Market Cap 277.21M
Revenue (ttm) 12.14M
Net Income (ttm) -99.50M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -819.60%
Debt to Equity Ratio 0.00
Volume 865,200
Avg Vol 345,342
Day's Range N/A - N/A
Shares Out 63.00M
Stochastic %K 49%
Beta 0.73
Analysts Strong Sell
Price Target $5.17

Company Profile

Prelude Therapeutics Incorporated, a clinical-stage precision oncology company, focuses on the discovery and development of novel precision cancer medicines to underserved patients. It is developing JAK2V617F, a driver mutation product for the treatment of myeloproliferative neoplasms, myelofibrosis (MF), polycythemia vera, and essential thrombocythemia (ET); KAT6A for the treatment of advanced breast cancer and other solid tumors; and mutated calreticulin degrader antibody conjugates to treat M...

Industry: Biotechnology
Sector: Healthcare
Phone: 302 467 1280
Address:
175 Innovation Boulevard, Wilmington, United States
RoyalImperial
RoyalImperial Apr. 24 at 9:37 PM
MITQ looking ready, keep eyes on this one. Latest news + contracts rolling in Low float (~sub 10M) NO dilution Record earnings trend 📈. MITQ super undervalued-The entire company trades at 5.5M. It’s sitting on $3.9M in cash. That means you’re effectively buying the entire operating business $18M+ in annual revenue, proprietary products. $SES $PRLD $NSRX $INEO ww..1
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vu_jade
vu_jade Apr. 24 at 7:34 PM
$PRLD Top two holders: Orbimed Baker Brothers Couple of retards
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Jaybird827
Jaybird827 Apr. 24 at 2:58 PM
$PRLD with all these shares being bought, how many shares can be remaining?
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kubota2323
kubota2323 Apr. 24 at 2:33 PM
$PRLD https://www.sec.gov/Archives/edgar/data/1678660/000094787126000461/xslF345X03/ownership.xml
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kubota2323
kubota2323 Apr. 24 at 2:27 PM
$PRLD Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total SEC Form 4 Bonita David P Director Apr 21 '26 Buy 4.44 2,815,315 12,499,999 11,808,945 Apr 23 06:50 PM ORBIMED ADVISORS LLC Director Apr 21 '26 Buy 4.44 2,815,315 12,499,999 11,808,945 Apr 23 06:48 PM open in yahoo | open in reuters | open in marketwatch | open in google | open in EDGAR
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Biotech_Pharma_Investor
Biotech_Pharma_Investor Apr. 24 at 6:23 AM
$PRLD btw less partnerships is not necesarily a disantantage It could mean; (1) cleaner acquisition target (2) room for new partnerships while PRLD is at strentgh It could also mean that potential partners preferred other degrader companies. But this feels unlikely given the way PRLD is trading, recent PIPE and strong involvement by biotech specialists institutions. @LabPsycho
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Biotech_Pharma_Investor
Biotech_Pharma_Investor Apr. 24 at 6:17 AM
$PRLD So both top holding institution added (see Sec filings these days) in the offering led by RA Capital Both own >10% each. Orbimed owns 16% Baker Bors own 15.5% Incyte also has a good %
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NasdaqPulse
NasdaqPulse Apr. 23 at 11:33 PM
Insider Buy Alert $PRLD 👉Click to view @NasdaqPulse for timely updates amid the volatility. OrbiMed Advisors LLC (Director / 10% owner) just scooped up 2,815,315 shares at $4.44, building a ~$12.5M position. Stock is now trading around $4.55 — essentially right at their entry with immediate unrealized gain on tape. This is a serious healthcare-focused capital allocator stepping in aggressively on a beaten-down clinical-stage oncology name. Prelude Therapeutics ($PRLD) is a precision oncology biotech targeting high-unmet-need cancers. Pipeline highlights include JAK2V617F programs for myeloproliferative neoplasms (myelofibrosis, polycythemia vera, essential thrombocythemia) and KAT6A for advanced breast cancer. When 10% holders accumulate size like this, it often signals conviction ahead of potential clinical or strategic catalysts. Biotech remains high-volatility — but this is the kind of insider footprint traders keep on radar.
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DisneyPalaceTrades
DisneyPalaceTrades Apr. 22 at 11:28 PM
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LabPsycho
LabPsycho Apr. 21 at 2:34 PM
$PRLD @Biotech_Pharma_Investor Very informative post and follow up opinion. Is PRLD worth more than CCCC with 2X the cash and more partnerships and further along in the clinic? Only if PRLD turns out to be like early stage and equally confusing ERAS IMO. Good luck
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Latest News on PRLD
Prelude Therapeutics Transcript: Conference

