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Volume 9,700
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Company Profile

NeOnc Technologies Holdings, Inc., a clinical-stage biopharmaceutical company, focuses on developing treatments for intracranial malignancies. Its lead product candidates include NEO100, a purified form of preillyl acid that is in Phase IIa clinical trials for the treatment of glioblastoma; and NEO212, a covalently conjugated molecule combining chemotherapeutic drug temozolomide with perillyl alcohol that is in Phase I/II clinical trials for its oral administration to patients with primary and s...

Industry: Biotechnology
Sector: Healthcare
Phone: 310-663-7831
Address:
23975 Park Sorrento, Suite 205, Calabasas, United States
NeOnc_Technologies
NeOnc_Technologies Nov. 26 at 1:22 PM
$NTHI Amir Heshmatpour on recent completion of enrollment in pivotal NEO100 Phase 2a trial for IDH-1 mutant recurrent high-grade glioma and expectation of interim data readout in Q2 2026: “Having now completed full enrollment, we can comprehensively assess NEO100’s impact across a complete patient population. The strength of the data observed to date reinforces our confidence that our proprietary intranasal delivery platform — uniquely designed to bypass the blood-brain barrier represents a breakthrough approach for treating aggressive brain tumors. We believe these data will not only strengthen our clinical position but also strategically advance NeOnc toward becoming a global leader in CNS oncology innovation, with a first-mover advantage and a defensible moat protecting our extensive intellectual property portfolio.”
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BioTechHealthX
BioTechHealthX Nov. 26 at 5:29 AM
$NTHI NeOnc Technologies Holdings Inc. (OTC:NTHI) delivered a major breakthrough in CNS oncology with NEO100 showing a 21 percent response rate versus less than 8 percent historically, 44 percent six-month PFS, and 33 percent eighteen-month survival in recurrent high-grade gliomas. As NTHI advances toward a May 2026 top-line readout and a $50 million Middle East partnership, investor interest is surging. https://biotechhealthx.com/biotech-news/neonc-technologies-nthi-stuns-wall-street-with-breakthrough-21-response-rate-in-brain-cancer-trial/
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topstockalerts
topstockalerts Nov. 25 at 8:03 PM
Top Gainers PT2 $BNED $WSHP $NTHI $QNTM $KZIA
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topstockalerts
topstockalerts Nov. 25 at 7:51 PM
$NTHI It wants to move higher..
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50shadesoftrades
50shadesoftrades Nov. 25 at 7:33 PM
$CETY $CSTE $PAVS $DKI $NTHI Intraday gainers https://go.trade-ideas.com/SH16c
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NeOnc_Technologies
NeOnc_Technologies Nov. 25 at 8:22 AM
$NTHI NeOnc Technologies delivered a strong Q3 marked by strategic expansion in the Middle East, meaningful non-dilutive funding, enhanced market visibility, and strengthened leadership across both corporate and scientific fronts. Middle East Expansion: NuroMENA appointed His Highness Sheikh Nahyan bin Zayed Al Nahyan as Executive Chairman, signed an MSA with M42’s IROS, completed ADGM incorporation, and advanced a proposed $50M partnership with Quazar Investment. Non-Dilutive Funding: Awarded $2.5M in NIH STTR grants to advance NEO212 for gliomas and leukemia. Tech Expansion: Executed agreement to acquire advanced AI + 3D bioprinting IP. Media Visibility: Featured on Fox Business, Bloomberg TV, Yahoo Finance’s Trader Talk, a 12-part New to The Street campaign, and a live interview with Kenny Polcari. Index Inclusion: Added to the Russell Microcap® Index. IP Strength: Global patents protecting core CNS oncology assets. https://investors.neonc.com/news-releases/news-release-details/neonc-technologies-holdings-reports-third-quarter-2025-results
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AlertsAndNews
AlertsAndNews Nov. 25 at 3:31 AM
$NTHI insider action here Neonc Technologies Holdings, Inc.: Amir F. Heshmatpour (Director, President, 10%+) Buys 30,000 Shares @ Avg Price $6.16 – Form 4
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NeOnc_Technologies
NeOnc_Technologies Nov. 20 at 10:05 AM
$NTHI NeOnc Technologies Q3 2025 Financial Results & Operational Highlights NeOnc Technologies delivered a defining Q3 2025 Financial Results and Operational Highlights, advancing both clinical and strategic milestones: - G&A expenses: $903K vs. $244K in Q3 2024, reflecting expanded marketing, travel, and Middle East partnership-related costs. - R&D expenses: $715K vs. $957K in Q3 2024, supporting NEO100 trial site management, patient recruitment, NEO212 preparation, and initiation of NEO100-3. - Net loss: $8.6M ($0.45 per share) vs. $2.2M ($0.12 per share) in Q3 2024, primarily due to increased G&A and stock-based compensation. Amir Heshmatpour: “Q3 2025 positions NeOnc at the forefront of innovation in CNS oncology. We delivered encouraging Phase 2a NEO100 data, signaling a potential paradigm shift for recurrent high-grade gliomas. We also achieved FDA clearance for NEO212 Phase 2 trials, strengthening the depth and momentum of our pipeline.”
