Dec. 7 at 9:43 PM
$ALZN For those that say well this is just a mouse model and they very rarely translate to humans. Well that is true for efficacy, but toxicicty results translate better. Besides, toxicity with lithium has always been the problem. Even though we don't yet have results of AL001 in the brain and plasma in humans, we do have results of regular lithium in humans and it compares similar as the mouse model. The main exception is in humans, the lithium peaks faster in the blood and brain and leaves the body faster. Having that to compare to, it may be safe to assume AL001 will perform similar to mouse model, which would mean AL001 does not peak high as lithium in the blood and while lithium in the brain has peaked, levels of AL001 in the brain are still going up and peak much later, thus reducing the possibility of toxicity because you can thus reduce the dose.
