Mar. 7 at 8:32 PM
$AFMD from Brave AI ..
-Roche has not terminated its partnership with Affimed, but it has discontinued certain development programs under their collaboration.
In July 2021, Roche announced the discontinuation of RG6296 (AFM26), a bispecific antibody targeting BCMA for multiple myeloma, developed under the Affimed collaboration. This decision was driven by intense competition in the BCMA space, with advanced CAR-T therapies and other bispecifics demonstrating strong efficacy. Despite Affimed’s promising NK cell-engaging platform, the project was halted due to the high bar for differentiation in this therapeutic area.
Roche also discontinued two gene therapy programs licensed from 4D Molecular (4D-110 and 4D-125) due to a "change in risk-benefit profile," which affected the broader ophthalmology gene therapy landscape.
However, the core strategic collaboration between Roche (via Genentech) and Affimed remains active.