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NeOnc_Technologies
NeOnc_Technologies Nov. 18 at 10:04 AM
$NTHI Last week was an incredible week for NeOnc. We announced 3 milestones that together underscore our momentum and position us for meaningful value creation in the CNS oncology space: Updated NEO100 clinical results: In 24 patients with recurrent IDH1‑mutant high-grade gliomas, NEO100 showed a 21% radiographic response rate, 44% progression-free survival at 6 months, and 33% of patients alive at 18+ months. No significant chronic toxicity was observed. Full enrollment of pivotal Phase 2a trial: Our trial for recurrent IDH1-mutant high-grade gliomas is now fully enrolled. Interim data is expected in Q2 2026. Q3 2025 results & operational updates: $50M strategic partnership via NuroMENA, $2.5M in STTR grants to advance NEO212, and listing in the Russell Microcap® Index. Net loss of $8.6M reflects strategic investment in pipeline growth. This is only the beginning for NeOnc. We aim to transform CNS oncology and bring new hope to patients.
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NeOnc_Technologies
NeOnc_Technologies Nov. 17 at 11:35 PM
$NTHI NeOnc Technologies: Exciting Upcoming Catalysts • We’re entering a pivotal period for value creation with three major near-term milestones: • Q4 2025: Completion of NEO212 Phase I final cohort dosing. • May 2026: Top-line data readout from NEO100-01 pivotal Phase 2a trial. Near-term: Closing and funding of the $50M Quazar Investment, supporting our CNS oncology pipeline and strategic growth. These catalysts mark critical steps in advancing our mission to deliver innovative therapies for patients with challenging CNS cancers. #CNSOncology #ClinicalTrials #Biotech #Investors #NEO100 #NEO212
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Latest News on NTHI
NeOnc Technologies: From Survival Mode To Expansion Mode

Oct 9, 2025, 2:25 PM EDT - 7 weeks ago

NeOnc Technologies: From Survival Mode To Expansion Mode


CORRECTING and REPLACING - NeOnc Technologies Holdings, Inc.

Jul 23, 2025, 10:53 AM EDT - 4 months ago

CORRECTING and REPLACING - NeOnc Technologies Holdings, Inc.


NeOnc_Technologies
NeOnc_Technologies Nov. 26 at 1:22 PM
$NTHI Amir Heshmatpour on recent completion of enrollment in pivotal NEO100 Phase 2a trial for IDH-1 mutant recurrent high-grade glioma and expectation of interim data readout in Q2 2026: “Having now completed full enrollment, we can comprehensively assess NEO100’s impact across a complete patient population. The strength of the data observed to date reinforces our confidence that our proprietary intranasal delivery platform — uniquely designed to bypass the blood-brain barrier represents a breakthrough approach for treating aggressive brain tumors. We believe these data will not only strengthen our clinical position but also strategically advance NeOnc toward becoming a global leader in CNS oncology innovation, with a first-mover advantage and a defensible moat protecting our extensive intellectual property portfolio.”
0 · Reply
BioTechHealthX
BioTechHealthX Nov. 26 at 5:29 AM
$NTHI NeOnc Technologies Holdings Inc. (OTC:NTHI) delivered a major breakthrough in CNS oncology with NEO100 showing a 21 percent response rate versus less than 8 percent historically, 44 percent six-month PFS, and 33 percent eighteen-month survival in recurrent high-grade gliomas. As NTHI advances toward a May 2026 top-line readout and a $50 million Middle East partnership, investor interest is surging. https://biotechhealthx.com/biotech-news/neonc-technologies-nthi-stuns-wall-street-with-breakthrough-21-response-rate-in-brain-cancer-trial/
0 · Reply
topstockalerts
topstockalerts Nov. 25 at 8:03 PM
Top Gainers PT2 $BNED $WSHP $NTHI $QNTM $KZIA
0 · Reply
topstockalerts
topstockalerts Nov. 25 at 7:51 PM
$NTHI It wants to move higher..
