prismmarketview
Oct 5, 2:24 PM
$ATHE
New Phase 2 analyses for ATH434 (iron chaperone) in MSA. 50mg: 4.64-pt advantage vs placebo on 11-item UMSARS Part I at Week 52 after baseline-severity adjustment, ~52% slowing of functional decline (p=0.032). Company cites ~3x the 1.5-pt clinically meaningful threshold.
CSF NfL biomarker predicted faster decline: +1,000 pg/mL baseline = ~0.9 extra points of worsening at 52 wks (p=0.033), which Alterity wants to use in future trials to adjust for baseline severity. 75mg: 2.81-pt benefit, not significant (p=0.179).
Key caveats: primary MRI endpoint (substantia nigra iron change) was missed. The dentate nucleus iron-redistribution explanation is still a hypothesis. Adjusted, post-analysis result in a small Phase 2. Plans a Phase 3, no timeline or financing disclosed here.
https://prismmarketview.com/alterity-reports-positive-ath434-data-in-multiple-system-atrophy-study/
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