CoffeeRocks
Oct 7, 6:16 PM
$BCTX
Bria-IMT™ (lead candidate): In an ongoing pivotal Phase 3 trial (Bria-ABC / NCT06072612) for metastatic breast cancer, testing Bria-IMT ± immune checkpoint inhibitor vs. physician’s choice. The combination regimen has FDA Fast Track designation. An independent Data Safety Monitoring Board (DSMB) has repeatedly recommended the trial continue without modifications (most recent public updates in 2026). Overall survival is the primary endpoint, with an interim analysis planned after 144 deaths. 
• Bria-BRES+™: FDA cleared the IND in May 2026, allowing initiation of a Phase 1/2a study in metastatic breast cancer. This is a next-generation personalized, off-the-shelf cell-based immunotherapy building on the Bria-OTS platform. 
• Bria-PROS+™: FDA cleared the IND in August 2026, enabling a Phase 1/2a study in prostate cancer. It is also a next-generation personalized immunotherapy; the program previously received a
$2M NCI grant. 
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