0 · Reply
50shadesoftrades
50shadesoftrades Nov. 25 at 7:33 PM
$CETY $CSTE $PAVS $DKI $NTHI Intraday gainers https://go.trade-ideas.com/SH16c
0 · Reply
NeOnc_Technologies
NeOnc_Technologies Nov. 25 at 8:22 AM
$NTHI NeOnc Technologies delivered a strong Q3 marked by strategic expansion in the Middle East, meaningful non-dilutive funding, enhanced market visibility, and strengthened leadership across both corporate and scientific fronts. Middle East Expansion: NuroMENA appointed His Highness Sheikh Nahyan bin Zayed Al Nahyan as Executive Chairman, signed an MSA with M42’s IROS, completed ADGM incorporation, and advanced a proposed $50M partnership with Quazar Investment. Non-Dilutive Funding: Awarded $2.5M in NIH STTR grants to advance NEO212 for gliomas and leukemia. Tech Expansion: Executed agreement to acquire advanced AI + 3D bioprinting IP. Media Visibility: Featured on Fox Business, Bloomberg TV, Yahoo Finance’s Trader Talk, a 12-part New to The Street campaign, and a live interview with Kenny Polcari. Index Inclusion: Added to the Russell Microcap® Index. IP Strength: Global patents protecting core CNS oncology assets. https://investors.neonc.com/news-releases/news-release-details/neonc-technologies-holdings-reports-third-quarter-2025-results
0 · Reply
AlertsAndNews
AlertsAndNews Nov. 25 at 3:31 AM
$NTHI insider action here Neonc Technologies Holdings, Inc.: Amir F. Heshmatpour (Director, President, 10%+) Buys 30,000 Shares @ Avg Price $6.16 – Form 4
0 · Reply
NeOnc_Technologies
NeOnc_Technologies Nov. 20 at 10:05 AM
$NTHI NeOnc Technologies Q3 2025 Financial Results & Operational Highlights NeOnc Technologies delivered a defining Q3 2025 Financial Results and Operational Highlights, advancing both clinical and strategic milestones: - G&A expenses: $903K vs. $244K in Q3 2024, reflecting expanded marketing, travel, and Middle East partnership-related costs. - R&D expenses: $715K vs. $957K in Q3 2024, supporting NEO100 trial site management, patient recruitment, NEO212 preparation, and initiation of NEO100-3. - Net loss: $8.6M ($0.45 per share) vs. $2.2M ($0.12 per share) in Q3 2024, primarily due to increased G&A and stock-based compensation. Amir Heshmatpour: “Q3 2025 positions NeOnc at the forefront of innovation in CNS oncology. We delivered encouraging Phase 2a NEO100 data, signaling a potential paradigm shift for recurrent high-grade gliomas. We also achieved FDA clearance for NEO212 Phase 2 trials, strengthening the depth and momentum of our pipeline.”
0 · Reply
NeOnc_Technologies
NeOnc_Technologies Nov. 18 at 10:04 AM
$NTHI Last week was an incredible week for NeOnc. We announced 3 milestones that together underscore our momentum and position us for meaningful value creation in the CNS oncology space: Updated NEO100 clinical results: In 24 patients with recurrent IDH1‑mutant high-grade gliomas, NEO100 showed a 21% radiographic response rate, 44% progression-free survival at 6 months, and 33% of patients alive at 18+ months. No significant chronic toxicity was observed. Full enrollment of pivotal Phase 2a trial: Our trial for recurrent IDH1-mutant high-grade gliomas is now fully enrolled. Interim data is expected in Q2 2026. Q3 2025 results & operational updates: $50M strategic partnership via NuroMENA, $2.5M in STTR grants to advance NEO212, and listing in the Russell Microcap® Index. Net loss of $8.6M reflects strategic investment in pipeline growth. This is only the beginning for NeOnc. We aim to transform CNS oncology and bring new hope to patients.
