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Market Cap 2.20B P/E - EPS this Y 27.80% Ern Qtrly Grth -
Income -445.67M Forward P/E -4.27 EPS next Y 22.40% 50D Avg Chg -24.00%
Sales 97.24M PEG -0.07 EPS past 5Y - 200D Avg Chg -16.00%
Dividend N/A Price/Book 1.94 EPS next 5Y 16.80% 52W High Chg -39.00%
Recommedations 2.90 Quick Ratio 9.51 Shares Outstanding 61.05M 52W Low Chg 14.00%
Insider Own 11.90% ROA -31.58% Shares Float 48.34M Beta 0.92
Inst Own 89.52% ROE -55.28% Shares Shorted/Prior 5.82M/5.93M Price 36.74
Gross Margin -213.59% Profit Margin - Avg. Volume 825,733 Target Price 14.59
Oper. Margin -1,286.11% Earnings Date Nov 5 Volume 1,280,809 Change 2.06%
About Sage Therapeutics, Inc.

Sage Therapeutics, Inc., a biopharmaceutical company, develops and commercializes brain health medicines. Its product candidates include ZULRESSO, a CIV injection for the treatment of postpartum depression (PPD) in adults; and ZURZUVAE, a neuroactive steroid, a positive allosteric modulator of GABAA receptors, targeting both synaptic and extrasynaptic GABAA receptors, for the treatment of postpartum depression. Its product pipeline also comprises SAGE-324, a compound that is in Phase II clinical trial to treat essential tremors, as well as has completed Phase I clinical trial for epilepsy and Parkinson's diseases; and SAGE-718, an oxysterol-based positive allosteric modulator of the NMDA receptor, which is in Phase II clinical trial for the treatment of depression, Huntington's disease, Parkinson's diseases, Alzheimer's disease, attention deficit hyperactivity disorder, schizophrenia, and neuropathic pain. The company has a strategic collaboration with Shionogi & Co., Ltd. for the development and commercialization of zuranolone in Japan, Taiwan, and South Korea; and a collaboration and license agreement with Biogen MA Inc. to jointly develop and commercialize SAGE-217 and SAGE-324 products. The company was formerly known as Sterogen Biopharma, Inc. and changed its name to Sage Therapeutics, Inc. in September 2011. Sage Therapeutics, Inc. was incorporated in 2010 and is headquartered in Cambridge, Massachusetts.

Sage Therapeutics, Inc. News
12:13 PM Biotech Stock Roundup: SAGE, INCY Suffer Setbacks, JAZZ Wins Oncology Drug Approval & More
11:56 AM Sage ends dalzanemdor development following Phase II trial failure
10:56 AM SAGE's Dalzanemdor Fails to Meet Goal in Huntington's Disease Study
11/20/24 After Failed Alzheimer's Study, Sage Therapeutics' Dalzanemdor Flunks Another Study In Patients With Inherited Brain Disorder
11/20/24 Sage’s string of research failures continues
11/20/24 Sage Therapeutics Announces Topline Results from the Phase 2 DIMENSION Study of Dalzanemdor (SAGE-718) in the Treatment of Cognitive Impairment Associated with Huntington’s Disease
10/31/24 Sage Therapeutics price target lowered to $26 from $52 at Piper Sandler
10/30/24 SAGE's Q3 Loss Wider Than Expected, Revenues Rise Y/Y, Stock Down
10/30/24 Biogen, Sage admit a defeat in major depression
10/30/24 Sage Therapeutics Inc (SAGE) Q3 2024 Earnings Call Highlights: Strong Revenue Growth Amid ...
10/29/24 Sage Therapeutics, Inc. (SAGE) Reports Q3 Loss, Tops Revenue Estimates
10/29/24 Sage Therapeutics Announces Third Quarter 2024 Financial Results and Highlights Pipeline and Business Updates
10/23/24 Neurocrine Biosciences (NBIX) Earnings Expected to Grow: Should You Buy?
10/22/24 Sage Therapeutics, Inc. (SAGE) Expected to Beat Earnings Estimates: What to Know Ahead of Q3 Release
10/18/24 State Street Corp's Strategic Acquisition of Sage Therapeutics Shares
10/18/24 Sage Therapeutics to Reduce Workforce by 33%, Stock Down
10/17/24 Sage lays off 55% of R&D workforce and refocuses pipeline
10/17/24 Sage Therapeutics Cuts Workforce by 33% in Reorganization, Focuses on ZURZUVAE Launch and Pipeline
10/17/24 Sage Therapeutics CFO, GC, CTO to depart in wide restructuring plan
10/17/24 After Series Of Trial Setbacks, Sage Therapeutics To Lay Off One-Third Workforce
SAGE Chatroom

User Image BioAB Posted - 4 hours ago

$SAGE $CLVSQ $CRXTQ another one joins the ranks.

User Image erevnon Posted - 7 hours ago

RBC Capital upgrades Sage Therapeutics $SAGE from Underperform to Sector Perform and maintains the price target at https://marketsblock.com/stock-upgrades-and-downgrades/

User Image BioAB Posted - 13 hours ago

$SAGE what’s left to target now that HD is done? Clinical trials wise.

