Market Cap 318.22M
Revenue (ttm) 2.85M
Net Income (ttm) -143.44M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -5,032.98%
Debt to Equity Ratio 0.00
Volume 421,200
Avg Vol 583,308
Day's Range N/A - N/A
Shares Out 54.77M
Stochastic %K 2%
Beta 1.28
Analysts Strong Sell
Price Target $33.67

Company Profile

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts.

Industry: Biotechnology
Sector: Healthcare
Phone: 781 208 2466
Address:
890 Winter Street, Suite 200, Waltham, United States
Xrx12
Xrx12 Sep. 16 at 12:14 AM
$UPB bid is at 4.99 overnight. Get ready for a colossal collapse
0 · Reply
Xrx12
Xrx12 Sep. 15 at 1:48 PM
$UPB possible to see 4s soon here
0 · Reply
Xrx12
Xrx12 Sep. 10 at 7:18 PM
$UPB still another 20% drop likely coming
0 · Reply
Xrx12
Xrx12 Sep. 10 at 3:03 PM
$UPB once this reaches a dollar ill buy a lot of shares
1 · Reply
Xrx12
Xrx12 Sep. 9 at 3:42 PM
$UPB down we go!
0 · Reply
Merlintrader
Merlintrader Sep. 8 at 4:31 PM
Biotech Radar | September 9 edition $ROIV $BEAM $UPB $BMY: clinical progress, evidence and next steps. News through September 8. Free Biotech Catalyst Calendar on Merlintrader. https://www.merlintrader.com/biotech-radar-september-9-2026/
0 · Reply
Trainguy1
Trainguy1 Sep. 8 at 12:57 PM
$UPB Verekitug’s efficacy for reducing asthma exacerbations appears comparable to Tezspire’s, However, Verekitug can be administered less frequently. Both therapeutics demonstrated a low incidence of serious TEAEs.
0 · Reply
Megabyte48
Megabyte48 Sep. 8 at 11:01 AM
$UPB Phase2 data dropped
0 · Reply
STACKD0E
STACKD0E Sep. 8 at 10:16 AM
0 · Reply
Autolus_Freakk
Autolus_Freakk Sep. 8 at 9:38 AM
$UPB Consistent with previous findings however Tezspire (tezepelumab) from AstraZeneca and Amgen significantly reduces the annualized asthma exacerbation rate by 56% to 71%. So Verekitug is second best
1 · Reply
Latest News on UPB
Upstream Bio price target lowered to $25 from $43 at Truist

