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Market Cap 239.45M P/E - EPS this Y -1.90% Ern Qtrly Grth -
Income -82.64M Forward P/E -2.74 EPS next Y -4.60% 50D Avg Chg -27.00%
Sales - PEG - EPS past 5Y - 200D Avg Chg -38.00%
Dividend N/A Price/Book 1.40 EPS next 5Y - 52W High Chg -60.00%
Recommedations 1.70 Quick Ratio 10.24 Shares Outstanding 37.58M 52W Low Chg 7.00%
Insider Own 9.15% ROA -32.55% Shares Float 16.61M Beta 1.78
Inst Own 84.04% ROE -54.13% Shares Shorted/Prior 0.92M/1.04M Price 6.71
Gross Margin - Profit Margin - Avg. Volume 79,748 Target Price 16.75
Oper. Margin - Earnings Date - Volume 57,074 Change -11.71%
About Vigil Neuroscience, Inc.

Vigil Neuroscience, Inc., a clinical-stage biotechnology company, focuses on developing treatments for rare and common neurodegenerative diseases by restoring the vigilance of microglia, the sentinel immune cells of the brain. Its lead candidate is VGL101(Iluzanebart), a human monoclonal antibody agonist targeting human triggering receptor expressed on myeloid cells 2 and is in a Phase 2 trial in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare and fatal neurodegenerative disease. The company is also developing VG-3927, an orally-available small molecule TREM2 agonist to treat common neurodegenerative diseases associated with microglial dysfunction, with an initial focus on Alzheimer's disease in genetically defined subpopulations, which is being evaluated in a Phase 1 clinical trial. It has license agreement with Amgen Inc. to commercially develop, manufacture, use, distribute, and sell therapeutic products containing compounds that bind to TREM2. The company was incorporated in 2020 and is headquartered in Watertown, Massachusetts.

Vigil Neuroscience, Inc. News
04/17/24 Vigil Presents Key Findings from ILLUMINATE & IGNITE Studies in ALSP at the 2024 American Academy of Neurology Annual Meeting
03/26/24 Vigil Neuroscience Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Business Update
03/24/24 Is Vigil Neuroscience (NASDAQ:VIGL) In A Good Position To Deliver On Growth Plans?
03/20/24 Vigil Neuroscience Appoints Petra Kaufmann, M.D., as Chief Medical Officer
03/13/24 Vigil Announces Upcoming Presentations at 2024 American Academy of Neurology Annual Meeting
03/12/24 Vigil Neuroscience to Present at Stifel 2024 Virtual CNS Days
03/06/24 Vigil Announces Oral Presentation on Small Molecule TREM2 Agonist VG-3927 as a Potential Disease-Modifying Therapeutic at AD/PD 2024
02/29/24 Vigil Presents Poster on Impacts of Misdiagnosis and Genetic Testing on Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) Patient Journey at ACTRIMS 2024
02/07/24 Vigil Neuroscience to Present at Guggenheim 6th Annual Biotechnology Conference
01/03/24 Vigil Neuroscience Provides 2023 Year-in-Review and Highlights Upcoming 2024 Milestones
11/22/23 Vigil Neuroscience to Present at Evercore ISI 6th Annual HealthCONx Conference
11/16/23 Vigil Neuroscience Reports Positive Interim Data from Phase 2 IGNITE Proof-of-Concept Clinical Trial Evaluating Iluzanebart (VGL101) as a Treatment for ALSP and from Ongoing Natural History Study ILLUMINATE
11/07/23 Vigil Neuroscience Reports Third Quarter 2023 Financial Results and Provides Business Update
10/17/23 Vigil Neuroscience Announces First Participant Dosed in Phase 1 Clinical Trial in Healthy Volunteers Evaluating VG-3927, a Small Molecule TREM2 Agonist, for Potential Treatment of Alzheimer’s Disease
10/15/23 Will Vigil Neuroscience (NASDAQ:VIGL) Spend Its Cash Wisely?
10/05/23 Vigil Neuroscience to Present at Jefferies Inaugural Biotech CNS/Neuro Summit
09/26/23 Vigil Neuroscience Receives Positive Opinion from European Medicines Agency on Orphan Drug Designation for VGL101 for the Treatment of ALSP
09/11/23 Vigil Neuroscience Presents VGL101 Complete Phase 1 Data and Phase 2 IGNITE Trial Design at the 2023 American Neurological Association Annual Meeting
09/08/23 Vigil Neuroscience Announces Update on its Small Molecule TREM2 Agonist Program
09/08/23 Vigil Neuroscience to Present at 2023 Morgan Stanley Global Healthcare Conference
VIGL Chatroom

