Market Cap 52.98M
Revenue (ttm) 0.00
Net Income (ttm) -28.85M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 872,000
Avg Vol 761,242
Day's Range N/A - N/A
Shares Out 29.27M
Stochastic %K 28%
Beta 1.37
Analysts Strong Sell
Price Target $11.67

Company Profile

Annovis Bio, Inc., a clinical stage drug platform company, develops drugs to treat neurodegeneration in the United States. The company's lead product candidate is Buntanetap, which is in phase 2/3 to treat alzheimer's disease, as well as in phase 3 to treat parkinson's disease; and is in phase 2 clinical trial to treat lewy body dementia. It also develops ANVS405, which is in phase 2 and 3 clinical trials for the treatment of traumatic brain injury and/or stroke; and ANVS301, which finished phas...

Industry: Biotechnology
Sector: Healthcare
Phone: 484 875 3192
Address:
101 Lindenwood Drive, Suite 225, Malvern, United States
jimmy18000
jimmy18000 Apr. 25 at 10:15 AM
$ANVS at 40% enrollment in late January and 75% enrollment in late March, I project we are fully enrolled by late May, early June. Add 6 months to that for database lock=January, then 6-8 weeks for analysis, and we have data read out in March 2027. Do we have enough cash till then? I hope so. Next cash raise won’t be till after 6 symptomatic AD data when pps should be higher.
0 · Reply
moneyonthebrain
moneyonthebrain Apr. 24 at 6:20 PM
$ANVS $NVDA is up $400,000 million today on no real news; meanwhile the entire market cap of a potentially effective treatment for Alzheimer's is less than $100 million... interesting market we have here...
1 · Reply
intrepiduser
intrepiduser Apr. 24 at 5:17 PM
$ANVS loser
0 · Reply
Mr_Charlie
Mr_Charlie Apr. 24 at 4:34 PM
$ANVS Director Michael B. Hoffman acquired 713,800 shares at about $2.10, boosting his holding by 27.72% to 3,288,539 shares, a significant insider purchase signaling confidence.
0 · Reply
Zeusgodmd
Zeusgodmd Apr. 24 at 4:10 PM
$ANVS Going to be a said day for some when it gets bought out but I have more than has been sold today so won’t be me
0 · Reply
Hankjessie
Hankjessie Apr. 24 at 2:13 PM
$ANVS as I’ve said before, Maria is going to prison.
0 · Reply
dwayne09
dwayne09 Apr. 24 at 12:11 PM
$ANVS still believe Maria has the magic, but so many old guards have left, i dont fault them, money can be better used elsewhere especially with AI revolution going on, but keep 5 percent here, it will be a good investment 12 month down the road.
1 · Reply
dwayne09
dwayne09 Apr. 24 at 12:08 PM
$ANVS get back to 2 today
0 · Reply
Mr_Charlie
Mr_Charlie Apr. 23 at 7:41 PM
$ANVS https://healthunlocked.com/cure-parkinsons/posts/152697914/annovis-bio-inc.-announces-progress-in-alzheimers-and-parkinsons-trials
1 · Reply
ForestFoxes
ForestFoxes Apr. 23 at 4:18 PM
This $ANVS post is likely relevant for the many former CFOs of Annovis Bio #jeffreymcgroarty #henryhagopian #williamfricker #andrewwalsh and #markguerin as well as any contractors who have been openly berated during their time serving the company. This includes any clinical research organizations who were screamed at and blamed for what Annovis Bio states happened: “To recap, here is what happened in our Phase 2/3 Alzheimer’s disease (AD) study: during post-trial analysis, we identified that a significant portion (about 40%) of participants enrolled did not meet diagnostic criteria for AD. This meant that many people were placed into studies that could not help them.” Yet it is CEO Dr. Maccecchini who continuously self-proclaims that she is “really good at development R&D, because that’s my background”. As such, how is it possible for Dr. Maccecchini to feign outrage regarding the outcome of her own study which she