Market Cap 44.62M
Revenue (ttm) 0.00
Net Income (ttm) -24.59M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 169,300
Avg Vol 286,964
Day's Range N/A - N/A
Shares Out 19.49M
Stochastic %K 27%
Beta 1.65
Analysts Strong Sell
Price Target $11.67

Company Profile

Annovis Bio, Inc., a clinical stage drug platform company, develops drugs to treat neurodegeneration in the United States. The company's lead product candidate is Buntanetap, which is in phase 2/3 to treat alzheimer's disease, as well as in phase 3 to treat parkinson's disease; and is in phase 2 clinical trial to treat lewy body dementia. It also develops ANVS405, which is in phase 2 and 3 clinical trials for the treatment of traumatic brain injury and/or stroke; and ANVS301, which finished phas...

Industry: Biotechnology
Sector: Healthcare
Phone: 484 875 3192
Address:
101 Lindenwood Drive, Suite 225, Malvern, United States
5DollarNana
5DollarNana Sep. 7 at 3:20 AM
$ANVS Maria is scamming you all. Trying to get you to buy more stocks so she can dilute it because no other company or investor wants to work with her. Worst investment ever. Pretty much leaving my money in there cause it’s already a loss. Anyways beware. Dont jump into this one
0 · Reply
ReturnOfEsquire
ReturnOfEsquire Sep. 6 at 6:17 PM
$ANVS Prediction: AD trial, if it ever fully enrolls, will be marred by error or failure to meet primary endpoint. I hope I'm wrong, but I think safe money stays away from this company. Unless you are looking for a lotto play, I say look elsewhere.
1 · Reply
ForestFoxes
ForestFoxes Sep. 6 at 3:22 PM
While I can appreciate your resolute belief in $ANVS and Dr. Maccecchini @ILikeDaStocks and the company's statements, past and present ... what I can share with you is that if you are indeed open to a balanced research of the Annovis Bio that you will find discrepancies and out right lies being stated the the CEO. I am not saying that these were just omissions and/or errors, but that some of her statements ARE lies. I’ve going to tag $AVXL since your original post refers to ANVS’ CEO basically saying that her Rx is better than AVXL’s Rx and let AVXL-Longs communicate with you on this matter. Yes, Dr. Maccecchini believes that her Rx is better than AVXL’s as well as any other on the planet as seen by her response to @ReturnOfEsquire “our drug looks more promising than any Alzheimer drug on the market or in development": https://stocktwits.com/MaccM/message/606412928 I’m also going to tag Dr. Maria Maccecchini directly via @MaccM because you feel that the “CEO feeling unappreciated for her success thus far, and bit insecure in her role …” referring to your original post. I don't think, Dr. Maccecchini, is the least bit insecure in any matters running her company. She has repeated taken the helm as her own CFO again and again and again. She also believes that she is very, very good at designing drug trials and states this publicly. She is also so confident that so doesn’t believe she needs a single MD on her team. She’s basically the perfect package for ANVS-Longs who she hope will go out into the with devotion of spread her gossip. (I am tempted to retract this last sentence, but re-reading your post I don’t think it’s inappropriate and is worthy of reflecting on generically for all investors in this space. Additionally, your post was tagged “Bullish” indicting the likelihood that you were seeking debate as opposed to engagement. Hopefully, AVXL-Longs can provide you the DD supporting their thesis vs. ANVS, which in my opinion should includes factors beyond science alone.) Whether you believe any of this or not is only “partially" relevant. I wish I could state that the ONLY thing that mattered are the "entities that specialize in this CNS sector are quite knowledgeable and cautious with their capital. Dr. Maria Maccecchini is over stating her case by continuously making the suggestion that other companies are purposefully closing their eyes to possibilities outside of the amyloid theory and hence missing out on her 900% certain drug." That quote is from an earlier post of mine: https://stocktwits.com/ForestFoxes/message/609179296 But I know that Dr. Maccecchini cannot advance her TBI or LBD pipeline. She has at the moment abandoned her pursuit of Parkinson's with the story line that her success with Alzheimer's will save the company (plus, some other excuses about Shorts being means and thoughtless and hating grandparents, etc.) There is virtually zero prospect that any functional or financially