Sep. 9 at 7:35 PM
$BCTX The Data Safety Monitoring Board (or IDMC / DSMB) is an independent multidisciplinary group (typically biostatisticians and clinical specialists) that reviews unblinded interim analyses. Because the sponsor and trial investigators remain blinded to prevent bias, only the IDMC / DSMB evaluates whether pre-specified statistical stopping boundaries (e.g., O'Brien-Fleming or Pocock boundaries for efficacy, conditional power/stochastic curtailment for futility) have been crossed. The IDMC / DSMB then issues a formal recommendation to the sponsor to stop, modify, or continue the study.
Let's hope that efficacy is the result at the end of day.