2026-08-17T09:22:30.000Z - 4 weeks ago

Upstream Bio price target lowered to $25 from $43 at Truist


Upstream Bio price target raised to $9 from $8 at JPMorgan

2026-08-16T13:38:40.000Z - 4 weeks ago

Upstream Bio price target raised to $9 from $8 at JPMorgan


Upstream Bio price target lowered to $25 from $43 at Truist

2026-08-11T18:55:22.000Z - 5 weeks ago

Upstream Bio price target lowered to $25 from $43 at Truist


Upstream Bio reports Q2 revenue $773,000, consensus $377,250

2026-08-11T11:15:27.000Z - 5 weeks ago

Upstream Bio reports Q2 revenue $773,000, consensus $377,250


Upstream Bio Earnings release: Q2 2026

Aug 11, 2026, 7:00 AM EDT - 5 weeks ago

Upstream Bio Earnings release: Q2 2026


Upstream Bio Quarterly report: Q2 2026

Aug 11, 2026, 7:00 AM EDT - 5 weeks ago

Upstream Bio Quarterly report: Q2 2026


Upstream Bio Slides: Corporate presentation

Aug 11, 2026, 7:00 AM EDT - 5 weeks ago

Upstream Bio Slides: Corporate presentation


Upstream Bio management to meet with Piper Sandler

2026-06-17T20:20:10.000Z - 3 months ago

Upstream Bio management to meet with Piper Sandler


KBRA Assigns Preliminary Ratings to OBX 2026-AHC2 Trust

Jun 12, 2026, 5:07 PM EDT - 3 months ago

KBRA Assigns Preliminary Ratings to OBX 2026-AHC2 Trust


Upstream Bio downgraded to Neutral from Overweight at JPMorgan

2026-06-12T08:55:22.000Z - 3 months ago

Upstream Bio downgraded to Neutral from Overweight at JPMorgan


Upstream Bio Transcript: AGM 2026

Jun 9, 2026, 9:00 AM EDT - 3 months ago

Upstream Bio Transcript: AGM 2026


Upstream Bio initiated with a Buy at H.C. Wainwright

2026-06-03T10:11:07.000Z - 3 months ago

Upstream Bio initiated with a Buy at H.C. Wainwright


Upstream Bio price target lowered to $50 from $51 at Mizuho

2026-05-14T12:37:47.000Z - 4 months ago

Upstream Bio price target lowered to $50 from $51 at Mizuho


Upstream Bio Earnings release: Q1 2026

May 13, 2026, 7:00 AM EDT - 4 months ago

Upstream Bio Earnings release: Q1 2026


Upstream Bio Quarterly report: Q1 2026

May 13, 2026, 7:00 AM EDT - 4 months ago

Upstream Bio Quarterly report: Q1 2026


Upstream Bio Slides: Corporate presentation

May 13, 2026, 7:00 AM EDT - 4 months ago

Upstream Bio Slides: Corporate presentation


Upstream Bio Proxy statement: Proxy filing

Apr 16, 2026, 8:00 AM EDT - 5 months ago

Upstream Bio Proxy statement: Proxy filing


Upstream Bio Proxy statement: Proxy filing

Apr 16, 2026, 8:00 AM EDT - 5 months ago

Upstream Bio Proxy statement: Proxy filing


Upstream Bio Slides: Corporate presentation

Apr 6, 2026, 7:00 AM EDT - 5 months ago

Upstream Bio Slides: Corporate presentation


Upstream Bio Annual report: Q4 2025

Mar 26, 2026, 7:00 AM EDT - 5 months ago

Upstream Bio Annual report: Q4 2025


Upstream Bio Earnings release: Q4 2025

Mar 26, 2026, 7:00 AM EDT - 5 months ago

Upstream Bio Earnings release: Q4 2025


Upstream Bio Slides: Corporate presentation

Mar 26, 2026, 7:00 AM EDT - 5 months ago

Upstream Bio Slides: Corporate presentation


Upstream Bio announces verekitug met the primary endpoint

2026-03-01T16:35:25.000Z - 6 months ago

Upstream Bio announces verekitug met the primary endpoint


Upstream Bio Transcript: Study result

Feb 11, 2026, 8:00 AM EST - 7 months ago

Upstream Bio Transcript: Study result


Upstream Bio Press release: Study result

Feb 11, 2026, 8:00 AM EST - 7 months ago

Upstream Bio Press release: Study result


Upstream Bio Slides: Study result

Feb 11, 2026, 8:00 AM EST - 7 months ago

Upstream Bio Slides: Study result


Upstream Bio Slides: Corporate presentation

Jan 9, 2026, 7:00 AM EST - 8 months ago

Upstream Bio Slides: Corporate presentation


Upstream Bio Transcript: Stifel 2025 Healthcare Conference

Nov 11, 2025, 9:20 AM EST - 10 months ago

Upstream Bio Transcript: Stifel 2025 Healthcare Conference


Upstream Bio Slides: Corporate Presentation

Nov 9, 2025, 6:00 PM EST - 10 months ago

Upstream Bio Slides: Corporate Presentation


Upstream Bio Quarterly report: Q3 2025

Nov 5, 2025, 7:00 AM EST - 10 months ago

Upstream Bio Quarterly report: Q3 2025


Upstream Bio Earnings release: Q3 2025

Nov 5, 2025, 7:00 AM EST - 10 months ago

Upstream Bio Earnings release: Q3 2025


Upstream Bio Transcript: Study Update

Sep 2, 2025, 8:00 AM EDT - 1 year ago

Upstream Bio Transcript: Study Update


Upstream Bio Press release: Study Update

Sep 2, 2025, 8:00 AM EDT - 1 year ago

Upstream Bio Press release: Study Update


Upstream Bio Slides: Study Update

Sep 2, 2025, 8:00 AM EDT - 1 year ago

Upstream Bio Slides: Study Update


Upstream Bio Earnings release: Q2 2025

