May. 4 at 11:18 PM
$ZNTL
Taking a deeper dive into WEE1 gene inhibitor which blocks the G2/M checkpoint in certain ovarian cancers. From what I know/have learned, high grade serous ovarian cancer (HGSOC) significantly relies on WEE1 because they already live in a state of constant replication stress. Need to learn more of why this is. Yearly new ovarian cancer diagnosis in USA number 15k – 20k of which many will become platinum resistant. Current treatment is suboptimal, and none targets WEE1 (ie low ORR, ~4–13% & short DOR in PROC).
I think there is something here… Any initial reactions about this pursuit?
Stay longs & disciplined my friends!