0 · Reply
NeOnc_Technologies
NeOnc_Technologies Nov. 17 at 11:35 PM
$NTHI NeOnc Technologies: Exciting Upcoming Catalysts • We’re entering a pivotal period for value creation with three major near-term milestones: • Q4 2025: Completion of NEO212 Phase I final cohort dosing. • May 2026: Top-line data readout from NEO100-01 pivotal Phase 2a trial. Near-term: Closing and funding of the $50M Quazar Investment, supporting our CNS oncology pipeline and strategic growth. These catalysts mark critical steps in advancing our mission to deliver innovative therapies for patients with challenging CNS cancers. #CNSOncology #ClinicalTrials #Biotech #Investors #NEO100 #NEO212
0 · Reply
NeOnc_Technologies
NeOnc_Technologies Nov. 16 at 1:33 PM
$NTHI “Completing enrollment for our Phase 2a trial marks a defining inflection point for NeOnc Technologies,” said Amir Heshmatpour, Executive Chairman, President & CEO. This milestone follows the Company’s recent announcement of positive results from a 24-patient cohort treated with NEO100. The findings were presented to the investment community during NeOnc’s November 12, 2025, investor conference call, which is available for replay at: https://www.webcaster5.com/Webcast/Page/3151/53234
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NeOnc_Technologies
NeOnc_Technologies Nov. 14 at 9:32 PM
$NTHI Q3 reflects a development-stage company allocating resources to advance its two core CNS-oncology programs. The company reported no product revenue, as expected, and directed spending toward clinical operations, trial support, and the infrastructure required for upcoming milestones. Q3 expenses reflect continued investment in R&D and clinical infrastructure. Operating costs also include non-cash items tied to stock-based compensation and uplisting-related obligations. The company ended the quarter with ~$1.5M in cash and continued using its equity facilities to support operations—standard for a clinical-stage biotech preparing for multiple data points. Looking Ahead NeOnc enters Q4 focused on clinical execution, data generation, and resource management. The most relevant indicators remain the progress of NEO100 and NEO212 as the company advances toward its next set of data-driven inflection points.
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NeOnc_Technologies
NeOnc_Technologies Nov. 13 at 11:13 AM
$NTHI Amir F. Heshmatpour, Executive Chairman, President & CEO of NeOnc Technologies, stated: “With these data, we believe NeOnc stands at the threshold of a true game-changer for one of medicine’s greatest unmet needs—recurrent IDH1-mutant hi grade gliomas. For the first time, we’re witnessing evidence of meaningful radiographic responses and support for durable survival in patients who previously had few, if any, options. As we approach full enrollment of the NEO100 trial—and our full data readout six months post-enrollment—we believe this may represent a potential paradigm shift in the treatment of brain cancer. The data will speak for itself—and for the patients whose lives we are determined to transform.” Mr. Heshmatpour added: “We view this trial as a pivotal value inflection point for NeOnc and for the broader neuro-oncology field signaling a potential move beyond palliation toward measurable, durable disease control and a possible new standard of care in malignant gliomas.”
