Spruce Biosciences Inc (SPRB)

$53.58 +3.86 (7.76%)
Market Cap 53.22M
Revenue (ttm) 4.91M
Net Income (ttm) -53.04M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -1,080.24%
Debt to Equity Ratio 0.10
Volume 41,300
Avg Vol 41,286
Day's Range N/A - N/A
Shares Out 1.07M
Stochastic %K 14%
Beta 3.52
Analysts Strong Sell
Price Target $225.50

Company Profile

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, includ...

Industry: Biotechnology
Sector: Healthcare
Phone: 415 655 4168
Address:
611 Gateway Boulevard, Suite 740, South San Francisco, United States
MochiMeerkat
MochiMeerkat Feb. 23 at 5:39 PM
.@SqueezeSharkie moving different. .Ice-cold vision, pure substance. Costs you nothing but a tap, follow him now!! $TOVX $SPRB $IPHA $EVGN *^
0 · Reply
_EmproX
_EmproX Feb. 23 at 4:21 PM
$PXS $SPRB $AAOI $AGRZ +•+•
0 · Reply
Benalish
Benalish Feb. 23 at 3:09 AM
$SPRB
0 · Reply
PortfolioObelisk
PortfolioObelisk Feb. 20 at 2:04 PM
$SPRB Spruce Biosciences develops endocrine therapies. Clinical validation drives valuation. Early-stage risk remains high.
0 · Reply
ILuvbiotech
ILuvbiotech Feb. 20 at 5:24 AM
$SPRB Many people became millionaires holding this, the next runner is $NWBO
3 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Feb. 20 at 12:45 AM
$SPRB RSI: 29.11, MACD: -5.7053 Vol: 10.30, MA20: 75.80, MA50: 79.01 🟢 BUY - Uptrend + healthy RSI 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
theflynews
theflynews Feb. 19 at 5:06 PM
Biotech Alert: Searches spiking for these stocks today - $SPRB - https://legacy.thefly.com/permalinks/entry.php/id4296596
0 · Reply
TheBasedTrader
TheBasedTrader Feb. 19 at 4:14 PM
$SPRB one last major bullet going in. +300 shares totaling 600.
0 · Reply
ErikTon
ErikTon Feb. 19 at 2:39 PM
$SPRB going to 45$
0 · Reply
Benalish
Benalish Feb. 19 at 2:11 PM
$SPRB HC Wainwright drops PT by 10% exactly how much it should have dropped, not 40% lol
0 · Reply
Latest News on SPRB
Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)

Feb 18, 2026, 7:00 AM EST - 5 days ago

Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)

Spruce Biosciences to Participate in the Oppenheimer 36th Annual Healthcare Life Sciences Conference

Feb 17, 2026, 4:05 PM EST - 6 days ago

Spruce Biosciences to Participate in the Oppenheimer 36th Annual Healthcare Life Sciences Conference

Long-Term Data Presented at the 22nd Annual WORLDSymposium™ Highlights Tralesinidase Alfa Enzyme Replacement Therapy's Potential as the First Disease-Modifying Treatment Option for Sanfilippo Syndrome Type B (MPS IIIB)

Feb 5, 2026, 4:05 PM EST - 18 days ago

Long-Term Data Presented at the 22nd Annual WORLDSymposium™ Highlights Tralesinidase Alfa Enzyme Replacement Therapy's Potential as the First Disease-Modifying Treatment Option for Sanfilippo Syndrome Type B (MPS IIIB)

Spruce Biosciences Adds Regulatory and Clinical Development Expertise to Leadership Team

Feb 3, 2026, 8:00 AM EST - 20 days ago

Spruce Biosciences Adds Regulatory and Clinical Development Expertise to Leadership Team

Spruce Biosciences Announces Data Presentations at the 22nd Annual WORLDSymposium™

Jan 28, 2026, 8:00 AM EST - 26 days ago

Spruce Biosciences Announces Data Presentations at the 22nd Annual WORLDSymposium™

Harbour BioMed Acquires Common Stock in Spruce Biosciences, Deepening Strategic Collaboration

Jan 18, 2026, 7:02 PM EST - 5 weeks ago

Harbour BioMed Acquires Common Stock in Spruce Biosciences, Deepening Strategic Collaboration

Spruce Biosciences Secures Up to $50 Million in Growth Capital from Avenue Capital

Jan 8, 2026, 8:00 AM EST - 6 weeks ago

Spruce Biosciences Secures Up to $50 Million in Growth Capital from Avenue Capital

Spruce Biosciences Appoints Proven Pharmaceutical Commercial Leader Keli Walbert to Board of Directors

Dec 15, 2025, 8:00 AM EST - 2 months ago

Spruce Biosciences Appoints Proven Pharmaceutical Commercial Leader Keli Walbert to Board of Directors

Spruce Biosciences Reports Third Quarter 2025 Financial Results and Provides Corporate Updates

Nov 10, 2025, 4:05 PM EST - 3 months ago

Spruce Biosciences Reports Third Quarter 2025 Financial Results and Provides Corporate Updates

Spruce: BTD For TA-ERT For MPS IIIB Could Ignite BLA Submission With Added Bonuses (Rating Upgrade)

Oct 7, 2025, 10:38 AM EDT - 4 months ago

Spruce: BTD For TA-ERT For MPS IIIB Could Ignite BLA Submission With Added Bonuses (Rating Upgrade)

This Biotech Stock Soared 1,400%. Investors Are Optimistic About Its Rare-Disease Drug.

