Spruce Biosciences Inc (SPRB)

$84.00 +0.26 (0.31%)
Market Cap 89.63M
Revenue (ttm) 4.91M
Net Income (ttm) -53.04M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -1,080.24%
Debt to Equity Ratio 0.10
Volume 14,200
Avg Vol 144,908
Day's Range N/A - N/A
Shares Out 1.07M
Stochastic %K 64%
Beta 3.45
Analysts Strong Sell
Price Target $213.00

Company Profile

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, includ...

Industry: Biotechnology
Sector: Healthcare
Phone: 415 655 4168
Address:
611 Gateway Boulevard, Suite 740, South San Francisco, United States
WallStreetBuyDip
WallStreetBuyDip Dec. 25 at 1:58 AM
$SPRB Massive volume spike today with 14,206 shares traded compared to the average of 146,304. Price has been quite volatile swinging between $7 and $2463.75 recently. With such extreme price movements and low volume today, it might be wise to wait for a lower H% before considering an entry.
0 · Reply
BanditQ
BanditQ Dec. 24 at 10:30 PM
$BHVN $CAPR $SPRB , $SRPT Martin shkreli's bagholder army getting bigger and bigger. Fkn losers
2 · Reply
opmankc
opmankc Dec. 24 at 10:15 PM
$OMER remember $SPRB ? both are 3-4bn mkt cap company
0 · Reply
LeaRoss
LeaRoss Dec. 24 at 4:17 PM
$SPRB microcap biotech barely trades asymmetry extreme with volume
0 · Reply
Benalish
Benalish Dec. 24 at 3:37 PM
$OMER Martin Skreli may put up a big bullish call soon! $SPRB
0 · Reply
SuperGreenToday
SuperGreenToday Dec. 24 at 12:57 PM
$SPRB
0 · Reply
FloatGlowCore_1416
FloatGlowCore_1416 Dec. 23 at 1:26 PM
$SPRB low attention microcap, quiet accumulation is the tell and volume ignition is the tell louder
0 · Reply
notreload_ai
notreload_ai Dec. 23 at 12:20 PM
Oppenheimer initiates coverage of $SPRB with an Outperform rating, citing strong FDA signals, accelerated approval potential, and possible acquisition interest from $BMRN https://notreload.xyz/oppenheimer-starts-coverage-on-spruce-biosciences-with-bullish-outlook/
0 · Reply
DARKP00L
DARKP00L Dec. 23 at 11:52 AM
$SPRB 06:41 on Dec. 23 2025 Oppenheimer Initiates Coverage On Spruce Biosciences with Outperform Rating, Announces Price Target of $283 #tradeideas
0 · Reply
JarvisFlow
JarvisFlow Dec. 23 at 11:42 AM
Oppenheimer has adjusted their stance on Spruce Biosciences ( $SPRB ), setting the rating to Outperform with a target price of 283.
0 · Reply
Latest News on SPRB
Spruce Biosciences Appoints Proven Pharmaceutical Commercial Leader Keli Walbert to Board of Directors

Dec 15, 2025, 8:00 AM EST - 10 days ago

Spruce Biosciences Appoints Proven Pharmaceutical Commercial Leader Keli Walbert to Board of Directors

Spruce Biosciences Reports Third Quarter 2025 Financial Results and Provides Corporate Updates

Nov 10, 2025, 4:05 PM EST - 6 weeks ago

Spruce Biosciences Reports Third Quarter 2025 Financial Results and Provides Corporate Updates

Spruce: BTD For TA-ERT For MPS IIIB Could Ignite BLA Submission With Added Bonuses (Rating Upgrade)

Oct 7, 2025, 10:38 AM EDT - 2 months ago

Spruce: BTD For TA-ERT For MPS IIIB Could Ignite BLA Submission With Added Bonuses (Rating Upgrade)

This Biotech Stock Soared 1,400%. Investors Are Optimistic About Its Rare-Disease Drug.

Oct 7, 2025, 9:44 AM EDT - 2 months ago

This Biotech Stock Soared 1,400%. Investors Are Optimistic About Its Rare-Disease Drug.

Spruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB)

Oct 6, 2025, 8:00 AM EDT - 2 months ago

Spruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB)

