Jul. 10 at 1:10 PM
$AVDL Taking market share away from xywav. Lawsuit overhang is pretty much removed. xywav did 1.4B, 30% on IH label. 225m is estimated for 2025 for LUMRYZ. Lumryz is slowly but surely taking market share.
Xywav
Q4 2024: ~14,150 active Xywav patients, with ~525 net adds in the quarter
Q1 2025: Patient base grew to ~14,600, adding ~450 net patients, including 325 IH patients, resulting in 4,225 IH and 10,375 narcolepsy patients
Q4 2024 → Q1 2025: +525 + 450 = ~975 patients added.
Run-rate suggests adding ~450–525 patients each quarter → projected ~16,400–17,150 patients by year-end.
LUMRYZ
Q4 2024: Base of 2,500 patients on therapy
Q1 2025: Grew to 2,800 patients, meaning +300 net adds in the quarter—a 50% increase from Q4 .
Guidance from Avadel expects 3,400–3,600 patients by end of 2025, implying another 600–800 net adds across
Jazz should be concerned about IH indication in 2026 competition.
Discontinuation is similar although there's some debate around it.