designed??? "Annovis CEO Maria Maccecchini says the suspect clinical trial locations in the study of buntanetap offered cash payments and generous spreads of food and beverages to entice volunteers. Many people, she adds, pretended to suffer from cognitive impairment to join the trial, for example by intentionally drawing a clock incorrectly. Maccecchini adds that the participants whose data had to be tossed out included many grandmothers who saw a chance to make thousands of dollars a year by simultaneously joining multiple trials for which they did not qualify.” These are well-known and long-established issues in the industry and if Dr. Maccecchini was “really good at development R&D, because that’s my background” then she would have taken measures to safeguard against this … if she had wanted to. A muddled study prolongs her story … and, the collection of retail investors’ hard-earned money, IMO. Dr. Maccecchini’s interests are neither aligned with retail investors or patients and their families, IMO. Dr. Maccecchini has never mentioned to me her personal interest in helping patients. Instead, she tells me she promises to "make every employee a millionaire”? 🥕 Is this her real focus? 🥕🥕🥕🥕🥕 Has this promise been realized by any of Dr. Maccecchini’s former financial officers/CFOs? Based on observations, those who have worked for or with Dr. Maccecchini have been harmed. This includes contract breaches and the sullying of reputation #tonyrusso #nicjohnson #russopartners based on both written and oral evidence. The referenced post (linked) by “mattil” was responded to by “kgw567,” which can be read on the right side of the attached image: “She (ForestFoxes) seems to be a very nice person, however …” This is a stark contrast from the same commentator, kgw567, who previously attacked me by stating, “Don’t Fuck With Me, I Guarantee you ain’t in the same league and you’re fucking with the wrong person,” (see middle section of the attached image 1). kgw567 appears coached by Dr. Maccecchini, as it reflects how the CEO handles situations when bullying is no longer effective. The CEO's comments, “It is better to disarm him than to fight him,” referring to #AdamFeuerstein. On some days, the CEO seems to have spent more time communicating directly with retail investors than on her “scientific” work and/or running her company. Is this what Annovis Bio investors want? Dr. Maccecchini has directed me in writing to go after specific authors focused in this field. Furthermore, she has written me that such efforts would be supported by her Director of Strategic Communications. Again, is this what patients or investors want in a CEO? Why is Dr. Maccecchini so focused on social media instead of the actual work at hand, which is obtaining funding via entities who specialize in this field and are fully capable of discerning the value of her drug’s valuable data? Unless her data is NOT valuable and NEVER has been 🚩 Annovis Bio’s former CFOs, PR teams, website builders, clinical research organizations (CROs), etc., whose reputation she has damaged based on the facts that I have come across, should be interested in what kgw567 outlined, stating, “Someone posting on here could be in some deep shit!” (see middle section of image 1). IMO ➡️ this person is CEO Maccecchini 👈 🚩 ”Defamation of character refers to a false statement presented as fact that injures an individual’s reputation, and it can take the form of slander (spoken) or libel (written).” as mentioned by kgw567 (middle panel of image 1). #jeffreymcgroarty #henryhagopian #williamfricker #andrewwalsh #markguerin
0 · Reply
Latest News on ANVS
Annovis to Host Corporate Update Webinar on January 28, 2026