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NeOnc_Technologies
NeOnc_Technologies Nov. 12 at 4:00 PM
$NTHI Incredible Milestone News: NeOnc Technologies Reports Updated Clinical Results Results of Clinical Trials Provide Evidence Supporting Significant Radiographic Response and Potential Long-Term Survival in Recurrent Grade III/IV IDH1-Mutant Astrocytoma Treated with Intranasal NEO100 https://finance.yahoo.com/news/neonc-technologies-reports-updated-clinical-130000491.html
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jdlman
jdlman Nov. 11 at 10:10 PM
$NTHI nice day
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NeOnc_Technologies
NeOnc_Technologies Nov. 11 at 11:00 AM
$NTHI In just 3 hours from now, NeOnc Technologies will host an investor conference call and webcast at 9:00 AM EST to present data updates from the ongoing NEO100-1 phase 1/2a clinical trial and compassionate use program. Watch the live webcast at the following link: https://www.webcaster5.com/Webcast/Page/3151/53234
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NeOnc_Technologies
NeOnc_Technologies Nov. 10 at 10:12 AM
$NTHI NeOnc Technologies will host an investor conference call and webcast on Wednesday, November 12, 2025, at 9:00 AM EST, to present data updates from ongoing NEO100-1 phase 1/2a clinical trial and compassionate use program. Featured Participants: • Dr. Henry S. Friedman, MD – Deputy Director, Preston Robert Tisch Brain Tumor Center, Duke University; Independent Member, NTHI Scientific Advisory Board • Dr. Alexander Miller, MD – Chief Neuro-oncology, Brain Tumor Program, NYU Langone Health; Independent Member, NTHI Scientific Advisory Board • Amir Heshmatpour – Chief Executive Officer, Executive Chairman and President • Dr. Thomas C. Chen, MD, PhD – Chief Medical Officer and Chief Scientific Officer • Dr. Josh Neman, PhD – Chief Clinical Officer • Keith Garnett – Chief Financial Officer Conference Call Details: Date: Wednesday, November 12, 2025 Time: 6:00 a.m. PT / 9:00 a.m. ET Webcast: https://www.webcaster5.com/Webcast/Page/3151/53234
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NeOnc_Technologies
NeOnc_Technologies Nov. 9 at 9:36 AM
$NTHI “It has been the honor of a lifetime to found NeOnc and lead it to this pivotal stage, and I have the utmost confidence that Amir is the ideal leader to steer the company into its future,” said Dr. Thomas Chen, Founder, CMO and CSO of NeOnc. “His proven expertise in corporate strategy, capital formation, and global business development is precisely what NeOnc needs as we advance our lead candidates toward commercialization. This transition allows me to dedicate my full attention to what I am most passionate about: accelerating our clinical trials and driving the science that has the potential to transform outcomes for patients with brain cancer.”
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NeOnc_Technologies
NeOnc_Technologies Nov. 6 at 9:50 AM
$NTHI NeOnc Technologies Appoints Amir Heshmatpour as Chief Executive Officer to Drive Next Phase of Clinical and Corporate Growth Dr. Thomas Chen, the company's founder, will transition from the CEO role to focus exclusively on his positions as Chief Medical Officer, Chief Scientific Officer, and member of the Board of Directors, ensuring his continued leadership over NeOnc's innovative scientific strategy and clinical development. https://www.globenewswire.com/news-release/2025/11/04/3180411/0/en/NeOnc-Technologies-Appoints-Amir-Heshmatpour-as-Chief-Executive-Officer-to-Drive-Next-Phase-of-Clinical-and-Corporate-Growth.html
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U_rappoport
U_rappoport Nov. 5 at 2:39 PM
$NTHI this level of transparency 🙌
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NeOnc_Technologies
NeOnc_Technologies Nov. 5 at 12:52 PM
$NTHI At NeOnc Technologies, our world-class leadership team unites scientific innovation with strategic vision to transform brain and central nervous system therapeutics. Led by Executive Chairman Amir Heshmatpour and Founder & CEO Dr. Thomas Chen, alongside CFO Keithly A. Garnett and Chief Clinical Officer Dr. Josh Neman, our leaders bring deep expertise in science, medicine, and business. Guided by a distinguished Board and Scientific Advisory Board, including leading clinicians and researchers such as Dr. David Ashley, Dr. Henry Friedman, and Dr. Steven Giannotta, we are pioneering new standards of care for patients worldwide. Our mission is clear: advance groundbreaking therapies, deliver meaningful patient outcomes, and create lasting value for all stakeholders.
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NeOnc_Technologies
NeOnc_Technologies Nov. 4 at 1:31 PM
$NTHI October has been an exciting month for NeOnc Technologies, marked by three significant announcements: • NuroMENA Signs Master Services Agreement with M42’s IROS and Expands Board of Directors: Our subsidiary, NuroMENA, strengthened its strategic footprint through this agreement, positioning us for accelerated growth and innovation. • His Highness Sheikh Nahyan bin Zayed Al Nahyan Assumes Executive Chairmanship of NeOnc Technologies’ Subsidiary: Strengthening UAE-US collaboration to advance breakthrough brain cancer treatment. • Appointment of Dr. David M. Ashley to Scientific Advisory Board: Dr. Ashley, Director of the Preston Robert Tisch Brain Tumor Center at Duke, joined our Scientific Advisory Board, bringing unparalleled expertise in neuro-oncology research and clinical practice. • Appointment of Dr. Alexandra M. Miller to Scientific Advisory Board: Dr. Miller joined our Scientific Advisory Board, further strengthening our leadership in cutting-edge brain tumor research.
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