Aug. 5 at 12:54 AM
$NWBO The trend was not positive for DCVax-L, the trend was towards harm. That is true for both PFS, and likely OS.
In addition to the median (23.1 months blended, 22.4 months DCVax-L), another OS data point is 36 month landmark survival. For the blended population, the 36 month survival was 28.2% (2018 Liau presentation). For the DCVax-L arm the 36 month survival was 20.2% (Zoom 2022 meeting).
Yes, one was from surgery and the other from randomization three months later, but the trend to harm in ITT survival for DCVax-L is undeniable.
I'll take that a step further, with an OS HR of 1.09 (mOS for placebo 24.5 months vs. DCVax-L 22.4 months), 2:1 randomization and assuming proportional hazards, the p-value on OS would be stat sig with 280 events. That is stat sig favoring placebo. If not, we can say, at the least, a strong trend favoring placebo was observed.
Yeah, something tells me they're not going to show the OS data!