Dec 16, 2025, 8:00 AM EST - 4 months ago

Annovis to Host Corporate Update Webinar on January 28, 2026


Annovis Announces Two Presentations at the CTAD 2025 Conference

Nov 24, 2025, 8:00 AM EST - 5 months ago

Annovis Announces Two Presentations at the CTAD 2025 Conference


Annovis Appoints Mark Guerin as Chief Financial Officer

Sep 25, 2025, 7:30 AM EDT - 7 months ago

Annovis Appoints Mark Guerin as Chief Financial Officer


Annovis Completes Full Patent Transfer to Crystal Buntanetap

Aug 7, 2025, 8:00 AM EDT - 9 months ago

Annovis Completes Full Patent Transfer to Crystal Buntanetap


Annovis to Attend the AAIC 2025 with Four Poster Presentations

Jun 26, 2025, 8:00 AM EDT - 10 months ago

Annovis to Attend the AAIC 2025 with Four Poster Presentations


Annovis to Host Webinar and Live Q&A on June 24, 2025

Jun 5, 2025, 8:00 AM EDT - 11 months ago

Annovis to Host Webinar and Live Q&A on June 24, 2025


Annovis Bio Appoints Hui Liu as Director of Biostatistics

Apr 29, 2025, 8:00 AM EDT - 1 year ago

Annovis Bio Appoints Hui Liu as Director of Biostatistics


Annovis to Host Patients' Live Forum on February 27, 2025

Feb 19, 2025, 8:30 AM EST - 1 year ago

Annovis to Host Patients' Live Forum on February 27, 2025


Annovis Bio, Inc. Announces Proposed Public Offering

Jan 31, 2025, 8:14 PM EST - 1 year ago

Annovis Bio, Inc. Announces Proposed Public Offering


/C O R R E C T I O N -- Today's Marketplace/

Dec 4, 2024, 2:21 PM EST - 1 year ago

/C O R R E C T I O N -- Today's Marketplace/


jimmy18000
jimmy18000 Apr. 25 at 10:15 AM
$ANVS at 40% enrollment in late January and 75% enrollment in late March, I project we are fully enrolled by late May, early June. Add 6 months to that for database lock=January, then 6-8 weeks for analysis, and we have data read out in March 2027. Do we have enough cash till then? I hope so. Next cash raise won’t be till after 6 symptomatic AD data when pps should be higher.
0 · Reply
moneyonthebrain
moneyonthebrain Apr. 24 at 6:20 PM
$ANVS $NVDA is up $400,000 million today on no real news; meanwhile the entire market cap of a potentially effective treatment for Alzheimer's is less than $100 million... interesting market we have here...
1 · Reply
intrepiduser
intrepiduser Apr. 24 at 5:17 PM
$ANVS loser
0 · Reply
Mr_Charlie
Mr_Charlie Apr. 24 at 4:34 PM
$ANVS Director Michael B. Hoffman acquired 713,800 shares at about $2.10, boosting his holding by 27.72% to 3,288,539 shares, a significant insider purchase signaling confidence.
0 · Reply
Zeusgodmd
Zeusgodmd Apr. 24 at 4:10 PM
$ANVS Going to be a said day for some when it gets bought out but I have more than has been sold today so won’t be me
0 · Reply
Hankjessie
Hankjessie Apr. 24 at 2:13 PM
$ANVS as I’ve said before, Maria is going to prison.
0 · Reply
dwayne09
dwayne09 Apr. 24 at 12:11 PM
$ANVS still believe Maria has the magic, but so many old guards have left, i dont fault them, money can be better used elsewhere especially with AI revolution going on, but keep 5 percent here, it will be a good investment 12 month down the road.
1 · Reply
dwayne09
dwayne09 Apr. 24 at 12:08 PM
$ANVS get back to 2 today
0 · Reply
Mr_Charlie
Mr_Charlie Apr. 23 at 7:41 PM
$ANVS https://healthunlocked.com/cure-parkinsons/posts/152697914/annovis-bio-inc.-announces-progress-in-alzheimers-and-parkinsons-trials
1 · Reply
ForestFoxes
ForestFoxes Apr. 23 at 4:18 PM
This $ANVS post is likely relevant for the many former CFOs of Annovis Bio #jeffreymcgroarty #henryhagopian #williamfricker #andrewwalsh and #markguerin as well as any contractors who have been openly berated during their time serving the company. This includes any clinical research organizations who were screamed at and blamed for what Annovis Bio states happened: “To recap, here is what happened in our Phase 2/3 Alzheimer’s disease (AD) study: during post-trial analysis, we identified that a significant portion (about 40%) of participants enrolled did not meet diagnostic criteria for AD. This meant that many people were placed into studies that could