Market Cap 2.86B
Revenue (ttm) 781.37M
Net Income (ttm) -197.88M
EPS (ttm) N/A
PE Ratio 74.35
Forward PE N/A
Profit Margin -25.32%
Debt to Equity Ratio 1.13
Volume 2,804,900
Avg Vol 2,938,842
Day's Range N/A - N/A
Shares Out 126.53M
Stochastic %K 73%
Beta 0.31
Analysts Strong Sell
Price Target $33.95

Company Profile

Apellis Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of novel therapeutic compounds to treat diseases with high unmet needs. It offers EMPAVELI for the treatment of paroxysmal nocturnal hemoglobinuria; and SYFOVRE for treating geographic atrophy secondary to age-related macular degeneration and geographic atrophy (GA). The company also develops EMPAVELI to treat C3 glomerulopathy and immune complex membranoproli...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 977 5700
Website: apellis.com
Address:
100 Fifth Avenue, Waltham, United States
Georgeson
Georgeson Feb. 2 at 7:30 PM
$APLS Maybe apls will do something similar to reverse CHMP's initial rejection: https://www.biospace.com/press-releases/press-release-sanofis-rezurock-recommended-for-eu-approval-by-the-chmp-to-treat-chronic-graft-vs-host-disease
0 · Reply
SigmaStrategist
SigmaStrategist Feb. 2 at 2:37 PM
$EOSE $APLS Energy storage innovation contrasts clinical biotech risk
0 · Reply
Night_Owl_Biotech
Night_Owl_Biotech Jan. 31 at 5:17 PM
Change in share price YTD for all comm'l-stage non-oncology focused bios with market caps of $1 to $5.5B. $OCUL is the worst performer YTD. It appears a rumored Sanofi acq north of the $16/share offered last September fizzled out. Recall Sanofi announced it was buying DVAX last December. Only 10 of 171 new comm'l-stage non-oncology focused bios went to to create meaningful gains for S/Hs by staying independent (0 of 61 in oncology). M&A exits are, overwhelmingly, best for S/Hs historically $TARS If anyone can explain what's happened here it would be appreciated. Was it the JPM exclusion? The insider sales? The last TARS press release is dated 11/24/25 (2 months ago). We bought TARS last summer for $40 ish then sold in the high $50 s only to see TARS run to $80 $TVTX appears to trade @ reasonable multiples after the FDA extended the FSGS PDUFA back 3 months. $LGND investors often cite TVTX's royalties due. There's uncertainty but... Again, $APLS ? This is not investment advice. Just sharing
1 · Reply
RunnerSignals
RunnerSignals Jan. 29 at 10:07 PM
Is your portfolio ready for 94% upside? $CRCL $APLS $AMPX $INSM $GRAB are flashing huge buy signals https://stocksrunner.com/news/2026-01-29-today-stock-upgrade-analysis
1 · Reply
ronaldo7
ronaldo7 Jan. 29 at 2:46 PM
$APLS Sold yesterday and made over $15K in 16 days, thank you APLs
0 · Reply
sepsis74
sepsis74 Jan. 29 at 2:24 PM
$APLS S&P SmallCap 600 constituent Advanced Energy Industries Inc. (NASD: AEIS) will replace Comerica Inc. (NYSE: CMA) in the S&P MidCap 400, and Apellis Pharmaceuticals Inc. (NASD: APLS) will replace Advanced Energy Industries in the S&P SmallCap 600 effective prior to the opening of trading on Monday, February 2. S&P 500 constituent Fifth Third Bancorp (NASD: FITB) is acquiring Comerica in a deal expected to be completed soon, pending final closing conditions.
0 · Reply
Jockne40
Jockne40 Jan. 28 at 3:16 PM
$APLS this company is ripe for hedge fund to buy big stake and push them to be bought out by big pharmaceutical. Their two drugs they have don’t make sense to be owned by them for sales
0 · Reply
Jockne40
Jockne40 Jan. 28 at 3:14 PM
$APLS buyout?
0 · Reply
JFais
JFais Jan. 28 at 3:08 PM
$APLS - I like the strength, good sign each time the stock is shaking off these gap downs on stagnant Syfovre sales (Empaveli takes center stage)
1 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Jan. 27 at 4:10 PM
$APLS RSI: 41.40, MACD: -0.7433 Vol: 2.40, MA20: 23.21, MA50: 22.85 🟢 BUY - Uptrend + healthy RSI 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
Latest News on APLS
Apellis Valuation Ignores Empaveli Potential, Says Analyst

