Market Cap 343.93M
Revenue (ttm) 2.85M
Net Income (ttm) -143.44M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -5,032.98%
Debt to Equity Ratio 0.00
Volume 469,800
Avg Vol 605,104
Day's Range N/A - N/A
Shares Out 54.42M
Stochastic %K 58%
Beta 1.10
Analysts Strong Sell
Price Target $38.43

Company Profile

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts.

Industry: Biotechnology
Sector: Healthcare
Phone: 781 208 2466
Address:
890 Winter Street, Suite 200, Waltham, United States
Gunnar1
Gunnar1 Jun. 25 at 1:55 PM
0 · Reply
Gunnar1
Gunnar1 Jun. 25 at 1:50 PM
$UPB Piper Sandler today with "BUY2 rating and a price target of 75$ (!) 💪
0 · Reply
SQUEAKSBANDIT
SQUEAKSBANDIT Jun. 14 at 11:56 PM
$UPB certainly "smells" like good news
0 · Reply
AlertsAndNews
AlertsAndNews Jun. 14 at 10:08 PM
$UPB Upstream Bio Presents New Responder Analyses Demonstrating Clinically Meaningful Improvements in CRSwNP in Significant Majority of Participants Treated with Verekitug in the Phase 2 VIBRANT Trial at EAACI 2026 "Verekitug, administered once every three months, led to clinically meaningful improvements in nasal polyp score (NPS) in approximately 80% of participants – – Majority of verekitug-treated participants experienced clinically meaningful improvements across key secondary endpoints, including 72% in nasal congestion and 83% in CRSwNP total symptom score"
0 · Reply
Rounderssss4
Rounderssss4 Jun. 14 at 3:18 PM
$UPB Placebo-adjusted nasal polyp score reduction of -1.95 at Week 24, nearly double the 1.0-point meaningful threshold
0 · Reply
Rounderssss4
Rounderssss4 Jun. 14 at 2:59 PM
$UPB Upstream Bio says Phase 2 VIBRANT trial shows verekitug improves nasal polyp score in about 80% of CRSwNP patients https://www.webullapp.com/news-detail/15056145028318208?__app_cfg__=%7B%22supportTheme%22%3Atrue%7D&sourcePage=QuotesFragment&tickerId=951001040&audioNewsPlayedDuration=&theme=1&color=2&hl=en&android_sdk_int=36&canary-version=&_v=1&sp=1&statusBarHeightV2=33&isLite=false&wbFontSetting=medium&wbFontUnit=29&wbFontSize=32&isSubsNews=false
0 · Reply
SQUEAKSBANDIT
SQUEAKSBANDIT Jun. 12 at 11:57 PM
$UPB took some before the close
0 · Reply
SQUEAKSBANDIT
SQUEAKSBANDIT Jun. 12 at 5:06 PM
$UPB bt the downgrade and upcoming presentation it appears as if no one wants to hold this name over the weekend appears so oversold but could just as easily be even more oversold in the 5s tempting but not sure i want to re-enter just yet
1 · Reply
Rounderssss4
Rounderssss4 Jun. 12 at 1:46 PM
$UPB interesting a downgrade before presentation this weekend, I'm guessing good news is coming
1 · Reply
Xrx12
Xrx12 Jun. 12 at 1:44 PM
$UPB I actually don't think this stock ever reaches double digits again
1 · Reply
Latest News on UPB
Upstream Bio management to meet with Piper Sandler