not help them.” Yet it is CEO Dr. Maccecchini who continuously self-proclaims that she is “really good at development R&D, because that’s my background”. As such, how is it possible for Dr. Maccecchini to feign outrage regarding the outcome of her own study which she designed??? "Annovis CEO Maria Maccecchini says the suspect clinical trial locations in the study of buntanetap offered cash payments and generous spreads of food and beverages to entice volunteers. Many people, she adds, pretended to suffer from cognitive impairment to join the trial, for example by intentionally drawing a clock incorrectly. Maccecchini adds that the participants whose data had to be tossed out included many grandmothers who saw a chance to make thousands of dollars a year by simultaneously joining multiple trials for which they did not qualify.” These are well-known and long-established issues in the industry and if Dr. Maccecchini was “really good at development R&D, because that’s my background” then she would have taken measures to safeguard against this … if she had wanted to. A muddled study prolongs her story … and, the collection of retail investors’ hard-earned money, IMO. Dr. Maccecchini’s interests are neither aligned with retail investors or patients and their families, IMO. Dr. Maccecchini has never mentioned to me her personal interest in helping patients. Instead, she tells me she promises to "make every employee a millionaire”? 🥕 Is this her real focus? 🥕🥕🥕🥕🥕 Has this promise been realized by any of Dr. Maccecchini’s former financial officers/CFOs? Based on observations, those who have worked for or with Dr. Maccecchini have been harmed. This includes contract breaches and the sullying of reputation #tonyrusso #nicjohnson #russopartners based on both written and oral evidence. The referenced post (linked) by “mattil” was responded to by “kgw567,” which can be read on the right side of the attached image: “She (ForestFoxes) seems to be a very nice person, however …” This is a stark contrast from the same commentator, kgw567, who previously attacked me by stating, “Don’t Fuck With Me, I Guarantee you ain’t in the same league and you’re fucking with the wrong person,” (see middle section of the attached image 1). kgw567 appears coached by Dr. Maccecchini, as it reflects how the CEO handles situations when bullying is no longer effective. The CEO's comments, “It is better to disarm him than to fight him,” referring to #AdamFeuerstein. On some days, the CEO seems to have spent more time communicating directly with retail investors than on her “scientific” work and/or running her company. Is this what Annovis Bio investors want? Dr. Maccecchini has directed me in writing to go after specific authors focused in this field. Furthermore, she has written me that such efforts would be supported by her Director of Strategic Communications. Again, is this what patients or investors want in a CEO? Why is Dr. Maccecchini so focused on social media instead of the actual work at hand, which is obtaining funding via entities who specialize in this field and are fully capable of discerning the value of her drug’s valuable data? Unless her data is NOT valuable and NEVER has been 🚩 Annovis Bio’s former CFOs, PR teams, website builders, clinical research organizations (CROs), etc., whose reputation she has damaged based on the facts that I have come across, should be interested in what kgw567 outlined, stating, “Someone posting on here could be in some deep shit!” (see middle section of image 1). IMO ➡️ this person is CEO Maccecchini 👈 🚩 ”Defamation of character refers to a false statement presented as fact that injures an individual’s reputation, and it can take the form of slander (spoken) or libel (written).” as mentioned by kgw567 (middle panel of image 1). #jeffreymcgroarty #henryhagopian #williamfricker #andrewwalsh #markguerin
0 · Reply
Mr_Charlie
Mr_Charlie Apr. 23 at 2:23 PM
$ANVS anybody alive here??? Just added 2500 shares
1 · Reply
5DollarNana
5DollarNana Apr. 22 at 6:27 PM
