Apr. 24 at 7:23 PM
$GLSI
As we all probably crunch numbers trying to predict the event count, what are your core assumptions?
1. Placebo recurrence rate - ~3.5%?
(Enhertu lowered the ARR compared to Kadcyla)
2. Total enrolled in blinded arm on December 2025 ~250?
3. Current screen rate 800/year, 66/month, but now allowing all HLA types?
4. Total screened, ~1300
5. Screened ~250 since December, enrolled ~100, so total 350/500 in blinded arm, will fill up in MAX 3 months (assuming those who didn't enroll due to HLA might now join in in a burst)
All in all, the coming ~5 months are the money time.
