Feb. 18 at 4:31 PM
$IFRX ABVX just passed
$10B mcap, primarily based on the success of a p3 study in UC using their once a day oral, obefazimod – impressive for a small biotech out of France, founded in 2013. Another drug that games the immune system (vs fixing what’s broken), this one toying with intracellular signaling to artificially boost cytokine dampening, primarily affecting TNF, IL-6, and IL-17 production.
Considering that hyperactive neutrophils are the primary drivers of tissue damage in UC, amplifying epithelial injury and sustaining the dreaded feedback loop as seen in many other diseases, wouldn’t it be great if there was a drug that actually fixes what’s broken: hyperactive neutrophils.
Another small non-US based biotech, InflaRx, was founded in 2007. Going after UC such a risk?
$10B vs
$0.06B. Nonsense.
https://finviz.com/quote.ashx?t=ABVX&ty=c&ta=1&p=m
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70056