User Image Thestocktraderhubzee Posted - 04/19/24

WATCHLIST APR 19 2024 $BPTH Roth MKM Reiterates Buy on Bio-Path Hldgs, Maintains $40 Price Target $USB DA Davidson Maintains Neutral on U.S. Bancorp, Lowers Price Target to $44 $VIGL JMP Securities Reiterates Market Outperform on Vigil Neuroscience, Maintains $23 Price Target $SPGI Stifel Maintains Buy on S&P Global, Lowers Price Target to $442 $SMTC Stifel Maintains Buy on Semtech, Raises Price Target to $36

User Image DonCorleone77 Posted - 04/17/24

$VIGL Vigil says interim IGNITE Phase 2 data demonstrate VGL101 potential for ALSP Vigil Neuroscience announced the presentation of multiple oral and poster presentations on the company's lead clinical candidate iluzanebart at the 2024 American Academy of Neurology AAN Annual Meeting. "We are excited to see our enthusiasm for iluzanebart matched by clinical leaders in the ALSP community. The interim findings from both the IGNITE Phase 2 and ILLUMINATE Natural History studies support the potential of iluzanebart to become the first, disease-modifying therapy for those living with ALSP," said Petra Kaufmann, M.D., F.A.A.N, Chief Medical Officer of Vigil. "Both trials have led to an incredible step forward - not only in understanding ALSP disease progression, but also in drawing parallels between biomarkers and correlating clinical outcomes. "Vigil's interim IGNITE data demonstrated that iluzanebart was well-tolerated, and the data suggest a favorable impact on the protein product of the CSF1R gene whose dysfunction is the causal driver of ALSP," said Zbigniew Wszolek, M.D., consultant in the Department of Neurology at the Mayo Clinic. "Positive trends on MRI measurements support slowing in irreversible neurodegeneration, and to see these signals in patients as early as six months is very encouraging."..."The findings from ILLUMINATE highlight sensitive markers of ALSP pathophysiology that have the potential to provide valuable insight into clinical endpoints and improve the overall understanding of ALSP disease progression to inform future study designs," said David Lynch, Ph.D., Honorary Research Fellow, Department of Neuromuscular Diseases, University College London.

User Image Stock_Titan Posted - 04/17/24

$VIGL Vigil Presents Key Findings from ILLUMINATE & IGNITE Studies in ALSP at the 2024 American Academy of Neurology Annual Meeting https://www.stocktitan.net/news/VIGL/vigil-presents-key-findings-from-illuminate-ignite-studies-in-alsp-ki32x35r0xlm.html

User Image Tshanky_ Posted - 04/11/24

$VIGL needs volume, but like the opportunity

User Image Tshanky_ Posted - 04/09/24

$VIGL 👀

User Image frontiere Posted - 04/06/24

$VIGL any reasons why Vigil is NOT a Buy at the current $3.33 price per share? 🤔

User Image G101SPM Posted - 03/28/24

@S_Franconi per request: $VIGL $3.20 carries SPM 79.14 tag as neutral suggests company doesn't have enough cash to complete trials for VGL101 (Iluzanebart) without major dilution. If a joint venture can be established, the tag increases to SPM 87.41 with EXIT at $25.00.

User Image S_Franconi Posted - 03/28/24

$VIGL 143 Watchers as of 3/28/24.

