Dec. 29 at 10:50 PM
$BYSI
‘Anti- Parasitic’
Many human illnesses are misdiagnosed…
Parasites 🦠 are the true problem..
Everything’s a lie in the matrix of lies..
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
2024, Bioorganic Chemistry
Magdalena Podolak, ... Anna Bielawska
3.1 Candidates in current clinical trials
Compounds classified to the clinical trials confirmed good anticancer properties of this group. Plinabulin (BPI-2358, Fig. 17) which is in the third phase of clinical trials has proven antitumor activity [119,120] through the colchicine-site microtubule-destabilizing effect [121]. From the chemical point of view, Plinabulin is a synthetic derivative of the natural product phenylahistin which is isolated from Aspergillus species [122]. Furthermore, a combination of plinabulin and docetaxel cause reduced side effects such as neutropenia, which are induced during the docetaxel monotherapy treatment [123].