Spruce Biosciences Resumes Trading on the Nasdaq Capital Market

Sep 15, 2025, 7:00 AM EDT - 3 months ago

Spruce Biosciences Resumes Trading on the Nasdaq Capital Market

WallStreetBuyDip
WallStreetBuyDip Dec. 25 at 1:58 AM
$SPRB Massive volume spike today with 14,206 shares traded compared to the average of 146,304. Price has been quite volatile swinging between $7 and $2463.75 recently. With such extreme price movements and low volume today, it might be wise to wait for a lower H% before considering an entry.
0 · Reply
BanditQ
BanditQ Dec. 24 at 10:30 PM
$BHVN $CAPR $SPRB , $SRPT Martin shkreli's bagholder army getting bigger and bigger. Fkn losers
2 · Reply
opmankc
opmankc Dec. 24 at 10:15 PM
$OMER remember $SPRB ? both are 3-4bn mkt cap company
0 · Reply
LeaRoss
LeaRoss Dec. 24 at 4:17 PM
$SPRB microcap biotech barely trades asymmetry extreme with volume
0 · Reply
Benalish
Benalish Dec. 24 at 3:37 PM
$OMER Martin Skreli may put up a big bullish call soon! $SPRB
0 · Reply
SuperGreenToday
SuperGreenToday Dec. 24 at 12:57 PM
$SPRB
0 · Reply
FloatGlowCore_1416
FloatGlowCore_1416 Dec. 23 at 1:26 PM
$SPRB low attention microcap, quiet accumulation is the tell and volume ignition is the tell louder
0 · Reply
notreload_ai
notreload_ai Dec. 23 at 12:20 PM
Oppenheimer initiates coverage of $SPRB with an Outperform rating, citing strong FDA signals, accelerated approval potential, and possible acquisition interest from $BMRN https://notreload.xyz/oppenheimer-starts-coverage-on-spruce-biosciences-with-bullish-outlook/
0 · Reply
DARKP00L
DARKP00L Dec. 23 at 11:52 AM
$SPRB 06:41 on Dec. 23 2025 Oppenheimer Initiates Coverage On Spruce Biosciences with Outperform Rating, Announces Price Target of $283 #tradeideas
0 · Reply
JarvisFlow
JarvisFlow Dec. 23 at 11:42 AM
Oppenheimer has adjusted their stance on Spruce Biosciences ( $SPRB ), setting the rating to Outperform with a target price of 283.
0 · Reply
LowFloatOnly
LowFloatOnly Dec. 22 at 4:36 PM
$SUGP $6 , 500k float Hit the treshold (Shorts fails to deliver list) which means dangerously shorted, , same list as $SMX & $SPRB They squeezed 10.000 % Also on watch $HXHX $SIDU today good vol https://www.nasdaqtrader.com/trader.aspx?id=RegSHOThreshold
1 · Reply
notreload_ai
notreload_ai Dec. 22 at 3:38 PM
$ZBIO , $SPRB , $CNTX , $OVID ... Citi, H.C. Wainwright, JonesResearch, and LifeSci Capital share new ratings and price targets on Zenas BioPharma, Spruce Biosciences, Context Therapeutics, and Ovid Therapeutics. https://notreload.xyz/biotech-stocks-update-zbio-sprb-cntx-ovid-ratings/
0 · Reply
JarvisFlow
JarvisFlow Dec. 22 at 11:32 AM
HC Wainwright & Co. has updated their rating for Spruce Biosciences ( $SPRB ) to Buy with a price target of 220.
0 · Reply
BanditQ
BanditQ Dec. 22 at 6:42 AM
$SPRB lots of "people" bagholding this trash
0 · Reply
ShakeThatMoneyMaker
ShakeThatMoneyMaker Dec. 17 at 8:08 PM
$SPRB down another 10% today to 70 dollars
0 · Reply
thegreatkaspi
thegreatkaspi Dec. 15 at 6:52 PM
$SPRB $NOV $PFE $CVS
0 · Reply
G_man318
G_man318 Dec. 15 at 6:17 PM
$SPRB https://www.businesswire.com/news/home/20251215189566/en/ Lets go!!! Also, took a position with $OWPC soon to be Isiah Thomas Enterprises, headquartered in Troy, Michigan. https://www.nasdaq.com/press-release/one-world-products-become-isiah-enterprises-targets-december-operational-breakeven
0 · Reply
Anxious_Carpenter
Anxious_Carpenter Dec. 15 at 5:33 PM
$RADX wait for shkreli throw $300 PT on it just like $SPRB
1 · Reply
Goldengun23
Goldengun23 Dec. 15 at 5:27 PM
$PCSA outstanding shares becomes roughly 2 mil Positive news (FDA Update is supposed to happen this month) could make this jump crazy. But RS fuckin sucks. $SPRB saw a RS before rocketing. Conflicted.
0 · Reply
Boellie
Boellie Dec. 14 at 9:36 AM
$SPRB $GALT Is the next big move
0 · Reply
ignoreo
ignoreo Dec. 14 at 9:07 AM
$SPRB volume + better-than-expected (at time of volume) raise says 50s are the floor
0 · Reply
DD_First
DD_First Dec. 13 at 3:40 PM
$SPRB $NOV $PFE $CVS A Measles Outbreak Brings With It Echoes of the Pandemic In South Carolina. Parents struggle to deal with infections that have brought quarantines and remote learning. Health care workers are bracing for an increase in cases. https://www.nytimes.com/2025/12/13/us/a-measles-outbreak-brings-with-it-echoes-of-the-pandemic.html?unlocked_article_code=1.8U8.YBCu.QaQhFSPyCdpo
1 · Reply