Jan 21, 2026, 1:14 PM EST - 12 days ago

Apellis Valuation Ignores Empaveli Potential, Says Analyst


Apellis Pharmaceuticals: The Picture Becomes Clearer

Aug 1, 2025, 2:29 PM EDT - 6 months ago

Apellis Pharmaceuticals: The Picture Becomes Clearer


Apellis Pharmaceuticals: Have Some Patience

May 20, 2025, 9:28 AM EDT - 9 months ago

Apellis Pharmaceuticals: Have Some Patience


Apellis Announces Craig Wheeler to Join the Board of Directors

Apr 21, 2025, 7:00 AM EDT - 10 months ago

Apellis Announces Craig Wheeler to Join the Board of Directors


FDA Reviews Kidney Disease Drug From Apellis Pharmaceuticals

Apr 1, 2025, 2:11 PM EDT - 10 months ago

FDA Reviews Kidney Disease Drug From Apellis Pharmaceuticals


Apellis Pharmaceuticals: A Mixed Bag

Mar 5, 2025, 2:06 PM EST - 11 months ago

Apellis Pharmaceuticals: A Mixed Bag


Georgeson
Georgeson Feb. 2 at 7:30 PM
$APLS Maybe apls will do something similar to reverse CHMP's initial rejection: https://www.biospace.com/press-releases/press-release-sanofis-rezurock-recommended-for-eu-approval-by-the-chmp-to-treat-chronic-graft-vs-host-disease
0 · Reply
SigmaStrategist
SigmaStrategist Feb. 2 at 2:37 PM
$EOSE $APLS Energy storage innovation contrasts clinical biotech risk
0 · Reply
Night_Owl_Biotech
Night_Owl_Biotech Jan. 31 at 5:17 PM
Change in share price YTD for all comm'l-stage non-oncology focused bios with market caps of $1 to $5.5B. $OCUL is the worst performer YTD. It appears a rumored Sanofi acq north of the $16/share offered last September fizzled out. Recall Sanofi announced it was buying DVAX last December. Only 10 of 171 new comm'l-stage non-oncology focused bios went to to create meaningful gains for S/Hs by staying independent (0 of 61 in oncology). M&A exits are, overwhelmingly, best for S/Hs historically $TARS If anyone can explain what's happened here it would be appreciated. Was it the JPM exclusion? The insider sales? The last TARS press release is dated 11/24/25 (2 months ago). We bought TARS last summer for $40 ish then sold in the high $50 s only to see TARS run to $80 $TVTX appears to trade @ reasonable multiples after the FDA extended the FSGS PDUFA back 3 months. $LGND investors often cite TVTX's royalties due. There's uncertainty but... Again, $APLS ? This is not investment advice. Just sharing
1 · Reply
RunnerSignals
RunnerSignals Jan. 29 at 10:07 PM
Is your portfolio ready for 94% upside? $CRCL $APLS $AMPX $INSM $GRAB are flashing huge buy signals https://stocksrunner.com/news/2026-01-29-today-stock-upgrade-analysis
1 · Reply
ronaldo7
ronaldo7 Jan. 29 at 2:46 PM
$APLS Sold yesterday and made over $15K in 16 days, thank you APLs
0 · Reply
sepsis74
sepsis74 Jan. 29 at 2:24 PM
$APLS S&P SmallCap 600 constituent Advanced Energy Industries Inc. (NASD: AEIS) will replace Comerica Inc. (NYSE: CMA) in the S&P MidCap 400, and Apellis Pharmaceuticals Inc. (NASD: APLS) will replace Advanced Energy Industries in the S&P SmallCap 600 effective prior to the opening of trading on Monday, February 2. S&P 500 constituent Fifth Third Bancorp (NASD: FITB) is acquiring Comerica in a deal expected to be completed soon, pending final closing conditions.
0 · Reply
Jockne40
Jockne40 Jan. 28 at 3:16 PM
$APLS this company is ripe for hedge fund to buy big stake and push them to be bought out by big pharmaceutical. Their two drugs they have don’t make sense to be owned by them for sales
0 · Reply
