Nov. 4 at 3:11 PM
Abpro Corporation shares rose after the company announced that its bispecific HER2/CD3 antibody, developed with Celltrion, was selected among the top 150 abstracts for the 2025 Society for Immunotherapy of Cancer (SITC) Annual Meeting.
The therapy, CT-P72/ABP-102, showed strong antitumor activity in preclinical studies, including efficacy against tumors resistant to Enhertu. It demonstrated selective binding to tumor cells with high HER2 expression while minimizing activity in normal tissues, suggesting an improved safety profile.
CEO Miles Suk said the antibody exhibited potent activity and high selectivity in HER2-overexpressing and Enhertu-resistant models, maintaining favorable safety in nonhuman primates.
Preclinical data will be presented at SITC 2025 in Maryland, with plans to move into human trials next year targeting HER2-positive breast, gastric, colorectal, and other solid tumors.
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