Aug. 20 at 2:23 PM
$ACIU AC Immune
Preliminary Phase 1/1b data for ACI-19764 (brain-penetrant NLRP3 inhibitor): safe/well tolerated up to 20mg/day, no serious adverse events, serum half-life >30 hours, clear CSF penetration, PK levels above IC90 at daily doses ≤10mg.
Stock Titan
Dose-dependent IL-1β inhibition also seen in blinded whole-blood analysis. Phase 1b cardiovascular-risk cohort dosing has now begun. Full H2 2026 readout is the next real catalyst — this is interim, not final data.
https://prismmarketview.com/ac-immune-reports-early-phase-1-progress-for-brain-penetrant-nlrp3-inhibitor-aci-19764/