User Image OCStockDoc Posted - 18 hours ago

$SAGE Idiot says Sage 718 has potential... Idiots runs parallel trials... Same idiot says there is a potential market for PPD... Who believes this idiot now?

User Image OCStockDoc Posted - 21 hours ago

$SAGE Company needs a department of DOGE to clean house!

User Image OCStockDoc Posted - 1 day ago

$SAGE So, Barry Greene, Laura Gault and the rest of the C-Suit going to get fired soon? When is the board going to be held accountable for not doing jack...

User Image scwillia Posted - 1 day ago

$SAGE History aside, this is a clear buy now. Pipeline of high-risk assets cleared out, restructuring underway and break-even a distinct possibility during 2026, if not earlier. Scrip trends suggest lead drug Zurzuvae on track for $100m in Q4 2025 (or $400m ARR).

User Image WhiteKnuckleInvestments Posted - 1 day ago

$SAGE Headlines in Boston this morning... Board is a disgrace. No accountability.

User Image Article_AI Posted - 1 day ago

$SAGE Sage Therapeutics to end Huntington's disease trial after key therapy fails again It was the third failed trial for the therapy, called dalzanemdor, which also failed to meet its goals in a Phase 2 trial as a treatment for mild cognitive impairment and mild dementia in Alzheimer's disease. https://www.stck.pro/news/SAGE/93671932/

User Image OpenOutcrier Posted - 1 day ago

$SAGE (-3.3% pre) Sage stock slips as Huntington’s Disease trial fails - SA https://ooc.bz/l/48769

User Image BioAB Posted - 1 day ago

$SAGE sorry guys…

User Image briefingcom Posted - 1 day ago

Gapping down: $TGT -17.4% $POWL -13.9% $SVM -13.5% $QDEL -6.7% $SAGE -5.7%

User Image Article_AI Posted - 1 day ago

$SAGE Sage Therapeutics scraps development of rare disease drug after it fails mid-stage study Sage Therapeutics will stop development of its experimental drug to treat cognitive impairment in patients with Huntington's disease after it failed a mid-stage study, the drug developer said on Wednesday. https://www.stck.pro/news/SAGE/93668884/

User Image DonCorleone77 Posted - 1 day ago

$SAGE Sage Therapeutics reports results from Phase 2 DIMENSION Study Sage Therapeutics announced topline results from the Phase 2 DIMENSION Study of dalzanemdor, or SAGE-718, in participants with cognitive impairment, or CI, associated with Huntington's Disease, or HD. In the study, dalzanemdor did not demonstrate a statistically significant difference versus placebo on the primary endpoint, the change from baseline on the Symbol Digit Modalities Test, or SDMT, at Day 84. Analyses of secondary endpoints did not demonstrate statistically significant or clinically meaningful differences in participants treated with dalzanemdor compared to placebo. Based on these results, the Company does not plan further development of dalzanemdor. The DIMENSION Study was a 12-week, double-blind, placebo-controlled Phase 2 study to evaluate the effects of dalzanemdor in participants with CI associated with HD. A total of 189 participants were randomized. The DIMENSION Study did not demonstrate a statistically significant difference from baseline in participants treated with dalzanemdor versus placebo on the SDMT, a measure of cognitive function, at Day 84, the primary endpoint. Dalzanemdor was generally well-tolerated and no new safety signals were observed. The majority of treatment emergent adverse events were mild to moderate in severity. Analyses of secondary endpoints did not demonstrate statistically significant or clinically meaningful differences between the dalzanemdor and placebo treatment groups. Given these findings, the Company also will close the ongoing PURVIEW Study, an open-label safety study of dalzanemdor in participants with HD.

User Image OCStockDoc Posted - 2 days ago

$SAGE Why is Sage still sponsoring Huntington's disease events? Why are they wasting money on sponsorships where they don't even have a drug for yet? Is this justified by the 10 years of research Laura Gault is talking about? What a joke stop burning money! Fire more people! Greene step down!

User Image Apoliak Posted - 2 days ago

$LUNR $SFTBY $KULR $SAGE time to load up! Low RSO and extremely bullish.

User Image EdwardYork Posted - 3 days ago

$XOMA $SAGE 😏🚀 MYNZ We know the date of the reverse split (RS) if there will be one, but possibly a Nasdaq extension will be granted. Last time it traded, 50 million and 19 million heavy shorts attacked. Now, it has huge credibility after the TMO partnership and the meeting. The company will decide by November 25th whether or not to do an RS based on Nasdaq's response. Anyway, after the RS, I'm not worried about what happens next. A $210 billion partner TMO signing a deal with a penny stock has never happened before. I will be loading heavy on Monday. This will go to the moon like the DRUG stock recently did. The price target (PT) is $50. The squeeze will be parabolic.