solvent company or entity that specializes in this space will partner with Annovis Bio. Going forward it's all going to be dilutive AND a full focus by Dr. Maccecchini to induce novice biotech investors and patients to buy her stock. Her statement published on October 1, 2024, "I will raise money at 30 cents with 100% warrant coverage" is a peek of the future and an affirmation that ONLY Retail money matters to Dr. Maccecchini. P.S. Dr. Maccecchini was repeatedly made aware in written communications that her statement "Buntanetap is the ONLY drug to attack multiple neurotoxic proteins simultaneously" yet persisted in using her byline despite knowing this fact. If she is so knowledgeable about this space as many ANVS-Long give her credit for, then it is absolutely IMPOSSIBLE for her to have NOT known this lie that she used for years to help sell her stock.
4 · Reply
pound69
pound69 Sep. 5 at 8:18 PM
$ANVS Another insider buy https://www.sec.gov/Archives/edgar/data/1290208/000110465925080981/xslF345X05/tm2523925-1_4seq1.xml
0 · Reply
ILikeDaStocks
ILikeDaStocks Sep. 5 at 8:17 PM
$ANVS @ForestFoxes FF is not happy with Maria and ANVS, so I'd like to ask her the following... 😁 Is it possible that your observations of ANVS could have been of a CEO feeling unappreciated for her success thus far, and a bit insecure in her role as chief? You previously mentioned her saying something along the lines of, "Our drug is better than Blarcamesine (AVXL) and their market cap is many times ours." My opinion: If Buntanetap is as various ANVS news releases have described, then --IT IS-- head and shoulders above Blarcamesine! So, is Maria simply pushing things beyond your comfort zone (aka: more than normal) while potentially having a strong and unappreciated drug candidate for the treatment of neurodegenerative disease? Would like to hear your response. Thank you.
0 · Reply
pound69
pound69 Sep. 5 at 8:17 PM
$ANVS stop buying Mr Hoffman, give retail a chance to scoop up! https://www.sec.gov/Archives/edgar/data/1477845/000110465925087077/xslF345X05/tm2525175-1_4seq1.xml
1 · Reply
Madsj79
Madsj79 Sep. 5 at 7:59 PM
$ANVS 💡 Valuation of a Small Pharma with 2 Phase 3 Programs (Alzheimer’s & Parkinson’s) and Sufficient Funding 1. Market Potential • Alzheimer’s: projected $20–25B annual market. • Parkinson’s: $6–8B annual market. • If the drugs capture modest shares: combined $4–7B peak annual sales potential. 2. Risk Adjustment (Phase 3 success probabilities) • Alzheimer’s Phase 3: ~25–35% chance of success. • Parkinson’s Phase 3: ~30–40%. • Combined diversification: ~50–60% probability that at least one succeeds. 3. Valuation Range • Small biotechs are often valued at 2–5x risk-adjusted peak sales. • With funding secured, typical market cap = $1–3B before readout. • If one program succeeds → valuation could jump to $5–10B+. • If both succeed → potential $10–20B, making the company a strong Big Pharma acquisition candidate.
2 · Reply
Madsj79
Madsj79 Sep. 5 at 7:54 PM
$ANVS 💡 Valuation of a Small Pharma with 2 Phase 3 Programs (Alzheimer’s & Parkinson’s) and Sufficient Funding 1. Market Potential • Alzheimer’s: projected $20–25B annual market. • Parkinson’s: $6–8B annual market. • If the drugs capture modest shares: combined $4–7B peak annual sales potential. 2. Risk Adjustment (Phase 3 success probabilities) • Alzheimer’s Phase 3: ~25–35% chance of success. • Parkinson’s Phase 3: ~30–40%. • Combined diversification: ~50–60% probability that at least one succeeds. 3. Valuation Range • Small biotechs are often valued at 2–5x risk-adjusted peak sales. • With funding secured, typical market cap = $1–3B before readout. • If one program succeeds → valuation could jump to $5–10B+. • If both succeed → potential $10–20B, making the company a strong Big Pharma acquisition candidate.
1 · Reply
5DollarNana
5DollarNana Sep. 4 at 5:55 PM
$ANVS Cash is Lean: About $17M cash, enough to run through the first phase (6 months) of the trial — but no cushion beyond that  . • Still Losing Money: No revenue yet; net losses continue ($30M TTM), so profitability is a long shot Ready for another dilutions
0 · Reply
NolAsrtormZ
NolAsrtormZ Sep. 4 at 4:59 PM
$ANVS remember when $SAVA both showed data and they pumped to like $100 a share??? Could be another thing going w iPf data. Time will tell. UTHR gained like 5billion in market cap. $GRI bio has iPf data soon 2.5million share float trades at $1.45
0 · Reply
Latest News on ANVS
Annovis Completes Full Patent Transfer to Crystal Buntanetap