Oct 7, 2025, 9:44 AM EDT - 4 months ago

This Biotech Stock Soared 1,400%. Investors Are Optimistic About Its Rare-Disease Drug.

Spruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB)

Oct 6, 2025, 8:00 AM EDT - 5 months ago

Spruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB)

Spruce Biosciences Resumes Trading on the Nasdaq Capital Market

Sep 15, 2025, 7:00 AM EDT - 5 months ago

Spruce Biosciences Resumes Trading on the Nasdaq Capital Market

MochiMeerkat
MochiMeerkat Feb. 23 at 5:39 PM
.@SqueezeSharkie moving different. .Ice-cold vision, pure substance. Costs you nothing but a tap, follow him now!! $TOVX $SPRB $IPHA $EVGN *^
0 · Reply
_EmproX
_EmproX Feb. 23 at 4:21 PM
$PXS $SPRB $AAOI $AGRZ +•+•
0 · Reply
Benalish
Benalish Feb. 23 at 3:09 AM
$SPRB
0 · Reply
PortfolioObelisk
PortfolioObelisk Feb. 20 at 2:04 PM
$SPRB Spruce Biosciences develops endocrine therapies. Clinical validation drives valuation. Early-stage risk remains high.
0 · Reply
ILuvbiotech
ILuvbiotech Feb. 20 at 5:24 AM
$SPRB Many people became millionaires holding this, the next runner is $NWBO
3 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Feb. 20 at 12:45 AM
$SPRB RSI: 29.11, MACD: -5.7053 Vol: 10.30, MA20: 75.80, MA50: 79.01 🟢 BUY - Uptrend + healthy RSI 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
theflynews
theflynews Feb. 19 at 5:06 PM
Biotech Alert: Searches spiking for these stocks today - $SPRB - https://legacy.thefly.com/permalinks/entry.php/id4296596
0 · Reply
TheBasedTrader
TheBasedTrader Feb. 19 at 4:14 PM
$SPRB one last major bullet going in. +300 shares totaling 600.
0 · Reply
ErikTon
ErikTon Feb. 19 at 2:39 PM
$SPRB going to 45$
0 · Reply
Benalish
Benalish Feb. 19 at 2:11 PM
$SPRB HC Wainwright drops PT by 10% exactly how much it should have dropped, not 40% lol
0 · Reply
DARKP00L
DARKP00L Feb. 19 at 12:20 PM
$SPRB 07:14 on Feb. 19 2026 HC Wainwright & Co. Maintains Buy on Spruce Biosciences, Lowers Price Target to $200 #tradeideas
0 · Reply
Benalish
Benalish Feb. 19 at 4:01 AM
$SPRB
0 · Reply
Benalish
Benalish Feb. 19 at 3:26 AM
$SPRB https://finance.yahoo.com/news/coty-downgraded-spruce-biosciences-initiated-143317044.html
0 · Reply
Aawilliam2003
Aawilliam2003 Feb. 18 at 11:54 PM
$SPRB long bag holding wait from here
0 · Reply
mikesterz7
mikesterz7 Feb. 18 at 9:32 PM
$SPRB Spruce Biosciences now anticipates making the submission for TA-ERT in the fourth quarter of 2026 to accommodate the clinical and other requirements flagged by the FDA in meetings.
0 · Reply
GilbJohn
GilbJohn Feb. 18 at 8:52 PM
$SPRB 0.70 protected repeatedly. That’s structural support. 0.79 already tested resistance. Float ~26% means elasticity both ways, but buyers showing up. Breakout candle could be 12%+ easy 🚀
0 · Reply
Benalish
Benalish Feb. 18 at 8:38 PM
$SPRB 9 month delay costs them around $10M in G&A expense, so you're talking maybe a 15% haircut. If the stock was at $80 before the delay, then 15% would put it at around $70. So if you can buy it at $55, that gives you around a 30% gain target when it heads back to $70.
0 · Reply
StocktwitsNews
StocktwitsNews Feb. 18 at 7:46 PM
SPRB Stock Drops After Company Pushes Back Application Submission Timeline For Experimental Sanfilippo Syndrome Therapy $SPRB $VXF https://stocktwits.com/news/equity/markets/sprb-stock-drops-after-company-pushes-back-application-submission-timeline-for-experimental-sanfilippo-syndrome-therapy/cZRKbNVR4vv
0 · Reply
Sympathy_Trader
Sympathy_Trader Feb. 18 at 3:40 PM
$CNSP $SNSE $SPRB
0 · Reply
ShakeThatMoneyMaker
ShakeThatMoneyMaker Feb. 18 at 2:45 PM
$SPRB POS stock, delaying again = more dilution meaning this will likely only go to 100 max for full approval
1 · Reply
Moneymike79
Moneymike79 Feb. 18 at 2:42 PM
$SPRB glad I got out wowie mowie
0 · Reply
perfectson
perfectson Feb. 18 at 2:06 PM
$SPRB obviously the delayed leaked, which explained the price action recently , which is typical bull crap. But there does seem to be aligned FDA expectations and that does seem bullish .
1 · Reply