Jun. 18 at 6:32 PM
$NAMS IL-6 is a far more relevant marker for inflammation in ASCVD than hs-CRP. hs-CRP has no significant predictive value for MACE after adjusting for elevated IL-6. Some drugs that reduce CRP also reduce IL-6 (ie statins, ziltivekimab), but bempedoic acid has no impact on IL-6. Thus, its hs-CRP reduction likely has little to no effect on MACE.
One day the ESPR bulls may stop spamming this board with "primary prevention!" and "hs-CRP!" but today is not that day.
https://www.atherosclerosis-journal.com/article/S0021-9150(24)00021-2/abstract