2026-06-17T20:20:10.000Z - 8 days ago

Upstream Bio management to meet with Piper Sandler


KBRA Assigns Preliminary Ratings to OBX 2026-AHC2 Trust

Jun 12, 2026, 5:07 PM EDT - 13 days ago

KBRA Assigns Preliminary Ratings to OBX 2026-AHC2 Trust


Upstream Bio Transcript: AGM 2026

Jun 9, 2026, 9:00 AM EDT - 16 days ago

Upstream Bio Transcript: AGM 2026


Upstream Bio initiated with a Buy at H.C. Wainwright

2026-06-03T10:11:07.000Z - 22 days ago

Upstream Bio initiated with a Buy at H.C. Wainwright


Upstream Bio price target lowered to $50 from $51 at Mizuho

2026-05-14T12:37:47.000Z - 6 weeks ago

Upstream Bio price target lowered to $50 from $51 at Mizuho


Upstream Bio Earnings release: Q1 2026

May 13, 2026, 7:00 AM EDT - 6 weeks ago

Upstream Bio Earnings release: Q1 2026


Upstream Bio Quarterly report: Q1 2026

May 13, 2026, 7:00 AM EDT - 6 weeks ago

Upstream Bio Quarterly report: Q1 2026


Upstream Bio Slides: Corporate presentation

May 13, 2026, 7:00 AM EDT - 6 weeks ago

Upstream Bio Slides: Corporate presentation


Upstream Bio Proxy statement: Proxy filing

Apr 16, 2026, 8:00 AM EDT - 2 months ago

Upstream Bio Proxy statement: Proxy filing


Upstream Bio Proxy statement: Proxy filing

Apr 16, 2026, 8:00 AM EDT - 2 months ago

Upstream Bio Proxy statement: Proxy filing


Upstream Bio Slides: Corporate presentation

Apr 6, 2026, 7:00 AM EDT - 2 months ago

Upstream Bio Slides: Corporate presentation


Upstream Bio Annual report: Q4 2025

Mar 26, 2026, 7:00 AM EDT - 3 months ago

Upstream Bio Annual report: Q4 2025


Upstream Bio Earnings release: Q4 2025

Mar 26, 2026, 7:00 AM EDT - 3 months ago

Upstream Bio Earnings release: Q4 2025


Upstream Bio Slides: Corporate presentation

Mar 26, 2026, 7:00 AM EDT - 3 months ago

Upstream Bio Slides: Corporate presentation


Upstream Bio announces verekitug met the primary endpoint

2026-03-01T16:35:25.000Z - 4 months ago

Upstream Bio announces verekitug met the primary endpoint


Upstream Bio Transcript: Study result

Feb 11, 2026, 8:00 AM EST - 4 months ago

Upstream Bio Transcript: Study result


Upstream Bio Press release: Study result

Feb 11, 2026, 8:00 AM EST - 4 months ago

Upstream Bio Press release: Study result


Upstream Bio Slides: Study result

Feb 11, 2026, 8:00 AM EST - 4 months ago

Upstream Bio Slides: Study result


Upstream Bio management to meet virtually with Piper Sandler

2026-01-20T19:55:30.000Z - 5 months ago

Upstream Bio management to meet virtually with Piper Sandler


Upstream Bio Slides: Corporate presentation

Jan 9, 2026, 7:00 AM EST - 5 months ago

Upstream Bio Slides: Corporate presentation


Upstream Bio initiated with an Outperform at Mizuho

2025-12-17T21:16:04.000Z - 6 months ago

Upstream Bio initiated with an Outperform at Mizuho


Upstream Bio initiated with an Outperform at LifeSci Capital

2025-12-02T12:15:17.000Z - 7 months ago

Upstream Bio initiated with an Outperform at LifeSci Capital


Upstream Bio Transcript: Stifel 2025 Healthcare Conference

Nov 11, 2025, 9:20 AM EST - 8 months ago

Upstream Bio Transcript: Stifel 2025 Healthcare Conference