Aug 7, 2025, 8:00 AM EDT - 4 weeks ago

Annovis Completes Full Patent Transfer to Crystal Buntanetap


Annovis to Attend the AAIC 2025 with Four Poster Presentations

Jun 26, 2025, 8:00 AM EDT - 2 months ago

Annovis to Attend the AAIC 2025 with Four Poster Presentations


Annovis to Host Webinar and Live Q&A on June 24, 2025

Jun 5, 2025, 8:00 AM EDT - 3 months ago

Annovis to Host Webinar and Live Q&A on June 24, 2025


Annovis Bio Appoints Hui Liu as Director of Biostatistics

Apr 29, 2025, 8:00 AM EDT - 4 months ago

Annovis Bio Appoints Hui Liu as Director of Biostatistics


Annovis to Host Patients' Live Forum on February 27, 2025

Feb 19, 2025, 8:30 AM EST - 7 months ago

Annovis to Host Patients' Live Forum on February 27, 2025


Annovis Bio, Inc. Announces Proposed Public Offering

Jan 31, 2025, 8:14 PM EST - 7 months ago

Annovis Bio, Inc. Announces Proposed Public Offering


/C O R R E C T I O N -- Today's Marketplace/

Dec 4, 2024, 2:21 PM EST - 9 months ago

/C O R R E C T I O N -- Today's Marketplace/


Annovis to Host Year-End Investor Webcast on December 11, 2024

Nov 25, 2024, 8:00 AM EST - 10 months ago

Annovis to Host Year-End Investor Webcast on December 11, 2024


Annovis stock more than doubled on Tuesday: what happened?

Jul 2, 2024, 4:13 PM EDT - 1 year ago

Annovis stock more than doubled on Tuesday: what happened?


