HamburgerTim
Posted - 15 hours ago
$KRON this bled back to $1 for no reason.? Reload...
TheGhostOfEd
Posted - 18 hours ago
$KRON One penny away from a nice doji on the weekly......
flyinghollaender
Posted - 19 hours ago
$XFOR what a roller coaster. We'll see how it ends. I have a good feeling. Still holding 5 thousand shares with avg. 0.65 . Already sold 15k shares with an avg price of 1.33$. $ADAP $HUMA bright weeks & months ahead! $MIST planning to use my earnings or losses from XFOR to buy more. $KRON will buy more at a later state.
Digital_Waffle_Pirate
Posted - 19 hours ago
$KRON Well here you go - in addition to shit response, it appears that SYK targeting HOX/MEIS elevation was the wrong approach for FLT3 in the first place. Immaterial to where we are now, but still a bum deal... they should offload ENTO and LANRA for pennies on the dollar if they can get them... sell em to Incyte since there seemed to be a preclinical rationale for a combo with ruxolitinib. https://www.cell.com/iscience/fulltext/S2589-0042(24)00798-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004224007983%3Fshowall%3Dtrue
Digital_Waffle_Pirate
Posted - 22 hours ago
$KRON An invisibility cloak for would-be cancers. Well ya don't sayyyyy... I wonder what company with roots out of the MIT TLO does a really good job of mapping transcriptional regulatory network and identifying critical co-factors of intrinsically disordered TFs? "But transcription factors such as the one encoded by the SOX17 gene are considered difficult to target using drugs, in part because of their structure. The researchers now plan to identify other proteins that this transcription factor interacts with, in hopes that it might be easier to block some of those interactions." https://www.technologyreview.com/2024/04/23/1090416/an-invisibility-cloak-for-would-be-cancers/
TheGhostOfEd
Posted - 23 hours ago
$KRON Back in with 50k shares. Will double up below .75 if we get there.
Digital_Waffle_Pirate
Posted - 23 hours ago
$KRON For those looking for a filing from Norbert today (I'm not sure I'm one of them) it is worth mentioning that this would look like his November buying... "and on the third day he returned the stock to compliance". Oh boy.... did I just compare Norbert to Jesus? heeeeeeeeeelllpp!
telomerase
Posted - 23 hours ago
$KRON I'm glad that we have A New Hope (Episode 4) now, because the old story was a lot less funny than "we can haz ds RNA and cancer cells would care". Old Story: "By inhibiting CDK9, KB-0742 prevents the phosphorylation of RNA polymerase II. This results in the inhibition of transcription elongation, particularly affecting the expression of short-lived genes that are rapidly induced and are essential for cell proliferation and survival. Many of these genes are oncogenes or other genes critical for cancer cell growth. Selective Impact on Cancer Cells: Cancer cells are often more dependent on such rapidly induced genes for their survival and proliferation compared to normal cells. Therefore, CDK9 inhibitors like KB-0742 can disproportionately affect cancer cells by inhibiting their ability to sustain necessary gene expression levels, leading to impaired growth and induction of apoptosis (programmed cell death).
Digital_Waffle_Pirate
Posted - 1 day ago
$KRON This is a very good/supportive paper, worth anyone's time who cares. TL:DR - KB-0742 disrupts RNA splicing, causing an accumulation of mis-spliced RNA that triggers protein kinase R (PKR), a double-stranded RNA sensor. As PKR activates, it initiates immune pathways akin to those used to fight viral infections. End result is that it targets cancer cells, and also boosts immune response.
RallyRaider
Posted - 1 day ago
$KRON Dear KRONIES It took me a while--- You get the science and thus ignore the business side. Some of the stuff regarding portfolio management, corporate and value creation is SUCH absolute nonsense,, it shocks me that you invest based upon these premises. https://www.youtube.com/playlist?list=PL8FB14A2200B87185 Please take a deeper look instead of trying to unveil the 19th aspect of some hidden agenda.
KavaStocks
Posted - 1 day ago
$KRON These MMs are starting to get cute with hovering it around 1.00.
They're continuing to weigh the R/R of bringing it lower but they're idling heavily on indecision.
Buy some shares, Norbert.
StockAuthority
Posted - 1 day ago
$POAI 37% in a day since my alert! Keep an eye on $EMKR $NUKK $KRON for more like this!
StockAuthority
Posted - 1 day ago
$KRON will you be in when the 13G hits??? :-)
GPS_OS_21_vs_SOC_5
Posted - 1 day ago
$SLS Time for the Regular Reminder, Bill William Walker, aka @telomerase not only is a Lying Scumbag, but it is also a reliable, contrarian indicator, when its posting, the share price always Climbs. Here you can see bill William lying on yahoo, about 009 being "just as toxic" and "cured lied again' on the day SLS published Key Safety data showing 009 is the First Ever Safe CDK9 Inhibitor - and then, in the second screen shot, you see the liar lying about his earlier lies. $VINC $CADL $MAIA $KRON @kubota2323 @peapope @rustycat @SuperTed182 now you know
StockAuthority
Posted - 1 day ago
$KRON OK so now this is a data runup play into ASCO AND a 13G expected play.
StockAuthority
Posted - 1 day ago
$KRON strong green today despite market dip. I was actually hoping to load more at .95 :-(
HamburgerTim
Posted - 2 days ago
$KRON are we expecting much from ER? I figure flat/non event.
Digital_Waffle_Pirate
Posted - 2 days ago
$KRON Former long time colleague of Angela Koehler, now CSO of Amgen, ostensibly the most vocal about undruggable targets among the major pharmas.
wolfywolfy13
Posted - 2 days ago
$KRON 👀
Stock_Titan
Posted - 2 days ago
$KRON Kronos Bio to Present Clinical Update on Phase 1/2 Trial of KB-0742 at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting
https://www.stocktitan.net/news/KRON/kronos-bio-to-present-clinical-update-on-phase-1-2-trial-of-kb-0742-a5dwom0flt00.html
KavaStocks
Posted - 2 days ago
$KRON A close at or above 1.00 would be welcome.
Can we move on from these fractionals, MMs?
Digital_Waffle_Pirate
Posted - 2 days ago
$KRON June 1, 9AM - a Saturday.
Digital_Waffle_Pirate
Posted - 2 days ago
$KRON ASCO it is.
BiotechValues
Posted - 2 days ago
$KRON data update at ASCO
XInFaMoUzZNaSxX
Posted - 3 days ago
$KRON back in. new avg .986
LetsgoDudeszi
Posted - 3 days ago
$KRON This one catching eyes, Soon push back to 1.40 !! Earnings in 14 days.
telomerase
Posted - 3 days ago
$KRON CADL has already recovered my KRON losses and more. Oncolytic viruses* are the future (yes, there will be that one zombie plague, but look at Rwanda, Pol Pot, Chicago etc.... humans are basically zombies anyway). *yes, yes, CAN-2049 is a vector. At least CADL uses DNA viruses instead of the mutating RNA crap that we had in the BL3 at Mayo. I'm still suprised that I'm not GFP green.
LetsgoDudeszi
Posted - 3 days ago
$KRON back over 1 incoming !!