$ANVS dreaming.. I’m always dreaming. Hoping. Some day she’ll squeeze! ANVS hurry up, make me my money, and help the old folks! OHhhHhHhhah dreaming. I’m always dreaming. 🎶🎶🎼🎵🎵
0 · Reply
Itsybitsybeanbag
Itsybitsybeanbag Apr. 22 at 4:17 PM
$ANVS What about trials on foxes?
6 · Reply
mattil
mattil Apr. 22 at 11:26 AM
$ANVS @ForestFoxes You are not honest. Are you bitter instead? Otherwise you would not mention the undeniable effect of Buntanetap in AD patients who are proven to have the disease. Not to mention the success of Buntanetap in the early AD patient population. You also completely ignore the proven effect of Buntanetap on cognition and motor skills in PD patients. Your statement would be much more concise (IMO) if you did not bury such very important issues in the shadow of a verbose, stigmatizing outpouring. On the other hand, your actions are understandable if, instead of striving for objectivity, your motive is to present the company in the worst possible light to as many people as possible.
3 · Reply
ForestFoxes
ForestFoxes Apr. 22 at 7:41 AM
$ANVS $AVXL @papatrick your repost from $CGTX about “nasal spray” had an accurate response from @Woundntyouliketoknow who stated, "Approximately 5% of therapeutic interventions that show positive results in animal studies (including mice) successfully translate to approved human treatments. While initial preclinical studies often show high concordance with human trials, roughly 90% of compounds that enter human clinical trials fail, largely due to differences in metabolism, genetics, and disease modeling." This basically means that only 10% of the positive mouse data translates to predicting human outcome. This is a fact. Despite this, Dr. Maccecchini, CEO of Annovis Bio, had been encouraging retail investors over the years that her data is great. All of it! Mouse and human... even people who aren't qualified to be on drug studies! She has even titled articles such as, "Do Mouse Data Lie? For Buntanetap, They Totally Predict Human Outcome": https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.075060 What has been consistent has been Dr. Maccecchini's: (1) falsification of facts (2) blaming those she hires (3) blaming investors, authors, and shorts (4) and blatantly disregarding SEC regulations, including those that were required as a prerequisite for her $250,000,000 S3: https://s3.amazonaws.com/sec.irpass.cc/2990/0001104659-26-041584.pdf Annovis Bio’s drug, buntanetap, IMO, and by all evidence is a pump ’n dump fantasy. Dr. Maccecchini approves of scripts such as, “Buntanetap: A Different Kind of Weapon”, “A Beacon of Hope”, and “Treatment for All”: https://www.youtube.com/watch?v=IWHt1sdH8bU She has given many “scientific interviews” which are actually paid promotional advertisements where she touts that she has been given “the green light to cure Alzheimer’s” by the FDA, that her patients on Buntanetap are “miracle walkers to cure”, and that she is 900% certain her drug works! She hurts patients and families with her false self-promotions, IMO. I have observed her website since 2021 which has been full of inconsistencies which included completely false statements. She has blamed her former CFOs #jeffreymcgroarty #henryhagopian #williamfricker #andrewwalsh #markguerin which included telephonic conversations with statements that are completely contrary to what she filed with the SEC. She tells me that her CFOs … it is too rude and hurtful for me to state this publicly, but these small samples of emails to follow demonstrate her willingness to blame her own people. This is all a game for Dr. Maccecchini. There’s little to no evidence that there was any Series B or C funding pre-IPO. This is HIGHLY unusually for a biotech, but not for a scam. There is virtually no support of this company other than by retail investors. Venture capital firms that specialize in biotech such as biospartner.com and royaltypharma.com know the difference between a compelling story and a great company lies in scientific defensibility and clinical utility. Annovis Bio has neither. Dr. Maccecchini will continue with this approach to lure in future retail investors ... and, her next CFO with false statements, IMO, and she will harm all those that disagree with her.