User Image S_Franconi Posted - 03/28/24

$VIGL April 14th - VGL101 - (ILLUMINATE) 2024 American Academy of Neurology (AAN) Annual Meeting.

User Image S_Franconi Posted - 03/28/24

$VIGL VGL101 - (IGNITE) 2024 American Academy of Neurology (AAN) Annual Meeting on April 17, 2024.

User Image S_Franconi Posted - 03/28/24

@G101SPM Can you run $VIGL?

User Image RamenLives Posted - 03/27/24

$VIGL

User Image DonCorleone77 Posted - 03/26/24

$VIGL Vigil Neuroscience sees cash runway into 2H25 Cash, cash equivalents, and marketable securities were $117.9 million as of December 31, 2023, compared to $133.6 million as of September 30, 2023. In January 2024, the Company announced that it extended its projected cash runway into the second half of 2025.

User Image DonCorleone77 Posted - 03/26/24

$VIGL Vigil Neuroscience reports Q4 EPS (57c), consensus (53c) "Among our many recent milestones, the most significant for Vigil was the positive data readout from our ongoing Phase 2 IGNITE trial and ILLUMINATE Natural History Study. Findings from these studies have provided critical insights and a rich dataset on biomarkers that we believe support our strategy to advance iluzanebart through clinical development as quickly as possible. We are also pleased to have enrolled 20 patients in our IGNITE trial, exceeding our target of 15 patients. This is a true testament to the importance of our mission to bring a novel therapy to ALSP patients," said Ivana Magovevi-Liebisch, Ph.D., J.D., President and Chief Executive Officer of Vigil. "Our Phase 1 clinical trial evaluating VG-3927 in healthy volunteers is progressing as planned and we are on track to provide an interim data readout in mid-2024. As the first and only clinical-stage small molecule TREM2 agonist..."

User Image Stock_Titan Posted - 03/26/24

$VIGL Vigil Neuroscience Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Business Update https://www.stocktitan.net/news/VIGL/vigil-neuroscience-reports-fourth-quarter-and-full-year-2023-v9onka42galq.html

User Image Ti5 Posted - 03/18/24

$VIGL mucho

User Image S_Franconi Posted - 03/16/24

$VIGL @G101SPM Can you run this?

User Image Ti5 Posted - 03/15/24

$VIGL tutes loading up for sure. Market down, but we up

User Image Stock_Titan Posted - 03/13/24

$VIGL Vigil Announces Upcoming Presentations at 2024 American Academy of Neurology Annual Meeting https://www.stocktitan.net/news/VIGL/vigil-announces-upcoming-presentations-at-2024-american-academy-of-2wmsziugno2r.html

User Image Stock_Titan Posted - 03/12/24

$VIGL Vigil Neuroscience to Present at Stifel 2024 Virtual CNS Days https://www.stocktitan.net/news/VIGL/vigil-neuroscience-to-present-at-stifel-2024-virtual-cns-fnymw26uz8vj.html

User Image Stock_Titan Posted - 03/06/24

$VIGL Vigil Announces Oral Presentation on Small Molecule TREM2 Agonist VG-3927 as a Potential Disease-Modifying Therapeutic at AD/PD 2024 https://www.stocktitan.net/news/VIGL/vigil-announces-oral-presentation-on-small-molecule-trem2-agonist-vg-0j4jwi8ch0jo.html

User Image Stock_Titan Posted - 02/29/24

$VIGL Vigil Presents Poster on Impacts of Misdiagnosis and Genetic Testing on Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) Patient Journey at ACTRIMS 2024 https://www.stocktitan.net/news/VIGL/vigil-presents-poster-on-impacts-of-misdiagnosis-and-genetic-testing-ymp5kev18m3a.html

User Image Bugseason Posted - 02/23/24

$VIGL haulted for great news.

User Image Bugseason Posted - 02/18/24

$VIGL I like the ceo and management. im in for the long haul. Science is interesting.

