Dec. 26 at 11:27 PM
$SGMO
A search on Nav 1.7 turned up something pretty interesting.
"Ihibition of Nav 1.7 reduces cancer cell migration, invasion and tumour growth."
"NaV1.7 (voltage-gated sodium channel 1.7) is a promising target for cancer treatment because its inhibition reduces cancer cell migration, invasion, and tumor growth, with research showing its overexpression in many cancers (like pancreatic, lung, thyroid, endometrial) linked to worse survival. Therapies focus on blocking NaV1.7 using small molecules, gene therapies (like RNA interference), or natural toxins, sometimes combined with chemotherapy, to stop cancer spread and manage cancer pain, a common side effect. "
"Gene Therapy: Using techniques like siRNA to temporarily repress the SCN9A gene (which codes for NaV1.7), showing promise in reducing invasion and increasing drug sensitivity."
"Dual Inhibition: Blocking NaV1.7 alongside other channels (like NCX1) to alleviate cancer-induced pain. "
More research required here. GLTA