Mar 10, 2026, 3:25 PM EDT - 6 weeks ago

Prelude Therapeutics Transcript: Conference


Prelude Therapeutics Earnings Call Transcript: Q3 2025

Nov 12, 2025, 8:00 AM EST - 5 months ago

Prelude Therapeutics Earnings Call Transcript: Q3 2025


Prelude Therapeutics Announces Strategic Business Update

Nov 4, 2025, 7:05 AM EST - 6 months ago

Prelude Therapeutics Announces Strategic Business Update


Prelude Announces Presentations at 2025 AACR Annual Meeting

Apr 25, 2025, 4:05 PM EDT - 1 year ago

Prelude Announces Presentations at 2025 AACR Annual Meeting


Prelude Therapeutics Transcript: Study Update

Sep 13, 2024, 12:00 PM EDT - 1 year ago

Prelude Therapeutics Transcript: Study Update


Prelude Therapeutics Announces $25 Million Private Placement

Dec 11, 2023, 9:34 AM EST - 2 years ago

Prelude Therapeutics Announces $25 Million Private Placement


RoyalImperial
RoyalImperial Apr. 24 at 9:37 PM
MITQ looking ready, keep eyes on this one. Latest news + contracts rolling in Low float (~sub 10M) NO dilution Record earnings trend 📈. MITQ super undervalued-The entire company trades at 5.5M. It’s sitting on $3.9M in cash. That means you’re effectively buying the entire operating business $18M+ in annual revenue, proprietary products. $SES $PRLD $NSRX $INEO ww..1
0 · Reply
vu_jade
vu_jade Apr. 24 at 7:34 PM
$PRLD Top two holders: Orbimed Baker Brothers Couple of retards
0 · Reply
Jaybird827
Jaybird827 Apr. 24 at 2:58 PM
$PRLD with all these shares being bought, how many shares can be remaining?
0 · Reply
kubota2323
kubota2323 Apr. 24 at 2:33 PM
$PRLD https://www.sec.gov/Archives/edgar/data/1678660/000094787126000461/xslF345X03/ownership.xml
0 · Reply
kubota2323
kubota2323 Apr. 24 at 2:27 PM
$PRLD Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total SEC Form 4 Bonita David P Director Apr 21 '26 Buy 4.44 2,815,315 12,499,999 11,808,945 Apr 23 06:50 PM ORBIMED ADVISORS LLC Director Apr 21 '26 Buy 4.44 2,815,315 12,499,999 11,808,945 Apr 23 06:48 PM open in yahoo | open in reuters | open in marketwatch | open in google | open in EDGAR
0 · Reply
Biotech_Pharma_Investor
Biotech_Pharma_Investor Apr. 24 at 6:23 AM
$PRLD btw less partnerships is not necesarily a disantantage It could mean; (1) cleaner acquisition target (2) room for new partnerships while PRLD is at strentgh It could also mean that potential partners preferred other degrader companies. But this feels unlikely given the way PRLD is trading, recent PIPE and strong involvement by biotech specialists institutions. @LabPsycho
1 · Reply
Biotech_Pharma_Investor
Biotech_Pharma_Investor Apr. 24 at 6:17 AM
$PRLD So both top holding institution added (see Sec filings these days) in the offering led by RA Capital Both own >10% each. Orbimed owns 16% Baker Bors own 15.5% Incyte also has a good %
0 · Reply
NasdaqPulse
NasdaqPulse Apr. 23 at 11:33 PM
Insider Buy Alert $PRLD 👉Click to view @NasdaqPulse for timely updates amid the volatility. OrbiMed Advisors LLC (Director / 10% owner) just scooped up 2,815,315 shares at $4.44, building a ~$12.5M position. Stock is now trading around $4.55 — essentially right at their entry with immediate unrealized gain on tape. This is a serious healthcare-focused capital allocator stepping in aggressively on a beaten-down clinical-stage oncology name. Prelude Therapeutics ($PRLD) is a precision oncology biotech targeting high-unmet-need cancers. Pipeline highlights include JAK2V617F programs for myeloproliferative neoplasms (myelofibrosis, polycythemia vera, essential thrombocythemia) and KAT6A for advanced breast cancer. When 10% holders accumulate size like this, it often signals conviction ahead of potential clinical or strategic catalysts. Biotech remains high-volatility — but this is the kind of insider footprint traders keep on radar.