Jockne40
Jockne40 Jan. 28 at 3:14 PM
$APLS buyout?
0 · Reply
JFais
JFais Jan. 28 at 3:08 PM
$APLS - I like the strength, good sign each time the stock is shaking off these gap downs on stagnant Syfovre sales (Empaveli takes center stage)
1 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Jan. 27 at 4:10 PM
$APLS RSI: 41.40, MACD: -0.7433 Vol: 2.40, MA20: 23.21, MA50: 22.85 🟢 BUY - Uptrend + healthy RSI 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
TickrTalk0007
TickrTalk0007 Jan. 25 at 4:48 PM
$APLS is as stale as milk on a porch in summer
1 · Reply
Whiskeyunderthebed
Whiskeyunderthebed Jan. 23 at 3:17 AM
$APLS LOL!-They are hiring a director of compensation at a tune of $220-270K- when the stock has underperformed by 45% last year and continues to languish. This is the spending that continues at the country club.
2 · Reply
philosophernutz
philosophernutz Jan. 22 at 4:18 AM
$APLS Management needs to learn how to under promise and over deliver. The fact that they're in year 3 and refuse to provide guidance, the mofos on wall street will continue to have wild expectations and APLS will continue to miss and disappoint quarter after quarter.
1 · Reply
Capitulation_0
Capitulation_0 Jan. 21 at 6:47 PM
$APLS I likr r/r here
0 · Reply
Ohzipit
Ohzipit Jan. 21 at 3:25 PM
$APLS $IBB $MIRM $NBI $XBI IMO Mirum has consistently under promised and over delivered Apellis has done the opposite. $APLS was trading in the low $90S in anticipation of Syfovre approval now has 3 drugs approved commercially and sits @$21. It has been a “wait until next quarter “ for far too long. There is value and eventually they will execute or be purchased. GL
0 · Reply
TickrTalk0007
TickrTalk0007 Jan. 21 at 1:51 PM
$APLS this turd is old and boring like a white liberal woman
1 · Reply
notreload_ai
notreload_ai Jan. 21 at 11:06 AM
Bank of America upgraded $APLS to Buy, citing undervalued shares and strong early uptake of Empaveli in rare kidney diseases. https://notreload.xyz/bofa-upgrades-apellis-as-empaveli-gains-traction/
1 · Reply
Spanner1968
Spanner1968 Jan. 20 at 5:47 PM
$APLS I never learn to take the profit! POS.... I hope the board see's the light and tells Cedric to do one!
2 · Reply
scott52
scott52 Jan. 20 at 2:40 PM
$APLS And the beat down goes on. No bottom in sight.
0 · Reply
Night_Owl_Biotech
Night_Owl_Biotech Jan. 19 at 5:19 PM
Analysts forecast $APLS to generate roughly 40% more in annual revenues than $MIRM over the next 10 years. Both comm'l-stage bios generate, more or less, the same gross profit margins & have the same cash/debt profiles yet APLS trades at roughly half MIRM's market cap. The attached graph shows the revenues analysts project & the raw data is provided at the bottom. This is not to bash MIRM but to highlight APLS. MIRM has generated meaningful gains for shareholders over the last 6 months & we assume MIRM revenue estimates reflect the Bluejay acquisition. APLS is trading near 52 week lows. We're considering an APLS purchase for our investment club so any input from APLS bulls or bears would be genuinely appreciated (without bashing management). We're simply trying to understand the risk v reward profile (see our recent post v FOLD). $XBI $IBB $NBI
3 · Reply
Whiskeyunderthebed
Whiskeyunderthebed Jan. 16 at 8:25 PM
$APLS complete DOG SHIT!
1 · Reply
Bolekjol
Bolekjol Jan. 16 at 7:37 PM
$APLS don’t even bother PR the eu approval 😅
1 · Reply