Jan. 8 at 2:25 PM
$TLSI This is mouse data only using Nelitolimod (SD-101). It is reported by a group of Chinese researchers. The mechanism of action is interesting.
Quote
Here, we developed a novel whole-cell vaccine, termed MDLSD, by combining mitoxantrone (MTX)-induced ICD with the TLR9 agonist SD-101. In murine Lewis lung carcinoma (LLC) models, MDLSD demonstrated superior prophylactic and therapeutic efficacy. Mechanistically, MTX-induced dying tumor cells (MDL) promoted dendritic cell (DC) phagocytosis, while the addition of SD-101 was essential for driving complete DC maturation through potent upregulation of CD80.
https://www.sciencedirect.com/science/article/abs/pii/S1567576925021411