Annovis Announces New Publication in a Peer-Reviewed Journal

May 21, 2024, 7:30 AM EDT - 1 year ago

Annovis Announces New Publication in a Peer-Reviewed Journal


5DollarNana
5DollarNana Sep. 7 at 3:20 AM
$ANVS Maria is scamming you all. Trying to get you to buy more stocks so she can dilute it because no other company or investor wants to work with her. Worst investment ever. Pretty much leaving my money in there cause it’s already a loss. Anyways beware. Dont jump into this one
0 · Reply
ReturnOfEsquire
ReturnOfEsquire Sep. 6 at 6:17 PM
$ANVS Prediction: AD trial, if it ever fully enrolls, will be marred by error or failure to meet primary endpoint. I hope I'm wrong, but I think safe money stays away from this company. Unless you are looking for a lotto play, I say look elsewhere.
1 · Reply
ForestFoxes
ForestFoxes Sep. 6 at 3:22 PM
While I can appreciate your resolute belief in $ANVS and Dr. Maccecchini @ILikeDaStocks and the company's statements, past and present ... what I can share with you is that if you are indeed open to a balanced research of the Annovis Bio that you will find discrepancies and out right lies being stated the the CEO. I am not saying that these were just omissions and/or errors, but that some of her statements ARE lies. I’ve going to tag $AVXL since your original post refers to ANVS’ CEO basically saying that her Rx is better than AVXL’s Rx and let AVXL-Longs communicate with you on this matter. Yes, Dr. Maccecchini believes that her Rx is better than AVXL’s as well as any other on the planet as seen by her response to @ReturnOfEsquire “our drug looks more promising than any Alzheimer drug on the market or in development": https://stocktwits.com/MaccM/message/606412928 I’m also going to tag Dr. Maria Maccecchini directly via @MaccM because you feel that the “CEO feeling unappreciated for her success thus far, and bit insecure in her role …” referring to your original post. I don't think, Dr. Maccecchini, is the least bit insecure in any matters running her company. She has repeated taken the helm as her own CFO again and again and again. She also believes that she is very, very good at designing drug trials and states this publicly. She is also so confident that so doesn’t believe she needs a single MD on her team. She’s basically the perfect package for ANVS-Longs who she hope will go out into the with devotion of spread her gossip. (I am tempted to retract this last sentence, but re-reading your post I don’t think it’s inappropriate and is worthy of reflecting on generically for all investors in this space. Additionally, your post was tagged “Bullish” indicting the likelihood that you were seeking debate as opposed to engagement. Hopefully, AVXL-Longs can provide you the DD supporting their thesis vs. ANVS, which in my opinion should includes factors beyond science alone.) Whether you believe any of this or not is only “partially" relevant. I wish I could state that the ONLY thing that mattered are the "entities that specialize in this CNS sector are quite knowledgeable and cautious with their capital. Dr. Maria Maccecchini is over stating her case by continuously making the suggestion that other companies are purposefully closing their eyes to possibilities outside of the amyloid theory and hence missing out on her 900% certain drug." That quote is from an earlier post of mine: https://stocktwits.com/ForestFoxes/message/609179296 But I know that Dr. Maccecchini cannot advance her TBI or LBD pipeline. She has at the moment abandoned her pursuit of Parkinson's with the story line that her success with Alzheimer's will save the company (plus, some other excuses about Shorts being means and thoughtless and hating grandparents, etc.) There is virtually zero prospect that any functional or financially solvent company or entity that specializes in this space will partner with Annovis Bio. Going forward it's all going to be dilutive AND a full focus by Dr. Maccecchini to induce novice biotech investors and patients to buy her stock. Her statement published on October 1, 2024, "I will raise money at 30 cents with 100% warrant coverage" is a peek of the future and an affirmation that ONLY Retail money matters to Dr. Maccecchini. P.S. Dr. Maccecchini was repeatedly made aware in written communications that her statement "Buntanetap is the ONLY drug to attack multiple neurotoxic proteins simultaneously" yet persisted in using her byline despite knowing this fact. If she is so knowledgeable about this space as many ANVS-Long give her credit for, then it is absolutely IMPOSSIBLE for her to have NOT known this lie that she used for years to help sell her stock.
4 · Reply
pound69
pound69 Sep. 5 at 8:18 PM
$ANVS Another insider buy https://www.sec.gov/Archives/edgar/data/1290208/000110465925080981/xslF345X05/tm2523925-1_4seq1.xml
0 · Reply
ILikeDaStocks
ILikeDaStocks Sep. 5 at 8:17 PM
$ANVS @ForestFoxes FF is not happy with Maria and ANVS, so I'd like to ask her the following... 😁 Is it possible that your observations of ANVS could have been of a CEO feeling unappreciated for her success thus far, and a bit insecure in her role as chief? You previously mentioned her saying something along the lines of, "Our drug is better than Blarcamesine (AVXL) and their market cap is many times ours." My opinion: If Buntanetap is as various ANVS news releases have described, then --IT IS-- head and shoulders above Blarcamesine! So, is Maria simply pushing things beyond your comfort zone (aka: more than normal) while potentially having a strong and unappreciated drug candidate for the treatment of neurodegenerative disease? Would like to hear your response. Thank you.