0 · Reply
DisneyPalaceTrades
DisneyPalaceTrades Apr. 22 at 11:28 PM
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LabPsycho
LabPsycho Apr. 21 at 2:34 PM
$PRLD @Biotech_Pharma_Investor Very informative post and follow up opinion. Is PRLD worth more than CCCC with 2X the cash and more partnerships and further along in the clinic? Only if PRLD turns out to be like early stage and equally confusing ERAS IMO. Good luck
1 · Reply
STACKD0E
STACKD0E Apr. 21 at 12:35 PM
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Biotech_Pharma_Investor
Biotech_Pharma_Investor Apr. 21 at 10:32 AM
$PRLD Share structure: • 80,971,642 shares • 2,252,252 new pre-funded warrants • 19,532,188 outstanding pre-funded warrants • 14,727,692 options with a weighted-average exercise price of $7.68 per share • 3,575,750 options with a weighted-average exercise price of $2.30 • 9,757,734 shares of common stock reserved for future issuance • around 500K unissued restricted stock units Accounting for common shares + prefunded warrants diluted share count is around 102,756,082. which ar $4.5 corresponds to $462M MC, vs estimated cash of around $170M (year-end cash + $85,949,756.80 proceeds from offering - estimated 1st quarter operating expenses). Guided runway into the second quarter of 2028 Seems expensive given stage of clinical development. But given assets with best-in-class potential in large TAMs + the ready-to-partner DAC platform + RA funding + $INCY partnership I am too stubborn to sell any).
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Biotech_Pharma_Investor
Biotech_Pharma_Investor Apr. 21 at 10:16 AM
$PRLD Around $20M of the $90M come from insiders
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Biotech_Pharma_Investor
Biotech_Pharma_Investor Apr. 21 at 7:41 AM
$PRLD next catalyst will be DAC partnership. Even though pipeline is early each asset has best-in-class potential in large TAMs RA funding (following Incyte partnership) further validates the potential. Recent expansion of $CCCC partnership with Roche also validates DAC interest. Not many public small/mid-cap DAC players $PRLD $CCCC $NRIX $GYRE (other?)
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KUMO2026
KUMO2026 Apr. 20 at 3:08 PM
$PRLD went short off algo trap
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moonmagic
moonmagic Apr. 20 at 2:52 PM
$PRLD 👀
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TheRealGreenBaron
TheRealGreenBaron Apr. 20 at 2:32 PM
$PRLD I'll give PRLD another hour to hit $5.10 to see if it's a Whale play today - in the mean time if you're watching energy stocks = massive trap today based on headlines from the ME - don't be fooled into chasing 'em. GLTA
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TheRealGreenBaron
TheRealGreenBaron Apr. 20 at 1:47 PM
$PRLD Right now she's coiling. But still weak a little bit (low volume) However, IF she can hit $5.50 then drop back to $5.30 - then our moon shot is officially on from there. We'll see. GLTA
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Jaybird827
Jaybird827 Apr. 20 at 1:45 PM
$PRLD so who bought the 18 million shares?
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OpenOutcrier
OpenOutcrier Apr. 20 at 12:54 PM
$PRLD (+12.8% pre) Prelude Therapeutics prices $90M stock offering at $4.44/share (2/2) https://ooc.bz/l/99288
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OpenOutcrier
OpenOutcrier Apr. 20 at 12:54 PM
$PRLD (+12.8% pre) Prelude Therapeutics Highlights Promising PRT13722 Preclinical Results (1/2) https://ooc.bz/l/99286
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Dizzier47
Dizzier47 Apr. 20 at 12:20 PM
$PRLD bruh no
1 · Reply