Jul. 13 at 10:25 PM
$AFMD Even Merck is in on this:
Affimed Trials AFM13 with Keytruda
Affimed N.V. (AFMD) announced a Phase 1b clinical trial evaluating AFM13 in combination with Merck & Co.'s (MRK) KEYTRUDA (pembrolizumab) for patients with Hodgkin lymphoma.
Phase 1b Clinical Trial: The trial investigated the combination of AFM13, a bispecific antibody targeting CD30 and CD16A, with KEYTRUDA, an anti-PD-1 therapy, for patients with relapsed or refractory Hodgkin lymphoma.
Preclinical Synergy: Preclinical studies demonstrated that AFM13, in combination with an anti-PD-1 antibody, showed significant synergy, with up to 90% of tumors eradicated in patient-derived xenograft models.
Publication of Results: The Phase 1b study results were published in Blood, showing an objective response rate (ORR) of 88% at the highest treatment dose, with a complete response (CR) rate of 46%.