Jan. 27 at 12:12 PM
$ACRS $3.83 bid.
CHANGE EXIT TO
$7.00
Holding long position as REVISIT at
$1.48
https://stocktwits.com/G101SPM/message/579757835
BRIEF: Aclaris Therapeutics announced recent positive preclinical results from its potent and selective ITK/JAK3 inhibitor ATI-2138 in a murine model of severe alopecia areata.
note: ATI-2138 and ritlecitinib were assessed using a reversal model of murine alopecia universalis, the most severe AA phenotype. Mice were randomized to control or drug formulated in chow (100 or 300 ppm ATI-2138; 300 ppm ritlecitinib) after hair loss was established. Hair regrowth was assessed at baseline and weeks 2, 4, and 6.
Rapid onset of hair regrowth was observed at week 2 in mice receiving 300 ppm ATI-2138 (mean percent hair regrowth of 37%) and reached near peak effect at week 4 (mean percent hair regrowth of 87%) compared to 300 ppm ritlecitinib (25% and 48%, respectively). Mice receiving control chow showed no improvement in hair regrowth.
At week 6, the mean percent hair regrowth was 93% for ATI-2138 (300 ppm) compared to 78% for ritlecitinib (300 ppm). Mice receiving control chow showed no improvement in hair regrowth.
Given the uniquely potent and selective mechanism of ATI-2138, Aclaris is assessing additional indications for ATI-2138, including alopecias, and expects to initiate a Phase 2b trial in the first half of 2026.