User Image WhiteKnuckleInvestments Posted - 6 days ago

$SAGE With a 325M MC, now valued at -199M from COH (based on 7M week burn). Clear signal from street that 718 HD is DOA. A stunning collapse under the disgraced CEO, Barry Greene, who has effectively burned out the entire pipeline and bungled MDD to the dismay of many early employees. Has fleeced billions of investor dollars and has recently seen a institutions dropping and selling off position. PPD Forward Valuation is zero and every single analyst has moved to the sidelines while expressing great disappointment of this C Suite. Yet, still 8 board members (where are they?!) and 300+ employees for what? Now a micro cap and falling by the day.

User Image BioAB Posted - 1 week ago

$LPCN give or take about 45 days till NDA for PPD, likely hear back in 60 days so puts us in end of Feb maybe March. I think it would be a 10 month. Jan 2026 likely action date. Run up usually starts up 6-7 months before action date. Of course Jan is when we get payment from verity of 1m $. We also have Q4 / 10k which can include the payments from the new partners. I expect those to be around 1-5m each. We likely could see a royalty payment from tlando. Of course we can target other geographic areas for tlando maybe Europe, APAC, etc. Then we have potential of 2401, if they figure out funding. $SAGE

User Image NewHighEveryDay Posted - 1 week ago

$SAGE what’s next catalyst and when?

User Image mcdicedtea Posted - 1 week ago

$SAGE greene, you have less than 6 weeks to get that trial data out. It better be good since your Head MD said sage has decades and centuries of data and research to make that a winning trial. Get it done or leave.

User Image JuggernautRaider Posted - 1 week ago

Both of what? You should own $BHVN or $AXSM . Avoid $SAGE until their CEO quits the board of $KPTI

User Image DividendKing77 Posted - 2 weeks ago

🚨 MYNZ HUGE PR drop incoming before the Nov 13 meeting 🔥 Someone is pushing these dates of upcoming NEWS 3 biggest stock alert channels announced, might consider to add now, who knows. $TKNO $XOMA $SAGE $BMEA

User Image BioAB Posted - 2 weeks ago

$SAGE do it, post a screenshot too. I never short bio, but go ahead. I want some more cheap shares. I actually wanted it to go to 3s. So I can add the 7K I sold.

User Image OCStockDoc Posted - 2 weeks ago

$SAGE BioAB is gonna hate me for this, but I am preparing to short LPCN after earnings as it will fade. I am also about to short XBI as a whole. We are about to have our next leg down as inflation is going to be back on the news shortly especially with the FED cutting rates. The entire Bond market is about to get ugly.

User Image BioAB Posted - 2 weeks ago

$SAGE PPD market not big for Sage (at current burn rate), but certainly for LPCN. They run lean as an org with about 25 or so employees. Led by a ceo with a PHD in physical chemistry degree. And board with former deal makers that sold company for 800m to Supurnus. When LPCN expands their PPD to MDD, TRD and Epilepsy. We are on the rise. Next they are looking to fund their Obesity drug for weight loss and gain lean muscle mass. Expand tlando to more geographic areas. Earnings next week I think. And obesity week conference with NDA next month and payment for tlando from partner in Jan.

User Image OCStockDoc Posted - 2 weeks ago

$SAGE Holding toilet paper? Short this crap to recover some of your money back!

User Image Bone_Spurs Posted - 2 weeks ago

$SAGE Why is this POS not below $1? geez they have non promising drug in their pipeline. Keep buying and keep getting underwater. Smart idea

User Image OCStockDoc Posted - 2 weeks ago

$SAGE “Collapsing birth rate is the biggest danger civilization faces, by far.” -Elon Musk Maybe if Trump gets in, Elon might help fix the birth rate issue and help fund Sage with government grants. 🤣 Probably not though...

User Image OCStockDoc Posted - 2 weeks ago

$SAGE $LPCN Welp better hope that last drug trial with Sage-718 works out because PPD market doesn't look too promising... 🤣

Analyst Ratings
Truist Securities Hold Aug 14, 24
JP Morgan Neutral Aug 6, 24
HC Wainwright & Co. Neutral Aug 2, 24
Piper Sandler Overweight Aug 1, 24
Needham Hold Aug 1, 24
TD Cowen Hold Jul 30, 24
Goldman Sachs Neutral Jul 26, 24
Scotiabank Sector Outperform Jul 25, 24
JP Morgan Neutral Jul 25, 24
Insider Trades Relationship Date Transactions Cost($) #Shares Value($) #Share Own SEC Form 4
Barrett Elizabeth Director Director Aug 09 Buy 18.6393 2,000 37,279 3,000 08/11/23
Barrett Elizabeth Director Director May 09 Buy 50.50 1,000 50,500 1,000 05/11/23
IGUCHI KIMI CFO & Treasurer CFO & Treasurer Feb 21 Option 1.36 1,000 1,360 62,560 02/23/23
Golumbeski George Director Director May 05 Buy 31.4454 8,000 251,563 8,000 05/09/22
JONAS JEFFREY M Director Director Apr 27 Option 0.45 30,944 13,925 115,807 04/29/22