Jun. 25 at 11:06 PM
$KYTX mRNA CAR-T via nano lipids has been around since at least 2020.
https://pubs.acs.org/doi/10.1021/acs.nanolett.9b04246
The updated efficacy is very cool and promising but it’s extremely early and there’s nothing to suggest that it is more effective than
$RNAC s Descartes 08 mRNA solution.
mRNA also has its fair share of roadblocks and challenges as do DNA based solutions. For starters mRNA is likely just less effective, it’s hard to get an accurate number but it seems like it would be 30-60% less effective at reducing symptoms based on the preliminary data floating around. Next, it’s also not commercially viable “yet” as Cartesian has said themselves. Even if it’s outpatient it requires leukapheresis and then 6 weekly doses every 1-3 years. At current scales each mRNA shot is not cheap to produce. If it’s at production scale it’ll be
$10K per shot if not significantly more.
$60-
$100K per year of ongoing treatment plus 6 doctor visits is a lot
