Jul. 25 at 3:56 AM
$ATNM
TUMOR TYPE 1 — NSCLC (EGFR, KRAS, HER3-high)
HERTHENA:
• Shows HER3 expression in EGFR/KRAS tumors
• Produces partial responses
• Resistance → HER3 ↑ + CDCP1 ↑
ATNM‑400:
• Follows with alpha radioconjugate
• Kills EGFR/KRAS clones regardless of mutation
• Kills ADC-resistant cells
• Kills hypoxic cores
Sequence:
HERTHENA signal → ATNM‑400 salvage → ATNM‑400 mid-line → ATNM‑400 front
TUMOR TYPE 2 — Breast (ER+/HER2-, HER2-low, ADC-failed)
HERTHENA:
• Shows HER3 expression in endocrine-resistant tumors
• ADC resistance → HER3 ↑ + CDCP1 ↑
ATNM‑400:
• Kills HER3/CDCP1-high salvage population
• Kills ADC-resistant clones
• Works post-Etcamah, post-Truqap, post-PARP
Sequence:
HERTHENA signal → ATNM‑400 salvage → ATNM‑400 mid-line → ATNM‑400 frontline
TUMOR TYPE 3 — Prostate (PSMA-negative, HER3-high)
HERTHENA:
• Maps HER3 expression in PSMA-negative disease
• ADC resistance → HER3 ↑
ATNM‑400:
• Kills PSMA-negative tumors
• Kills HER3/CDCP1-high clones