Jun. 4 at 3:28 PM
$CLLS
🧬 How to unlock safer gene therapies with non-viral technology? 🧬
Gene editing holds incredible promise for treating diseases like cancer, autoimmune disorders, and genetic conditions by precisely modifying disease-related genes.
But traditional methods using viral vectors - tools that deliver new DNA into cells - face challenges, like inserting genes in unpredictable spots, which can harm cells, or complex manufacturing processes.
Our research, presented at #ASGCT2025, explores a safer, more precise approach using TALEN® gene editing with non-viral single-stranded DNA (ssDNA).
✂️ Think of TALEN® as molecular scissors that cut DNA exactly where needed. Then, a circular ssDNA template (CssDNA) acts like a precise instruction manual, guiding new genetic material into that spot to restore or enhance cell functions - such as enabling immune cells to target cancer.
