack Prevention Clinic on Coronary Artery Disease Study

Organized
Organized Jan. 14 at 2:21 AM
$CDIO
0 · Reply
Organized
Organized Jan. 14 at 2:21 AM
$CDIO
0 · Reply
VibraniumClaw
VibraniumClaw Jan. 14 at 2:00 AM
[{@CoralSharkie playing chess while others playing checkers 😮‍❄️ Different vision. Different execution. If you’re not paying attention, you’re behind. One follow = clarity… Real ones already know 💎 $PMW.X $BBAI $MGRX $CDIO ~ on watch as well.
0 · Reply
Redsox1975
Redsox1975 Jan. 13 at 10:54 PM
$CDIO same social media posts over and over from these scumbags at cardio such a fraud
0 · Reply
Trader1141
Trader1141 Jan. 13 at 10:23 PM
$CDIO fck you!!! Buying more!!
0 · Reply
Redsox1975
Redsox1975 Jan. 13 at 9:29 PM
$CDIO bankruptcy soon
0 · Reply
Redsox1975
Redsox1975 Jan. 13 at 8:56 PM
$CDIO timberrrrrr 1.50 tomorrow
0 · Reply
Trader1141
Trader1141 Jan. 13 at 8:17 PM
$CDIO when you least expect it
2 · Reply
Redsox1975
Redsox1975 Jan. 13 at 8:17 PM
$CDIO .06 stock
0 · Reply
Trader1141
Trader1141 Jan. 13 at 8:17 PM
$CDIO so when is the turnaround on this d@mn thing???
0 · Reply
Organized
Organized Jan. 13 at 6:56 PM
$CDIO The market does the opposite of what you think a lot of times.
0 · Reply
Organized
Organized Jan. 13 at 6:55 PM
$CDIO This will probably Skyrocket! 🚀
0 · Reply
TIGHTSTOPLOSS
TIGHTSTOPLOSS Jan. 13 at 5:24 PM
$CDIO Bottom is in target will be $2.34 out
0 · Reply
Redsox1975
Redsox1975 Jan. 13 at 4:18 PM
$CDIO $4 on india news premarket to 1.85 filthy
0 · Reply
Coupedayville
Coupedayville Jan. 13 at 4:10 PM
$CDIO Sums up this play!
0 · Reply
Redsox1975
Redsox1975 Jan. 13 at 2:45 PM
$CDIO new all time low today tomorrow thursday and friday guaranteed
0 · Reply
Redsox1975
Redsox1975 Jan. 13 at 2:44 PM
$CDIO how much revenues from the ymca in tennessee? none these scumbags have never sold a test scam they do no business
0 · Reply
Redsox1975
Redsox1975 Jan. 13 at 2:40 PM
$CDIO how low today under $1 soon
0 · Reply
TIGHTSTOPLOSS
TIGHTSTOPLOSS Jan. 13 at 2:25 PM
$CDIO Looking for $2.35 Exit from here +15% Gain 🚀
1 · Reply
Organized
Organized Jan. 13 at 1:26 PM
$CDIO
0 · Reply
Organized
Organized Jan. 13 at 1:25 PM
$CDIO here we go! 🚀
0 · Reply
TIGHTSTOPLOSS
TIGHTSTOPLOSS Jan. 13 at 1:03 PM
$CDIO Broke the downtrend 🚀
0 · Reply