3 · Reply
Hankjessie
Hankjessie Apr. 21 at 7:51 PM
$ANVS is there ever any positive news in this trash company? Horrible.
1 · Reply
StMichaelTwits
StMichaelTwits Apr. 21 at 2:55 PM
$ANVS And price is movin up to the offering price.. Board director purchasing over 700k of shares at 2.10, gives you a hint what will happen in 2027😘 Anything below the duece will make you a killing in a year or so. I will re post this in 2027.😉💎💪
0 · Reply
papatrick
papatrick Apr. 21 at 11:01 AM
$AVXL $ANVS Competitive technology and approach around the corner...BP will jump on that soon and bring it to market...how long will it take??5-10 years?
2 · Reply
pelyod
pelyod Apr. 20 at 5:39 PM
$ANVS So we're given a 17 price target by the folks who just handled our direct offering. Who am I to blow against the wind?
0 · Reply
B2iDigital
B2iDigital Apr. 20 at 5:31 PM
Jupiter Neurosciences, Inc. (NASDAQ: $JUNS ), a B2i Digital Featured Company, recently presented at the Virtual Investor Conferences Life Sciences Investor Forum. In the clip below, President and CBO Alison Silva outlines the timeline for the company's Phase 2A Parkinson's disease study. View Clip Here: https://youtube.com/shorts/23IRp5Y6m_E Learn more about Jupiter Neurosciences at the B2i Digital Featured Companies profile: https://b2idigital.com/jupiter-neurosciences-1 "Our trial timelines are rapidly accelerating at this point. We are just activating our sites. We expect to enroll the first patient and subsequently dose the first patient. I'd say in the next few weeks here -- it's always hard to tell exactly when it's going to happen, but we've made significant progress in 2026. Again, it's 30 subjects and three months of dosing. We expect pretty concurrent enrollment. So as soon as we get all subjects in, we'll report out on that. And then it's three months of dosing and then probably about a two-month readout at the end of last patient last dose. So we hope to be announcing top-line results early next year, about 12 months from now. If all goes according to plan, we're very e xcited to be able to use the data from this trial to build out the pipeline and also move into a larger phase 2B or 3 in Parkinson's." In the full presentation, the company also discussed: • The JOTROL platform's 9x bioavailability advantage and the IP protecting it through 2036 • The 30-patient Phase 2A trial design at Georgetown University, including the panel of up to 22 biomarkers being assessed • What positive data could mean for pharma partnering discussions and pipeline expansion into Alzheimer's and MCI • The Nugevia direct-to-consumer longevity line as a commercial complement to the Parkinson's program Watch the complete presentation: https://www.virtualinvestorconferences.com/wcc/eh/4814904/lp/5271529/jupiter-neurosciences-inc-nasdaq-juns?utm_source=b2i&utm_medium=marketing&utm_campaign=0326LifeSciencesVIC Jupiter Neurosciences is led by Christer Rosén, Founder, Chairman and CEO; Alison Silva, President and CBO; Saleem Elmasri, CPA, CFO; and Marsh Hayward Ph.D., Co-Founder and CSO. To learn more about the company, visit www.jupiterneurosciences.com. For investor inquiries, contact [email protected]. Discover more emerging growth Featured Companies, industry-leading Featured Experts, and upcoming Featured Conferences at https://b2idigital.com. Disclosure: B2i Digital is not a broker-dealer or investment adviser. This post is informational and not an offer or solicitation regarding any security. $INMB, $ANVS, $AVXL, $ATHA, $XBI
1 · Reply
Fritzipooch
Fritzipooch Apr. 20 at 2:39 PM
$ANVS Funny this Anvs is one of the few that are green today!
0 · Reply
Veni_Vidi_Vici
Veni_Vidi_Vici Apr. 20 at 1:16 PM
$ANVS I am no expert. Do your own due diligence. Understand the risks before investing in a clinical stage biotech. Annovis Followers on Stocktwits = 9,869
0 · Reply