Upstream Bio Slides: Corporate Presentation

Nov 9, 2025, 6:00 PM EST - 8 months ago

Upstream Bio Slides: Corporate Presentation


Upstream Bio Quarterly report: Q3 2025

Nov 5, 2025, 7:00 AM EST - 8 months ago

Upstream Bio Quarterly report: Q3 2025


Upstream Bio Earnings release: Q3 2025

Nov 5, 2025, 7:00 AM EST - 8 months ago

Upstream Bio Earnings release: Q3 2025


Upstream Bio Transcript: Study Update

Sep 2, 2025, 8:00 AM EDT - 10 months ago

Upstream Bio Transcript: Study Update


Upstream Bio Press release: Study Update

Sep 2, 2025, 8:00 AM EDT - 10 months ago

Upstream Bio Press release: Study Update


Upstream Bio Slides: Study Update

Sep 2, 2025, 8:00 AM EDT - 10 months ago

Upstream Bio Slides: Study Update


Upstream Bio Earnings release: Q2 2025

Aug 6, 2025, 4:00 PM EDT - 11 months ago

Upstream Bio Earnings release: Q2 2025


Upstream Bio Quarterly report: Q2 2025

Aug 6, 2025, 4:00 PM EDT - 11 months ago

Upstream Bio Quarterly report: Q2 2025


Upstream Bio Appoints Stacy Price as Chief Technology Officer

May 20, 2025, 7:00 AM EDT - 1 year ago

Upstream Bio Appoints Stacy Price as Chief Technology Officer


Upstream Bio Quarterly report: Q1 2025

May 6, 2025, 7:00 AM EDT - 1 year ago

Upstream Bio Quarterly report: Q1 2025


Upstream Bio Earnings release: Q1 2025

May 6, 2025, 7:00 AM EDT - 1 year ago

Upstream Bio Earnings release: Q1 2025


Upstream Bio Proxy statement: Proxy Filing

Apr 17, 2025, 8:00 AM EDT - 1 year ago

Upstream Bio Proxy statement: Proxy Filing


Upstream Bio Proxy statement: Proxy Filing

Apr 17, 2025, 8:00 AM EDT - 1 year ago

Upstream Bio Proxy statement: Proxy Filing


Upstream Bio Earnings release: Q4 2024

Mar 12, 2025, 7:00 AM EDT - 1 year ago

Upstream Bio Earnings release: Q4 2024


Upstream Bio Annual report: Q4 2024

Mar 12, 2025, 7:00 AM EDT - 1 year ago

Upstream Bio Annual report: Q4 2024


Upstream Bio Announces Addition to Russell 2000® Index

Dec 16, 2024, 8:00 AM EST - 1 year ago

Upstream Bio Announces Addition to Russell 2000® Index


Upstream Bio Quarterly report: Q3 2024

Nov 7, 2024, 7:00 AM EST - 1 year ago

Upstream Bio Quarterly report: Q3 2024


Upstream Bio Earnings release: Q3 2024

Nov 7, 2024, 7:00 AM EST - 1 year ago

Upstream Bio Earnings release: Q3 2024


Upstream Bio valued at $1.1 bln as shares jump in Nasdaq debut

Oct 11, 2024, 12:49 PM EDT - 1 year ago

Upstream Bio valued at $1.1 bln as shares jump in Nasdaq debut


Upstream Bio raises $255 mln in US IPO

Oct 10, 2024, 7:42 PM EDT - 1 year ago

Upstream Bio raises $255 mln in US IPO


Gunnar1
Gunnar1 Jun. 25 at 1:55 PM
0 · Reply
Gunnar1
Gunnar1 Jun. 25 at 1:50 PM
$UPB Piper Sandler today with "BUY2 rating and a price target of 75$ (!) 💪
0 · Reply
SQUEAKSBANDIT
SQUEAKSBANDIT Jun. 14 at 11:56 PM
$UPB certainly "smells" like good news
0 · Reply
AlertsAndNews
AlertsAndNews Jun. 14 at 10:08 PM