User Image Ti5 Posted - 02/12/24

$VIGL something must be cooking

User Image Bugseason Posted - 02/09/24

$VIGL conference had to be good

User Image Stock_Titan Posted - 02/07/24

$VIGL Vigil Neuroscience to Present at Guggenheim 6th Annual Biotechnology Conference https://www.stocktitan.net/news/VIGL/vigil-neuroscience-to-present-at-guggenheim-6th-annual-biotechnology-yvy4apnly4i9.html

User Image Bugseason Posted - 01/31/24

$VIGL buy and hold $10 by the fall . mid year results

User Image frontiere Posted - 01/20/24

$BNOX a + sign for me is that Spyros and his team was v likely poached / convinced to join from $VIGL , not fired / other negative. Resigned 11 Dec’22 effective 4 Jan’23. Signed w BNOX 16 Dec’22 effective 5 Jan’23. Base salary up 25% from 400k to $500k+, plus 50% bonus, plus 27m stock options (Aus? So ≈150k ADS??) struck at effective $3+ ADS (5day trailing pre 21 Feb’23…very approx). Can Spyros achieve what Jan Skvarka did with $TRIL Trillium? 🤔😁 Dream, dream, dream.

User Image StockAutomatePro Posted - 01/17/24

$VIGL Not a good sign on the charts stock is headed downwards. We alerted the SELL signal at $3.45 and we were able to close this one with profit at $2.98 🥳

Analyst Ratings
JMP Securities Market Outperform Apr 19, 24
JMP Securities Market Outperform Apr 18, 24
HC Wainwright & Co. Buy Mar 27, 24
Morgan Stanley Underweight Dec 19, 23
Wedbush Outperform Nov 17, 23
Wedbush Outperform Nov 8, 23
JMP Securities Market Outperform Oct 18, 23
HC Wainwright & Co. Buy Sep 14, 23
HC Wainwright & Co. Buy Aug 9, 23
Insider Trades Relationship Date Transactions Cost($) #Shares Value($) #Share Own SEC Form 4
Magovcevic-Liebisch Ivana President and CEO President and CEO Nov 20 Buy 3.75 4,000 15,000 207,687 11/20/23
Papapetropoulos Spyros Chief Medical Office.. Chief Medical Officer Nov 18 Option 1.89 300 567 4,300 11/22/22
Papapetropoulos Spyros Chief Medical Office.. Chief Medical Officer Nov 18 Sell 14 300 4,200 4,000 11/22/22
Thorp Clay Director Director May 16 Buy 2.86 36,695 104,948 1,556,030 05/17/22
Thackaberry Evan SVP, Head of Early D.. SVP, Head of Early Development May 05 Buy 4.00 1,500 6,000 1,500 05/06/22
Verni Christopher General Counsel General Counsel May 03 Buy 3.7686 4,000 15,074 4,000 05/04/22
Magovcevic-Liebisch Ivana President and CEO President and CEO May 02 Buy 3.77 5,000 18,850 203,687 05/04/22
Ziolkowski Jennifer Lynn Chief Financial Offi.. Chief Financial Officer May 03 Buy 3.7744 4,000 15,098 4,000 05/04/22
Papapetropoulos Spyros Chief Medical Office.. Chief Medical Officer May 03 Buy 3.3978 4,000 13,591 4,000 05/04/22
Thorp Clay Director Director Jan 11 Buy 14 265,000 3,710,000 1,519,335 01/11/22
Vida Ventures GP III, L.L.C. 10% Owner 10% Owner Jan 11 Buy 14 1,675,000 23,450,000 11,536 01/11/22
Atlas Venture Fund XII, L.P. 10% Owner 10% Owner Jan 11 Buy 14 535,000 7,490,000 4,808,896 01/11/22
Booth Bruce Director Director Jan 11 Buy 14 535,000 7,490,000 4,808,896 01/11/22
Vitorovic Stefan Director Director Jan 11 Buy 14 1,675,000 23,450,000 11,536 01/11/22
Northpond Ventures GP, LLC 10% Owner 10% Owner Jan 11 Buy 14 355,000 4,970,000 1,382,978 01/11/22