0 · Reply
pound69
pound69 Sep. 5 at 8:17 PM
$ANVS stop buying Mr Hoffman, give retail a chance to scoop up! https://www.sec.gov/Archives/edgar/data/1477845/000110465925087077/xslF345X05/tm2525175-1_4seq1.xml
1 · Reply
Madsj79
Madsj79 Sep. 5 at 7:59 PM
$ANVS 💡 Valuation of a Small Pharma with 2 Phase 3 Programs (Alzheimer’s & Parkinson’s) and Sufficient Funding 1. Market Potential • Alzheimer’s: projected $20–25B annual market. • Parkinson’s: $6–8B annual market. • If the drugs capture modest shares: combined $4–7B peak annual sales potential. 2. Risk Adjustment (Phase 3 success probabilities) • Alzheimer’s Phase 3: ~25–35% chance of success. • Parkinson’s Phase 3: ~30–40%. • Combined diversification: ~50–60% probability that at least one succeeds. 3. Valuation Range • Small biotechs are often valued at 2–5x risk-adjusted peak sales. • With funding secured, typical market cap = $1–3B before readout. • If one program succeeds → valuation could jump to $5–10B+. • If both succeed → potential $10–20B, making the company a strong Big Pharma acquisition candidate.
2 · Reply
Madsj79
Madsj79 Sep. 5 at 7:54 PM
$ANVS 💡 Valuation of a Small Pharma with 2 Phase 3 Programs (Alzheimer’s & Parkinson’s) and Sufficient Funding 1. Market Potential • Alzheimer’s: projected $20–25B annual market. • Parkinson’s: $6–8B annual market. • If the drugs capture modest shares: combined $4–7B peak annual sales potential. 2. Risk Adjustment (Phase 3 success probabilities) • Alzheimer’s Phase 3: ~25–35% chance of success. • Parkinson’s Phase 3: ~30–40%. • Combined diversification: ~50–60% probability that at least one succeeds. 3. Valuation Range • Small biotechs are often valued at 2–5x risk-adjusted peak sales. • With funding secured, typical market cap = $1–3B before readout. • If one program succeeds → valuation could jump to $5–10B+. • If both succeed → potential $10–20B, making the company a strong Big Pharma acquisition candidate.
1 · Reply
5DollarNana
5DollarNana Sep. 4 at 5:55 PM
$ANVS Cash is Lean: About $17M cash, enough to run through the first phase (6 months) of the trial — but no cushion beyond that  . • Still Losing Money: No revenue yet; net losses continue ($30M TTM), so profitability is a long shot Ready for another dilutions
0 · Reply
NolAsrtormZ
NolAsrtormZ Sep. 4 at 4:59 PM
$ANVS remember when $SAVA both showed data and they pumped to like $100 a share??? Could be another thing going w iPf data. Time will tell. UTHR gained like 5billion in market cap. $GRI bio has iPf data soon 2.5million share float trades at $1.45
0 · Reply
Action80gr
Action80gr Sep. 4 at 4:13 PM
$ANVS I would like to understand if. and close to bankruptcy
1 · Reply
5DollarNana
5DollarNana Sep. 4 at 1:53 PM
$ANVS this hold better be worth it. 😒 also Maria sucks balls.
2 · Reply
wahoowa96
wahoowa96 Sep. 4 at 3:00 AM
$ANVS Attacking 3's tomorrow...gonna close on 2's after that hopefully. Been a long way from a first buy at 15 last year but pretty much nobody knows what he's doing in Parkinson's and keeps thinking about best antibody to clear extra alpha-syn in the brain...when answer might be Buntanetap!
0 · Reply
ReturnOfEsquire
ReturnOfEsquire Sep. 3 at 4:18 PM
$ANVS This is when you KNOW your P3 investment is disruptive. Be mindful of everything, and don't just rely on your assessment of the science.
3 · Reply
JarvisFlow
JarvisFlow Sep. 3 at 11:00 AM
HC Wainwright & Co. has adjusted their stance on Annovis Bio ( $ANVS ), setting the rating to Buy with a target price of 12 → 10.
1 · Reply
wahoowa96
wahoowa96 Sep. 3 at 3:37 AM
$ANVS I like Buntanetap because it targets the same SNCA gene mRNA (Arrowhead/NOV) plus other neuro-toxic genes mRNAs. My gut feeling is the time past the early stage is where not many healthy neurons are left to be saved..Nerves are not regenerative once severely damaged.
0 · Reply
wahoowa96
wahoowa96 Sep. 3 at 2:27 AM
$ANVS Arrowhead and Novaritas coming back to basics again for Parkinson's in inhibiting the components that produces them. Novartis aims at alpha-synuclein again with Arrowhead deal https://share.google/IiiNJ2VM5cwfl7cAP
0 · Reply
Madsj79
Madsj79 Sep. 2 at 6:24 PM
$ANVS https://www.annovisbio.com/press-release/annovis-to-present-at-the-h-c-wainwright-27th-annual-global-investment-conference
0 · Reply
Guptasulo
Guptasulo Sep. 2 at 3:23 PM
$CGTX $ANVS $AVXL With the monoclonals fading with time, its the Oral treatments to lead the way. CGTX lower p-tau217 due for Ph3 entry. ANVS Higher p-tau217 to be confirmed with Ph3 trial. AVXL leading the charge towards EMA approval. The market is large enough, some specialize and some with common overlaps.
1 · Reply
Veni_Vidi_Vici
Veni_Vidi_Vici Sep. 2 at 1:20 PM
$ANVS https://clinicaltrials.gov/study/NCT06709014?cond=Buntanetap&rank=2
0 · Reply
Veni_Vidi_Vici
Veni_Vidi_Vici Sep. 2 at 1:16 PM
$ANVS I am no expert. Do your own due diligence. Understand the risks before investing in a clinical stage biotech. Annovis Followers on Stocktwits = 9,489
1 · Reply
WallStreetBuyDip
WallStreetBuyDip Aug. 30 at 3:27 PM
I only buy the dip for a reversal trade when its H% is low. These are just few examples of many plays. I make this chart of my prev trade/alert to show why it's important to know what H% is. Are you the type to trade momentum or the type to buy the dip for a reversal trade? Will trade $ANVS like how I did for the tickers shown here.
0 · Reply