Aug 6, 2025, 4:00 PM EDT - 1 year ago

Upstream Bio Earnings release: Q2 2025


Upstream Bio Quarterly report: Q2 2025

Aug 6, 2025, 4:00 PM EDT - 1 year ago

Upstream Bio Quarterly report: Q2 2025


Upstream Bio Appoints Stacy Price as Chief Technology Officer

May 20, 2025, 7:00 AM EDT - 1 year ago

Upstream Bio Appoints Stacy Price as Chief Technology Officer


Upstream Bio Quarterly report: Q1 2025

May 6, 2025, 7:00 AM EDT - 1 year ago

Upstream Bio Quarterly report: Q1 2025


Upstream Bio Earnings release: Q1 2025

May 6, 2025, 7:00 AM EDT - 1 year ago

Upstream Bio Earnings release: Q1 2025


Upstream Bio Proxy statement: Proxy Filing

Apr 17, 2025, 8:00 AM EDT - 1 year ago

Upstream Bio Proxy statement: Proxy Filing


Upstream Bio Proxy statement: Proxy Filing

Apr 17, 2025, 8:00 AM EDT - 1 year ago

Upstream Bio Proxy statement: Proxy Filing


Upstream Bio Earnings release: Q4 2024

Mar 12, 2025, 7:00 AM EDT - 1 year ago

Upstream Bio Earnings release: Q4 2024


Upstream Bio Annual report: Q4 2024

Mar 12, 2025, 7:00 AM EDT - 1 year ago

Upstream Bio Annual report: Q4 2024


Upstream Bio Announces Addition to Russell 2000® Index

Dec 16, 2024, 8:00 AM EST - 1 year ago

Upstream Bio Announces Addition to Russell 2000® Index


Upstream Bio Quarterly report: Q3 2024

Nov 7, 2024, 7:00 AM EST - 1 year ago

Upstream Bio Quarterly report: Q3 2024


Upstream Bio Earnings release: Q3 2024

Nov 7, 2024, 7:00 AM EST - 1 year ago

Upstream Bio Earnings release: Q3 2024


Upstream Bio valued at $1.1 bln as shares jump in Nasdaq debut

Oct 11, 2024, 12:49 PM EDT - 1 year ago

Upstream Bio valued at $1.1 bln as shares jump in Nasdaq debut


Upstream Bio raises $255 mln in US IPO

Oct 10, 2024, 7:42 PM EDT - 1 year ago

Upstream Bio raises $255 mln in US IPO


Xrx12
Xrx12 Sep. 16 at 12:14 AM
$UPB bid is at 4.99 overnight. Get ready for a colossal collapse
0 · Reply
Xrx12
Xrx12 Sep. 15 at 1:48 PM
$UPB possible to see 4s soon here
0 · Reply
Xrx12
Xrx12 Sep. 10 at 7:18 PM
$UPB still another 20% drop likely coming
0 · Reply
Xrx12
Xrx12 Sep. 10 at 3:03 PM
$UPB once this reaches a dollar ill buy a lot of shares
1 · Reply
Xrx12
Xrx12 Sep. 9 at 3:42 PM
$UPB down we go!
0 · Reply
Merlintrader
Merlintrader Sep. 8 at 4:31 PM
Biotech Radar | September 9 edition $ROIV $BEAM $UPB $BMY: clinical progress, evidence and next steps. News through September 8. Free Biotech Catalyst Calendar on Merlintrader. https://www.merlintrader.com/biotech-radar-september-9-2026/
0 · Reply
Trainguy1
Trainguy1 Sep. 8 at 12:57 PM
$UPB Verekitug’s efficacy for reducing asthma exacerbations appears comparable to Tezspire’s, However, Verekitug can be administered less frequently. Both therapeutics demonstrated a low incidence of serious TEAEs.
0 · Reply
Megabyte48
Megabyte48 Sep. 8 at 11:01 AM
$UPB Phase2 data dropped
0 · Reply
STACKD0E
STACKD0E Sep. 8 at 10:16 AM
0 · Reply
Autolus_Freakk
Autolus_Freakk Sep. 8 at 9:38 AM
$UPB Consistent with previous findings however Tezspire (tezepelumab) from AstraZeneca and Amgen significantly reduces the annualized asthma exacerbation rate by 56% to 71%. So Verekitug is second best
1 · Reply
Autolus_Freakk
Autolus_Freakk Sep. 8 at 9:14 AM
$UPB https://www.stocktitan.net/news/UPB/upstream-bio-presents-results-from-the-phase-2-valiant-trial-of-vo0cjr49wgjc.html
0 · Reply
Autolus_Freakk
Autolus_Freakk Sep. 8 at 9:09 AM
$UPB Great data
0 · Reply
Autolus_Freakk
Autolus_Freakk Sep. 8 at 9:08 AM
$UPB https://www.globenewswire.com/news-release/2026/09/08/3357341/0/en/upstream-bio-presents-results-from-the-phase-2-valiant-trial-of-verekitug-for-the-treatment-of-severe-asthma-in-oral-presentation-at-ers-congress-2026.html
0 · Reply
Megabyte48
Megabyte48 Sep. 5 at 10:13 AM
$UPB I got a little let’s see how the phase updates go, i mean someone bought 102k shares at 6.01 so why not.
0 · Reply
Xrx12
Xrx12 Sep. 4 at 8:12 PM
$UPB wonder if we see $1.0 by next year
0 · Reply
SimplyFussFree
SimplyFussFree Sep. 4 at 7:11 AM
$UPB I’m simultaneously upset I have funds tied up here with it going nowhere lately, yet reluctant to sell because I’m still optimistic…
2 · Reply
Xrx12
Xrx12 Sep. 3 at 5:40 PM
$UPB no bounce from the 52 week low and no buying pressure. This thing is going all the way down
0 · Reply
SQUEAKSBANDIT
SQUEAKSBANDIT Sep. 3 at 4:28 PM
$UPB any news out today?
2 · Reply
Xrx12
Xrx12 Sep. 3 at 2:02 PM
$UPB 📉📉📉📉
0 · Reply
Xrx12
Xrx12 Sep. 3 at 1:46 PM
$UPB will probably hit $5.00 here soon
0 · Reply
Gunnar1
Gunnar1 Sep. 2 at 3:17 PM
$UPB Stepping back in here.
1 · Reply
Xrx12
Xrx12 Sep. 2 at 3:10 PM
$UPB here comes the drop
0 · Reply