$UPB Upstream Bio Presents New Responder Analyses Demonstrating Clinically Meaningful Improvements in CRSwNP in Significant Majority of Participants Treated with Verekitug in the Phase 2 VIBRANT Trial at EAACI 2026 "Verekitug, administered once every three months, led to clinically meaningful improvements in nasal polyp score (NPS) in approximately 80% of participants – – Majority of verekitug-treated participants experienced clinically meaningful improvements across key secondary endpoints, including 72% in nasal congestion and 83% in CRSwNP total symptom score"
0 · Reply
Rounderssss4
Rounderssss4 Jun. 14 at 3:18 PM
$UPB Placebo-adjusted nasal polyp score reduction of -1.95 at Week 24, nearly double the 1.0-point meaningful threshold
0 · Reply
Rounderssss4
Rounderssss4 Jun. 14 at 2:59 PM
$UPB Upstream Bio says Phase 2 VIBRANT trial shows verekitug improves nasal polyp score in about 80% of CRSwNP patients https://www.webullapp.com/news-detail/15056145028318208?__app_cfg__=%7B%22supportTheme%22%3Atrue%7D&sourcePage=QuotesFragment&tickerId=951001040&audioNewsPlayedDuration=&theme=1&color=2&hl=en&android_sdk_int=36&canary-version=&_v=1&sp=1&statusBarHeightV2=33&isLite=false&wbFontSetting=medium&wbFontUnit=29&wbFontSize=32&isSubsNews=false
0 · Reply
SQUEAKSBANDIT
SQUEAKSBANDIT Jun. 12 at 11:57 PM
$UPB took some before the close
0 · Reply
SQUEAKSBANDIT
SQUEAKSBANDIT Jun. 12 at 5:06 PM
$UPB bt the downgrade and upcoming presentation it appears as if no one wants to hold this name over the weekend appears so oversold but could just as easily be even more oversold in the 5s tempting but not sure i want to re-enter just yet
1 · Reply
Rounderssss4
Rounderssss4 Jun. 12 at 1:46 PM
$UPB interesting a downgrade before presentation this weekend, I'm guessing good news is coming
1 · Reply
Xrx12
Xrx12 Jun. 12 at 1:44 PM
$UPB I actually don't think this stock ever reaches double digits again
1 · Reply
Rounderssss4
Rounderssss4 Jun. 12 at 9:40 AM
$UPB New data to be presented this weekend. Looking for a rebound in stock price
0 · Reply
Xrx12
Xrx12 Jun. 8 at 6:05 PM
$UPB going to penny stock territory soon
0 · Reply
Xrx12
Xrx12 Jun. 5 at 8:05 PM
$UPB good chance this hits it's all time low. Stock may have performed better if they failed Ph2b
0 · Reply
Xrx12
Xrx12 Jun. 5 at 3:26 PM
$UPB RIP
0 · Reply
notreload_ai
notreload_ai Jun. 3 at 2:51 PM
$DOCN $UPB $WPP -- THE WSJ
0 · Reply
Xrx12
Xrx12 Jun. 2 at 8:02 PM
$UPB buy tomorrow on another 15% haircut.
0 · Reply
Xrx12
Xrx12 Jun. 2 at 7:22 PM
$UPB no buying even at these prices. Looks like it's going far down
0 · Reply
Xrx12
Xrx12 Jun. 2 at 2:39 PM
$UPB going to 6s even
0 · Reply
Gunnar1
Gunnar1 May. 29 at 3:33 PM
$UPB Stepping back in here, starter for me.
0 · Reply
Xrx12
Xrx12 May. 28 at 8:46 PM
$UPB do we see 7s tomorrow?
0 · Reply
Xrx12
Xrx12 May. 19 at 7:57 PM
$UPB it's crazy how they can drag a phase 3 ready asset that is highly derisked to cash levels, but will be a buyer off this manipulation soon
0 · Reply
Trainguy1
Trainguy1 May. 15 at 3:26 PM
$UPB Upstream Bio will present new data on two posters from their Phase 2 VIBRANT trial of verekitug at the American Thoracic Society (ATS) 2026 International Conference in Orlando, Florida, on Monday, May 18, 2026, from 11:30 AM to 1:15 PM ET. The posters will be presented during the "B32 – Rise of the Biologics: A New Hope for Breathing Easier" session.
0 · Reply