Aug. 4 at 2:04 PM
$BLRX New Phase IV trial for Aphexda, will be conducted at Emory University in Atlanta. The PARADE trial.
https://clinicaltrials.gov/study/NCT07101445
One of the side effects of Aphexda is injection site reactions. Currently, patients are given a premedication regimen with dexamethasone to help reduce the incidence of injection site reactions.
However, dexamethasone is associated with other side effects like headache, difficulty sleeping, high blood glucose, high blood pressure, mood changes, fluid retention, and infection. This trial will test whether replacing dexamethasone with methylprednisolone in the premedication regimen will help reduce Aphexda-related injection site reactions while also avoiding other side effects related to dexamethasone.
94 patients expected to enroll. Primary completion expected in Dec 2025, with study completion expected in Dec 2026.
